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Select item 36368661.

Structure and Interactions of the Human Programmed Cell Death 1 Receptor

Xiaoxiao Cheng, Vaclav Veverka, Anand Radhakrishnan, Lorna C. Waters, Frederick W. Muskett, Sara H. Morgan, Jiandong Huo, Chao Yu, Edward J. Evans, Alasdair J. Leslie, Meryn Griffiths, Colin Stubberfield, Robert Griffin, Alistair J. Henry, Andreas Jansson, John E. Ladbury, Shinji Ikemizu, Mark D. Carr, Simon J. Davis

J Biol Chem. 2013 Apr 26; 288(17): 11771–11785. Published online 2013 Feb 15. doi: 10.1074/jbc.M112.448126

PMCID:: PMC3636866

Abstract Article PDF–2.6M

Select item 28148222.

Regulatory T Cells and Human Myeloid Dendritic Cells Promote Tolerance via Programmed Death Ligand-1

Shoba Amarnath, Carliann M. Costanzo, Jacopo Mariotti, Jessica L. Ullman, William G. Telford, Veena Kapoor, James L. Riley, Bruce L. Levine, Carl H. June, Timothy Fong, Noel L. Warner, Daniel H. Fowler

PLoS Biol. 2010 Feb; 8(2): e1000302. Published online 2010 Feb 2. doi: 10.1371/journal.pbio.1000302

PMCID:: PMC2814822

Abstract Article PDF–2.8M

Select item 22685763.

The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors

David Yin-wei Lin, Yoshimasa Tanaka, Masashi Iwasaki, Apostolos G. Gittis, Hua-Poo Su, Bunzo Mikami, Taku Okazaki, Tasuku Honjo, Nagahiro Minato, David N. Garboczi

Proc Natl Acad Sci U S A. 2008 Feb 26; 105(8): 3011–3016. Published online 2008 Feb 14. doi: 10.1073/pnas.0712278105

PMCID:: PMC2268576

Abstract Article PDF–723K

Select item 21933114.

Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation

Gordon J. Freeman, Andrew J. Long, Yoshiko Iwai, Karen Bourque, Tatyana Chernova, Hiroyuki Nishimura, Lori J. Fitz, Nelly Malenkovich, Taku Okazaki, Michael C. Byrne, Heidi F. Horton, Lynette Fouser, Laura Carter, Vincent Ling, Michael R. Bowman, Beatriz M. Carreno, Mary Collins, Clive R. Wood, Tasuku Honjo

J Exp Med. 2000 Oct 2; 192(7): 1027–1034. doi: 10.1084/jem.192.7.1027

PMCID:: PMC2193311

Abstract Article PDF–365K

Select item 68770885.

Soluble PD-L1 generated by endogenous retroelement exaptation is a receptor antagonist

Kevin W Ng, Jan Attig, George R Young, Eleonora Ottina, Spyros I Papamichos, Ioannis Kotsianidis, George Kassiotis

eLife. 2019; 8: e50256. Published online 2019 Nov 15. doi: 10.7554/eLife.50256

PMCID:: PMC6877088

Abstract Article PDF–3.5M

Select item 68303306.

Mesenchymal Stem Cells in the Adult Human Liver: Hype or Hope?

Irina V. Kholodenko, Leonid K. Kurbatov, Roman V. Kholodenko, Garik V. Manukyan, Konstantin N. Yarygin

Cells. 2019 Oct; 8(10): 1127. Published online 2019 Sep 22. doi: 10.3390/cells8101127

PMCID:: PMC6830330

Abstract Article PDF–1.7M

Select item 67894347.

Inflammation induced PD-L1-specific T cells

Shamaila Munir, Mia Thorup Lundsager, Mia Aabroe Jørgensen, Morten Hansen, Trine Hilkjær Petersen, Charlotte Menne Bonefeld, Christina Friese, Özcan Met, Per thor Straten, Mads Hald Andersen

Cell Stress. 2019 Oct; 3(10): 319–327. Published online 2019 Sep 13. doi: 10.15698/cst2019.10.201

PMCID:: PMC6789434

Abstract Article PDF–845K

Select item 66070578.

Lentivirus-mediated RNA interference targeting programmed death receptor ligand 1 increases the immunologic anti-tumor effect of dendritic cell vaccination against pancreatic cancer in SCID-hu mice

Jin Wang, Mingbing Sun, Xinguo Zhu, Hua Zhao, Deli Mao, Zhe Zhang, Xin Zhao

Oncol Lett. 2019 Aug; 18(2): 1539–1547. Published online 2019 May 31. doi: 10.3892/ol.2019.10426

PMCID:: PMC6607057

Abstract Article PDF–726K

Select item 59223789.

Correlation between lower balance of Th2 helper T-cells and expression of PD-L1/PD-1 axis genes enables prognostic prediction in patients with glioblastoma

Yasuo Takashima, Atsushi Kawaguchi, Tomohiko Kanayama, Azusa Hayano, Ryuya Yamanaka

Oncotarget. 2018 Apr 10; 9(27): 19065–19078. Published online 2018 Apr 10. doi: 10.18632/oncotarget.24897

PMCID:: PMC5922378

Abstract Article PDF–5.6M

Select item 581167610.

