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Select item 94544571.

Substitution of l-Tryptophan by α-Methyl-l-Tryptophan in ¹⁷⁷Lu-RM2 Results in ¹⁷⁷Lu-AMTG, a High-Affinity Gastrin-Releasing Peptide Receptor Ligand with Improved In Vivo Stability

Thomas Günther, Sandra Deiser, Veronika Felber, Roswitha Beck, Hans-Jürgen Wester

J Nucl Med. 2022 Sep; 63(9): 1364–1370. doi: 10.2967/jnumed.121.263323

PMCID:: PMC9454457

Abstract Article PDF–1.0M

Select item 85338842.

The Role of Indoleamine 2,3-Dioxygenase in Renal Tubular Epithelial Cells Senescence under Anoxia or Reoxygenation

Theodoros Eleftheriadis, Georgios Pissas, Georgios Filippidis, Vassilios Liakopoulos, Ioannis Stefanidis

Biomolecules. 2021 Oct; 11(10): 1522. Published online 2021 Oct 15. doi: 10.3390/biom11101522

PMCID:: PMC8533884

Abstract Article PDF–3.5M

Select item 82018533.

Tryptophanemia is controlled by a tryptophan-sensing mechanism ubiquitinating tryptophan 2,3-dioxygenase

Simon Klaessens, Vincent Stroobant, Delia Hoffmann, Mads Gyrd-Hansen, Luc Pilotte, Nathalie Vigneron, Etienne De Plaen, Benoit J. Van den Eynde

Proc Natl Acad Sci U S A. 2021 Jun 8; 118(23): e2022447118. Published online 2021 May 31. doi: 10.1073/pnas.2022447118

PMCID:: PMC8201853

Abstract Article PDF–1.7M

Select item 80388554.

α-Methyl-l-tryptophan as a weight-loss agent in multiple models of obesity in mice

Sathish Sivaprakasam, Sabarish Ramachandran, Mohd Omar Faruk Sikder, Yangzom D. Bhutia, Mitchell W. Wachtel, Vadivel Ganapathy

Biochem J. 2021 Apr 16; 478(7): 1347–1358. Prepublished online 2021 Mar 15. Published online 2021 Apr 6. doi: 10.1042/BCJ20210100

PMCID:: PMC8038855

Abstract Article PDF–2.1M

Select item 71824415.

SLC6A14, a Na⁺/Cl⁻-coupled amino acid transporter, functions as a tumor promoter in colon and is a target for Wnt signaling

Mohd O. F. Sikder, Sathish Sivaprakasam, Timothy P. Brown, Muthusamy Thangaraju, Yangzom D. Bhutia, Vadivel Ganapathy

Biochem J. 2020 Apr 30; 477(8): 1409–1425. Prepublished online 2020 Mar 27. Published online 2020 Apr 23. doi: 10.1042/BCJ20200099

PMCID:: PMC7182441

Abstract Article PDF–5.2M

Select item 67260016.

Octopamine and Experience-Dependent Modulation of Aggression in Crickets

Paul A. Stevenson, Varya Dyakonova, Jan Rillich, Klaus Schildberger

J Neurosci. 2005 Feb 9; 25(6): 1431–1441. doi: 10.1523/JNEUROSCI.4258-04.2005

PMCID:: PMC6726001

Abstract Article PDF–636K

Select item 62804597.

The treatment value of IL-1β monoclonal antibody under the targeting location of alpha-methyl-l-tryptophan and superparamagnetic iron oxide nanoparticles in an acute temporal lobe epilepsy model

Yanli Wang, Yanling Wang, Ran Sun, Xingrao Wu, Xu Chu, Shuhu Zhou, Xibin Hu, Lingyun Gao, Qingxia Kong

J Transl Med. 2018; 16: 337. Published online 2018 Dec 4. doi: 10.1186/s12967-018-1712-3

PMCID:: PMC6280459

Abstract Article PDF–7.1M

Select item 60703038.

A distinct microRNA expression profile is associated with α[¹¹C]-methyl-L-tryptophan (AMT) PET uptake in epileptogenic cortical tubers resected from patients with tuberous sclerosis complex

Shruti Bagla, Daniela Cukovic, Eishi Asano, Sandeep Sood, Aimee Luat, Harry T. Chugani, Diane C. Chugani, Alan A. Dombkowski

Neurobiol Dis. Author manuscript; available in PMC 2019 Jan 1.

Published in final edited form as: Neurobiol Dis. 2018 Jan; 109(Pt A): 76–87. Published online 2017 Oct 7. doi: 10.1016/j.nbd.2017.10.004

PMCID:: PMC6070303

Abstract Article PDF–1.3M

Select item 57386629.

Amino acid transporter SLC6A14 is a novel and effective drug target for pancreatic cancer

V Coothankandaswamy, S Cao, Y Xu, P D Prasad, P K Singh, C P Reynolds, S Yang, J Ogura, V Ganapathy, Y D Bhutia

Br J Pharmacol. 2016 Dec; 173(23): 3292–3306. Published online 2016 Oct 18. doi: 10.1111/bph.13616

PMCID:: PMC5738662

Abstract Article PDF–1.5M

Select item 538052310.

