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Select item 100270401.

Silencing of STE20-type kinase TAOK1 confers protection against hepatocellular lipotoxicity through metabolic rewiring

Ying Xia, Emma Andersson, Sumit K. Anand, Emmelie Cansby, Mara Caputo, Sima Kumari, Rando Porosk, Kalle Kilk, Syam Nair, Hanns-Ulrich Marschall, Matthias Blüher, Margit Mahlapuu

Hepatol Commun. 2023 Apr; 7(4): e0037. Published online 2023 Mar 17. doi: 10.1097/HC9.0000000000000037

PMCID:: PMC10027040

Abstract Article PDF–2.2M

Select item 100176642.

Hepatitis C virus nonstructural protein 4B induces lipogenesis via the Hippo pathway

Chen Zou, Hongxi Tan, Jun Zeng, Minqi Liu, Guangping Zhang, Yi Zheng, Zhanfeng Zhang

Arch Virol. 2023; 168(4): 113. Published online 2023 Mar 15. doi: 10.1007/s00705-023-05743-4

PMCID:: PMC10017664

Abstract Article PDF–1.7M

Select item 98184213.

PNPLA3(I148M) Inhibits Lipolysis by Perilipin-5-Dependent Competition with ATGL

Hagen Roland Witzel, Inga Maria Gertrud Schwittai, Nils Hartmann, Sebastian Mueller, Jörn M. Schattenberg, Xue-Min Gong, Johannes Backs, Peter Schirmacher, Detlef Schuppan, Wilfried Roth, Beate Katharina Straub

Cells. 2023 Jan; 12(1): 73. Published online 2022 Dec 24. doi: 10.3390/cells12010073

PMCID:: PMC9818421

Abstract Article PDF–18M

Select item 93040654.

MiR-103-3p promotes hepatic steatosis to aggravate nonalcoholic fatty liver disease by targeting of ACOX1

Jiexia Ding, Caixia Xia, Panpan Cen, Siying Li, Lifei Yu, Jing Zhu, Jie Jin

Mol Biol Rep. 2022; 49(8): 7297–7305. Published online 2022 May 23. doi: 10.1007/s11033-022-07515-w

PMCID:: PMC9304065

Abstract Article PDF–1.4M

Select item 91711495.

Dysregulated m6A modification promotes lipogenesis and development of non-alcoholic fatty liver disease and hepatocellular carcinoma

Yeming Yang, Jingshu Cai, Xue Yang, Kaifang Wang, Kuanxiang Sun, Zhenglin Yang, Lin Zhang, Lu Yang, Chun Gu, Xiang Huang, Ziyan Wang, Xianjun Zhu

Mol Ther. 2022 Jun 1; 30(6): 2342–2353. Published online 2022 Feb 19. doi: 10.1016/j.ymthe.2022.02.021

PMCID:: PMC9171149

Abstract Article PDF–4.1M

Select item 87831296.

TM6SF2/PNPLA3/MBOAT7 Loss-of-Function Genetic Variants Impact on NAFLD Development and Progression Both in Patients and in In Vitro Models

Miriam Longo, Marica Meroni, Erika Paolini, Veronica Erconi, Fabrizia Carli, Francesco Fortunato, Dario Ronchi, Roberto Piciotti, Silvia Sabatini, Chiara Macchi, Anna Alisi, Luca Miele, Giorgio Soardo, Giacomo Pietro Comi, Luca Valenti, Massimiliano Ruscica, Anna L. Fracanzani, Amalia Gastaldelli, Paola Dongiovanni

Cell Mol Gastroenterol Hepatol. 2022; 13(3): 759–788. Published online 2021 Nov 23. doi: 10.1016/j.jcmgh.2021.11.007

PMCID:: PMC8783129

Abstract Article PDF–7.0M

Select item 87640737.

