PMC Links for GEO Profiles (Select 97225415) - PMC

Select item 101575401.

Nuclear localization of human MEIOB requires its NLS in the OB domain and interaction with SPATA22: Human SPATA22 assists MEIOB to enter the nucleus

Yating Xu, Zhen Chen, Panfeng Wu, Wei Qu, Hanqing Shi, Muyang Cheng, Yumin Xu, Tingyu Jin, Cong Liu, Cong Liu, Yi Li, Mengcheng Luo

Acta Biochim Biophys Sin (Shanghai) 2023 Jan; 55(1): 154–161. Published online 2022 Nov 2. doi: 10.3724/abbs.2022156

PMCID:: PMC10157540

Abstract Article PDF–2.0M

Select item 91063032.

Genome-wide CRISPR screens using isogenic cells reveal vulnerabilities conferred by loss of tumor suppressors

Xu Feng, Mengfan Tang, Merve Dede, Dan Su, Guangsheng Pei, Dadi Jiang, Chao Wang, Zhen Chen, Mi Li, Litong Nie, Yun Xiong, Siting Li, Jeong-Min Park, Huimin Zhang, Min Huang, Klaudia Szymonowicz, Zhongming Zhao, Traver Hart, Junjie Chen

Sci Adv. 2022 May; 8(19): eabm6638. Published online 2022 May 13. doi: 10.1126/sciadv.abm6638

PMCID:: PMC9106303

Abstract Article PDF–918K

Select item 88421653.

CFTR interactome mapping using the mammalian membrane two‐hybrid high‐throughput screening system

Sang Hyun Lim, Jamie Snider, Liron Birimberg‐Schwartz, Wan Ip, Joana C Serralha, Hugo M Botelho, Miquéias Lopes‐Pacheco, Madalena C Pinto, Mohamed Taha Moutaoufik, Mara Zilocchi, Onofrio Laselva, Mohsen Esmaeili, Max Kotlyar, Anna Lyakisheva, Priscilla Tang, Lucía López Vázquez, Indira Akula, Farzaneh Aboualizadeh, Victoria Wong, Ingrid Grozavu, Teuta Opacak‐Bernardi, Zhong Yao, Meg Mendoza, Mohan Babu, Igor Jurisica, Tanja Gonska, Christine E Bear, Margarida D Amaral, Igor Stagljar

Mol Syst Biol. 2022 Feb; 18(2): e10629. Published online 2022 Feb 14. doi: 10.15252/msb.202110629

PMCID:: PMC8842165

Abstract Article PDF–3.0M

Select item 81650304.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 78771875.

The cancer-testis gene, MEIOB, sensitizes triple-negative breast cancer to PARP1 inhibitors by inducing homologous recombination deficiency

Yayun Gu, Cheng Wang, Rongxuan Zhu, Jianshui Yang, Wenwen Yuan, Yanhui Zhu, Yan Zhou, Na Qin, Hongbing Shen, Hongxia Ma, Hongxia Wang, Xiaoan Liu, Zhibin Hu

Cancer Biol Med. 2021 Feb 15; 18(1): 74–87. Published online 2021 Feb 15. doi: 10.20892/j.issn.2095-3941.2020.0071

PMCID:: PMC7877187

Abstract Article PDF–1.0M

Select item 77080776.

The ssDNA-binding protein MEIOB acts as a dosage-sensitive regulator of meiotic recombination

Rui Guo, Yang Xu, N Adrian Leu, Lei Zhang, Serge Y Fuchs, Lan Ye, P Jeremy Wang

Nucleic Acids Res. 2020 Dec 2; 48(21): 12219–12233. Published online 2020 Nov 9. doi: 10.1093/nar/gkaa1016

PMCID:: PMC7708077

Abstract Article PDF–6.7M

Select item 64918787.

