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Select item 101696361.

The KMT2A recombinome of acute leukemias in 2023

C. Meyer, P. Larghero, B. Almeida Lopes, T. Burmeister, D. Gröger, R. Sutton, N. C. Venn, G. Cazzaniga, L. Corral Abascal, G. Tsaur, L. Fechina, M. Emerenciano, M. S. Pombo-de-Oliveira, T. Lund-Aho, T. Lundán, M. Montonen, V. Juvonen, J. Zuna, J. Trka, P. Ballerini, H. Lapillonne, V. H. J. Van der Velden, E. Sonneveld, E. Delabesse, R. R. C. de Matos, M. L. M. Silva, S. Bomken, K. Katsibardi, M. Keernik, N. Grardel, J. Mason, R. Price, J. Kim, C. Eckert, L. Lo Nigro, C. Bueno, P. Menendez, U. zur Stadt, P. Gameiro, L. Sedék, T. Szczepański, A. Bidet, V. Marcu, K. Shichrur, S. Izraeli, H. O. Madsen, B. W. Schäfer, S. Kubetzko, R. Kim, E. Clappier, H. Trautmann, M. Brüggemann, P. Archer, J. Hancock, J. Alten, A. Möricke, M. Stanulla, J. Lentes, A. K. Bergmann, S. Strehl, S. Köhrer, K. Nebral, M. N. Dworzak, O. A. Haas, C. Arfeuille, A. Caye-Eude, H. Cavé, R. Marschalek

Leukemia. 2023; 37(5): 988–1005. Published online 2023 Apr 5. doi: 10.1038/s41375-023-01877-1

PMCID:: PMC10169636

Abstract Article PDF–3.7M

Select item 99079632.

Allogeneic stem cell transplantation without preconditioning in a child with therapy-related myelodysplastic syndrome: A case report

Yi-Ling Tung, Yi-Lun Wang, Tsung-Yen Chang, Chia-Chi Chiu, Yu-Chuan Wen, Tang-Her Jaing

Medicine (Baltimore) 2023 Feb 10; 102(6): e32770. Published online 2023 Feb 10. doi: 10.1097/MD.0000000000032770

PMCID:: PMC9907963

Abstract Article PDF–495K

Select item 93573043.

Poor treatment responses were related to poor outcomes in pediatric B cell acute lymphoblastic leukemia with KMT2A rearrangements

Jinquan Wen, Min Zhou, Yali Shen, Yueting long, Yuxia Guo, Lin Song, Jianwen Xiao

BMC Cancer. 2022; 22: 859. Published online 2022 Aug 6. doi: 10.1186/s12885-022-09804-w

PMCID:: PMC9357304

Abstract Article PDF–1.3M

Select item 87273024.

Identification and characterization of relapse-initiating cells in MLL-rearranged infant ALL by single-cell transcriptomics

Tito Candelli, Pauline Schneider, Patricia Garrido Castro, Luke A. Jones, Eduard Bodewes, Dedeke Rockx-Brouwer, Rob Pieters, Frank C. P. Holstege, Thanasis Margaritis, Ronald W. Stam

Leukemia. 2022; 36(1): 58–67. Published online 2021 Jul 24. doi: 10.1038/s41375-021-01341-y

PMCID:: PMC8727302

Abstract Article PDF–5.0M

Select item 86796795.

Hematopoietic stem cell transplantation for infants with high-risk KMT2A gene–rearranged acute lymphoblastic leukemia

Takayuki Takachi, Tomoyuki Watanabe, Takako Miyamura, Akiko Moriya Saito, Takao Deguchi, Toshinori Hori, Tomomi Yamada, Shigeru Ohmori, Masami Haba, Yuki Aoki, Sae Ishimaru, Shinya Sasaki, Junjiro Ohshima, Akihiro Iguchi, Yoshiyuki Takahashi, Nobuyuki Hyakuna, Atsushi Manabe, Keizo Horibe, Eiichi Ishii, Katsuyoshi Koh, Daisuke Tomizawa

Blood Adv. 2021 Oct 12; 5(19): 3891–3899. Published online 2021 Oct 12. doi: 10.1182/bloodadvances.2020004157

PMCID:: PMC8679679

Abstract Article PDF–1.0M

Select item 86169576.

A human fetal liver-derived infant MLL-AF4 acute lymphoblastic leukemia model reveals a distinct fetal gene expression program

Siobhan Rice, Thomas Jackson, Nicholas T. Crump, Nicholas Fordham, Natalina Elliott, Sorcha O’Byrne, Maria del Mar Lara Fanego, Dilys Addy, Trisevgeni Crabb, Carryl Dryden, Sarah Inglott, Dariusz Ladon, Gary Wright, Jack Bartram, Philip Ancliff, Adam J. Mead, Christina Halsey, Irene Roberts, Thomas A. Milne, Anindita Roy

Nat Commun. 2021; 12: 6905. Published online 2021 Nov 25. doi: 10.1038/s41467-021-27270-z

PMCID:: PMC8616957

Abstract Article PDF–3.7M

Select item 86116177.

