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Items: 1 to 20 of 626

1.
Methylation of Werner syndrome protein is associated with the occurrence and development of invasive meningioma via the regulation of Myc and p53 expression
PUXIAN LI, SHUYU HAO, ZHIYONG BI, JUNTING ZHANG, ZHEN WU, XIAOHUI REN
Exp Ther Med. 2015 Aug; 10(2): 498–502. Published online 2015 May 26. doi: 10.3892/etm.2015.2519
PMCID:
PMC4509361
AbstractArticlePDF–446K
2.
Werner-Syndrom. Eine prototypische Form der segmentalen Progerie
D. Lessel, J. Oshima, C. Kubisch
Med Genet. Author manuscript; available in PMC 2014 Oct 9.German.
Published in final edited form as: Med Genet. 2012 Dec; 24(4): 262–267. doi: 10.1007/s11825-012-0360-x
PMCID:
PMC4191733
AbstractArticlePDF–632K
3.
Cellular deficiency of Werner Syndrome protein or RECQ1 promotes genotoxic potential of hydroquinone and benzo[a]pyrene exposure
Mamatha Garige, Sudha Sharma
Int J Toxicol. Author manuscript; available in PMC 2015 Sep 15.
Published in final edited form as: Int J Toxicol. 2014 Sep; 33(5): 373–381. Published online 2014 Sep 15. doi: 10.1177/1091581814547422
PMCID:
PMC4194143
AbstractArticlePDF–1.1M
4.
Expression profile of Caenorhabditis elegans mutant for the Werner syndrome gene ortholog reveals the impact of vitamin C on development to increase life span
Alexandra Dallaire, Sophie Proulx, Martin J Simard, Michel Lebel
BMC Genomics. 2014; 15(1): 940. Published online 2014 Oct 27. doi: 10.1186/1471-2164-15-940
PMCID:
PMC4221712
AbstractArticlePDF–1.0M
5.
Checkpoint-dependent and independent roles of the Werner syndrome protein in preserving genome integrity in response to mild replication stress
Giorgia Basile, Giuseppe Leuzzi, Pietro Pichierri, Annapaola Franchitto
Nucleic Acids Res. 2014 Nov 10; 42(20): 12628–12639. Published online 2014 Oct 28. doi: 10.1093/nar/gku1022
PMCID:
PMC4227752
AbstractArticlePDF–490K
6.
Reprogramming Suppresses Premature Senescence Phenotypes of Werner Syndrome Cells and Maintains Chromosomal Stability over Long-Term Culture
Akira Shimamoto, Harunobu Kagawa, Kazumasa Zensho, Yukihiro Sera, Yasuhiro Kazuki, Mitsuhiko Osaki, Mitsuo Oshimura, Yasuhito Ishigaki, Kanya Hamasaki, Yoshiaki Kodama, Shinsuke Yuasa, Keiichi Fukuda, Kyotaro Hirashima, Hiroyuki Seimiya, Hirofumi Koyama, Takahiko Shimizu, Minoru Takemoto, Koutaro Yokote, Makoto Goto, Hidetoshi Tahara
PLoS One. 2014; 9(11): e112900. Published online 2014 Nov 12. doi: 10.1371/journal.pone.0112900
PMCID:
PMC4229309
AbstractArticlePDF–10M
7.
The Werner syndrome protein limits the error-prone 8-oxo-dG lesion bypass activity of human DNA polymerase kappa
Leena Maddukuri, Amit Ketkar, Sarah Eddy, Maroof K. Zafar, Robert L. Eoff
Nucleic Acids Res. 2014 Oct 29; 42(19): 12027–12040. Published online 2014 Oct 7. doi: 10.1093/nar/gku913
PMCID:
PMC4231769
AbstractArticlePDF–3.0M
8.
Werner Syndrome-specific induced pluripotent stem cells: recovery of telomere function by reprogramming
Akira Shimamoto, Koutaro Yokote, Hidetoshi Tahara
Front Genet. 2015; 6: 10. Published online 2015 Jan 29. doi: 10.3389/fgene.2015.00010
PMCID:
PMC4310323
AbstractArticlePDF–1.4M
9.
