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Select item 81705081.

Topoisomerase II-Induced Chromosome Breakage and Translocation Is Determined by Chromosome Architecture and Transcriptional Activity

Andres Canela, Yaakov Maman, Shar-yin N. Huang, Gordana Wutz, Wen Tang, Guido Zagnoli-Vieira, Elsa Callen, Nancy Wong, Amanda Day, Jan-Michael Peters, Keith W. Caldecott, Yves Pommier, André Nussenzweig

Mol Cell. Author manuscript; available in PMC 2021 Jun 2.

Published in final edited form as: Mol Cell. 2019 Jul 25; 75(2): 252–266.e8. Published online 2019 Jun 12. doi: 10.1016/j.molcel.2019.04.030

PMCID:: PMC8170508

Abstract Article PDF–2.4M

Select item 79806532.

New insights in phenotype and treatment of lung disease immuno-deficiency and chromosome breakage syndrome (LICS)

Brigitte W. M. Willemse, Saskia N. van der Crabben, Wilhelmina S. Kerstjens-Frederikse, Wim Timens, Joris M. van Montfrans, Caroline A. Lindemans, Jaap Jan Boelens, Marije P. Hennus, Gijs van Haaften

Orphanet J Rare Dis. 2021; 16: 137. Published online 2021 Mar 19. doi: 10.1186/s13023-021-01770-z

PMCID:: PMC7980653

Abstract Article PDF–1009K

Select item 75494303.

Replication Stress Induces Global Chromosome Breakage in the Fragile X Genome

Arijita Chakraborty, Piroon Jenjaroenpun, Jing Li, Sami El Hilali, Andrew McCulley, Brian Haarer, Elizabeth A. Hoffman, Aimee Belak, Audrey Thorland, Heidi Hehnly, Carl Schildkraut, Chun-long Chen, Vladimir A. Kuznetsov, Wenyi Feng

Cell Rep. Author manuscript; available in PMC 2020 Oct 12.

Published in final edited form as: Cell Rep. 2020 Sep 22; 32(12): 108179. doi: 10.1016/j.celrep.2020.108179

Correction in:: Cell Rep. 2021 Mar 23; 34(12): 108838.

PMCID:: PMC7549430

Abstract Article PDF–3.0M

Select item 66148994.

Homolog-Dependent Repair Following Dicentric Chromosome Breakage in Drosophila melanogaster

Jayaram Bhandari, Travis Karg, Kent G. Golic

Genetics. 2019 Jul; 212(3): 615–630. Published online 2019 May 3. doi: 10.1534/genetics.119.302247

PMCID:: PMC6614899

Abstract Article PDF–1.3M

Select item 64961885.

Normal red blood cells partially decrease diepoxybutane‐induced chromosome breakage in cultured lymphocytes from Fanconi anaemia patients

B. Porto, R. Sousa, I. Malheiro, J. Gaspar, J. Rueff, C. Gonçalves, J. Barbot

Cell Prolif. 2010 Dec; 43(6): 573–578. Published online 2010 Oct 29. doi: 10.1111/j.1365-2184.2010.00706.x

PMCID:: PMC6496188

Abstract Article PDF–415K

Select item 61595396.

A tri-serine cluster within the topoisomerase IIα-interaction domain of the BLM helicase is required for regulating chromosome breakage in human cells

Julia Harris Behnfeldt, Samir Acharya, Larissa Tangeman, April Sandy Gocha, Jeremy Keirsey, Joanna Groden

Hum Mol Genet. 2018 Apr 1; 27(7): 1241–1251. Published online 2018 Jan 27. doi: 10.1093/hmg/ddy038

PMCID:: PMC6159539

Abstract Article PDF–670K

Select item 56581927.

Defective replication initiation results in locus specific chromosome breakage and a ribosomal RNA deficiency in yeast

Joseph C. Sanchez, Elizabeth X. Kwan, Thomas J. Pohl, Haley M. Amemiya, M. K. Raghuraman, Bonita J. Brewer

PLoS Genet. 2017 Oct; 13(10): e1007041. Published online 2017 Oct 16. doi: 10.1371/journal.pgen.1007041

PMCID:: PMC5658192

Abstract Article PDF–6.7M

Select item 54949828.

Do Some Patients With Seckel Syndrome Have Hematological Problems and/or Chromosome Breakage?

Merlin G. Butler, Bryan D. Hall, Ronald N. Maclean, Carmen B. Lozzio

Am J Med Genet. Author manuscript; available in PMC 2017 Jul 3.

Published in final edited form as: Am J Med Genet. 1987 Jul; 27(3): 645–649. doi: 10.1002/ajmg.1320270318

PMCID:: PMC5494982

Abstract Article PDF–386K

Select item 54634199.

Analysis of Chromosome Breakage in the Prader-Labhart-Willi Syndrome

Merlin G. Butler, Bonnie B. Jenkins

Am J Med Genet. Author manuscript; available in PMC 2017 Jun 8.

Published in final edited form as: Am J Med Genet. 1989 Apr; 32(4): 514–519. doi: 10.1002/ajmg.1320320418

PMCID:: PMC5463419

Abstract Article PDF–342K

Select item 520091110.

Stephen L. McDaniel, Erica Zweifel, Peter K. W. Harris, Meng-Chao Yao, Eric S. Cole, Douglas L. Chalker

Biol Open. 2016 Dec 15; 5(12): 1790–1798. Published online 2016 Oct 28. doi: 10.1242/bio.021576

PMCID:: PMC5200911

Abstract Article PDF–2.7M

Select item 509592511.

