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Select item 69423071.

Rapid response of stage IV colorectal cancer with APC/TP53/KRAS mutations to FOLFIRI and Bevacizumab combination chemotherapy: a case report of use of liquid biopsy

Alexander Hendricks, Philip Rosenstiel, Sebastian Hinz, Greta Burmeister, Christoph Röcken, Kathrin Boersch, Clemens Schafmayer, Thomas Becker, Andre Franke, Michael Forster

BMC Med Genet. 2020; 21: 3. Published online 2020 Jan 3. doi: 10.1186/s12881-019-0941-5

PMCID:: PMC6942307

Abstract Article PDF–1.1M

Select item 68281382.

Correction to: Identification of novel mutations in FFPE lung adenocarcinomas using DEPArray sorting technology and next-generation sequencing

Ji Won Lee, Jong-Yeon Shin, Jeong-Sun Seo

J Appl Genet. 2018; 59(3): 279–280. Published online 2018 Apr 24. doi: 10.1007/s13353-018-0442-9

Corrects:: J Appl Genet. 2018; 59(3): 269–277.

PMCID:: PMC6828138

Correction PDF–284K

Select item 66913353.

The DNA walk and its demonstration of deterministic chaos—relevance to genomic alterations in lung cancer

Blake Hewelt, Haiqing Li, Mohit Kumar Jolly, Prakash Kulkarni, Isa Mambetsariev, Ravi Salgia

Bioinformatics. 2019 Aug 15; 35(16): 2738–2748. Published online 2019 Jan 7. doi: 10.1093/bioinformatics/bty1021

PMCID:: PMC6691335

Abstract Article PDF–1.0M

Select item 66607004.

A clinical survey of mosaic single nucleotide variants in disease-causing genes detected by exome sequencing

Ye Cao, Mari J. Tokita, Edward S. Chen, Rajarshi Ghosh, Tiansheng Chen, Yanming Feng, Elizabeth Gorman, Federica Gibellini, Patricia A. Ward, Alicia Braxton, Xia Wang, Linyan Meng, Rui Xiao, Weimin Bi, Fan Xia, Christine M. Eng, Yaping Yang, Tomasz Gambin, Chad Shaw, Pengfei Liu, Pawel Stankiewicz

Genome Med. 2019; 11: 48. Published online 2019 Jul 26. doi: 10.1186/s13073-019-0658-2

PMCID:: PMC6660700

Abstract Article PDF–980K

Select item 66173925.

Genomic and Transcriptomic Determinants of Therapy Resistance and Immune Landscape Evolution during Anti-EGFR Treatment in Colorectal Cancer

Andrew Woolston, Khurum Khan, Georgia Spain, Louise J. Barber, Beatrice Griffiths, Reyes Gonzalez-Exposito, Lisa Hornsteiner, Marco Punta, Yatish Patil, Alice Newey, Sonia Mansukhani, Matthew N. Davies, Andrew Furness, Francesco Sclafani, Clare Peckitt, Mirta Jiménez, Kyriakos Kouvelakis, Romana Ranftl, Ruwaida Begum, Isma Rana, Janet Thomas, Annette Bryant, Sergio Quezada, Andrew Wotherspoon, Nasir Khan, Nikolaos Fotiadis, Teresa Marafioti, Thomas Powles, Stefano Lise, Fernando Calvo, Sebastian Guettler, Katharina von Loga, Sheela Rao, David Watkins, Naureen Starling, Ian Chau, Anguraj Sadanandam, David Cunningham, Marco Gerlinger

Cancer Cell. 2019 Jul 8; 36(1): 35–50.e9. doi: 10.1016/j.ccell.2019.05.013

PMCID:: PMC6617392

Abstract Article PDF–4.9M

Select item 65940816.

Integrative Analysis Defines Distinct Prognostic Subgroups of Intrahepatic Cholangiocarcinoma

Benjamin Goeppert, Reka Toth, Stephan Singer, Thomas Albrecht, Daniel B. Lipka, Pavlo Lutsik, David Brocks, Marion Baehr, Oliver Muecke, Yassen Assenov, Lei Gu, Volker Endris, Albrecht Stenzinger, Arianeb Mehrabi, Peter Schirmacher, Christoph Plass, Dieter Weichenhan, Stephanie Roessler

Hepatology. 2019 May; 69(5): 2091–2106. Published online 2019 Feb 28. doi: 10.1002/hep.30493

PMCID:: PMC6594081

Abstract Article PDF–1.0M

Select item 64764987.

Arsenite malignantly transforms human prostate epithelial cells in vitro by gene amplification of mutated KRAS

B. Alex Merrick, Dhiral P. Phadke, Meredith A. Bostrom, Ruchir R. Shah, Garron M. Wright, Xinguo Wang, Oksana Gordon, Katherine E. Pelch, Scott S. Auerbach, Richard S. Paules, Michael J. DeVito, Michael P. Waalkes, Erik J. Tokar

PLoS One. 2019; 14(4): e0215504. Published online 2019 Apr 22. doi: 10.1371/journal.pone.0215504

PMCID:: PMC6476498

Abstract Article PDF–2.5M

Select item 64059728.