Microwave-Assisted Synthesis of a MK2 Inhibitor by Suzuki-Miyaura Coupling for Study in Werner Syndrome Cells
Mark C. Bagley, Mohammed Baashen, Irina Chuckowree, Jessica E. Dwyer, David Kipling, Terence Davis
Pharmaceuticals (Basel) 2015 Jun; 8(2): 257–276. Published online 2015 Jun 3. doi: 10.3390/ph8020257
PMCID:
PMC4491660
AbstractArticlePDF–1.0M
10.
A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging
Weiqi Zhang, Jingyi Li, Keiichiro Suzuki, Jing Qu, Ping Wang, Junzhi Zhou, Xiaomeng Liu, Ruotong Ren, Xiuling Xu, Alejandro Ocampo, Tingting Yuan, Jiping Yang, Ying Li, Liang Shi, Dee Guan, Huize Pan, Shunlei Duan, Zhichao Ding, Mo Li, Fei Yi, Ruijun Bai, Yayu Wang, Chang Chen, Fuquan Yang, Xiaoyu Li, Zimei Wang, Emi Aizawa, April Goebl, Rupa Devi Soligalla, Pradeep Reddy, Concepcion Rodriguez Esteban, Fuchou Tang, Guang-Hui Liu, Juan Carlos Izpisua Belmonte
Science. Author manuscript; available in PMC 2015 Jul 7.
Published in final edited form as: Science. 2015 Jun 5; 348(6239): 1160–1163. Published online 2015 Apr 30. doi: 10.1126/science.aaa1356
PMCID:
PMC4494668
AbstractArticlePDF–413K
11.
Acetylation of Werner syndrome protein (WRN): relationships with DNA damage, DNA replication and DNA metabolic activities
Enerlyn Lozada, Jingjie Yi, Jianyuan Luo, David K. Orren
Biogerontology. Author manuscript; available in PMC 2015 Aug 1.
Published in final edited form as: Biogerontology. 2014 Aug; 15(4): 347–366. Published online 2014 Jun 26. doi: 10.1007/s10522-014-9506-3
PMCID:
PMC4122284
AbstractArticlePDF–1.4M
12.
The clinical characteristics of Werner syndrome: molecular and biochemical diagnosis
Meltem Muftuoglu, Junko Oshima, Cayetano von Kobbe, Wen-Hsing Cheng, Dru F. Leistritz, Vilhelm A. Bohr
Hum Genet. Author manuscript; available in PMC 2015 Sep 29.
Published in final edited form as: Hum Genet. 2008 Nov; 124(4): 369–377. Published online 2008 Sep 23. doi: 10.1007/s00439-008-0562-0
PMCID:
PMC4586253
AbstractArticlePDF–917K
13.
Metabolic and Phenotypic Differences between Mice Producing a Werner Syndrome Helicase Mutant Protein and Wrn Null Mice
Lucie Aumailley, Chantal Garand, Marie Julie Dubois, F. Brad Johnson, André Marette, Michel Lebel
PLoS One. 2015; 10(10): e0140292. Published online 2015 Oct 8. doi: 10.1371/journal.pone.0140292
PMCID:
PMC4598085
AbstractArticlePDF–3.1M
14.
Epigenetic Regulation of Werner Syndrome Gene in Age-Related Cataract
Xi Zhu, Guowei Zhang, Lihua Kang, Huaijin Guan
J Ophthalmol. 2015; 2015: 579695. Published online 2015 Oct 5. doi: 10.1155/2015/579695
PMCID:
PMC4609838
AbstractArticlePDF–1.3M
15.
A novel Werner Syndrome mutation: pharmacological treatment by read-through of nonsense mutations and epigenetic therapies
Ruben Agrelo, Miguel Arocena Sutz, Fernando Setien, Fabian Aldunate, Manel Esteller, Valeria Da Costa, Ricardo Achenbach
Epigenetics. 2015 Apr; 10(4): 329–341. Published online 2015 Apr 1. doi: 10.1080/15592294.2015.1027853
PMCID:
PMC4622951
AbstractArticlePDF–1.1M
16.
