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Select item 111419391.

BET inhibition reforms the immune microenvironment and alleviates T cell dysfunction in chronic lymphocytic leukemia

Audrey L. Smith, Sydney A. Skupa, Alexandria P. Eiken, Timothy E. Reznicek, Elizabeth Schmitz, Nolan Williams, Dalia Y. Moore, Christopher R. D’Angelo, Avyakta Kallam, Matthew A. Lunning, R. Gregory Bociek, Julie M. Vose, Eslam Mohamed, Anna R. Mahr, Paul W. Denton, Ben Powell, Gideon Bollag, M. Jordan Rowley, Dalia El-Gamal

JCI Insight. 2024 May 22; 9(10): e177054. Published online 2024 May 22. doi: 10.1172/jci.insight.177054

PMCID:: PMC11141939

Abstract Article PDF–2.7M

Select item 110870762.

Expression of CD39 is associated with T cell exhaustion in ovarian cancer and its blockade reverts T cell dysfunction

Witt Marius, Oliveira-Ferrer Leticia, Koch-Nolte Friedrich, Menzel Stephan, Hell Louisa, Sturmheit Tabea, Seubert Elisa, Weimer Pauline, Ding Yi, Minyue Qi, Schmalfeldt Barbara, Bokemeyer Carsten, Fiedler Walter, Wellbrock Jasmin, Brauneck Franziska

Oncoimmunology. 2024; 13(1): 2346359. Published online 2024 May 9. doi: 10.1080/2162402X.2024.2346359

PMCID:: PMC11087076

Abstract Article PDF–10M

Select item 110284973.

Surgical trauma induces postoperative T-cell dysfunction in lung cancer patients through the programmed death-1 pathway

Pingbo Xu, Ping Zhang, Zhirong Sun, Yun Wang, Jiawei Chen, Changhong Miao

Cancer Immunol Immunother. 2015 Nov; 64(11): 1383–1392. Published online 2015 Jul 17. doi: 10.1007/s00262-015-1740-2

PMCID:: PMC11028497

Abstract Article PDF–1.5M

Select item 109876994.

T cell dysfunction in elderly ARDS patients based on miRNA and mRNA integration analysis

Yumi Mitsuyama, Hisatake Matsumoto, Yuki Togami, Sayaka Oda, Shinya Onishi, Jumpei Yoshimura, Arisa Murtatsu, Hiroshi Ito, Hiroshi Ogura, Daisuke Okuzaki, Jun Oda

Front Immunol. 2024; 15: 1368446. Published online 2024 Mar 20. doi: 10.3389/fimmu.2024.1368446

PMCID:: PMC10987699

Abstract Article PDF–3.8M

Select item 109876245.

Alexander Piening, Emily Ebert, Carter Gottlieb, Niloufar Khojandi, Lindsey M. Kuehm, Stella G. Hoft, Kelly D. Pyles, Kyle S. McCommis, Richard J. DiPaolo, Stephen T. Ferris, Elise Alspach, Ryan M. Teague

Nat Commun. 2024; 15: 2835. Published online 2024 Apr 2. doi: 10.1038/s41467-024-47359-5

PMCID:: PMC10987624

Abstract Article PDF–2.6M

Select item 108932106.

Examining Chronic Inflammation, Immune Metabolism, and T Cell Dysfunction in HIV Infection

Wenli Mu, Vaibhavi Patankar, Scott Kitchen, Anjie Zhen

Viruses. 2024 Feb; 16(2): 219. Published online 2024 Jan 31. doi: 10.3390/v16020219

PMCID:: PMC10893210

Abstract Article PDF–766K

Select item 108887277.

Disrupting CD38-driven T cell dysfunction restores sensitivity to cancer immunotherapy

Or-Yam Revach, Angelina M. Cicerchia, Ofir Shorer, Boryana Petrova, Seth Anderson, Joshua Park, Lee Chen, Arnav Mehta, Samuel J. Wright, Niamh McNamee, Aya Tal-Mason, Giulia Cattaneo, Payal Tiwari, Hongyan Xie, Johanna M. Sweere, Li-Chun Cheng, Natalia Sigal, Elizabeth Enrico, Marisa Miljkovic, Shane A. Evans, Ngan Nguyen, Mark E. Whidden, Ramji Srinivasan, Matthew H. Spitzer, Yi Sun, Tatyana Sharova, Aleigha R. Lawless, William A. Michaud, Martin Q. Rasmussen, Jacy Fang, Claire A. Palin, Feng Chen, Xinhui Wang, Cristina R. Ferrone, Donald P. Lawrence, Ryan J. Sullivan, David Liu, Uma M. Sachdeva, Debattama R. Sen, Keith T. Flaherty, Robert T. Manguso, Lloyd Bod, Manolis Kellis, Genevieve M. Boland, Keren Yizhak, Jiekun Yang, Naama Kanarek, Moshe Sade-Feldman, Nir Hacohen, Russell W. Jenkins

Version 3. bioRxiv. Preprint. NaN NaN [revised 2024 Mar 26]. doi: 10.1101/2024.02.12.579184

PMCID:: PMC10888727

Abstract Article PDF–14M

Select item 108787198.

Hallmarks of CD8 T cell dysfunction are established within hours of tumor antigen encounter prior to cell division

Michael W. Rudloff, Paul Zumbo, Natalie R. Favret, Jessica J. Roetman, Carlos R. Detrés Román, Megan M. Erwin, Kristen A. Murray, Sriya T. Jonnakuti, Friederike Dündar, Doron Betel, Mary Philip

Nat Immunol. Author manuscript; available in PMC 2024 Mar 1.