Prognostic Molecular and Imaging Biomarkers in Primary Glioblastoma

Edit Bosnyák, Sharon K. Michelhaugh, Neil V. Klinger, David O. Kamson, Geoffrey R. Barger, Sandeep Mittal, Csaba Juhász

Clin Nucl Med. Author manuscript; available in PMC 2018 May 1.

Published in final edited form as: Clin Nucl Med. 2017 May; 42(5): 341–347. doi: 10.1097/RLU.0000000000001577

PMCID:: PMC5380523

Abstract Article PDF–741K

Select item 392680211.

Transporter targeted gatifloxacin prodrugs: Synthesis, permeability, and topical ocular delivery

Sunil K. Vooturi, Rajendra S. Kadam, Uday B. Kompella

Mol Pharm. Author manuscript; available in PMC 2014 Feb 17.

Published in final edited form as: Mol Pharm. 2012 Nov 5; 9(11): 3136–3146. Published online 2012 Oct 11. doi: 10.1021/mp300245r

PMCID:: PMC3926802

Abstract Article PDF–674K

Select item 380411912.

Differentiation of Glioblastomas from Metastatic Brain Tumors by Tryptophan Uptake and Kinetic Analysis: a Pet Study with MRI Comparison

David O. Kamson, Sandeep Mittal, Amy Buth, Otto Muzik, William J. Kupsky, Natasha L. Robinette, Geoffrey R. Barger, Csaba Juhász

Mol Imaging. Author manuscript; available in PMC 2014 Jul 1.

Published in final edited form as: Mol Imaging. 2013 Jul-Aug; 12(5): 327–337.

PMCID:: PMC3804119

Abstract Article PDF–477K

Select item 377723413.

Accurate Differentiation of Recurrent Gliomas from Radiation Injury by Kinetic Analysis of α-¹¹C-Methyl-l-Tryptophan PET

Bálint Alkonyi, Geoffrey R. Barger, Sandeep Mittal, Otto Muzik, Diane C. Chugani, Gautam Bahl, Natasha L. Robinette, William J. Kupsky, Pulak K. Chakraborty, Csaba Juhász

J Nucl Med. Author manuscript; available in PMC 2013 Sep 19.

Published in final edited form as: J Nucl Med. 2012 Jul; 53(7): 1058–1064. Published online 2012 May 31. doi: 10.2967/jnumed.111.097881

PMCID:: PMC3777234

Abstract Article PDF–507K

Select item 367791714.

Brain Regional α-[¹¹C]Methyl-L-Tryptophan Trapping in Medication-Free Patients With Obsessive-Compulsive Disorder

Dr. Alexandre Berney, Dr. Marco Leyton, Mr. Paul Gravel, Dr. Igor Sibon, Dr. Debbie Sookman, Dr. Pedro Rosa Neto, Dr. Mirko Diksic, Dr. Akio Nakai, Dr. Gilbert Pinard, Dr. Christo Todorov, Dr. Hidehiko Okazawa, Dr. Pierre Blier, Dr. Thomas Edward Nordahl, Dr. Chawki Benkelfat

Arch Gen Psychiatry. Author manuscript; available in PMC 2013 Jun 10.

Published in final edited form as: Arch Gen Psychiatry. 2011 Jul; 68(7): 732–741. Published online 2011 Mar 7. doi: 10.1001/archgenpsychiatry.2011.16

PMCID:: PMC3677917

Abstract Article PDF–484K

Select item 353092115.

Clinical and Histopathological Correlates of ¹¹C-Alpha-Methyl-L-Tryptophan (AMT) PET Abnormalities in Children with Intractable Epilepsy

Harry T Chugani, Ajay Kumar, William Kupsky, Eishi Asano, Sandeep Sood, Csaba Juhász

Epilepsia. Author manuscript; available in PMC 2012 Dec 27.

Published in final edited form as: Epilepsia. 2011 Sep; 52(9): 1692–1698. Published online 2011 May 13. doi: 10.1111/j.1528-1167.2011.03103.x

PMCID:: PMC3530921

Abstract Article PDF–512K

Select item 344332216.

TRYPTOPHAN METABOLISM IN BREAST CANCERS: MOLECULAR IMAGING AND IMMUNOHISTOCHEMISTRY STUDIES

Csaba Juhász, Zeina Nahleh, Ian Zitron, Diane C. Chugani, Majid Z. Janabi, Sudeshna Bandyopadhyay, Rouba Ali-Fehmi, Thomas J. Mangner, Pulak K. Chakraborty, Sandeep Mittal, Otto Muzik

Nucl Med Biol. Author manuscript; available in PMC 2013 Oct 1.

Published in final edited form as: Nucl Med Biol. 2012 Oct; 39(7): 926–932. Published online 2012 Mar 22. doi: 10.1016/j.nucmedbio.2012.01.010