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Select item 52076901.

Anti-Diabetic Effects of Jiang Tang Xiao Ke Granule via PI3K/Akt Signalling Pathway in Type 2 Diabetes KKAy Mice

Na Yu, Xin Fang, Dandan Zhao, Qianqian Mu, Jiacheng Zuo, Yue Ma, Yi Zhang, Fangfang Mo, Dongwei Zhang, Guangjian Jiang, Rui Wu, Sihua Gao

PLoS One. 2017; 12(1): e0168980. Published online 2017 Jan 3. doi: 10.1371/journal.pone.0168980

PMCID:: PMC5207690

Abstract Article PDF–2.4M

Select item 49663072.

IRF3 promotes adipose inflammation and insulin resistance and represses browning

Manju Kumari, Xun Wang, Louise Lantier, Anna Lyubetskaya, Jun Eguchi, Sona Kang, Danielle Tenen, Hyun Cheol Roh, Xingxing Kong, Lawrence Kazak, Rasheed Ahmad, Evan D. Rosen

J Clin Invest. 2016 Aug 1; 126(8): 2839–2854. Published online 2016 Jul 11. doi: 10.1172/JCI86080

PMCID:: PMC4966307

Abstract Article PDF–2.3M

Select item 49706863.

Rare variant associations with waist-to-hip ratio in European-American and African-American women from the NHLBI-Exome Sequencing Project

Mengyuan Kan, Paul L Auer, Gao T Wang, Kristine L Bucasas, Stanley Hooker, Alejandra Rodriguez, Biao Li, Jaclyn Ellis, L Adrienne Cupples, Yii-Der Ida Chen, Josée Dupuis, Caroline S Fox, Myron D Gross, Joshua D Smith, Nancy Heard-Costa, James B Meigs, James S Pankow, Jerome I Rotter, David Siscovick, James G Wilson, Jay Shendure, Rebecca Jackson, Ulrike Peters, Hua Zhong, Danyu Lin, Li Hsu, Nora Franceschini, Chris Carlson, Goncalo Abecasis, Stacey Gabriel, Michael J Bamshad, David Altshuler, Deborah A Nickerson, Kari E North, Leslie A Lange, Alexander P Reiner, NHLBI-Exome Sequencing Project, Suzanne M Leal

Eur J Hum Genet. 2016 Aug; 24(8): 1181–1187. Published online 2016 Jan 13. doi: 10.1038/ejhg.2015.272

PMCID:: PMC4970686

Abstract Article PDF–541K

Select item 49856534.

Insulin receptor alternative splicing is regulated by insulin signaling and modulates beta cell survival

Pushkar Malakar, Lital Chartarifsky, Ayat Hija, Gil Leibowitz, Benjamin Glaser, Yuval Dor, Rotem Karni

Sci Rep. 2016; 6: 31222. Published online 2016 Aug 16. doi: 10.1038/srep31222

PMCID:: PMC4985653

Abstract Article PDF–2.0M

Select item 49887855.

IGF1R Derived PI3K/AKT Signaling Maintains Growth in a Subset of Human T-Cell Acute Lymphoblastic Leukemias

Samuel Gusscott, Catherine E. Jenkins, Sonya H. Lam, Vincenzo Giambra, Michael Pollak, Andrew P. Weng

PLoS One. 2016; 11(8): e0161158. Published online 2016 Aug 17. doi: 10.1371/journal.pone.0161158

PMCID:: PMC4988785

Abstract Article PDF–1011K

Select item 50059676.

Changes in the expression of the type 2 diabetes-associated gene VPS13C in the β-cell are associated with glucose intolerance in humans and mice

Zenobia B. Mehta, Nicholas Fine, Timothy J. Pullen, Matthew C. Cane, Ming Hu, Pauline Chabosseau, Gargi Meur, Antonio Velayos-Baeza, Anthony P. Monaco, Lorella Marselli, Piero Marchetti, Guy A. Rutter

Am J Physiol Endocrinol Metab. 2016 Aug 1; 311(2): E488–E507. Published online 2016 Jun 21. doi: 10.1152/ajpendo.00074.2016

PMCID:: PMC5005967

Abstract Article

Select item 50092577.