Selection and characterization of the novel anti-human PD-1 FV78 antibody from a targeted epitope mammalian cell-displayed antibody library

Longlong Luo, Shi Wang, Xiaoling Lang, Tingting Zhou, Jing Geng, Xinying Li, Chunxia Qiao, Jiannan Feng, Beifen Shen, Ming Lv, Yan Li

Cell Mol Immunol. 2018 Feb; 15(2): 146–157. Published online 2016 Aug 8. doi: 10.1038/cmi.2016.38

PMCID:: PMC5811676

Abstract Article PDF–1.5M

Select item 579700211.

PD-L1 confers resistance to EGFR mutation-independent tyrosine kinase inhibitors in non-small cell lung cancer via upregulation of YAP1 expression

Jai-Nien Tung, Po-Lin Lin, Yao-Chen Wang, De-Wei Wu, Chi-Yi Chen, Huei Lee

Oncotarget. 2018 Jan 12; 9(4): 4637–4646. Published online 2017 Dec 8. doi: 10.18632/oncotarget.23161

PMCID:: PMC5797002

Abstract Article PDF–1.7M

Select item 574617012.

Oncogenic RAS Signaling Promotes Tumor Immunoresistance by Stabilizing PD-L1 mRNA

Matthew A. Coelho, Sophie de Carné Trécesson, Sareena Rana, Davide Zecchin, Christopher Moore, Miriam Molina-Arcas, Philip East, Bradley Spencer-Dene, Emma Nye, Karin Barnouin, Ambrosius P. Snijders, Wi S. Lai, Perry J. Blackshear, Julian Downward

Immunity. 2017 Dec 19; 47(6): 1083–1099.e6. doi: 10.1016/j.immuni.2017.11.016

PMCID:: PMC5746170

Abstract Article

Select item 560383313.

A combination of anti‐PD‐L1 mAb plus Lm‐LLO‐E6 vaccine efficiently suppresses tumor growth and metastasis in HPV‐infected cancers

Po‐Lin Lin, Ya‐Min Cheng, De‐Wei Wu, Yu‐Ju Huang, Hun‐Chi Lin, Chih‐Yi Chen, Huei Lee

Cancer Med. 2017 Sep; 6(9): 2052–2062. Published online 2017 Aug 9. doi: 10.1002/cam4.1143

PMCID:: PMC5603833

Abstract Article PDF–633K

Select item 556161814.

miR-140-5p suppresses the proliferation, migration and invasion of gastric cancer by regulating YES1

Zheng Fang, Shuai Yin, Ruochuan Sun, Shangxin Zhang, Min Fu, Youliang Wu, Tao Zhang, Junaid Khaliq, Yongxiang Li

Mol Cancer. 2017; 16: 139. Published online 2017 Aug 17. doi: 10.1186/s12943-017-0708-6

PMCID:: PMC5561618

Abstract Article PDF–8.5M

Select item 542603915.

Epigenetic modifications of the immune-checkpoint genes CTLA4 and PDCD1 in non-small cell lung cancer results in increased expression

Sebastian Marwitz, Swetlana Scheufele, Sven Perner, Martin Reck, Ole Ammerpohl, Torsten Goldmann

Clin Epigenetics. 2017; 9: 51. Published online 2017 May 11. doi: 10.1186/s13148-017-0354-2

PMCID:: PMC5426039

Abstract Article PDF–533K

Select item 521672816.

The tumor suppressor miR-138-5p targets PD-L1 in colorectal cancer

Lian Zhao, Haibo Yu, Shuijing Yi, Xiaowei Peng, Peng Su, Zhiming Xiao, Rui Liu, Anliu Tang, Xiayu Li, Fen Liu, Shourong Shen

Oncotarget. 2016 Jul 19; 7(29): 45370–45384. Published online 2016 May 27. doi: 10.18632/oncotarget.9659

PMCID:: PMC5216728

Abstract Article PDF–8.1M

Select item 493545617.

Altered expression of mir-222 and mir-25 influences diverse gene expression changes in transformed normal and anaplastic thyroid cells, and impacts on MEK and TRAIL protein expression

Sinéad T. Aherne, Paul Smyth, Michael Freeley, Leila Smith, Cathy Spillane, John O'leary, Orla Sheils

Int J Mol Med. 2016 Aug; 38(2): 433–445. Published online 2016 Jun 22. doi: 10.3892/ijmm.2016.2653

PMCID:: PMC4935456

Abstract Article PDF–864K

Select item 488090618.

Intestinal APCs of the endogenous nanomineral pathway fail to express PD-L1 in Crohn’s disease

Jack Robertson, Carolin T. Haas, Laetitia C. Pele, Tom P. Monie, Charles Charalambos, Miles Parkes, Rachel E. Hewitt, Jonathan J. Powell

Sci Rep. 2016; 6: 26747. Published online 2016 May 26. doi: 10.1038/srep26747

PMCID:: PMC4880906

Abstract Article PDF–1.3M

Select item 448263819.

Transcriptome-based identification of new anti-anti-inflammatory and vasodilating properties of the n-3 fatty acid docosahexaenoic acid in vascular endothelial cell under proinflammatory conditions

Marika Massaro, Rosanna Martinelli, Valentina Gatta, Egeria Scoditti, Mariangela Pellegrino, Maria Annunziata Carluccio, Nadia Calabriso, Tonia Buonomo, Liborio Stuppia, Carlo Storelli, Raffaele De Caterina

PLoS One. 2015; 10(6): e0129652. Published online 2015 Jun 26. doi: 10.1371/journal.pone.0129652