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Select item 93005531.

LY450139 Inhibited Ti-Particle-Induced Bone Dissolution via Suppressing Notch and NF-κB Signaling Pathways

Jijian Gao, Peng Wu, Yingjun Chi, Hongyu Xu, Yong Zhao, Nanyan Song, Yuanqing Mao

Calcif Tissue Int. 2022; 111(2): 211–223. Published online 2022 May 19. doi: 10.1007/s00223-022-00980-2

PMCID:: PMC9300553

Abstract Article PDF–6.6M

Select item 81080662.

Hidradenitis Suppurativa-Like Lesions Associated with Pharmacologic Inhibition of Gamma-Secretase

Geraldine O’Sullivan Coyne, Therese S. Woodring, Chyi-Chia R. Lee, Alice P. Chen, Heidi H. Kong

J Invest Dermatol. Author manuscript; available in PMC 2021 May 10.

Published in final edited form as: J Invest Dermatol. 2018 Apr; 138(4): 979–981. Published online 2017 Nov 11. doi: 10.1016/j.jid.2017.09.051

PMCID:: PMC8108066

Article PDF–575K

Select item 77388553.

Expansion of murine and human olfactory epithelium/mucosa colonies and generation of mature olfactory sensory neurons under chemically defined conditions

Wenwen Ren, Li Wang, Xiujuan Zhang, Xiaoyu Feng, Liujing Zhuang, Nan Jiang, Rui Xu, Xuewen Li, Ping Wang, Xicai Sun, Hongmeng Yu, Yiqun Yu

Theranostics. 2021; 11(2): 684–699. Published online 2021 Jan 1. doi: 10.7150/thno.46750

PMCID:: PMC7738855

Abstract Article PDF–2.6M

Select item 76791394.

Asymmetric neurogenic commitment of retinal progenitors involves Notch through the endocytic pathway

Elisa Nerli, Mauricio Rocha-Martins, Caren Norden

eLife. 2020; 9: e60462. Published online 2020 Nov 3. doi: 10.7554/eLife.60462

PMCID:: PMC7679139

Abstract Article PDF–5.4M

Select item 66217065.

Differential Effects between γ-Secretase Inhibitors and Modulators on Cognitive Function in Amyloid Precursor Protein-Transgenic and Nontransgenic Mice

Yasuyuki Mitani, Junko Yarimizu, Kyoko Saita, Hiroshi Uchino, Hiroki Akashiba, Yoshitsugu Shitaka, Keni Ni, Nobuya Matsuoka

J Neurosci. 2012 Feb 8; 32(6): 2037–2050. doi: 10.1523/JNEUROSCI.4264-11.2012

PMCID:: PMC6621706

Abstract Article PDF–6.1M

Select item 64945566.

Pharmacological interventions for apathy in Alzheimer's disease

Myuri T Ruthirakuhan, Nathan Herrmann, Eleenor H Abraham, Sarah Chan, Krista L Lanctôt, Cochrane Dementia and Cognitive Improvement Group

Cochrane Database Syst Rev. 2018; 2018(5): CD012197. Published online 2018 May 4. doi: 10.1002/14651858.CD012197.pub2

PMCID:: PMC6494556

Abstract Article PDF–1014K

Select item 64937897.

REVIEW: γ‐Secretase Inhibitors for the Treatment of Alzheimer's Disease: The Current State

Francesco Panza, Vincenza Frisardi, Bruno P. Imbimbo, Cristiano Capurso, Giancarlo Logroscino, Daniele Sancarlo, Davide Seripa, Gianluigi Vendemiale, Alberto Pilotto, Vincenzo Solfrizzi

CNS Neurosci Ther. 2010 Oct; 16(5): 272–284. Published online 2010 Jun 16. doi: 10.1111/j.1755-5949.2010.00164.x

PMCID:: PMC6493789

Abstract Article PDF–212K

Select item 49237548.

Cognitive Impairment Precedes and Predicts Functional Impairment in Mild Alzheimer’s Disease

Hong Liu-Seifert, Eric Siemers, Karen Price, Baoguang Han, Katherine J. Selzler, David Henley, Karen Sundell, Paul Aisen, Jeffrey Cummings, Joel Raskin, Richard Mohs, the Alzheimer’s Disease Neuroimaging Initiative

J Alzheimers Dis. 2015; 47(1): 205–214. Published online 2015 Jul 9. doi: 10.3233/JAD-142508

PMCID:: PMC4923754

Abstract Article PDF–181K

Select item 47801489.

A single dose of the γ-secretase inhibitor semagacestat alters the cerebrospinal fluid peptidome in humans

Mikko Hölttä, Robert A. Dean, Eric Siemers, Kwasi G. Mawuenyega, Wendy Sigurdson, Patrick C. May, David M. Holtzman, Erik Portelius, Henrik Zetterberg, Randall J. Bateman, Kaj Blennow, Johan Gobom

Alzheimers Res Ther. 2016; 8: 11. Published online 2016 Mar 7. doi: 10.1186/s13195-016-0178-x

PMCID:: PMC4780148

Abstract Article PDF–1.4M

Select item 464692610.

Methodological challenges in assessing the impact of comorbidities on costs in Alzheimer’s disease clinical trials

Kristin Kahle-Wrobleski, Howard Fillit, Jonathan Kurlander, Catherine Reed, Mark Belger

Eur J Health Econ. 2015; 16(9): 995–1004. Published online 2014 Nov 20. doi: 10.1007/s10198-014-0648-7

PMCID:: PMC4646926

Abstract Article PDF–403K

Select item 455637211.

γ-Secretase and Human Disease: The role of an enzyme in disease pathogenesis extends beyond Alzheimer’s disease to a skin disorder.