Mice Deficient in Angiopoietin-like Protein 2 (Angptl2) Gene Show Increased Susceptibility to Bacterial Infection Due to Attenuated Macrophage Activity

Masaki Yugami, Haruki Odagiri, Motoyoshi Endo, Hiroyasu Tsutsuki, Shigemoto Fujii, Tsuyoshi Kadomatsu, Tetsuro Masuda, Keishi Miyata, Kazutoyo Terada, Hironori Tanoue, Hitoshi Ito, Jun Morinaga, Haruki Horiguchi, Taichi Sugizaki, Takaaki Akaike, Tomomi Gotoh, Toshiyuki Takai, Tomohiro Sawa, Hiroshi Mizuta, Yuichi Oike

J Biol Chem. 2016 Sep 2; 291(36): 18843–18852. Published online 2016 Jul 11. doi: 10.1074/jbc.M116.720870

PMCID:: PMC5009257

Abstract Article PDF–1.7M

Select item 50212978.

Benzylglucosinolate Derived Isothiocyanate from Tropaeolum majus Reduces Gluconeogenic Gene and Protein Expression in Human Cells

Valentina Guzmán-Pérez, Christiane Bumke-Vogt, Monika Schreiner, Inga Mewis, Andrea Borchert, Andreas F. H. Pfeiffer

PLoS One. 2016; 11(9): e0162397. Published online 2016 Sep 13. doi: 10.1371/journal.pone.0162397

PMCID:: PMC5021297

Abstract Article PDF–6.1M

Select item 50301779.

Clinical Aspects of Type 3 Long QT Syndrome, an international multicenter study

Arthur A.M. Wilde, Arthur J. Moss, Elizabeth S. Kaufman, Wataru Shimizu, Derick R. Peterson, Jesaia Benhorin, Coeli Lopes, Jeffrey A. Towbin, Carla Spazzolini, Lia Crotti, Wojciech Zareba, Ilan Goldenberg, Jørgen K. Kanters, Jennifer L. Robinson, Ming Qi, Nynke Hofman, David J. Tester, Connie R Bezzina, Marielle Alders, Takeshi Aiba, Shiro Kamakura, Yoshihiro Miyamoto, Mark L Andrews, Scott McNitt, Bronislava Polonsky, Peter J. Schwartz, Michael J. Ackerman

Circulation. Author manuscript; available in PMC 2017 Sep 20.

Published in final edited form as: Circulation. 2016 Sep 20; 134(12): 872–882. Published online 2016 Aug 26. doi: 10.1161/CIRCULATIONAHA.116.021823

PMCID:: PMC5030177

Abstract Article PDF–646K

Select item 503326310.

SERCA2 Deficiency Impairs Pancreatic β-Cell Function in Response to Diet-Induced Obesity

Xin Tong, Tatsuyoshi Kono, Emily K. Anderson-Baucum, Wataru Yamamoto, Patrick Gilon, Djamel Lebeche, Richard N. Day, Gary E. Shull, Carmella Evans-Molina

Diabetes. 2016 Oct; 65(10): 3039–3052. Published online 2016 Aug 3. doi: 10.2337/db16-0084

PMCID:: PMC5033263

Abstract Article PDF–1.9M

Select item 505234011.

Plasma Taurine, Diabetes Genetic Predisposition, and Changes of Insulin Sensitivity in Response to Weight-Loss Diets

Yan Zheng, Uta Ceglarek, Tao Huang, Tiange Wang, Yoriko Heianza, Wenjie Ma, George A. Bray, Joachim Thiery, Frank M. Sacks, Lu Qi

J Clin Endocrinol Metab. 2016 Oct; 101(10): 3820–3826. Published online 2016 Jul 28. doi: 10.1210/jc.2016-1760

PMCID:: PMC5052340

Abstract Article

Select item 511260312.

Integrative mutation, haplotype and G × G interaction evidence connects ABGL4, LRP8 and PCSK9 genes to cardiometabolic risk

Tao Guo, Rui-Xing Yin, Li-Mei Yao, Feng Huang, Ling Pan, Wei-Xiong Lin, De-Zhai Yang, Shang-Ling Pan

Sci Rep. 2016; 6: 37375. Published online 2016 Nov 17. doi: 10.1038/srep37375

PMCID:: PMC5112603

Abstract Article PDF–1.4M

Select item 512320813.

Gut microbiota and glucometabolic alterations in response to recurrent partial sleep deprivation in normal-weight young individuals

Christian Benedict, Heike Vogel, Wenke Jonas, Anni Woting, Michael Blaut, Annette Schürmann, Jonathan Cedernaes

Mol Metab. 2016 Dec; 5(12): 1175–1186. Published online 2016 Oct 24. doi: 10.1016/j.molmet.2016.10.003

PMCID:: PMC5123208

Abstract Article PDF–911K

Select item 513380314.

