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Select item 111580391.

Plasma membrane‐associated sialidase (NEU3) promotes formation of colonic aberrant crypt foci in azoxymethane‐treated transgenic mice

Kazuhiro Shiozaki, Kazunori Yamaguchi, Ikuro Sato, Taeko Miyagi

Cancer Sci. 2009 Apr; 100(4): 588–594. Published online 2009 Feb 2. doi: 10.1111/j.1349-7006.2008.01080.x

PMCID:: PMC11158039

Abstract Article PDF–1.0M

Select item 110415592.

EPO promotes the progression of rheumatoid arthritis by inducing desialylation via increasing the expression of neuraminidase 3

Gan Wu, Ben Cao, Haige Zhai, Bin Liu, Yuan Huang, Xiaowei Chen, Hanzhi Ling, Sunwang Ling, Shengwei Jin, Xinyu Yang, Jianguang Wang

Ann Rheum Dis. 2024 May; 83(5): 564–575. Published online 2024 Jan 25. doi: 10.1136/ard-2023-224852

PMCID:: PMC11041559

Abstract Article PDF–16M

Select item 107203253.

Characterization of a phenotypically severe animal model for human AB-Variant GM2 gangliosidosis

Natalie M. Deschenes, Camilyn Cheng, Prem Khanal, Brianna M. Quinville, Alex E. Ryckman, Melissa Mitchell, Alexey V. Pshezhetsky, Jagdeep S. Walia

Front Mol Neurosci. 2023; 16: 1242814. Published online 2023 Nov 30. doi: 10.3389/fnmol.2023.1242814

PMCID:: PMC10720325

Abstract Article PDF–2.4M

Select item 106945974.

Sialidase NEU3 action on GM1 ganglioside is neuroprotective in GM1 gangliosidosis

Maria L. Allende, Y. Terry Lee, Colleen Byrnes, Cuiling Li, Galina Tuymetova, Jenna Y. Bakir, Elena-Raluca Nicoli, Virginia K. James, Jennifer S. Brodbelt, Cynthia J. Tifft, Richard L. Proia

J Lipid Res. 2023 Dec; 64(12): 100463. Published online 2023 Oct 21. doi: 10.1016/j.jlr.2023.100463

PMCID:: PMC10694597

Abstract Article PDF–3.1M

Select item 105184885.

Innate mechanism of mucosal barrier erosion in the pathogenesis of acquired colitis

Won Ho Yang, Peter V. Aziz, Douglas M. Heithoff, Yeolhoe Kim, Jeong Yeon Ko, Jin Won Cho, Michael J. Mahan, Markus Sperandio, Jamey D. Marth

iScience. 2023 Oct 20; 26(10): 107883. Published online 2023 Sep 9. doi: 10.1016/j.isci.2023.107883

PMCID:: PMC10518488

Abstract Article PDF–9.1M

Select item 100197436.

Autophagic flux is impaired in the brain tissue of Tay-Sachs disease mouse model

Tugce Sengul, Melike Can, Nurselin Ateş, Volkan Seyrantepe

PLoS One. 2023; 18(3): e0280650. Published online 2023 Mar 16. doi: 10.1371/journal.pone.0280650

PMCID:: PMC10019743

Abstract Article PDF–2.6M

Select item 93234737.

The Janus‐like role of neuraminidase isoenzymes in inflammation

Md. Amran Howlader, Ekaterina P. Demina, Suzanne Samarani, Tianlin Guo, Antoine Caillon, Ali Ahmad, Alexey V. Pshezhetsky, Christopher W. Cairo

FASEB J. 2022 May; 36(5): e22285. Published online 2022 Apr 1. doi: 10.1096/fj.202101218R

PMCID:: PMC9323473

Abstract Article PDF–2.3M

Select item 83076188.

Neu3 neuraminidase induction triggers intestinal inflammation and colitis in a model of recurrent human food-poisoning

Won Ho Yang, Julia S. Westman, Douglas M. Heithoff, Markus Sperandio, Jin Won Cho, Michael J. Mahan, Jamey D. Marth

Proc Natl Acad Sci U S A. 2021 Jul 20; 118(29): e2100937118. Published online 2021 Jul 15. doi: 10.1073/pnas.2100937118

PMCID:: PMC8307618

Abstract Article PDF–1.9M

Select item 77860799.

High-Fat Diet–Induced Adipose Tissue and Liver Inflammation and Steatosis in Mice Are Reduced by Inhibiting Sialidases

Darrell Pilling, Tejas R. Karhadkar, Richard H. Gomer

Am J Pathol. 2021 Jan; 191(1): 131–143. doi: 10.1016/j.ajpath.2020.09.011

PMCID:: PMC7786079

Abstract Article PDF–3.6M

Select item 708994810.

The sialidase inhibitor 2,3-dehydro-2-deoxy-N-acetylneuraminic acid is a glucose-dependent potentiator of insulin secretion

Akira Minami, Yuka Fujita, Sumika Shimba, Mako Shiratori, Yukiko K. Kaneko, Toshiaki Sawatani, Tadamune Otsubo, Kiyoshi Ikeda, Hiroaki Kanazawa, Yasuyo Mikami, Risa Sekita, Yuuki Kurebayashi, Tadanobu Takahashi, Taeko Miyagi, Tomohisa Ishikawa, Takashi Suzuki

Sci Rep. 2020; 10: 5198. Published online 2020 Mar 23. doi: 10.1038/s41598-020-62203-8

PMCID:: PMC7089948

Abstract Article PDF–3.2M

Select item 698587011.

