PMC Links for Nucleotide (Select 1159731390) - PMC

Select item 61566101.

Ragulator and SLC38A9 activate the Rag GTPases through noncanonical GEF mechanisms

Kuang Shen, David M. Sabatini

Proc Natl Acad Sci U S A. 2018 Sep 18; 115(38): 9545–9550. Published online 2018 Sep 4. doi: 10.1073/pnas.1811727115

PMCID:: PMC6156610

Select item 57049642.

mTORC1 activator SLC38A9 is required to efflux essential amino acids from lysosomes and use protein as a nutrient

Gregory A. Wyant, Monther Abu-Remaileh, Rachel L. Wolfson, Walter W. Chen, Elizaveta Freinkman, Laura V. Danai, Matthew G. Vander Heiden, David M. Sabatini

Cell. Author manuscript; available in PMC 2018 Oct 19.

Published in final edited form as: Cell. 2017 Oct 19; 171(3): 642–654.e12. doi: 10.1016/j.cell.2017.09.046

PMCID:: PMC5704964

Abstract Article PDF–915K

Select item 44759193.

Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9

Jennifer Jung, Heide Marika Genau, Christian Behrends

Mol Cell Biol. 2015 Jul; 35(14): 2479–2494. Prepublished online 2015 May 11. Published online 2015 Jun 19. doi: 10.1128/MCB.00125-15

PMCID:: PMC4475919

Abstract Article PDF–2.7M

Select item 43766654.

SLC38A9 is a component of the lysosomal amino acid-sensing machinery that controls mTORC1

Manuele Rebsamen, Lorena Pochini, Taras Stasyk, Mariana E. G. de Araújo, Michele Galluccio, Richard K. Kandasamy, Berend Snijder, Astrid Fauster, Elena L. Rudashevskaya, Manuela Bruckner, Stefania Scorzoni, Przemyslaw A. Filipek, Kilian V. M. Huber, Johannes Bigenzahn, Leonhard X. Heinz, Claudine Kraft, Keiryn L. Bennett, Cesare Indiveri, Lukas A. Huber, Giulio Superti-Furga

Nature. Author manuscript; available in PMC 2015 Sep 26.

Published in final edited form as: Nature. 2015 Mar 26; 519(7544): 477–481. Published online 2015 Jan 7. doi: 10.1038/nature14107

PMCID:: PMC4376665

Abstract Article PDF–2.4M

Select item 43513795.

Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci

Meian He, Min Xu, Ben Zhang, Jun Liang, Peng Chen, Jong-Young Lee, Todd A. Johnson, Huaixing Li, Xiaobo Yang, Juncheng Dai, Liming Liang, Lixuan Gui, Qibin Qi, Jinyan Huang, Yanping Li, Linda S. Adair, Tin Aung, Qiuyin Cai, Ching-Yu Cheng, Myeong-Chan Cho, Yoon Shin Cho, Minjie Chu, Bin Cui, Yu-Tang Gao, Min Jin Go, Dongfeng Gu, Weiqiong Gu, Huan Guo, Yongchen Hao, Jie Hong, Zhibin Hu, Yanling Hu, Jianfeng Huang, Joo-Yeon Hwang, Mohammad Kamran Ikram, Guangfu Jin, Dae-Hee Kang, Chiea Chuen Khor, Bong-Jo Kim, Hung Tae Kim, Michiaki Kubo, Jeannette Lee, Juyoung Lee, Nanette R. Lee, Ruoying Li, Jun Li, JianJun Liu, Jirong Longe, Wei Lu, Xiangfeng Lu, Xiaoping Miao, Yukinori Okada, Rick Twee-Hee Ong, Gaokun Qiu, Mark Seielstad, Xueling Sim, Huaidong Song, Fumihiko Takeuchi, Toshihiro Tanaka, Phil R. Taylor, Laiyuan Wang, Weiqing Wang, Yiqin Wang, Chen Wu, Ying Wu, Yong-Bing Xiang, Ken Yamamoto, Handong Yang, Ming Liao, Mitsuhiro Yokota, Terri Young, Xiaomin Zhang, Norihiro Kato, Qing K. Wang, Wei Zheng, Frank B. Hu, Dongxin Lin, Hongbing Shen, Yik Ying Teo, Zengnan Mo, Tien Yin Wong, Xu Lin, Karen L. Mohlke, Guang Ning, Tatsuhiko Tsunoda, Bok-Ghee Han, Xiao-Ou Shu, E. Shyong Tai, Tangchun Wu, Lu Qi

Hum Mol Genet. 2015 Mar 15; 24(6): 1791–1800. Published online 2014 Nov 26. doi: 10.1093/hmg/ddu583

PMCID:: PMC4351379

Abstract Article PDF–436K

Select item 42958266.

The amino acid transporter SLC38A9 is a key component of a lysosomal membrane complex that signals arginine sufficiency to mTORC1

Shuyu Wang, Zhi-Yang Tsun, Rachel Wolfson, Kuang Shen, Gregory A. Wyant, Molly E. Plovanich, Elizabeth D. Yuan, Tony D. Jones, Lynne Chantranupong, William Comb, Tim Wang, Liron Bar-Peled, Roberto Zoncu, Christoph Straub, Choah Kim, Jiwon Park, Bernardo L. Sabatini, David M. Sabatini

Science. Author manuscript; available in PMC 2015 Jan 15.

Published in final edited form as: Science. 2015 Jan 9; 347(6218): 188–194. Published online 2015 Jan 7. doi: 10.1126/science.1257132

PMCID:: PMC4295826

Abstract Article PDF–1.6M

Select item 39990947.

New Genetic Biomarkers Predicting Azathioprine Blood Concentrations in Combination Therapy with 5-Aminosalicylic Acid

Kazuhiko Uchiyama, Tomohisa Takagi, Yasunori Iwamoto, Norihiko Kondo, Tetsuya Okayama, Naohisa Yoshida, Kazuhiro Kamada, Kazuhiro Katada, Osamu Handa, Takeshi Ishikawa, Hiroaki Yasuda, Junichi Sakagami, Hideyuki Konishi, Nobuaki Yagi, Yuji Naito, Yoshito Itoh

PLoS One. 2014; 9(4): e95080. Published online 2014 Apr 24. doi: 10.1371/journal.pone.0095080

PMCID:: PMC3999094

Abstract Article PDF–1.1M

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