A Clinical Trial about a Food Supplement Containing α-Lipoic Acid on Oxidative Stress Markers in Type 2 Diabetic Patients

Giuseppe Derosa, Angela D’Angelo, Davide Romano, Pamela Maffioli

Int J Mol Sci. 2016 Nov; 17(11): 1802. Published online 2016 Oct 28. doi: 10.3390/ijms17111802

PMCID:: PMC5133803

Abstract Article PDF–493K

Select item 515361315.

Hypogonadism alters cecal and fecal microbiota in male mice

Naoki Harada, Ryo Hanaoka, Kazuki Hanada, Takeshi Izawa, Hiroshi Inui, Ryoichi Yamaji

Gut Microbes. 2016; 7(6): 533–539. Published online 2016 Sep 22. doi: 10.1080/19490976.2016.1239680

PMCID:: PMC5153613

Abstract Article PDF–659K

Select item 520385916.

Guidelines for diagnosis and management of the cobalamin-related remethylation disorders cblC, cblD, cblE, cblF, cblG, cblJ and MTHFR deficiency

Martina Huemer, Daria Diodato, Bernd Schwahn, Manuel Schiff, Anabela Bandeira, Jean-Francois Benoist, Alberto Burlina, Roberto Cerone, Maria L. Couce, Angeles Garcia-Cazorla, Giancarlo la Marca, Elisabetta Pasquini, Laura Vilarinho, James D. Weisfeld-Adams, Viktor Kožich, Henk Blom, Matthias R. Baumgartner, Carlo Dionisi-Vici

J Inherit Metab Dis. 2017; 40(1): 21–48. Published online 2016 Nov 30. doi: 10.1007/s10545-016-9991-4

PMCID:: PMC5203859

Abstract Article PDF–909K

Select item 494661817.

Type 1 diabetes genetic susceptibility and dendritic cell function: potential targets for treatment

Chie Hotta-Iwamura, Kristin V. Tarbell

J Leukoc Biol. 2016 Jul; 100(1): 65–80. Published online 2016 Jan 20. doi: 10.1189/jlb.3MR1115-500R

PMCID:: PMC4946618

Abstract Article

Select item 521517518.

The Role of HMGB1 in the Pathogenesis of Type 2 Diabetes

Yanan Wang, Jixin Zhong, Xiangzhi Zhang, Ziwei Liu, Yuan Yang, Quan Gong, Boxu Ren

J Diabetes Res. 2016; 2016: 2543268. Published online 2016 Dec 22. doi: 10.1155/2016/2543268

PMCID:: PMC5215175

Abstract Article PDF–885K

Select item 521696019.

Effective molecular targeting of CDK4/6 and IGF-1R in a rare FUS-ERG fusion CDKN2A-deletion doxorubicin-resistant Ewing's sarcoma patient-derived orthotopic xenograft (PDOX) nude-mouse model

Takashi Murakami, Arun S. Singh, Tasuku Kiyuna, Sarah M. Dry, Yunfeng Li, Aaron W. James, Kentaro Igarashi, Kei Kawaguchi, Jonathan C. DeLong, Yong Zhang, Yukihiko Hiroshima, Tara Russell, Mark A. Eckardt, Jane Yanagawa, Noah Federman, Ryusei Matsuyama, Takashi Chishima, Kuniya Tanaka, Michael Bouvet, Itaru Endo, Fritz C. Eilber, Robert M. Hoffman

Oncotarget. 2016 Jul 26; 7(30): 47556–47564. Published online 2016 Jun 7. doi: 10.18632/oncotarget.9879

PMCID:: PMC5216960

Abstract Article PDF–3.1M

Select item 522039320.

Celastrol ameliorates liver metabolic damage caused by a high-fat diet through Sirt1

Yinliang Zhang, Chao Geng, Xiaoyan Liu, Meixia Li, Mingyue Gao, Xiaojun Liu, Fude Fang, Yongsheng Chang

Mol Metab. 2017 Jan; 6(1): 138–147. Published online 2016 Nov 17. doi: 10.1016/j.molmet.2016.11.002

PMCID:: PMC5220393

Abstract Article PDF–1.7M

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