Multiplex cytokine analysis of Werner syndrome
Makoto Goto, Koichiro Hayata, Junji Chiba, Masaaki Matsuura, Sachiko Iwaki-Egawa, Yasuhiro Watanabe
Intractable Rare Dis Res. 2015 Nov; 4(4): 190–197. doi: 10.5582/irdr.2015.01035
PMCID:
PMC4660860
AbstractArticlePDF–386K
17.
Coronary Artery Disease in a Werner Syndrome-Like Form of Progeria Characterized by Low Levels of Progerin, a Splice Variant of Lamin A
Fuki M. Hisama, Davor Lessel, Dru Leistritz, Katrin Friedrich, Kim L. McBride, Matthew T. Pastore, Gary S. Gottesman, Bidisha Saha, George M. Martin, Christian Kubisch, Junko Oshima
Am J Med Genet A. Author manuscript; available in PMC 2015 Dec 15.
Published in final edited form as: Am J Med Genet A. 2011 Dec; 0(12): 3002–3006. Published online 2011 Nov 7. doi: 10.1002/ajmg.a.34336
PMCID:
PMC4679285
AbstractArticlePDF–383K
18.
POLD1 Germline Mutations in Patients Initially Diagnosed with Werner Syndrome
Davor Lessel, Fuki M. Hisama, Katalin Szakszon, Bidisha Saha, Alexander Barrios Sanjuanelo, Bonnie A. Salbert, Pamela D. Steele, Jennifer Baldwin, W. Ted Brown, Charles Piussan, Henri Plauchu, Judit Szilvássy, Edit Horkay, Josef Hoögel, George M. Martin, Alan J. Herr, Junko Oshima, Christian Kubisch
Hum Mutat. Author manuscript; available in PMC 2015 Dec 18.
Published in final edited form as: Hum Mutat. 2015 Nov; 36(11): 1070–1079. Published online 2015 Aug 6. doi: 10.1002/humu.22833
PMCID:
PMC4684254
AbstractArticlePDF–726K
19.
WRN mutations in Werner syndrome patients: genomic rearrangements, unusual intronic mutations and ethnic-specific alterations
Katrin Friedrich, Lin Lee, Dru F. Leistritz, Gudrun Nürnberg, Bidisha Saha, Fuki M. Hisama, Daniel K. Eyman, Davor Lessel, Peter Nürnberg, Chumei Li, María J. Garcia-F-Villalta, Carolien M. Kets, Joerg Schmidtke, Vítor Tedim Cruz, Peter C. Van den Akker, Joseph Boak, Dincy Peter, Goli Compoginis, Kivanc Cefle, Sukru Ozturk, Norberto López, Theda Wessel, Martin Poot, P. F. Ippel, Birgit Groff-Kellermann, Holger Hoehn, George M. Martin, Christian Kubisch, Junko Oshima
Hum Genet. Author manuscript; available in PMC 2015 Dec 21.
Published in final edited form as: Hum Genet. 2010 Jul; 128(1): 103–111. Published online 2010 May 5. doi: 10.1007/s00439-010-0832-5
PMCID:
PMC4686336
AbstractArticlePDF–743K
20.
Ethnic-specific WRN mutations in South Asian Werner syndrome patients: potential founder effect in patients with Indian or Pakistani ancestry
Bidisha Saha, Davor Lessel, Sheela Nampoothiri, Anuradha S Rao, Fuki M Hisama, Dincy Peter, Chris Bennett, Gudrun Nürnberg, Peter Nürnberg, George M Martin, Christian Kubisch, Junko Oshima
Mol Genet Genomic Med. 2013 May; 1(1): 7–14. Published online 2013 Mar 28. doi: 10.1002/mgg3.1
PMCID:
PMC3736606
AbstractArticlePDF–458K

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