RNF43/ZNRF3 loss predisposes to hepatocellular-carcinoma by impairing liver regeneration and altering the liver lipid metabolic ground-state

Germán Belenguer, Gianmarco Mastrogiovanni, Clare Pacini, Zoe Hall, Anna M. Dowbaj, Robert Arnes-Benito, Aleksandra Sljukic, Nicole Prior, Sofia Kakava, Charles R. Bradshaw, Susan Davies, Michele Vacca, Kourosh Saeb-Parsy, Bon-Kyoung Koo, Meritxell Huch

Nat Commun. 2022; 13: 334. Published online 2022 Jan 17. doi: 10.1038/s41467-021-27923-z

PMCID:: PMC8764073

Abstract Article PDF–3.7M

Select item 80873458.

High-fat diet induces fibrosis in mice lacking CYP2A5 and PPARα: a new model for steatohepatitis-associated fibrosis

Xue Chen, George K. Acquaah-Mensah, Krista L. Denning, Jonathan M. Peterson, Kesheng Wang, James Denvir, Feng Hong, Arthur I. Cederbaum, Yongke Lu

Am J Physiol Gastrointest Liver Physiol. 2020 Nov 1; 319(5): G626–G635. Published online 2020 Sep 2. doi: 10.1152/ajpgi.00213.2020

PMCID:: PMC8087345

Abstract Article

Select item 80843369.

Hepatitis C virus infection restricts human LINE-1 retrotransposition in hepatoma cells

Anja Schöbel, Van Nguyen-Dinh, Gerald G. Schumann, Eva Herker

PLoS Pathog. 2021 Apr; 17(4): e1009496. Published online 2021 Apr 19. doi: 10.1371/journal.ppat.1009496

PMCID:: PMC8084336

Abstract Article PDF–4.9M

Select item 790971210.

Autophagy and Lipid Droplets in the Liver

Nuria Martinez-Lopez, Rajat Singh

Annu Rev Nutr. Author manuscript; available in PMC 2021 Feb 26.

Published in final edited form as: Annu Rev Nutr. 2015; 35: 215–237. Published online 2015 May 6. doi: 10.1146/annurev-nutr-071813-105336

PMCID:: PMC7909712

Abstract Article PDF–597K

Select item 788126811.

Hypoxia-inducible lipid droplet-associated induces DGAT1 and promotes lipid storage in hepatocytes

Montserrat A. de la Rosa Rodriguez, Lei Deng, Anne Gemmink, Michel van Weeghel, Marie Louise Aoun, Christina Warnecke, Rajat Singh, Jan Willem Borst, Sander Kersten

Mol Metab. 2021 May; 47: 101168. Published online 2021 Jan 16. doi: 10.1016/j.molmet.2021.101168

PMCID:: PMC7881268

Abstract Article PDF–4.4M

Select item 731832212.

Review article: the emerging role of genetics in precision medicine for patients with non‐alcoholic steatohepatitis

Björn Carlsson, Daniel Lindén, Gabriella Brolén, Mathias Liljeblad, Mikael Bjursell, Stefano Romeo, Rohit Loomba

Aliment Pharmacol Ther. 2020 Jun; 51(12): 1305–1320. Published online 2020 May 7. doi: 10.1111/apt.15738

PMCID:: PMC7318322

Abstract Article PDF–1.1M

Select item 716420113.

MiR-30b-5p regulates the lipid metabolism by targeting PPARGC1A in Huh-7 cell line

Qing Zhang, Xue-Feng Ma, Meng-Zhen Dong, Jie Tan, Jie Zhang, Li-Kun Zhuang, Shou-Sheng Liu, Yong-Ning Xin

Lipids Health Dis. 2020; 19: 76. Published online 2020 Apr 16. doi: 10.1186/s12944-020-01261-3

PMCID:: PMC7164201

Abstract Article PDF–2.7M

Select item 592844114.

Increased liver tumor formation in neutral sphingomyelinase-2-deficient mice

Liansheng Zhong, Ji Na Kong, Michael B. Dinkins, Silvia Leanhart, Zhihui Zhu, Stefka D. Spassieva, Haiyan Qin, Hsuan-Pei Lin, Ahmed Elsherbini, Rebecca Wang, Xue Jiang, Mariana Nikolova-Karakashian, Guanghu Wang, Erhard Bieberich

J Lipid Res. 2018 May; 59(5): 795–804. Published online 2018 Mar 22. doi: 10.1194/jlr.M080879

PMCID:: PMC5928441

Abstract Article PDF–2.4M

Select item 575293515.

