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Select item 113226311.

Structural insights into the mechanism and dynamics of proteorhodopsin biogenesis and retinal scavenging

Stephan Hirschi, Thomas Lemmin, Nooraldeen Ayoub, David Kalbermatter, Daniele Pellegata, Zöhre Ucurum, Jürg Gertsch, Dimitrios Fotiadis

Nat Commun. 2024; 15: 6950. Published online 2024 Aug 13. doi: 10.1038/s41467-024-50960-3

PMCID:: PMC11322631

Abstract Article PDF–4.3M

Select item 112950672.

Activating an invertebrate bistable opsin with the all-trans 6.11 retinal analog

Matthew J. Rodrigues, Oliver Tejero, Jonas Mühle, Filip Pamula, Ishita Das, Ching-Ju Tsai, Akihisa Terakita, Mordechai Sheves, Gebhard F. X. Schertler

Proc Natl Acad Sci U S A. 2024 Jul 30; 121(31): e2406814121. Published online 2024 Jul 23. doi: 10.1073/pnas.2406814121

PMCID:: PMC11295067

Abstract Article PDF–1.7M

Select item 112236203.

The First Steps of the Visual Cycle in Human Rod and Cone Photoreceptors

Chunhe Chen, Leopold Adler, IV, Cole Milliken, Bushra Rahman, Masahiro Kono, Lynn Poole Perry, Federico Gonzalez-Fernandez, Yiannis Koutalos

Invest Ophthalmol Vis Sci. 2024 Jul; 65(8): 9. Published online 2024 Jul 3. doi: 10.1167/iovs.65.8.9

PMCID:: PMC11223620

Abstract Article PDF–1.5M

Select item 112140564.

Ultrafast terahertz Stark spectroscopy reveals the excited-state dipole moments of retinal in bacteriorhodopsin

Jia Zhang, Poonam Singh, Dieter Engel, Benjamin P. Fingerhut, Matthias Broser, Peter Hegemann, Thomas Elsaesser

Proc Natl Acad Sci U S A. 2024 Jun 25; 121(26): e2319676121. Published online 2024 Jun 20. doi: 10.1073/pnas.2319676121

PMCID:: PMC11214056

Abstract Article PDF–3.5M

Select item 111429225.

Carotenoid cleavage enzymes evolved convergently to generate the visual chromophore

Yasmeen J. Solano, Michael P. Everett, Kelly S. Dang, Jude Abueg, Philip D. Kiser

Nat Chem Biol. 2024; 20(6): 779–788. Published online 2024 Feb 14. doi: 10.1038/s41589-024-01554-z

PMCID:: PMC11142922

Abstract Article PDF–6.9M

Select item 111386086.

Specific isomerization of rhodopsin-bound 11-cis-retinal to all-trans-retinal under thermal denaturation

L. J. Del Valle, E. Ramon, L. Bosch, J. Manyosa, P. Garriga

Cell Mol Life Sci. 2003 Nov; 60(11): 2532–2537. doi: 10.1007/s00018-003-3113-9

PMCID:: PMC11138608

Abstract Article PDF–145K

Select item 111384747.

Alcohol dehydrogenase 2 is a major hepatic enzyme for human retinol metabolism

M. Hellgren, P. Strömberg, O. Gallego, S. Martras, J. Farrés, B. Persson, X. Parés, J. -O. Höög

Cell Mol Life Sci. 2007 Feb; 64(4): 498. Published online 2007 Feb 5. doi: 10.1007/s00018-007-6449-8

PMCID:: PMC11138474

Abstract Article PDF–733K

Select item 111203308.

Retinoid Synthesis Regulation by Retinal Cells in Health and Disease

Massimiliano Andreazzoli, Biancamaria Longoni, Debora Angeloni, Gian Carlo Demontis

Cells. 2024 May; 13(10): 871. Published online 2024 May 18. doi: 10.3390/cells13100871

PMCID:: PMC11120330

Abstract Article PDF–2.8M

Select item 110874709.

Uncommon opsin’s retinal isomer is involved in mammalian sperm thermotaxis

Alexander Brandis, Debarun Roy, Ishita Das, Mordechai Sheves, Michael Eisenbach

Sci Rep. 2024; 14: 10699. Published online 2024 May 10. doi: 10.1038/s41598-024-61488-3

PMCID:: PMC11087470

Abstract Article PDF–2.1M

Select item 1095088810.

Unraveling the mystery of ocular retinoid turnover: Insights from albino mice and the role of STRA6

Srinivasagan Ramkumar, Beata Jastrzebska, Diego Montenegro, Janet R. Sparrow, Johannes von Lintig

J Biol Chem. 2024 Mar; 300(3): 105781. Published online 2024 Feb 21. doi: 10.1016/j.jbc.2024.105781

PMCID:: PMC10950888

Abstract Article PDF–2.1M

Select item 1087763111.