Published in final edited form as: Nat Immunol. 2023 Sep; 24(9): 1527–1539. Published online 2023 Aug 3. doi: 10.1038/s41590-023-01578-y

PMCID:: PMC10878719

Abstract Article PDF–7.1M

Select item 108478639.

Identification of CD8 T-cell dysfunction associated with symptoms in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and Long COVID and treatment with a nebulized antioxidant/anti-pathogen agent in a retrospective case series

Anna Gil, George E. Hoag, John P. Salerno, Mady Hornig, Nancy Klimas, Liisa K. Selin

Brain Behav Immun Health. 2024 Mar; 36: 100720. Published online 2023 Dec 27. doi: 10.1016/j.bbih.2023.100720

PMCID:: PMC10847863

Abstract Article PDF–2.7M

Select item 1074929210.

Trogocytosis of CAR molecule regulates CAR-T cell dysfunction and tumor antigen escape

You Zhai, Yicong Du, Guanzhang Li, Mingchen Yu, Huimin Hu, Changqing Pan, Di Wang, Zhongfang Shi, Xu Yan, Xuesong Li, Tao Jiang, Wei Zhang

Signal Transduct Target Ther. 2023; 8: 457. Published online 2023 Dec 25. doi: 10.1038/s41392-023-01708-w

PMCID:: PMC10749292

Abstract Article PDF–4.8M

Select item 1073516911.

The GPCR–Gα_s–PKA signaling axis promotes T cell dysfunction and cancer immunotherapy failure

Victoria H. Wu, Bryan S. Yung, Farhoud Faraji, Robert Saddawi-Konefka, Zhiyong Wang, Alexander T. Wenzel, Miranda J. Song, Meghana S. Pagadala, Lauren M. Clubb, Joshua Chiou, Sanju Sinha, Marin Matic, Francesco Raimondi, Thomas S. Hoang, Rebecca Berdeaux, Dario A. A. Vignali, Ramiro Iglesias-Bartolome, Hannah Carter, Eytan Ruppin, Jill P. Mesirov, J. Silvio Gutkind

Nat Immunol. Author manuscript; available in PMC 2023 Dec 21.

Published in final edited form as: Nat Immunol. 2023 Aug; 24(8): 1318–1330. Published online 2023 Jun 12. doi: 10.1038/s41590-023-01529-7

PMCID:: PMC10735169

Abstract Article PDF–3.8M

Select item 1069155412.

HERV1-env induces unfolded protein response activation in autoimmune liver disease – a potential mechanism for regulatory T cell dysfunction

Kumar Subramanian, Saikat Paul, Andrew Libby, Jordan Patterson, Adam Arterbery, James Knight, Christopher Castaldi, Guilin Wang, Yaron Avitzur, Mercedes Martinez, Steve Lobritto, Yanhong Deng, Gan Geliang, Alexander Kroemer, Thomas Fishbein, Andrew Mason, Margarita Dominguez-Villar, Malaiyalam Mariappan, Udeme D. Ekong

J Immunol. Author manuscript; available in PMC 2024 Mar 15.

Published in final edited form as: J Immunol. 2023 Mar 15; 210(6): 732–744. doi: 10.4049/jimmunol.2100186

PMCID:: PMC10691554

Abstract Article PDF–1.9M

Select item 1063260913.

T-cell dysfunction by pseudohypoxia and autocrine purinergic signaling in chronic lymphocytic leukemia

Chiara Montironi, Chaja F. Jacobs, Gaspard Cretenet, Fleur S. Peters, Bauke V. Schomakers, Michel van Weeghel, Arnon P. Kater, Helga Simon-Molas, Eric Eldering

Blood Adv. 2023 Nov 14; 7(21): 6540–6552. Published online 2023 Aug 10. doi: 10.1182/bloodadvances.2023010305

PMCID:: PMC10632609

Abstract Article PDF–1.1M

Select item 1060036414.

Corrigendum: Egg-phosphatidylcholine attenuates T-cell dysfunction in high-fat diet fed male Wistar rats

Jessy Azarcoya-Barrera, Bethany Wollin, Hellen Veida-Silva, Alexander Makarowski, Susan Goruk, Catherine J. Field, René L. Jacobs, Caroline Richard

Front Nutr. 2023; 10: 1304098. Published online 2023 Oct 11. doi: 10.3389/fnut.2023.1304098

Corrects:: Front Nutr. 2022; 9: 811469.

PMCID:: PMC10600364

Correction PDF–64K

Select item 1057980015.

PSGL-1: a novel immune checkpoint driving T-cell dysfunction in obstructive sleep apnea

Elena Díaz-García, Aldara García-Sánchez, Enrique Alfaro, Cristina López-Fernández, Eva Mañas, Irene Cano-Pumarega, Eduardo López-Collazo, Francisco García-Río, Carolina Cubillos-Zapata

Front Immunol. 2023; 14: 1277551. Published online 2023 Oct 3. doi: 10.3389/fimmu.2023.1277551

PMCID:: PMC10579800

Abstract Article PDF–2.8M

Select item 1041537516.

Complementarity-determining region clustering may cause CAR-T cell dysfunction

Tina Sarén, Giulia Saronio, Paula Marti Torrell, Xu Zhu, Josefin Thelander, Yasmin Andersson, Camilla Hofström, Marika Nestor, Anna Dimberg, Helena Persson, Mohanraj Ramachandran, Di Yu, Magnus Essand

Nat Commun. 2023; 14: 4732. Published online 2023 Aug 10. doi: 10.1038/s41467-023-40303-z