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Select item 105664511.

The Inherited KRAS-variant as a Biomarker of Cetuximab Response in NSCLC

Joanne B. Weidhaas, Chen Hu, Ritsuko Komaki, Gregory A. Masters, George R. Blumenschein, Joe Y. Chang, Bo Lu, Adam P. Dicker, Jeffrey A. Bogart, Yolanda I. Garces, Samir Narayan, Clifford G. Robinson, Vivek S. Kavadi, Joel S. Greenberger, Christopher D. Koprowski, James Welsh, Elizabeth M. Gore, Robert M. MacRae, Rebecca Paulus, Jeffrey D. Bradley

Cancer Res Commun. 2023 Oct; 3(10): 2074–2081. Published online 2023 Oct 11. doi: 10.1158/2767-9764.CRC-23-0084

PMCID:: PMC10566451

Abstract Article PDF–4.1M

Select item 85649082.

Caveolin-1 and Sox-2 are predictive biomarkers of cetuximab response in head and neck cancer

Mehdi Bouhaddou, Rex H. Lee, Hua Li, Neil E. Bhola, Rachel A. O’Keefe, Mohammad Naser, Tian Ran Zhu, Kelechi Nwachuku, Umamaheswar Duvvuri, Adam B. Olshen, Ritu Roy, Aaron Hechmer, Jennifer Bolen, Stephen B. Keysar, Antonio Jimeno, Gordon B. Mills, Scott Vandenberg, Danielle L. Swaney, Daniel E. Johnson, Nevan J. Krogan, Jennifer R. Grandis

JCI Insight. 2021 Oct 22; 6(20): e151982. Published online 2021 Oct 22. doi: 10.1172/jci.insight.151982

PMCID:: PMC8564908

Abstract Article PDF–5.9M

Select item 54704223.

The KRAS-Variant and Cetuximab Response in Head and Neck Squamous Cell Cancer: A Secondary Analysis of a Randomized Clinical Trial

Joanne B. Weidhaas, Jonathan Harris, Dörthe Schaue, Allen M. Chen, Robert Chin, Rita Axelrod, Adel K. El-Naggar, Anurag K. Singh, Thomas J. Galloway, David Raben, Dian Wang, Chance Matthiesen, Vilija N. Avizonis, Rafael R. Manon, Omar Yumen, Phuc Felix Nguyen-Tan, Andy Trotti, Heath Skinner, Qiang Zhang, Robert L. Ferris, David Sidransky, Christine H. Chung

JAMA Oncol. 2017 Apr; 3(4): 483–491. Prepublished online 2016 Dec 22. Published online 2017 Apr 13. doi: 10.1001/jamaoncol.2016.5478

PMCID:: PMC5470422

Abstract Article

Select item 52266044.

Cetuximab response in CRC patient-derived xenografts seems predicted by an expression based RAS pathway signature

Sheng Guo, Dawei Chen, Xuesong Huang, Jie Cai, Jean-Pierre Wery, Qi-Xiang Li

Oncotarget. 2016 Aug 2; 7(31): 50575–50581. Published online 2016 Jul 8. doi: 10.18632/oncotarget.10499

PMCID:: PMC5226604

Abstract Article PDF–1.7M

Select item 47531735.

Evaluation of antibody-dependent cell-mediated cytotoxicity activity and cetuximab response in KRAS wild-type metastatic colorectal cancer patients

Cristiana Lo Nigro, Vincenzo Ricci, Daniela Vivenza, Martino Monteverde, Giuliana Strola, Francesco Lucio, Federica Tonissi, Emanuela Miraglio, Cristina Granetto, Mirella Fortunato, Marco Carlo Merlano

World J Gastrointest Oncol. 2016 Feb 15; 8(2): 222–230. Published online 2016 Feb 15. doi: 10.4251/wjgo.v8.i2.222

PMCID:: PMC4753173

Abstract Article PDF–937K

Select item 46657826.

PRMT1-mediated methylation of the EGF receptor regulates signaling and cetuximab response

Hsin-Wei Liao, Jung-Mao Hsu, Weiya Xia, Hung-Ling Wang, Ying-Nai Wang, Wei-Chao Chang, Stefan T. Arold, Chao-Kai Chou, Pei-Hsiang Tsou, Hirohito Yamaguchi, Yueh-Fu Fang, Hong-Jen Lee, Heng-Huan Lee, Shyh-Kuan Tai, Mhu-Hwa Yang, Maria P. Morelli, Malabika Sen, John E. Ladbury, Chung-Hsuan Chen, Jennifer R. Grandis, Scott Kopetz, Mien-Chie Hung

J Clin Invest. 2015 Dec 1; 125(12): 4529–4543. Published online 2015 Nov 16. doi: 10.1172/JCI82826

PMCID:: PMC4665782

Abstract Article PDF–4.5M

Select item 39037897.