Retinylidene chromophore hydrolysis from mammalian visual and non-visual opsins

John D. Hong, David Salom, Elliot H. Choi, Samuel W. Du, Aleksander Tworak, Roman Smidak, Fangyuan Gao, Yasmeen J. Solano, Jianye Zhang, Philip D. Kiser, Krzysztof Palczewski

J Biol Chem. 2024 Mar; 300(3): 105678. Published online 2024 Jan 23. doi: 10.1016/j.jbc.2024.105678

PMCID:: PMC10877631

Abstract Article PDF–4.0M

Select item 1082448912.

Tuning the metabolic stability of visual cycle modulators through modification of an RPE65 recognition motif

Marco Bassetto, Jordan Zaluski, Bowen Li, Jianye Zhang, Mohsen Badiee, Philip Kiser, Gregory P. Tochtrop

J Med Chem. Author manuscript; available in PMC 2024 Jun 22.

Published in final edited form as: J Med Chem. 2023 Jun 22; 66(12): 8140–8158. Published online 2023 Jun 6. doi: 10.1021/acs.jmedchem.3c00461

PMCID:: PMC10824489

Abstract Article PDF–1.3M

Select item 1077900113.

Scavenging of Cation Radicals of the Visual Cycle Retinoids by Lutein, Zeaxanthin, Taurine, and Melanin

Malgorzata Rozanowska, Ruth Edge, Edward J. Land, Suppiah Navaratnam, Tadeusz Sarna, T. George Truscott

Int J Mol Sci. 2024 Jan; 25(1): 506. Published online 2023 Dec 29. doi: 10.3390/ijms25010506

PMCID:: PMC10779001

Abstract Article PDF–5.2M

Select item 1072305014.

Distinct mouse models of Stargardt disease display differences in pharmacological targeting of ceramides and inflammatory responses

Zachary J. Engfer, Dominik Lewandowski, Zhiqian Dong, Grazyna Palczewska, Jianye Zhang, Katarzyna Kordecka, Jagoda Płaczkiewicz, Damian Panas, Andrzej T. Foik, Marcin Tabaka, Krzysztof Palczewski

Proc Natl Acad Sci U S A. 2023 Dec 12; 120(50): e2314698120. Published online 2023 Dec 8. doi: 10.1073/pnas.2314698120

PMCID:: PMC10723050

Abstract Article PDF–5.4M

Select item 1061470115.

A short story on how chromophore is hydrolyzed from rhodopsin for recycling

John D. Hong, Krzysztof Palczewski

Bioessays. Author manuscript; available in PMC 2023 Oct 30.

Published in final edited form as: Bioessays. 2023 Sep; 45(9): e2300068. Published online 2023 Jul 16. doi: 10.1002/bies.202300068

PMCID:: PMC10614701

Abstract Article PDF–1.7M

Select item 1053049416.

Rapid RGR-dependent visual pigment recycling is mediated by the RPE and specialized Müller glia

Aleksander Tworak, Alexander V. Kolesnikov, John D. Hong, Elliot H. Choi, Jennings C. Luu, Grazyna Palczewska, Zhiqian Dong, Dominik Lewandowski, Matthew J. Brooks, Laura Campello, Anand Swaroop, Philip D. Kiser, Vladimir J. Kefalov, Krzysztof Palczewski

Cell Rep. Author manuscript; available in PMC 2023 Sep 27.

Published in final edited form as: Cell Rep. 2023 Aug 29; 42(8): 112982. Published online 2023 Aug 15. doi: 10.1016/j.celrep.2023.112982

PMCID:: PMC10530494

Abstract Article PDF–3.2M

Select item 1051991917.

Therapeutic Extracellular Vesicles from Tonsil-Derived Mesenchymal Stem Cells for the Treatment of Retinal Degenerative Disease

Seung Woo Choi, Sooin Seo, Hye Kyoung Hong, So Jung Yoon, Minah Kim, Sunghyun Moon, Joo Yong Lee, Jaeseung Lim, Jong Bum Lee, Se Joon Woo

Tissue Eng Regen Med. 2023 Oct; 20(6): 951–964. Published online 2023 Jul 13. doi: 10.1007/s13770-023-00555-8

PMCID:: PMC10519919

Abstract Article PDF–2.1M

Select item 1042856818.

Stargardt disease-associated in-frame ABCA4 exon 17 skipping results in significant ABCA4 function

Melita Kaltak, Rocio Blanco-Garavito, Laurie L. Molday, Claire-Marie Dhaenens, Eric E. Souied, Gerard Platenburg, Jim Swildens, Robert S. Molday, Frans P. M. Cremers

J Transl Med. 2023; 21: 546. Published online 2023 Aug 16. doi: 10.1186/s12967-023-04406-x