N-Myc Downstream-Regulated Gene 1 Restricts Hepatitis C Virus Propagation by Regulating Lipid Droplet Biogenesis and Viral Assembly

Cameron J. Schweitzer, Fang Zhang, Audrey Boyer, Kristin Valdez, Maggie Cam, T. Jake Liang

J Virol. 2018 Jan 15; 92(2): e01166-17. Prepublished online 2017 Nov 8. Published online 2018 Jan 2. doi: 10.1128/JVI.01166-17

PMCID:: PMC5752935

Abstract Article PDF–4.9M

Select item 558089916.

Chemical chaperone 4-phenyl butyric acid (4-PBA) reduces hepatocellular lipid accumulation and lipotoxicity through induction of autophagy

Ashraf U. Nissar, Love Sharma, Malik A. Mudasir, Lone A. Nazir, Sheikh A. Umar, Parduman R. Sharma, Ram A. Vishwakarma, Sheikh A. Tasduq

J Lipid Res. 2017 Sep; 58(9): 1855–1868. Published online 2017 Jun 27. doi: 10.1194/jlr.M077537

PMCID:: PMC5580899

Abstract Article PDF–2.0M

Select item 408236917.

PNPLA3 has retinyl-palmitate lipase activity in human hepatic stellate cells

Carlo Pirazzi, Luca Valenti, Benedetta Maria Motta, Piero Pingitore, Kristina Hedfalk, Rosellina Margherita Mancina, Maria Antonella Burza, Cesare Indiveri, Yvelise Ferro, Tiziana Montalcini, Cristina Maglio, Paola Dongiovanni, Silvia Fargion, Raffaela Rametta, Arturo Pujia, Linda Andersson, Saswati Ghosal, Malin Levin, Olov Wiklund, Michelina Iacovino, Jan Borén, Stefano Romeo

Hum Mol Genet. 2014 Aug 1; 23(15): 4077–4085. Published online 2014 Mar 25. doi: 10.1093/hmg/ddu121

PMCID:: PMC4082369

Abstract Article PDF–1020K

Select item 380648118.

Endoplasmic reticulum factor ERLIN2 regulates cytosolic lipid content in cancer cells

Guohui Wang, Xuebao Zhang, Jin-Sook Lee, Xiaogang Wang, Zeng-Quan Yang, Kezhong Zhang

Biochem J. Author manuscript; available in PMC 2013 Oct 23.

Published in final edited form as: Biochem J. 2012 Sep 15; 446(3): 415–425. doi: 10.1042/BJ20112050

PMCID:: PMC3806481

Abstract Article PDF–2.3M

Select item 356281319.

CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylglycerol-mediated hepatic insulin resistance

Jennifer L. Cantley, Toru Yoshimura, Joao Paulo G. Camporez, Dongyan Zhang, Francois R. Jornayvaz, Naoki Kumashiro, Fitsum Guebre-Egziabher, Michael J. Jurczak, Mario Kahn, Blas A. Guigni, Julie Serr, Joseph Hankin, Robert C. Murphy, Gary W. Cline, Sanjay Bhanot, Vara Prasad Manchem, J. Mark Brown, Varman T. Samuel, Gerald I. Shulman

Proc Natl Acad Sci U S A. 2013 Jan 29; 110(5): 1869–1874. Published online 2013 Jan 9. doi: 10.1073/pnas.1219456110

PMCID:: PMC3562813

Abstract Article PDF–702K

Select item 291912420.

Activity-based Protein Profiling Identifies a Host Enzyme, Carboxylesterase 1, Which Is Differentially Active during Hepatitis C Virus Replication

David R. Blais, Rodney K. Lyn, Michael A. Joyce, Yanouchka Rouleau, Rineke Steenbergen, Nicola Barsby, Lin-Fu Zhu, Adrian F. Pegoraro, Albert Stolow, David L. Tyrrell, John Paul Pezacki

J Biol Chem. 2010 Aug 13; 285(33): 25602–25612. Published online 2010 Jun 8. doi: 10.1074/jbc.M110.135483

PMCID:: PMC2919124

Abstract Article PDF–3.3M

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