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Select item 111568991.

High-throughput screening unveils nitazoxanide as a potent PRRSV inhibitor by targeting NMRAL1

Zhanding Cui, Jinlong Liu, Chong Xie, Tao Wang, Pu Sun, Jinlong Wang, Jiaoyang Li, Guoxiu Li, Jicheng Qiu, Ying Zhang, Dengliang Li, Ying Sun, Juanbin Yin, Kun Li, Zhixun Zhao, Hong Yuan, Xingwen Bai, Xueqing Ma, Pinghua Li, Yuanfang Fu, Huifang Bao, Dong Li, Qiang Zhang, Zaixin Liu, Yimei Cao, Jing Zhang, Zengjun Lu

Nat Commun. 2024; 15: 4813. Published online 2024 Jun 6. doi: 10.1038/s41467-024-48807-y

PMCID:: PMC11156899

Abstract Article PDF–3.0M

Select item 110101282.

Systemic efficacy on Cryptosporidium parvum infection of aminoxanide (RM-5061), a new amino-acid ester thiazolide prodrug of tizoxanide

El Hadji Diawara, Arnaud François, Andrew V. Stachulski, Romy Razakandrainibe, Damien Costa, Loïc Favennec, Jean-François Rossignol, Gilles Gargala

Parasitology. 2021 Jul; 148(8): 975–984. Published online 2021 Mar 29. doi: 10.1017/S0031182021000524

PMCID:: PMC11010128

Abstract Article PDF–777K

Select item 100559173.

Tizoxanide Antiviral Activity on Dengue Virus Replication

Kristie A. Yamamoto, Kevin Blackburn, Michael B. Goshe, Dennis T. Brown, Edimilson Migoswski, Isabele B. Campanhon, Monica F. Moreira, Davis F. Ferreira, Marcia R. Soares

Viruses. 2023 Mar; 15(3): 696. Published online 2023 Mar 7. doi: 10.3390/v15030696

PMCID:: PMC10055917

Abstract Article PDF–716K

Select item 74772004.

Quantitative proteomic analysis of the tizoxanide effect in vero cells

K. A. Yamamoto, K. Blackburn, E. Migowski, M. B. Goshe, D. T. Brown, D. F. Ferreira, M. R. Soares

Sci Rep. 2020; 10: 14733. Published online 2020 Sep 7. doi: 10.1038/s41598-020-71634-2

PMCID:: PMC7477200

Abstract Article PDF–1.4M

Select item 71170455.

Prophylactic and therapeutic efficacy of nitazoxanide against Cryptosporidium parvum in experimentally challenged neonatal calves

M. Schnyder, L. Kohler, A. Hemphill, P. Deplazes

Vet Parasitol. 2009 Mar 9; 160(1): 149–154. Published online 2008 Nov 5. doi: 10.1016/j.vetpar.2008.10.094

PMCID:: PMC7117045

Abstract Article PDF–402K

Select item 62010766.

Nitazoxanide Inhibits Human Norovirus Replication and Synergizes with Ribavirin by Activation of Cellular Antiviral Response

Wen Dang, Lei Xu, Buyun Ma, Sunrui Chen, Yuebang Yin, Kyeong-Ok Chang, Maikel P. Peppelenbosch, Qiuwei Pan

Antimicrob Agents Chemother. 2018 Nov; 62(11): e00707-18. Prepublished online 2018 Aug 13. Published online 2018 Oct 24. doi: 10.1128/AAC.00707-18

PMCID:: PMC6201076

Abstract Article PDF–2.7M

Select item 60413197.

Nitazoxanide inhibits paramyxovirus replication by targeting the Fusion protein folding: role of glycoprotein-specific thiol oxidoreductase ERp57

Sara Piacentini, Simone La Frazia, Anna Riccio, Jens Z. Pedersen, Alessandra Topai, Orazio Nicolotti, Jean-Francois Rossignol, M. Gabriella Santoro

Sci Rep. 2018; 8: 10425. Published online 2018 Jul 11. doi: 10.1038/s41598-018-28172-9

PMCID:: PMC6041319

Abstract Article PDF–4.4M

Select item 48900118.

Thiazolides Elicit Anti-Viral Innate Immunity and Reduce HIV Replication

Daria Trabattoni, Federica Gnudi, Salomè V. Ibba, Irma Saulle, Simone Agostini, Michela Masetti, Mara Biasin, Jean-Francois Rossignol, Mario Clerici

Sci Rep. 2016; 6: 27148. Published online 2016 Jun 2. doi: 10.1038/srep27148

PMCID:: PMC4890011

Abstract Article PDF–1.3M

Select item 48644909.

Activity of Nitazoxanide and Tizoxanide against Mycobacterium tuberculosis in vitro and in whole blood culture

Elizabeth P. Harausz, Keith A. Chervenak, Caryn E. Good, Michael R. Jacobs, Robert S. Wallis, Manuel Sanchez-Felix, W. Henry Boom, for the TB Research Unit (TBRU) at Case Western Reserve University

Tuberculosis (Edinb) Author manuscript; available in PMC 2017 May 1.

Published in final edited form as: Tuberculosis (Edinb). 2016 May; 98: 92–96. Published online 2016 Mar 22. doi: 10.1016/j.tube.2016.03.002

PMCID:: PMC4864490

Abstract Article PDF–485K

Select item 380729310.

Thiazolides, a New Class of Antiviral Agents Effective against Rotavirus Infection, Target Viral Morphogenesis, Inhibiting Viroplasm Formation

Simone La Frazia, Alessandra Ciucci, Francesca Arnoldi, Maurizio Coira, Patrizia Gianferretti, Mara Angelini, Giuseppe Belardo, Oscar R. Burrone, Jean-Francois Rossignol, M. Gabriella Santoro

J Virol. 2013 Oct; 87(20): 11096–11106. doi: 10.1128/JVI.01213-13

PMCID:: PMC3807293

Abstract Article PDF–3.2M

Select item 335206811.

Effects of Doxycycline on gene expression in Wolbachia and Brugia malayi adult female worms in vivo

Ramakrishna U Rao, Yuefang Huang, Sahar Abubucker, Michael Heinz, Seth D Crosby, Makedonka Mitreva, Gary J Weil

J Biomed Sci. 2012; 19(1): 21. Published online 2012 Feb 9. doi: 10.1186/1423-0127-19-21

PMCID:: PMC3352068

Abstract Article PDF–1.4M

Select item 334975212.

Nitazoxanide Stimulates Autophagy and Inhibits mTORC1 Signaling and Intracellular Proliferation of Mycobacterium tuberculosis

Karen K. Y. Lam, Xingji Zheng, Roberto Forestieri, Aruna D. Balgi, Matt Nodwell, Sarah Vollett, Hilary J. Anderson, Raymond J. Andersen, Yossef Av-Gay, Michel Roberge

PLoS Pathog. 2012 May; 8(5): e1002691. Published online 2012 May 10. doi: 10.1371/journal.ppat.1002691