Does lineage plasticity enable escape from CAR-T cell therapy? Lessons from MLL-r leukemia

Wenjuan Liao, M. Eric Kohler, Terry Fry, Patricia Ernst

Exp Hematol. Author manuscript; available in PMC 2021 Nov 24.

Published in final edited form as: Exp Hematol. 2021 Aug; 100: 1–11. Published online 2021 Jul 21. doi: 10.1016/j.exphem.2021.07.002

Correction in:: Exp Hematol. 2021 Sep 20

PMCID:: PMC8611617

Abstract Article PDF–854K

Select item 83300448.

Clinical application of whole transcriptome sequencing for the classification of patients with acute lymphoblastic leukemia

Wencke Walter, Rabia Shahswar, Anna Stengel, Manja Meggendorfer, Wolfgang Kern, Torsten Haferlach, Claudia Haferlach

BMC Cancer. 2021; 21: 886. Published online 2021 Aug 2. doi: 10.1186/s12885-021-08635-5

PMCID:: PMC8330044

Abstract Article PDF–1.2M

Select item 83253169.

Mature B cell acute lymphoblastic leukaemia with KMT2A-MLLT3 transcripts in children: three case reports and literature reviews

Yinghui Cui, Min Zhou, Pinli Zou, Xin Liao, Jianwen Xiao

Orphanet J Rare Dis. 2021; 16: 331. Published online 2021 Jul 30. doi: 10.1186/s13023-021-01972-5

PMCID:: PMC8325316

Abstract Article PDF–1.2M

Select item 824518410.

Integrative methylome-transcriptome analysis unravels cancer cell vulnerabilities in infant MLL-rearranged B cell acute lymphoblastic leukemia

Juan Ramón Tejedor, Clara Bueno, Meritxell Vinyoles, Paolo Petazzi, Antonio Agraz-Doblas, Isabel Cobo, Raúl Torres-Ruiz, Gustavo F. Bayón, Raúl F. Pérez, Sara López-Tamargo, Francisco Gutierrez-Agüera, Pablo Santamarina-Ojeda, Manuel Ramírez-Orellana, Michela Bardini, Giovanni Cazzaniga, Paola Ballerini, Pauline Schneider, Ronald W. Stam, Ignacio Varela, Mario F. Fraga, Agustín F. Fernández, Pablo Menéndez

J Clin Invest. 2021 Jul 1; 131(13): e138833. Published online 2021 Jul 1. doi: 10.1172/JCI138833

PMCID:: PMC8245184

Abstract Article PDF–3.7M

Select item 812491711.

Nuclear FGFR2 Interacts with the MLL-AF4 Oncogenic Chimera and Positively Regulates HOXA9 Gene Expression in t(4;11) Leukemia Cells

Tiziana Fioretti, Armando Cevenini, Mariateresa Zanobio, Maddalena Raia, Daniela Sarnataro, Fabio Cattaneo, Rosario Ammendola, Gabriella Esposito

Int J Mol Sci. 2021 May; 22(9): 4623. Published online 2021 Apr 28. doi: 10.3390/ijms22094623

PMCID:: PMC8124917

Abstract Article PDF–14M

Select item 787818012.

Targeting critical kinases and anti-apoptotic molecules overcomes steroid resistance in MLL-rearranged leukaemia

Anne P. de Groot, Yoriko Saito, Eiryo Kawakami, Mari Hashimoto, Yuki Aoki, Rintaro Ono, Ikuko Ogahara, Saera Fujiki, Akiko Kaneko, Kaori Sato, Hiroshi Kajita, Takashi Watanabe, Masatoshi Takagi, Daisuke Tomizawa, Katsuyoshi Koh, Mariko Eguchi, Eiichi Ishii, Osamu Ohara, Leonard D. Shultz, Shuki Mizutani, Fumihiko Ishikawa

EBioMedicine. 2021 Feb; 64: 103235. Published online 2021 Feb 10. doi: 10.1016/j.ebiom.2021.103235

PMCID:: PMC7878180

Abstract Article PDF–3.1M

Select item 778797313.

H3K79me2/3 controls enhancer–promoter interactions and activation of the pan-cancer stem cell marker PROM1/CD133 in MLL-AF4 leukemia cells

Laura Godfrey, Nicholas T. Crump, Sorcha O’Byrne, I-Jun Lau, Siobhan Rice, Joe R. Harman, Thomas Jackson, Natalina Elliott, Gemma Buck, Christopher Connor, Ross Thorne, David J. H. F. Knapp, Olaf Heidenreich, Paresh Vyas, Pablo Menendez, Sarah Inglott, Philip Ancliff, Huimin Geng, Irene Roberts, Anindita Roy, Thomas A. Milne

Leukemia. 2021; 35(1): 90–106. Published online 2020 Apr 2. doi: 10.1038/s41375-020-0808-y

PMCID:: PMC7787973

Abstract Article PDF–2.3M

Select item 730235014.