A truncating MEIOB mutation responsible for familial primary ovarian insufficiency abolishes its interaction with its partner SPATA22 and their recruitment to DNA double-strand breaks

Sandrine Caburet, Anne-Laure Todeschini, Cynthia Petrillo, Emmanuelle Martini, Nada D. Farran, Bérangère Legois, Gabriel Livera, Johnny S. Younis, Stavit Shalev, Reiner A. Veitia

EBioMedicine. 2019 Apr; 42: 524–531. Published online 2019 Apr 15. doi: 10.1016/j.ebiom.2019.03.075

PMCID:: PMC6491878

Abstract Article PDF–1.4M

Select item 63551048.

Meiosis-specific proteins MEIOB and SPATA22 cooperatively associate with the single-stranded DNA-binding replication protein A complex and DNA double-strand breaks

Yang Xu, Roger A. Greenberg, Ernst Schonbrunn, P. Jeremy Wang

Biol Reprod. 2017 May; 96(5): 1096–1104. Published online 2017 Apr 27. doi: 10.1093/biolre/iox040

PMCID:: PMC6355104

Abstract Article PDF–1.6M

Select item 55316119.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 461721110.

The BioPlex Network: A Systematic Exploration of the Human Interactome

Edward L. Huttlin, Lily Ting, Raphael J. Bruckner, Fana Gebreab, Melanie P. Gygi, John Szpyt, Stanley Tam, Gabriela Zarraga, Greg Colby, Kurt Baltier, Rui Dong, Virginia Guarani, Laura Pontano Vaites, Alban Ordureau, Ramin Rad, Brian K. Erickson, Martin Wühr, Joel Chick, Bo Zhai, Deepak Kolippakkam, Julian Mintseris, Robert A. Obar, Tim Harris, Spyros Artavanis-Tsakonas, Mathew E. Sowa, Pietro DeCamilli, Joao A. Paulo, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2016 Jul 16.

Published in final edited form as: Cell. 2015 Jul 16; 162(2): 425–440. doi: 10.1016/j.cell.2015.06.043

PMCID:: PMC4617211

Abstract Article PDF–2.2M

Select item 389183111.

MEIOB exhibits single-stranded DNA-binding and exonuclease activities and is essential for meiotic recombination

Mengcheng Luo, Fang Yang, N. Adrian Leu, Jessica Landaiche, Mary Ann Handel, Ricardo Benavente, Sophie La Salle, P. Jeremy Wang

Nat Commun. Author manuscript; available in PMC 2014 May 18.

Published in final edited form as: Nat Commun. 2013; 4: 2788. doi: 10.1038/ncomms3788

PMCID:: PMC3891831

Abstract Article PDF–4.4M

Select item 386161612.

The HECT Type Ubiquitin Ligase NEDL2 Is Degraded by Anaphase-promoting Complex/Cyclosome (APC/C)-Cdh1, and Its Tight Regulation Maintains the Metaphase to Anaphase Transition

Li Lu, Shaohua Hu, Rongfei Wei, Xiao Qiu, Kefeng Lu, Yesheng Fu, Hongchang Li, Guichun Xing, Dong Li, Ruiyun Peng, Fuchu He, Lingqiang Zhang

J Biol Chem. 2013 Dec 13; 288(50): 35637–35650. Published online 2013 Oct 25. doi: 10.1074/jbc.M113.472076

PMCID:: PMC3861616

Abstract Article PDF–4.4M

Select item 377800913.

MEIOB Targets Single-Strand DNA and Is Necessary for Meiotic Recombination

Benoit Souquet, Emilie Abby, Roxane Hervé, Friederike Finsterbusch, Sophie Tourpin, Ronan Le Bouffant, Clotilde Duquenne, Sébastien Messiaen, Emmanuelle Martini, Jacqueline Bernardino-Sgherri, Attila Toth, René Habert, Gabriel Livera

PLoS Genet. 2013 Sep; 9(9): e1003784. Published online 2013 Sep 19. doi: 10.1371/journal.pgen.1003784