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Items: 1 to 20 of 500

1.
Efficacy of novel agents against cellular models of familial platelet disorder with myeloid malignancy (FPD-MM)
Christopher P. Mill, Warren C. Fiskus, Courtney D. DiNardo, Patrick Reville, John A. Davis, Christine E. Birdwell, Kaberi Das, Hanxi Hou, Koichi Takahashi, Lauren Flores, Xinjia Ruan, Xiaoping Su, Sanam Loghavi, Joseph D. Khoury, Kapil N. Bhalla
Blood Cancer J. 2024 Dec; 14(1): 25. Published online 2024 Feb 5. doi: 10.1038/s41408-024-00981-4
PMCID:
PMC10844204
AbstractArticlePDF–3.7M
2.
A RUNX1-FPDMM rhesus macaque model reproduces the human phenotype and predicts challenges to curative gene therapies
Byung-Chul Lee, Yifan Zhou, Erica Bresciani, Neval Ozkaya, Alina Dulau-Florea, Blake Carrington, Tae-Hoon Shin, Valentina Baena, Zulfeqhar A. Syed, So Gun Hong, Tao Zhen, Katherine R. Calvo, Paul Liu, Cynthia E. Dunbar
Blood. 2023 Jan 19; 141(3): 231–237. Published online 2022 Nov 4. doi: 10.1182/blood.2022018193
PMCID:
PMC9936307
AbstractArticle
3.
家族性血小板疾病并急性髓系白血病倾向一例报告并文献复习
张 然然, 陈 晓娟, 任 媛媛, 杨 文钰, 竺 晓凡
Zhonghua Xue Ye Xue Za Zhi. 2021 Apr; 42(4): 308–312. Chinese. doi: 10.3760/cma.j.issn.0253-2727.2021.04.007
PMCID:
PMC8120121
AbstractArticlePDF–1.1M
4.
FLI1 is associated with regulation of DNA methylation and megakaryocytic differentiation in FPDMM caused by a RUNX1 transactivation domain mutation
Yuki Tanaka, Yuri Nakanishi, Erina Furuhata, Ken-ichi Nakada, Rino Maruyama, Harukazu Suzuki, Takahiro Suzuki
Sci Rep. 2024; 14: 14080. Published online 2024 Jun 18. doi: 10.1038/s41598-024-64829-4
PMCID:
PMC11189521
AbstractArticlePDF–3.1M
5.
Acquired TET2 mutation in one patient with familial platelet disorder with predisposition to AML led to the development of pre‐leukaemic clone resulting in T2‐ALL and AML‐M0
Vladimir T. Manchev, Hind Bouzid, Iléana Antony‐Debré, Betty Leite, Guillaume Meurice, Nathalie Droin, Thomas Prebet, Régis T. Costello, William Vainchenker, Isabelle Plo, M'boyba Diop, Elizabeth Macintyre, Vahid Asnafi, Rémi Favier, Véronique Baccini, Hana Raslova
J Cell Mol Med. 2017 Jun; 21(6): 1237–1242. Published online 2016 Dec 20. doi: 10.1111/jcmm.13051
PMCID:
PMC5431233
AbstractArticlePDF–375K
6.
Runx1 deficiency predisposes mice to T-lymphoblastic lymphoma
Mondira Kundu, Sheila Compton, Lisa Garrett-Beal, Terryl Stacy, Matthew F. Starost, Michael Eckhaus, Nancy A. Speck, P. Paul Liu
Blood. 2005 Nov 15; 106(10): 3621–3624. Prepublished online 2005 Jul 28. doi: 10.1182/blood-2005-04-1447
PMCID:
PMC1459843
AbstractArticle
7.
RUNX1-deficient human megakaryocytes demonstrate thrombopoietic and platelet half-life and functional defects
Kiwon Lee, Hyun Sook Ahn, Brian Estevez, Mortimer Poncz
Blood. 2023 Jan 19; 141(3): 260–270. Published online 2022 Oct 14. doi: 10.1182/blood.2022017561
PMCID:
PMC9936297
AbstractArticle
8.
RUNX-1 haploinsufficiency causes a marked deficiency of megakaryocyte-biased hematopoietic progenitor cells
Brian Estevez, Sara Borst, Danuta Jarocha, Varun Sudunagunta, Michael Gonzalez, James Garifallou, Hakon Hakonarson, Peng Gao, Kai Tan, Paul Liu, Sumedha Bagga, Nicholas Holdreith, Wei Tong, Nancy Speck, Deborah L. French, Paul Gadue, Mortimer Poncz
Blood. 2021 May 13; 137(19): 2662–2675. doi: 10.1182/blood.2020006389
PMCID:
PMC8120143
AbstractArticle
9.