Cetuximab response of lung cancer-derived EGF receptor mutants is associated with asymmetric dimerization

Jeonghee Cho, Liang Chen, Naveen Sangji, Takafumi Okabe, Kimio Yonesaka, Joshua M. Francis, Richard J. Flavin, William Johnson, Jihyun Kwon, Soyoung Yu, Heidi E. Greulich, Bruce E. Johnson, Michael J. Eck, Pasi A. Jänne, Kwok-Kin Wong, Matthew Meyerson

Cancer Res. Author manuscript; available in PMC 2014 Nov 15.

Published in final edited form as: Cancer Res. 2013 Nov 15; 73(22): 6770–6779. Published online 2013 Sep 24. doi: 10.1158/0008-5472.CAN-13-1145

PMCID:: PMC3903789

Abstract Article PDF–2.8M

Select item 25276158.

Potential value of PTEN in predicting cetuximab response in colorectal cancer: An exploratory study

Evangelia Razis, Evangelos Briasoulis, Eleni Vrettou, Dimosthenis V Skarlos, Dimitrios Papamichael, Ioannis Kostopoulos, Epaminontas Samantas, Ioannis Xanthakis, Mattheos Bobos, Eleni Galanidi, Maria Bai, Ioanna Gikonti, Alona Koukouma, Georgia Kafiri, Pavlos Papakostas, Konstantine T Kalogeras, Paris Kosmidis, George Fountzilas

BMC Cancer. 2008; 8: 234. Published online 2008 Aug 13. doi: 10.1186/1471-2407-8-234

PMCID:: PMC2527615

Abstract Article PDF–455K

Select item 102655979.

Establishment of patient-derived tumor organoids to functionally inform treatment decisions in metastatic colorectal cancer

G. Martini, V. Belli, S. Napolitano, V. Ciaramella, D. Ciardiello, A. Belli, F. Izzo, A. Avallone, F. Selvaggi, F. Menegon Tasselli, W. Santaniello, R. Franco, I. Puig, L. Ramirez, I. Chicote, F. Mancuso, G. Caratu, X. Serres, R. Fasani, J. Jimenez, J. Ros, I. Baraibar, N. Mulet, C.M. Della Corte, T. Troiani, A. Vivancos, R. Dienstmann, E. Elez, H.G. Palmer, J. Tabernero, E. Martinelli, F. Ciardiello, G. Argilés

ESMO Open. 2023 Jun; 8(3): 101198. Published online 2023 Apr 27. doi: 10.1016/j.esmoop.2023.101198

PMCID:: PMC10265597

Abstract Article PDF–635K

Select item 989815910.

Cetuximab responses in HNSCC patients correlate to clonal expansion feature of peripheral and tumor-infiltrating T cells with top T cell receptor (TCR) clonotypes

Huaibin Ge, Robert L. Ferris, Jing H Wang

Clin Cancer Res. Author manuscript; available in PMC 2023 Aug 1.

Published in final edited form as: Clin Cancer Res. 2023 Feb 1; 29(3): 647–658. doi: 10.1158/1078-0432.CCR-22-2355

PMCID:: PMC9898159

Abstract Article PDF–2.0M

Select item 861140311.

Expression of neurofibromin 1 in colorectal cancer and cetuximab resistance

Eunyoung Tak, Minhee Kim, Youngra Cho, Sueun Choi, Jihun Kim, Buhm Han, Hyung-Don Kim, Chloe Soo-Hyun Jang, Jeong Eun Kim, Yong Sang Hong, Sun Young Kim, Tae Won Kim

Oncol Rep. 2022 Jan; 47(1): 15. Published online 2021 Nov 12. doi: 10.3892/or.2021.8226

PMCID:: PMC8611403

Abstract Article PDF–1.5M

Select item 519964012.

HER3 targeting sensitizes HNSCC to cetuximab by reducing HER3 activity and HER2/HER3 dimerization - evidence from cell line and patient derived xenograft models

Dongsheng Wang, Guoqing Qian, Hongzheng Zhang, Kelly R. Magliocca, Sreenivas Nannapaneni, A.R.M. Ruhul Amin, Michael Rossi, Mihir Patel, Mark El-Deiry, J Trad Wadsworth, Zhengjia Chen, Fadlo R. Khuri, Dong M. Shin, Nabil F. Saba, Zhuo G. Chen

Clin Cancer Res. Author manuscript; available in PMC 2018 Feb 1.

Published in final edited form as: Clin Cancer Res. 2017 Feb 1; 23(3): 677–686. Published online 2016 Jun 29. doi: 10.1158/1078-0432.CCR-16-0558

PMCID:: PMC5199640

Abstract Article PDF–2.4M

Select item 477073013.

MicroRNA expression profiling identifies miR-31-5p/3p as associated with time to progression in wild-type RAS metastatic colorectal cancer treated with cetuximab

Jitka Mlcochova, Petra Faltejskova-Vychytilova, Manuela Ferracin, Barbara Zagatti, Lenka Radova, Marek Svoboda, Radim Nemecek, Stanislav John, Igor Kiss, Rostislav Vyzula, Massimo Negrini, Ondrej Slaby

Oncotarget. 2015 Nov 17; 6(36): 38695–38704. Published online 2015 Oct 20. doi: 10.18632/oncotarget.5735

PMCID:: PMC4770730

Abstract Article PDF–1.9M

Select item 414165514.