Attenuated pulmonary fibrosis in sialidase-3 knockout (Neu3^−/−) mice

Tejas R. Karhadkar, Wensheng Chen, Richard H. Gomer

Am J Physiol Lung Cell Mol Physiol. 2020 Jan 1; 318(1): L165–L179. Published online 2019 Oct 16. doi: 10.1152/ajplung.00275.2019

PMCID:: PMC6985870

Abstract Article

Select item 622366112.

Accelerated aging and clearance of host anti-inflammatory enzymes by discrete pathogens fuels sepsis

Won Ho Yang, Douglas M. Heithoff, Peter V. Aziz, Benjamin Haslund-Gourley, Julia S. Westman, Sonoko Narisawa, Anthony B. Pinkerton, José Luis Millán, Victor Nizet, Michael J. Mahan, Jamey D. Marth

Cell Host Microbe. Author manuscript; available in PMC 2019 Oct 10.

Published in final edited form as: Cell Host Microbe. 2018 Oct 10; 24(4): 500–513.e5. doi: 10.1016/j.chom.2018.09.011

PMCID:: PMC6223661

Article PDF–1.8M

Select item 620193713.

Presence of aberrant epididymal tubules revealing undifferentiated epithelial cells and absence of spermatozoa in a combined neuraminidase-3 and -4 deficient adult mouse model

Regiana Oliveira, Louis Hermo, Alexey V. Pshezhetsky, Carlos R. Morales

PLoS One. 2018; 13(10): e0206173. Published online 2018 Oct 25. doi: 10.1371/journal.pone.0206173

PMCID:: PMC6201937

Abstract Article PDF–5.4M

Select item 596676114.

Neuraminidase activity mediates IL-6 production by activated lupus-prone mesangial cells

Kamala Sundararaj, Jessalyn I. Rodgers, Subathra Marimuthu, Leah J. Siskind, Evelyn Bruner, Tamara K. Nowling

Am J Physiol Renal Physiol. 2018 Apr 1; 314(4): F630–F642. Published online 2017 Dec 20. doi: 10.1152/ajprenal.00421.2017

PMCID:: PMC5966761

Abstract Article

Select item 405560415.

Sialidase NEU3 Dynamically Associates to Different Membrane Domains Specifically Modifying Their Ganglioside Pattern and Triggering Akt Phosphorylation

Dario Bonardi, Nadia Papini, Mario Pasini, Loredana Dileo, Flavia Orizio, Eugenio Monti, Luigi Caimi, Bruno Venerando, Roberto Bresciani

PLoS One. 2014; 9(6): e99405. Published online 2014 Jun 12. doi: 10.1371/journal.pone.0099405

PMCID:: PMC4055604

Abstract Article PDF–2.8M

Select item 358127216.

Hepatocyte Nuclear Factor 4α Is Essential for Embryonic Development of the Mouse Colon

Wendy D. Garrison, Michele A. Battle, Chuhu Yang, Klaus H. Kaestner, Frances M. Sladek, Stephen A. Duncan

Gastroenterology. Author manuscript; available in PMC 2013 Feb 25.

Published in final edited form as: Gastroenterology. 2006 Apr; 130(4): 1207–1220. doi: 10.1053/j.gastro.2006.01.003

PMCID:: PMC3581272

Abstract Article PDF–7.8M

Select item 357241017.

A conditional knockout resource for the genome–wide study of mouse gene function

William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley

Nature. Author manuscript; available in PMC 2013 Feb 14.

Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163

PMCID:: PMC3572410

Abstract Article PDF–1.1M

Select item 356153718.

NEU3 Sialidase Is Activated under Hypoxia and Protects Skeletal Muscle Cells from Apoptosis through the Activation of the Epidermal Growth Factor Receptor Signaling Pathway and the Hypoxia-inducible Factor (HIF)-1α

Raffaella Scaringi, Marco Piccoli, Nadia Papini, Federica Cirillo, Erika Conforti, Sonia Bergante, Cristina Tringali, Andrea Garatti, Cecilia Gelfi, Bruno Venerando, Lorenzo Menicanti, Guido Tettamanti, Luigi Anastasia

J Biol Chem. 2013 Feb 1; 288(5): 3153–3162. Published online 2012 Dec 3. doi: 10.1074/jbc.M112.404327

PMCID:: PMC3561537

Abstract Article PDF–5.3M

Select item 348807719.

Sialidases on Mammalian Sperm Mediate Deciduous Sialylation during Capacitation

Fang Ma, Diana Wu, Liwen Deng, Patrick Secrest, June Zhao, Nissi Varki, Steven Lindheim, Pascal Gagneux

J Biol Chem. 2012 Nov 2; 287(45): 38073–38079. Published online 2012 Sep 18. doi: 10.1074/jbc.M112.380584

PMCID:: PMC3488077

Abstract Article PDF–1.4M

Select item 339893920.

Reduced Susceptibility to Colitis-Associated Colon Carcinogenesis in Mice Lacking Plasma Membrane-Associated Sialidase

Kazunori Yamaguchi, Kazuhiro Shiozaki, Setsuko Moriya, Koichi Koseki, Tadashi Wada, Hiroo Tateno, Ikuro Sato, Masahide Asano, Yoichiro Iwakura, Taeko Miyagi

PLoS One. 2012; 7(7): e41132. Published online 2012 Jul 17. doi: 10.1371/journal.pone.0041132