Disease mutations in RUNX1 and RUNX2 create nonfunctional, dominant-negative, or hypomorphic alleles
Christina J Matheny, Maren E Speck, Patrick R Cushing, Yunpeng Zhou, Takeshi Corpora, Michael Regan, Miki Newman, Liya Roudaia, Caroline L Speck, Ting-Lei Gu, Stephen M Griffey, John H Bushweller, Nancy A Speck
EMBO J. 2007 Feb 21; 26(4): 1163–1175. Published online 2007 Feb 8. doi: 10.1038/sj.emboj.7601568
PMCID:
PMC1852839
AbstractArticlePDF–430K
10.
RUNX1-mutated families show phenotype heterogeneity and a somatic mutation profile unique to germline predisposed AML
Anna L. Brown, Peer Arts, Catherine L. Carmichael, Milena Babic, Julia Dobbins, Chan-Eng Chong, Andreas W. Schreiber, Jinghua Feng, Kerry Phillips, Paul P. S. Wang, Thuong Ha, Claire C. Homan, Sarah L. King-Smith, Lesley Rawlings, Cassandra Vakulin, Andrew Dubowsky, Jessica Burdett, Sarah Moore, Grace McKavanagh, Denae Henry, Amanda Wells, Belinda Mercorella, Mario Nicola, Jeffrey Suttle, Ella Wilkins, Xiao-Chun Li, Joelle Michaud, Peter Brautigan, Ping Cannon, Meryl Altree, Louise Jaensch, Miriam Fine, Carolyn Butcher, Richard J. D’Andrea, Ian D. Lewis, Devendra K. Hiwase, Elli Papaemmanuil, Marshall S. Horwitz, Georges Natsoulis, Hugh Y. Rienhoff, Jr, Nigel Patton, Sally Mapp, Rachel Susman, Susan Morgan, Julian Cooney, Mark Currie, Uday Popat, Tilmann Bochtler, Shai Izraeli, Kenneth Bradstock, Lucy A. Godley, Alwin Krämer, Stefan Fröhling, Andrew H. Wei, Cecily Forsyth, Helen Mar Fan, Nicola K. Poplawski, Christopher N. Hahn, Hamish S. Scott
Blood Adv. 2020 Mar 24; 4(6): 1131–1144. Published online 2020 Mar 24. doi: 10.1182/bloodadvances.2019000901
PMCID:
PMC7094007
AbstractArticlePDF–1.1M
11.
The Clinical, Molecular, and Mechanistic Basis of RUNX1 Mutations Identified in Hematological Malignancies
Asumi Yokota, Li Huo, Fengli Lan, Jianqiang Wu, Gang Huang
Mol Cells. 2020 Feb 29; 43(2): 145–152. Published online 2020 Jan 22. doi: 10.14348/molcells.2019.0252
PMCID:
PMC7057846
AbstractArticlePDF–648K
12.
Integrative analysis of RUNX1 downstream pathways and target genes
Joëlle Michaud, Ken M Simpson, Robert Escher, Karine Buchet-Poyau, Tim Beissbarth, Catherine Carmichael, Matthew E Ritchie, Frédéric Schütz, Ping Cannon, Marjorie Liu, Xiaofeng Shen, Yoshiaki Ito, Wendy H Raskind, Marshall S Horwitz, Motomi Osato, David R Turner, Terence P Speed, Maria Kavallaris, Gordon K Smyth, Hamish S Scott
BMC Genomics. 2008; 9: 363. Published online 2008 Jul 31. doi: 10.1186/1471-2164-9-363
PMCID:
PMC2529319
AbstractArticlePDF–1.4M
13.
An old dog has a new trick: somatic exonic deletions in RUNX1 are frequent in AML
Joyeeta Chakraborty, Kristy R. Stengel
Clin Cancer Res. Author manuscript; available in PMC 2024 Feb 1.
Published in final edited form as: Clin Cancer Res. 2023 Aug 1; 29(15): 2742–2744. doi: 10.1158/1078-0432.CCR-23-1065
PMCID:
PMC10525005
AbstractArticlePDF–350K
14.
Altered platelet-megakaryocyte endocytosis and trafficking of albumin and fibrinogen in RUNX1 haplodeficiency
Fabiola Del Carpio-Cano, Guangfen Mao, Lawrence E. Goldfinger, Jeremy Wurtzel, Liying Guan, Mohammad Afaque Alam, Kiwon Lee, Mortimer Poncz, A. Koneti Rao
Blood Adv. 2024 Apr 9; 8(7): 1699–1714. Published online 2024 Feb 10. doi: 10.1182/bloodadvances.2023011098
PMCID:
PMC10997914
AbstractArticlePDF–4.8M
15.
