PMC Links for OMIM (Select 601763) - PMC

Select item 88226201.

Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway

Daniel S. Simpson, Jiyi Pang, Ashley Weir, Isabella Y. Kong, Melanie Fritsch, Maryam Rashidi, James P. Cooney, Kathryn C. Davidson, Mary Speir, Tirta M. Djajawi, Sebastian Hughes, Liana Mackiewicz, Merle Dayton, Holly Anderton, Marcel Doerflinger, Yexuan Deng, Allan Shuai Huang, Stephanie A. Conos, Hazel Tye, Seong H. Chow, Arfatur Rahman, Raymond S. Norton, Thomas Naderer, Sandra E. Nicholson, Gaetan Burgio, Si Ming Man, Joanna R. Groom, Marco J. Herold, Edwin D. Hawkins, Kate E. Lawlor, Andreas Strasser, John Silke, Marc Pellegrini, Hamid Kashkar, Rebecca Feltham, James E. Vince

Immunity. 2022 Mar 8; 55(3): 423–441.e9. Published online 2022 Feb 8. doi: 10.1016/j.immuni.2022.01.003

PMCID:: PMC8822620

Abstract Article PDF–6.5M

Select item 73752592.

cFLIP_L protects macrophages from LPS-induced pyroptosis via inhibition of complex II formation

Hayley I. Muendlein, David Jetton, Wilson M. Connolly, Keith P. Eidell, Zoie Magri, Irina Smirnova, Alexander Poltorak

Science. Author manuscript; available in PMC 2020 Jul 22.

Published in final edited form as: Science. 2020 Mar 20; 367(6484): 1379–1384. doi: 10.1126/science.aay3878

PMCID:: PMC7375259

Abstract Article PDF–1.6M

Select item 73060013.

Caspase-8-dependent inflammatory responses are controlled by its adapter, FADD, and necroptosis

Bart Tummers, Luigi Mari, Clifford S. Guy, Bradlee L. Heckmann, Diego A. Rodriguez, Sebastian Rühl, Julien Moretti, Jeremy Chase Crawford, Patrick Fitzgerald, Thirumala-Devi Kanneganti, Laura J. Janke, Stephane Pelletier, J. Magarian Blander, Douglas R. Green

Immunity. Author manuscript; available in PMC 2021 Jun 16.

Published in final edited form as: Immunity. 2020 Jun 16; 52(6): 994–1006.e8. Published online 2020 May 18. doi: 10.1016/j.immuni.2020.04.010

PMCID:: PMC7306001

Abstract Article PDF–1.8M

Select item 60646394.

Caspase-8 Collaborates with Caspase-11 to Drive Tissue Damage and Execution of Endotoxic Shock

Pratyusha Mandal, Yanjun Feng, John D. Lyons, Scott B. Berger, Shunsuke Otani, Alexandra DeLaney, Gregory K. Tharp, Kristal Maner-Smith, Eileen M. Burd, Michelle Schaeffer, Sandra Hoffman, Carol Capriotti, Linda Roback, Cedrick B. Young, Zhe Liang, Eric A. Ortlund, Nelson C. DiPaolo, Steven Bosinger, John Bertin, Peter J. Gough, Igor E. Brodsky, Craig M. Coopersmith, Dmitry M. Shayakhmetov, Edward S. Mocarski

Immunity. Author manuscript; available in PMC 2019 Jul 17.

Published in final edited form as: Immunity. 2018 Jul 17; 49(1): 42–55.e6. doi: 10.1016/j.immuni.2018.06.011

PMCID:: PMC6064639

Abstract Article PDF–2.4M

Select item 33737305.

Caspase-8 regulates TNF-alpha induced epithelial necroptosis and terminal ileitis

Claudia Günther, Eva Martini, Nadine Wittkopf, Kerstin Amann, Benno Weigmann, Helmut Neumann, Maximilian Waldner, Stephen M. Hedrick, Stefan Tenzer, Markus F. Neurath, Christoph Becker

Nature. Author manuscript; available in PMC 2012 Jun 12.

Published in final edited form as: Nature. 2011 Sep 15; 477(7364): 335–339. Published online 2011 Sep 14. doi: 10.1038/nature10400

PMCID:: PMC3373730

Abstract Article PDF–1.1M

Select item 32296616.

CASPASE 8 inhibits programmed necrosis by processing CYLD

Marie Anne O’Donnell, Eva Perez-Jimenez, Andrew Oberst, Aylwin Ng, Ramin Massoumi, Ramnik Xavier, Douglas R. Green, Adrian T. Ting

Nat Cell Biol. Author manuscript; available in PMC 2012 Jun 1.

