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Select item 68830721.

The targetable kinase PIM1 drives ALK inhibitor resistance in high-risk neuroblastoma independent of MYCN status

Ricky M. Trigg, Liam C. Lee, Nina Prokoph, Leila Jahangiri, C. Patrick Reynolds, G. A. Amos Burke, Nicola A. Probst, Miaojun Han, Jamie D. Matthews, Hong Kai Lim, Eleanor Manners, Sonia Martinez, Joaquin Pastor, Carmen Blanco-Aparicio, Olaf Merkel, Ines Garces de los Fayos Alonso, Petra Kodajova, Simone Tangermann, Sandra Högler, Ji Luo, Lukas Kenner, Suzanne D. Turner

Nat Commun. 2019; 10: 5428. Published online 2019 Nov 28. doi: 10.1038/s41467-019-13315-x

PMCID:: PMC6883072

Abstract Article PDF–1.7M

Select item 66940962.

PIM1 is responsible for IL-6-induced breast cancer cell EMT and stemness via c-myc activation

Xueqiang Gao, Xiangping Liu, Yangyong Lu, Yu Wang, Weihong Cao, Xiaoyi Liu, Haiyan Hu, Haibo Wang

Breast Cancer. 2019; 26(5): 663–671. Published online 2019 Apr 15. doi: 10.1007/s12282-019-00966-3

PMCID:: PMC6694096

Abstract Article PDF–7.3M

Select item 64790523.

PIM kinases facilitate lentiviral evasion from SAMHD1 restriction via Vpx phosphorylation

Kei Miyakawa, Satoko Matsunaga, Masaru Yokoyama, Masako Nomaguchi, Yayoi Kimura, Mayuko Nishi, Hirokazu Kimura, Hironori Sato, Hisashi Hirano, Tomohiko Tamura, Hirofumi Akari, Tomoyuki Miura, Akio Adachi, Tatsuya Sawasaki, Naoki Yamamoto, Akihide Ryo

Nat Commun. 2019; 10: 1844. Published online 2019 Apr 23. doi: 10.1038/s41467-019-09867-7

PMCID:: PMC6479052

Abstract Article PDF–1.8M

Select item 4526984.

The pim-1 oncogene encodes two related protein-serine/threonine kinases by alternative initiation at AUG and CUG.

C J Saris, J Domen, A Berns

EMBO J. 1991 Mar; 10(3): 655–664. doi: 10.1002/j.1460-2075.1991.tb07994.x

PMCID:: PMC452698

Summary Page Browse PDF–2.5M

Select item 3633085.

Identification of the human pim-1 gene product as a 33-kilodalton cytoplasmic protein with tyrosine kinase activity.

A Telerman, R Amson, R Zakut-Houri, D Givol

Mol Cell Biol. 1988 Apr; 8(4): 1498–1503. doi: 10.1128/mcb.8.4.1498

PMCID:: PMC363308

Summary Page Browse PDF–1.2M

Select item 2983896.

The human protooncogene product p33pim is expressed during fetal hematopoiesis and in diverse leukemias.

R Amson, F Sigaux, S Przedborski, G Flandrin, D Givol, A Telerman

Proc Natl Acad Sci U S A. 1989 Nov; 86(22): 8857–8861. doi: 10.1073/pnas.86.22.8857

PMCID:: PMC298389

Summary Page Browse PDF–1.4M

Select item 66942727.

Differential expression of genes associated with hypoxia pathway on bone marrow stem cells in osteoporosis patients with different bone mass index

Qi Zhu, Chang Shan, Ling Li, Lige Song, Keqin Zhang, Yun Zhou

Ann Transl Med. 2019 Jul; 7(14): 309. doi: 10.21037/atm.2019.06.27

PMCID:: PMC6694272

Abstract Article PDF–3.5M

Select item 65879248.

Expression of STAT3-regulated genes in circulating CD4+ T cells discriminates rheumatoid arthritis independently of clinical parameters in early arthritis

Amy E Anderson, Nicola J Maney, Nisha Nair, Dennis W Lendrem, Andrew J Skelton, Julie Diboll, Philip M Brown, Graham R Smith, Ruaidhrí J Carmody, Anne Barton, John D Isaacs, Arthur G Pratt

Rheumatology (Oxford) 2019 Jul; 58(7): 1250–1258. Published online 2019 Feb 8. doi: 10.1093/rheumatology/kez003

PMCID:: PMC6587924

Abstract Article PDF–540K

Select item 65586289.