MiR-1205 functions as a tumor suppressor by disconnecting the synergy between KRAS and MDM4/E2F1 in non-small cell lung cancer

Hong Yan, Xiaoying Chen, Yu Li, Lei Fan, Yusi Tai, Yang Zhou, Yuxiang Chen, Xinming Qi, Ruimin Huang, Jin Ren

Am J Cancer Res. 2019; 9(2): 312–329. Published online 2019 Feb 1.

PMCID:: PMC6405972

Abstract Article PDF–5.0M

Select item 61764629.

Differential expression profiles of microRNAs in highly and weakly invasive/metastatic pancreatic cancer cells

Xiaodong Tan, Lei Zhou, Huaitao Wang, Yifan Yang, Yang Sun, Zhaoping Wang, Xiaobo Zhang, Feng Gao, Hansi Li

Oncol Lett. 2018 Nov; 16(5): 6026–6038. Published online 2018 Aug 23. doi: 10.3892/ol.2018.9352

PMCID:: PMC6176462

Abstract Article PDF–1.5M

Select item 617271910.

Genetic diagnosis of neurofibromatosis type 1: targeted next- generation sequencing with Multiple Ligation-Dependent Probe Amplification analysis

Yah-Huei Wu-Chou, Tzu-Chao Hung, Yin-Ting Lin, Hsing-Wen Cheng, Ju-Li Lin, Chih-Hung Lin, Chung-Chih Yu, Kuo-Ting Chen, Tu-Hsueh Yeh, Yu-Ray Chen

J Biomed Sci. 2018; 25: 72. Published online 2018 Oct 5. doi: 10.1186/s12929-018-0474-9

PMCID:: PMC6172719

Abstract Article PDF–1.9M

Select item 617101911.

Inhibition of Phospholipase D1 mRNA Expression Slows Down the Proliferation Rate of Prostate Cancer Cells That Have Transited to Androgen Independence

Wu Zhou, Keqing Shi, Lili Ji, Ruihao Wu, Yuehui Chen, Hongxiang Tu, Beibei Zhou, Zhongyong Wang, Meijuan Zhang

J Cancer. 2018; 9(19): 3620–3625. Published online 2018 Sep 8. doi: 10.7150/jca.26689

PMCID:: PMC6171019

Abstract Article PDF–767K

Select item 616295112.

Clinical exome sequencing for fetuses with ultrasound abnormalities and a suspected Mendelian disorder

Elizabeth A. Normand, Alicia Braxton, Salma Nassef, Patricia A. Ward, Francesco Vetrini, Weimin He, Vipulkumar Patel, Chunjing Qu, Lauren E. Westerfield, Samantha Stover, Avinash V. Dharmadhikari, Donna M. Muzny, Richard A. Gibbs, Hongzheng Dai, Linyan Meng, Xia Wang, Rui Xiao, Pengfei Liu, Weimin Bi, Fan Xia, Magdalena Walkiewicz, Ignatia B. Van den Veyver, Christine M. Eng, Yaping Yang

Genome Med. 2018; 10: 74. Published online 2018 Sep 28. doi: 10.1186/s13073-018-0582-x

PMCID:: PMC6162951

Abstract Article PDF–844K

Select item 613859113.

Overexpression of MutL homolog 1 and MutS homolog 2 proteins have reversed prognostic implications for stage I–II colon cancer patients

Shih-Chiang Huang, Shiu-Feng Huang, Ya-Ting Chen, Yu Chang, Yu-Ting Chiu, Il-Chi Chang, Hong-Dar Isaac Wu, Jinn-Shiun Chen

Biomed J. 2017 Feb; 40(1): 39–48. Published online 2017 Mar 14. doi: 10.1016/j.bj.2017.01.004

PMCID:: PMC6138591

Abstract Article PDF–1.1M

Select item 613115314.

Frequent functional activation of RAS signalling not explained by RAS/RAF mutations in relapsed/refractory multiple myeloma

Kwan Yeung Wong, Qiumei Yao, Ling-Qing Yuan, Zhenhai Li, Edmond Shiu Kwan Ma, Chor Sang Chim

Sci Rep. 2018; 8: 13522. Published online 2018 Sep 10. doi: 10.1038/s41598-018-31820-9

PMCID:: PMC6131153

Abstract Article PDF–1.5M

Select item 612139515.

The Role of the Nuclear Factor κB Pathway in the Cellular Response to Low and High Linear Energy Transfer Radiation

Christine E. Hellweg, Luis F. Spitta, Kristina Koch, Arif A. Chishti, Bernd Henschenmacher, Sebastian Diegeler, Bikash Konda, Sebastian Feles, Claudia Schmitz, Thomas Berger, Christa Baumstark-Khan

Int J Mol Sci. 2018 Aug; 19(8): 2220. Published online 2018 Jul 30. doi: 10.3390/ijms19082220