Modeling RAS phenotype in colorectal cancer uncovers novel molecular traits of RAS dependency and improves prediction of response to targeted agents in patients

Justin Guinney, Charles Ferté, Jonathan Dry, Robert McEwen, Gilles Manceau, KJ Kao, Kai-Ming Chang, Claus Bendtsen, Kevin Hudson, Erich Huang, Brian Dougherty, Michel Ducreux, Jean-Charles Soria, Stephen Friend, Jonathan Derry, Pierre Laurent-Puig

Clin Cancer Res. Author manuscript; available in PMC 2015 Jan 1.

Published in final edited form as: Clin Cancer Res. 2014 Jan 1; 20(1): 265–272. Published online 2013 Oct 29. doi: 10.1158/1078-0432.CCR-13-1943

PMCID:: PMC4141655

Abstract Article PDF–474K

Select item 397221615.

PIK3CA mutation / PTEN expression status predicts response of colon cancer cells to the EGFR inhibitor cetuximab

Minaxi Jhawer, Sanjay Goel, Andrew J. Wilson, Cristina Montagna, Yi-He Ling, Do-Sun Byun, Shannon Nasser, Diego Arango, Joongho Shin, Lidija Klampfer, Leonard H. Augenlicht, Roman Perez Soler, John M. Mariadason

Cancer Res. Author manuscript; available in PMC 2014 Apr 1.

Published in final edited form as: Cancer Res. 2008 Mar 15; 68(6): 1953–1961. doi: 10.1158/0008-5472.CAN-07-5659

Correction in:: volume 68 on page 6859

Correction in:: volume 69 on page 9156

PMCID:: PMC3972216

Abstract Article PDF–2.0M

Select item 381100716.

Cetuximab reverses the Warburg effect by inhibiting HIF-1–regulated LDH-A

Haiquan Lu, Xinqun Li, Zhongguang Luo, Jie Liu, Zhen Fan

Mol Cancer Ther. Author manuscript; available in PMC 2014 Oct 1.

Published in final edited form as: Mol Cancer Ther. 2013 Oct; 12(10): 10.1158/1535-7163.MCT-12-1245. Published online 2013 Aug 6. doi: 10.1158/1535-7163.MCT-12-1245

PMCID:: PMC3811007

Abstract Article PDF–1.2M

Select item 314279817.

Pyrosequencing-based methods reveal marked inter-individual differences in oncogene mutation burden in human colorectal tumours

S Weidlich, K Walsh, D Crowther, M E Burczynski, G Feuerstein, F A Carey, R J C Steele, C R Wolf, G Miele, G Smith

Br J Cancer. 2011 Jul 12; 105(2): 246–254. Published online 2011 Jun 28. doi: 10.1038/bjc.2011.197

PMCID:: PMC3142798

Abstract Article PDF–515K

Select item 243206418.

A polymorphism of EGFR extracellular domain is associated with progression free-survival in metastatic colorectal cancer patients receiving cetuximab-based treatment

Anthony Gonçalves, Séverine Esteyries, Brynn Taylor-Smedra, Arnaud Lagarde, Mounay Ayadi, Geneviève Monges, François Bertucci, Benjamin Esterni, Jean-Robert Delpero, Olivier Turrini, Bernard Lelong, Patrice Viens, Jean-Paul Borg, Daniel Birnbaum, Sylviane Olschwang, Frédéric Viret

BMC Cancer. 2008; 8: 169. Published online 2008 Jun 10. doi: 10.1186/1471-2407-8-169

PMCID:: PMC2432064

Abstract Article PDF–564K

Select item 1078439119.

Inhibition of autocrine HGF maturation overcomes cetuximab resistance in colorectal cancer

Vivian Truong Jones, Ramona Graves-Deal, Zheng Cao, Galina Bogatcheva, Marisol A. Ramirez, Sarah J. Harmych, James N. Higginbotham, Vineeta Sharma, Vishnu C. Damalanka, Claudia C. Wahoski, Neeraj Joshi, Maria Johnson Irudayam, Joseph T. Roland, Gregory D. Ayers, Qi Liu, Robert J. Coffey, James W. Janetka, Bhuminder Singh

Cell Mol Life Sci. 2024 Dec; 81(1): 28. Published online 2024 Jan 12. doi: 10.1007/s00018-023-05071-5

PMCID:: PMC10784391

Abstract Article PDF–2.1M

Select item 940615520.

Current Evidence of a Deintensification Strategy for Patients with HPV-Related Oropharyngeal Cancer

Soo-Yoon Sung, Yeon-Sil Kim, Sung Hwan Kim, Seung Jae Lee, Sea-Won Lee, Yoo-Kang Kwak

Cancers (Basel) 2022 Aug; 14(16): 3969. Published online 2022 Aug 17. doi: 10.3390/cancers14163969

PMCID:: PMC9406155

Abstract Article PDF–433K

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