Published in final edited form as: Nat Cell Biol. 2011 Dec; 13(12): 1437–1442. Published online 2011 Oct 30. doi: 10.1038/ncb2362

PMCID:: PMC3229661

Abstract Article PDF–1.3M

Select item 30778937.

Catalytic activity of the caspase-8-FLIP_L complex inhibits RIPK3-dependent necrosis

Andrew Oberst, Christopher P. Dillon, Ricardo Weinlich, Laura L. McCormick, Patrick Fitzgerald, Cristina Pop, Razq Hakem, Guy S. Salvesen, Douglas R. Green

Nature. Author manuscript; available in PMC 2011 Sep 17.

Published in final edited form as: Nature. 2011 Mar 17; 471(7338): 363–367. Published online 2011 Mar 2. doi: 10.1038/nature09852

PMCID:: PMC3077893

Abstract Article PDF–1022K

Select item 30602928.

RIP3 mediates the embryonic lethality of caspase-8-deficient mice

William J. Kaiser, Jason W. Upton, Alyssa B. Long, Devon Livingston-Rosanoff, Lisa P. Daley, Razqallah Hakem, Tamara Caspary, Edward S. Mocarski

Nature. Author manuscript; available in PMC 2011 Sep 17.

Published in final edited form as: Nature. 2011 Mar 17; 471(7338): 368–372. Published online 2011 Mar 2. doi: 10.1038/nature09857

PMCID:: PMC3060292

Abstract Article PDF–1.4M

Select item 26662619.

Dynamic expression of epidermal caspase-8 simulates a wound healing response

Nature. Author manuscript; available in PMC 2009 Sep 26.

Published in final edited form as: Nature. 2009 Mar 26; 458(7237): 519–523. Published online 2009 Feb 8. doi: 10.1038/nature07687

PMCID:: PMC2666261

Abstract Article PDF–1.7M

Select item 244231110.

Identification of a Critical Tyrosine Residue in Caspase 8 That Promotes Cell Migration

Simone Barbero, Daniela Barilà, Ainhoa Mielgo, Venturina Stagni, Kiran Clair, Dwayne Stupack

J Biol Chem. 2008 May 9; 283(19): 13031–13034. doi: 10.1074/jbc.M800549200

PMCID:: PMC2442311

Abstract Article PDF–455K

Select item 221295411.

Caspase-8 deficiency in T cells leads to a lethal lymphoinfiltrative immune disorder

Leonardo Salmena, Razqallah Hakem

J Exp Med. 2005 Sep 19; 202(6): 727–732. doi: 10.1084/jem.20050683

PMCID:: PMC2212954

Abstract Article PDF–1.3M

Select item 221191812.

Absence of Caspase 8 and High Expression of PED Protect Primitive Neural Cells from Cell Death

Lucia Ricci-Vitiani, Francesca Pedini, Cristiana Mollinari, Gerolama Condorelli, Désirée Bonci, Alessandra Bez, Augusto Colombo, Eugenio Parati, Cesare Peschle, Ruggero De Maria

J Exp Med. 2004 Nov 15; 200(10): 1257–1266. doi: 10.1084/jem.20040921

PMCID:: PMC2211918

Abstract Article PDF–3.6M

Select item 16466713.

Caspase 8 small interfering RNA prevents acute liver failure in mice

Lars Zender, Sebastian Hütker, Christian Liedtke, Hans Ludger Tillmann, Steffen Zender, Bettina Mundt, Morlen Waltemathe, Thomas Gösling, Peer Flemming, Nisar Peter Malek, Christian Trautwein, Michael Peter Manns, Florian Kühnel, Stefan Kubicka

Proc Natl Acad Sci U S A. 2003 Jun 24; 100(13): 7797–7802. Published online 2003 Jun 16. doi: 10.1073/pnas.1330920100

PMCID:: PMC164667

Abstract Article PDF–418K

Select item 3876714.

In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains.

T Fernandes-Alnemri, R C Armstrong, J Krebs, S M Srinivasula, L Wang, F Bullrich, L C Fritz, J A Trapani, K J Tomaselli, G Litwack, E S Alnemri

Proc Natl Acad Sci U S A. 1996 Jul 23; 93(15): 7464–7469. doi: 10.1073/pnas.93.15.7464

PMCID:: PMC38767

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