CHROMOSOME BREAKAGE AND SISTER CHROMATID EXCHANGE ANALYSIS IN COMPUTER OPERATORS

Merlin G. Butler, Jennifer Yost, Bonnie B. Jenkins

J Environ Sci Health A Environ Sci Eng. Author manuscript; available in PMC 2016 Nov 4.

Published in final edited form as: J Environ Sci Health A Environ Sci Eng. 1987; 22(8): 729–741. doi: 10.1080/10934528709375383

PMCID:: PMC5095925

Abstract Article PDF–52K

Select item 496631212.

Destabilized SMC5/6 complex leads to chromosome breakage syndrome with severe lung disease

Saskia N. van der Crabben, Marije P. Hennus, Grant A. McGregor, Deborah I. Ritter, Sandesh C.S. Nagamani, Owen S. Wells, Magdalena Harakalova, Ivan K. Chinn, Aaron Alt, Lucie Vondrova, Ron Hochstenbach, Joris M. van Montfrans, Suzanne W. Terheggen-Lagro, Stef van Lieshout, Markus J. van Roosmalen, Ivo Renkens, Karen Duran, Isaac J. Nijman, Wigard P. Kloosterman, Eric Hennekam, Jordan S. Orange, Peter M. van Hasselt, David A. Wheeler, Jan J. Palecek, Alan R. Lehmann, Antony W. Oliver, Laurence H. Pearl, Sharon E. Plon, Johanne M. Murray, Gijs van Haaften

J Clin Invest. 2016 Aug 1; 126(8): 2881–2892. Published online 2016 Jul 18. doi: 10.1172/JCI82890

PMCID:: PMC4966312

Abstract Article PDF–1.1M

Select item 453248713.

Binding of Multiple Rap1 Proteins Stimulates Chromosome Breakage Induction during DNA Replication

Greicy H. Goto, Sevil Zencir, Yukinori Hirano, Hiroo Ogi, Andreas Ivessa, Katsunori Sugimoto

PLoS Genet. 2015 Aug; 11(8): e1005283. Published online 2015 Aug 11. doi: 10.1371/journal.pgen.1005283

PMCID:: PMC4532487

Abstract Article PDF–4.4M

Select item 424868614.

Tetrahymena Pot2 Is a Developmentally Regulated Paralog of Pot1 That Localizes to Chromosome Breakage Sites but Not to Telomeres

Stacey Cranert, Serena Heyse, Benjamin R. Linger, Rachel Lescasse, Carolyn Price

Eukaryot Cell. 2014 Dec; 13(12): 1519–1529. doi: 10.1128/EC.00204-14

PMCID:: PMC4248686

Abstract Article PDF–1.6M

Select item 422729415.

Chromosome-breakage genomic instability and chromothripsis in breast cancer

Ewa Przybytkowski, Elizabeth Lenkiewicz, Michael T Barrett, Kathleen Klein, Sheida Nabavi, Celia MT Greenwood, Mark Basik

BMC Genomics. 2014; 15(1): 579. Published online 2014 Jul 9. doi: 10.1186/1471-2164-15-579

PMCID:: PMC4227294

Abstract Article PDF–2.2M

Select item 422500016.

Comparison of Chromosome Breakage in Non-Mosaic and Mosaic Patients with Fanconi Anemia, Relatives, and Patients with Other Inherited Bone Marrow Failure Syndromes

John H Fargo, Andrzej Rochowski, Neelam Giri, Sharon A Savage, Susan B Olson, Blanche P Alter

Cytogenet Genome Res. Author manuscript; available in PMC 2015 Sep 11.

Published in final edited form as: Cytogenet Genome Res. 2014; 144(1): 15–27. Published online 2014 Sep 11. doi: 10.1159/000366251

PMCID:: PMC4225000

Abstract Article PDF–1.1M

Select item 354831817.

Chromosome breakage is regulated by the interaction of the BLM helicase and topoisomerase IIα

Beatriz Russell, Saumitri Bhattacharyya, Jeremy Keirsey, April Sandy, Patrick Grierson, Erin Perchiniak, Juraj Kavecansky, Samir Acharya, Joanna Groden

Cancer Res. Author manuscript; available in PMC 2013 Jan 18.

Published in final edited form as: Cancer Res. 2011 Jan 15; 71(2): 561–571. Published online 2011 Jan 11. doi: 10.1158/0008-5472.CAN-10-1727

PMCID:: PMC3548318

Abstract Article PDF–3.3M

Select item 327615218.

Replication Stress-Induced Chromosome Breakage Is Correlated with Replication Fork Progression and Is Preceded by Single-Stranded DNA Formation

Wenyi Feng, Sara C. Di Rienzi, M. K. Raghuraman, Bonita J. Brewer

G3 (Bethesda) 2011 Oct; 1(5): 327–335. Published online 2011 Oct 1. doi: 10.1534/g3.111.000554

PMCID:: PMC3276152

Abstract Article PDF–1.8M

Select item 314125919.

Irreparable complex DNA double-strand breaks induce chromosome breakage in organotypic three-dimensional human lung epithelial cell culture

Aroumougame Asaithamby, Burong Hu, Oliver Delgado, Liang-Hao Ding, Michael D. Story, John D. Minna, Jerry W. Shay, David J. Chen

Nucleic Acids Res. 2011 Jul; 39(13): 5474–5488. Published online 2011 Mar 18. doi: 10.1093/nar/gkr149

PMCID:: PMC3141259

Abstract Article PDF–13M

Select item 310092020.

Unrepaired clustered DNA lesions induce chromosome breakage in human cells

Aroumougame Asaithamby, Burong Hu, David J. Chen

Proc Natl Acad Sci U S A. 2011 May 17; 108(20): 8293–8298. Published online 2011 Apr 28. doi: 10.1073/pnas.1016045108

PMCID:: PMC3100920

Abstract Article PDF–1.0M

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