Evaluation of patients and families with concern for predispositions to hematologic malignancies within the Hereditary Hematologic Malignancy Clinic (HHMC)
Courtney D DiNardo, Sarah A Bannon, Mark Routbort, Anna Franklin, Maureen Mork, Mary Armanios, Emily M Mace, Jordan S Orange, Meselle Jeff-Eke, Jane E Churpek, Koichi Takahashi, Jeffrey L Jorgensen, Guillermo Garcia-Manero, Steve Kornblau, Alison Bertuch, Hannah Cheung, Kapil Bhalla, Andrew Futreal, Lucy A Godley, Keyur P Patel
Clin Lymphoma Myeloma Leuk. Author manuscript; available in PMC 2017 Jul 1.
Published in final edited form as: Clin Lymphoma Myeloma Leuk. 2016 Jul; 16(7): 417–428.e2. Published online 2016 Apr 27. doi: 10.1016/j.clml.2016.04.001
PMCID:
PMC4925265
AbstractArticlePDF–486K
16.
Haematological spectrum and genotype-phenotype correlations in nine unrelated families with RUNX1 mutations from the French network on inherited platelet disorders
Veronique Latger-Cannard, Christophe Philippe, Alexandre Bouquet, Veronique Baccini, Marie-Christine Alessi, Annick Ankri, Anne Bauters, Sophie Bayart, Pascale Cornillet-Lefebvre, Sylvie Daliphard, Marie-Joelle Mozziconacci, Aline Renneville, Paola Ballerini, Guy Leverger, Hagay Sobol, Philippe Jonveaux, Claude Preudhomme, Paquita Nurden, Thomas Lecompte, Remi Favier
Orphanet J Rare Dis. 2016; 11: 49. Published online 2016 Apr 26. doi: 10.1186/s13023-016-0432-0
PMCID:
PMC4845427
AbstractArticlePDF–859K
17.
Genetic Predisposition Syndromes: When Should They Be Considered In The Work-up of MDS?
Daria V. Babushok, Monica Bessler
Best Pract Res Clin Haematol. Author manuscript; available in PMC 2016 Mar 1.
Published in final edited form as: Best Pract Res Clin Haematol. 2015 Mar; 28(1): 55–68. Published online 2014 Nov 12. doi: 10.1016/j.beha.2014.11.004
PMCID:
PMC4323616
AbstractArticlePDF–828K
18.
Targeted correction of RUNX1 mutation in FPD patient-specific induced pluripotent stem cells rescues megakaryopoietic defects
Jon P. Connelly, Erika M. Kwon, Yongxing Gao, Niraj S. Trivedi, Abdel G. Elkahloun, Marshall S. Horwitz, Linzhao Cheng, P. Paul Liu
Blood. 2014 Sep 18; 124(12): 1926–1930. Prepublished online 2014 Aug 11. doi: 10.1182/blood-2014-01-550525
PMCID:
PMC4168347
AbstractArticle
19.
Genomic landscape of patients with germline RUNX1 variants and familial platelet disorder with myeloid malignancy
Kai Yu, Natalie Deuitch, Matthew Merguerian, Lea Cunningham, Joie Davis, Erica Bresciani, Jamie Diemer, Elizabeth Andrews, Alice Young, Frank Donovan, Raman Sood, Kathleen Craft, Shawn Chong, Settara Chandrasekharappa, Jim Mullikin, Paul P. Liu
Blood Adv. 2024 Jan 23; 8(2): 497–511. Published online 2023 Nov 29. doi: 10.1182/bloodadvances.2023011165
PMCID:
PMC10837196
AbstractArticlePDF–2.7M
20.
RUNX1 is required in granulocyte–monocyte progenitors to attenuate inflammatory cytokine production by neutrophils
Alexandra U. Zezulin, Daniel Yen, Darwin Ye, Elizabeth D. Howell, Erica Bresciani, Jamie Diemer, Jian-gang Ren, Mohd Hafiz Ahmad, Lucio H. Castilla, Ivo P. Touw, Andy J. Minn, Wei Tong, P. Paul Liu, Kai Tan, Wenbao Yu, Nancy A. Speck
Genes Dev. 2023 Jul 1; 37(13-14): 605–620. doi: 10.1101/gad.350418.123
PMCID:
PMC10499021
AbstractArticlePDF–3.5M

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