Raymond J. Kelleher, III, Jie Shen

Science. Author manuscript; available in PMC 2015 Sep 1.

Published in final edited form as: Science. 2010 Nov 19; 330(6007): 1055–1056. doi: 10.1126/science.1198668

PMCID:: PMC4556372

Article PDF–490K

Select item 445784012.

Differential Inhibition of Signal Peptide Peptidase Family Members by Established γ-Secretase Inhibitors

Yong Ran, Gabriela Z. Ladd, Carolina Ceballos-Diaz, Joo In Jung, Doron Greenbaum, Kevin M. Felsenstein, Todd E. Golde

PLoS One. 2015; 10(6): e0128619. Published online 2015 Jun 5. doi: 10.1371/journal.pone.0128619

PMCID:: PMC4457840

Abstract Article PDF–2.4M

Select item 437463713.

Effect of Potent γ-Secretase Modulator in Human Neurons Derived From Multiple Presenilin 1–Induced Pluripotent Stem Cell Mutant Carriers

Qing Liu, Shannon Waltz, Grace Woodruff, Joe Ouyang, Mason A. Israel, Cheryl Herrera, Floyd Sarsoza, Rudolph E. Tanzi, Edward H. Koo, John M. Ringman, Lawrence S. B. Goldstein, Steven L. Wagner, Shauna H. Yuan

JAMA Neurol. Author manuscript; available in PMC 2015 Mar 26.

Published in final edited form as: JAMA Neurol. 2014 Dec; 71(12): 1481–1489. doi: 10.1001/jamaneurol.2014.2482

PMCID:: PMC4374637

Abstract Article PDF–1.0M

Select item 404424814.

Genetic Modulation of Soluble Aβ Rescues Cognitive and Synaptic Impairment in a Mouse Model of Alzheimer's Disease

Stephanie W. Fowler, Angie C. A. Chiang, Ricky R. Savjani, Megan E. Larson, Mathew A. Sherman, Dorothy R. Schuler, John R. Cirrito, Sylvain E. Lesné, Joanna L. Jankowsky

J Neurosci. 2014 Jun 4; 34(23): 7871–7885. doi: 10.1523/JNEUROSCI.0572-14.2014

Correction in:: J Neurosci. 2014 Dec 10; 34(50): 16917.

PMCID:: PMC4044248

Abstract Article PDF–2.7M

Select item 396428115.

Lgr5-Positive Supporting Cells Generate New Hair Cells in the Postnatal Cochlea

Naomi F. Bramhall, Fuxin Shi, Katrin Arnold, Konrad Hochedlinger, Albert S.B. Edge

Stem Cell Reports. 2014 Mar 11; 2(3): 311–322. Published online 2014 Feb 20. doi: 10.1016/j.stemcr.2014.01.008

PMCID:: PMC3964281

Abstract Article PDF–4.6M

Select item 384110516.

Capture and 3D culture of colonic crypts and colonoids in a microarray platform

Yuli Wang, Asad A. Ahmad, Pavak K. Shah, Christopher E. Sims, Scott T. Magness, Nancy L. Allbritton

Lab Chip. Author manuscript; available in PMC 2014 Dec 7.

Published in final edited form as: Lab Chip. 2013 Dec 7; 13(23): 4625–4634. doi: 10.1039/c3lc50813g

PMCID:: PMC3841105

Abstract Article PDF–1.9M

Select item 383743617.

Controlled Cortical Impact Results in an Extensive Loss of Dendritic Spines that Is Not Mediated by Injury-Induced Amyloid-Beta Accumulation

Charisse N. Winston, Deepa Chellappa, Tiffany Wilkins, David J. Barton, Patricia M. Washington, David J. Loane, David N. Zapple, Mark P. Burns

J Neurotrauma. 2013 Dec 1; 30(23): 1966–1972. doi: 10.1089/neu.2013.2960

PMCID:: PMC3837436

Abstract Article PDF–379K

Select item 360970618.

Aβ_1-15/16 as a marker for γ-secretase inhibition in Alzheimer’s disease

Erik Portelius, Henrik Zetterberg, Robert A. Dean, Alexandre Marcil, Philippe Bourgeois, Magdalena Nutu, Ulf Andreasson, Eric Siemers, Kwasi G. Mawuenyega, Wendy C. Sigurdson, Patrick C. May, Steven M. Paul, David M. Holtzman, Kaj Blennow, Randall J. Bateman

J Alzheimers Dis. Author manuscript; available in PMC 2013 Mar 27.

Published in final edited form as: J Alzheimers Dis. 2012; 31(2): 335–341. doi: 10.3233/JAD-2012-120508

PMCID:: PMC3609706

Abstract Article PDF–1.3M

Select item 357385919.

Notch Inhibition Induces Cochlear Hair Cell Regeneration and Recovery of Hearing after Acoustic Trauma

Kunio Mizutari, Masato Fujioka, Makoto Hosoya, Naomi Bramhall, Hirotaka James Okano, Hideyuki Okano, Albert S.B. Edge

Neuron. Author manuscript; available in PMC 2014 Jan 9.

Published in final edited form as: Neuron. 2013 Jan 9; 77(1): 58–69. doi: 10.1016/j.neuron.2012.10.032

Correction in:: volume 78 on page 403

PMCID:: PMC3573859

Abstract Article PDF–2.5M

Select item 352435720.

Transcriptome analysis for Notch3 target genes identifies Grip2 as a novel regulator of myogenic response in the cerebrovasculature

Charles Fouillade, Céline Baron-Menguy, Valérie Domenga-Denier, Christelle Thibault, Kogo Takamiya, Richard Huganir, Anne Joutel

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2014 Jan 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2013 Jan; 33(1): 76–86. Published online 2012 Nov 1. doi: 10.1161/ATVBAHA.112.251736