LncRNA HOXA11-AS Promotes Proliferation and Cisplatin Resistance of Oral Squamous Cell Carcinoma by Suppression of miR-214-3p Expression

Xiaoyan Wang, Hong Li, Jing Shi

Biomed Res Int. 2019; 2019: 8645153. Published online 2019 May 28. doi: 10.1155/2019/8645153

PMCID:: PMC6558628

Abstract Article PDF–1.9M

Select item 595542710.

Gene expression profiling in prognosis of distant recurrence in HR-positive and HER2-negative breast cancer patients

Tzu-Ting Huang, Nicolas Pennarun, Yu-Hao Cheng, Cheng-Fang Horng, Jason Lei, Skye Hung-Chun Cheng

Oncotarget. 2018 May 1; 9(33): 23173–23182. Published online 2018 May 1. doi: 10.18632/oncotarget.25258

PMCID:: PMC5955427

Abstract Article PDF–2.6M

Select item 529965611.

A case report of concurrent embryonal rhabdomyosarcoma and diffuse large B-cell lymphoma in an adult without identifiable cancer predisposition

M. D. Mathias, M. V. Ortiz, H. Magnan, S. R. Ambati, E. K. Slotkin, A. J. Chou, M. F. Walsh, K. Offit, C. Moskowitz, A. Kentsis, L. H. Wexler

Biomark Res. 2017; 5: 7. Published online 2017 Feb 8. doi: 10.1186/s40364-017-0086-7

PMCID:: PMC5299656

Abstract Article PDF–871K

Select item 473696112.

Dexamethasone Regulates EphA5, a Potential Inhibitory Factor with Osteogenic Capability of Human Bone Marrow Stromal Cells

Tsuyoshi Yamada, Toshitaka Yoshii, Hiroaki Yasuda, Atsushi Okawa, Shinichi Sotome

Stem Cells Int. 2016; 2016: 1301608. Published online 2016 Jan 10. doi: 10.1155/2016/1301608

PMCID:: PMC4736961

Abstract Article PDF–3.8M

Select item 455767913.

Vγ2Vδ2 T-cell co-stimulation increases natural killer cell killing of monocyte-derived dendritic cells

Cristiana Cairo, Naveen Surendran, Kristina M Harris, Krystyna Mazan-Mamczarz, Yukimi Sakoda, Felisa Diaz-Mendez, Koji Tamada, Ronald B Gartenhaus, Dean L Mann, C David Pauza

Immunology. 2015 Mar; 144(3): 422–430. doi: 10.1111/imm.12386

PMCID:: PMC4557679

Abstract Article PDF–568K

Select item 447764814.

Duplex stem-loop-containing quadruplex motifs in the human genome: a combined genomic and structural study

Kah Wai Lim, Piroon Jenjaroenpun, Zhen Jie Low, Zi Jian Khong, Yi Siang Ng, Vladimir Andreevich Kuznetsov, Anh Tuân Phan

Nucleic Acids Res. 2015 Jun 23; 43(11): 5630–5646. Published online 2015 May 9. doi: 10.1093/nar/gkv355

PMCID:: PMC4477648

Abstract Article PDF–4.6M

Select item 422770415.

PIM Kinases as Potential Therapeutic Targets in a Subset of Peripheral T Cell Lymphoma Cases

Esperanza Martín-Sánchez, Lina Odqvist, Socorro M. Rodríguez-Pinilla, Margarita Sánchez-Beato, Giovanna Roncador, Beatriz Domínguez-González, Carmen Blanco-Aparicio, Ana M. García Collazo, Esther González Cantalapiedra, Joaquín Pastor Fernández, Soraya Curiel del Olmo, Helena Pisonero, Rebeca Madureira, Carmen Almaraz, Manuela Mollejo, F. Javier Alves, Javier Menárguez, Fernando González-Palacios, José Luis Rodríguez-Peralto, Pablo L. Ortiz-Romero, Francisco X. Real, Juan F. García, James R. Bischoff, Miguel A. Piris

PLoS One. 2014; 9(11): e112148. Published online 2014 Nov 11. doi: 10.1371/journal.pone.0112148