The lncRNA LAMP5-AS1 drives leukemia cell stemness by directly modulating DOT1L methyltransferase activity in MLL leukemia

Wen-Tao Wang, Tian-Qi Chen, Zhan-Cheng Zeng, Qi Pan, Wei Huang, Cai Han, Ke Fang, Lin-Yu Sun, Qian-Qian Yang, Dan Wang, Xue-Qun Luo, Yu-Meng Sun, Yue-Qin Chen

J Hematol Oncol. 2020; 13: 78. Published online 2020 Jun 17. doi: 10.1186/s13045-020-00909-y

Correction in:: J Hematol Oncol. 2021; 14: 42.

PMCID:: PMC7302350

Abstract Article PDF–3.3M

Select item 724995615.

Observation of the molecular genetics among children with acute lymphoblastic leukemia: A retrospective study based on the SEER database

Ying Sun, Sili Long, Wenjun Liu

Medicine (Baltimore) 2020 May 22; 99(21): e20009. Published online 2020 May 22. doi: 10.1097/MD.0000000000020009

PMCID:: PMC7249956

Abstract Article PDF–535K

Select item 722711716.

A Menin-MLL inhibitor induces specific chromatin changes and eradicates disease in models of MLL-rearranged leukemia

Andrei V. Krivtsov, Kathryn Evans, Jayant Y. Gadrey, Benjamin K. Eschle, Charlie Hatton, Hannah J. Uckelmann, Kenneth N. Ross, Florian Perner, Sarah N. Olsen, Tara Pritchard, Lisa McDermott, Connor D. Jones, Duohui Jing, Ali Braytee, Diego Chacon, Eric Earley, Brian M. McKeever, David Claremon, Andrew J. Gifford, Heather J. Lee, Beverly A. Teicher, John E. Pimanda, Dominik Beck, Jennifer A. Perry, Malcolm A. Smith, Gerard M. McGeehan, Richard B. Lock, Scott A. Armstrong

Cancer Cell. Author manuscript; available in PMC 2020 Dec 9.

Published in final edited form as: Cancer Cell. 2019 Dec 9; 36(6): 660–673.e11. doi: 10.1016/j.ccell.2019.11.001

PMCID:: PMC7227117

Abstract Article PDF–3.4M

Select item 691283017.

MLL-Rearranged Acute Leukemia with t(4;11)(q21;q23)—Current Treatment Options. Is There a Role for CAR-T Cell Therapy?

Oliver Britten, Denise Ragusa, Sabrina Tosi, Yasser Mostafa Kamel

Cells. 2019 Nov; 8(11): 1341. Published online 2019 Oct 29. doi: 10.3390/cells8111341

PMCID:: PMC6912830

Abstract Article PDF–2.1M

Select item 669301018.

The efficiency of murine MLL-ENL–driven leukemia initiation changes with age and peaks during neonatal development

Theresa Okeyo-Owuor, Yanan Li, Riddhi M. Patel, Wei Yang, Emily B. Casey, Andrew S. Cluster, Shaina N. Porter, David Bryder, Jeffrey A. Magee

Blood Adv. 2019 Aug 13; 3(15): 2388–2399. Published online 2019 Aug 12. doi: 10.1182/bloodadvances.2019000554

PMCID:: PMC6693010

Abstract Article PDF–1.7M

Select item 667663719.

Differential network analysis and protein-protein interaction study reveals active protein modules in glucocorticoid resistance for infant acute lymphoblastic leukemia

Zaynab Mousavian, Abbas Nowzari-Dalini, Yasir Rahmatallah, Ali Masoudi-Nejad

Mol Med. 2019; 25: 36. Published online 2019 Aug 1. doi: 10.1186/s10020-019-0106-1

PMCID:: PMC6676637

Abstract Article PDF–1.0M

Select item 654584920.

Unraveling the cellular origin and clinical prognostic markers of infant B-cell acute lymphoblastic leukemia using genome-wide analysis

Antonio Agraz-Doblas, Clara Bueno, Rachael Bashford-Rogers, Anindita Roy, Pauline Schneider, Michela Bardini, Paola Ballerini, Gianni Cazzaniga, Thaidy Moreno, Carlos Revilla, Marta Gut, Maria G. Valsecchi, Irene Roberts, Rob Pieters, Paola De Lorenzo, Ignacio Varela, Pablo Menendez, Ronald W. Stam

Haematologica. 2019 Jun; 104(6): 1176–1188. Prepublished online 2019 Jan 24. doi: 10.3324/haematol.2018.206375

PMCID:: PMC6545849

Abstract Article PDF–4.7M

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