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Items: 1 to 20 of 40

1.
POT1a deficiency in mesenchymal niches perturbs B-lymphopoiesis
Kentaro Nakashima, Yuya Kunisaki, Kentaro Hosokawa, Kazuhito Gotoh, Hisayuki Yao, Ryosuke Yuta, Yuichiro Semba, Jumpei Nogami, Yoshikane Kikushige, Patrick S. Stumpf, Ben D. MacArthur, Dongchon Kang, Koichi Akashi, Shouichi Ohga, Fumio Arai
Commun Biol. 2023; 6: 996. Published online 2023 Sep 29. doi: 10.1038/s42003-023-05374-0
PMCID:
PMC10541440
AbstractArticlePDF–5.5M
2.
A mouse model for Li-Fraumeni-Like Syndrome with cardiac angiosarcomas associated to POT1 mutations
Paula Martínez, Raúl Sánchez-Vázquez, Iole Ferrara-Romeo, Rosa Serrano, Juana M. Flores, Maria A. Blasco
PLoS Genet. 2022 Jun; 18(6): e1010260. Published online 2022 Jun 21. doi: 10.1371/journal.pgen.1010260
PMCID:
PMC9212151
AbstractArticlePDF–3.4M
3.
TRF2-mediated telomere protection is dispensable in pluripotent stem cells
Marta Markiewicz-Potoczny, Anastasia Lobanova, Anisha M. Loeb, Oktay Kirak, Teresa Olbrich, Sergio Ruiz, Eros Lazzerini Denchi
Nature. Author manuscript; available in PMC 2022 Jun 2.
Published in final edited form as: Nature. 2021 Jan; 589(7840): 110–115. Published online 2020 Nov 25. doi: 10.1038/s41586-020-2959-4
PMCID:
PMC9161009
AbstractArticlePDF–5.8M
4.
Functional genomic landscape of cancer-intrinsic evasion of killing by T cells
Keith A. Lawson, Cristovão M. Sousa, Xiaoyu Zhang, Eiru Kim, Rummy Akthar, Joseph J. Caumanns, Yuxi Yao, Nicholas Mikolajewicz, Catherine Ross, Kevin R. Brown, Abdelrahman Abou Zid, Zi Peng Fan, Shirley Hui, Jordan A. Krall, Donald M. Simons, Chloe J. Slater, Victor De Jesus, Lujia Tang, Richa Singh, Joshua E. Goldford, Sarah Martin, Qian Huang, Elizabeth A. Francis, Andrea Habsid, Ryan Climie, David Tieu, Jiarun Wei, Ren Li, Amy Hin Yan Tong, Michael Aregger, Katherine S. Chan, Hong Han, Xiaowei Wang, Patricia Mero, John H. Brumell, Antonio Finelli, Laurie Ailles, Gary Bader, Gromoslaw A. Smolen, Gillian A. Kingsbury, Traver Hart, Charles Kung, Jason Moffat
Nature. Author manuscript; available in PMC 2022 Apr 18.
Published in final edited form as: Nature. 2020 Oct; 586(7827): 120–126. Published online 2020 Sep 23. doi: 10.1038/s41586-020-2746-2
PMCID:
PMC9014559
AbstractArticlePDF–6.6M
5.
The Replisome Mediates A-NHEJ Repair of Telomeres Lacking POT1-TPP1 Independently of MRN Function
Rekha Rai, Peili Gu, Cayla Broton, Chandan Kumar-Sinha, Yong Chen, Sandy Chang
Cell Rep. Author manuscript; available in PMC 2020 Feb 5.
Published in final edited form as: Cell Rep. 2019 Dec 10; 29(11): 3708–3725.e5. Published online 2019 Dec 10. doi: 10.1016/j.celrep.2019.11.012
PMCID:
PMC7001145
AbstractArticlePDF–3.0M
6.
Telomere Replication Stress Induced by POT1 Inactivation Accelerates Tumorigenesis
Alexandra M. Pinzaru, Robert A. Hom, Angela Beal, Aaron F. Phillips, Eric Ni, Timothy Cardozo, Nidhi Nair, Jaehyuk Choi, Deborah S. Wuttke, Agnel Sfeir, Eros Lazzerini Denchi
Cell Rep. Author manuscript; available in PMC 2018 Sep 19.
Published in final edited form as: Cell Rep. 2016 Jun 7; 15(10): 2170–2184. Published online 2016 May 26. doi: 10.1016/j.celrep.2016.05.008
PMCID:
PMC6145145
AbstractArticlePDF–3.8M
7.
Protection of telomeres 1 proteins POT1a and POT1b can repress ATR signaling by RPA exclusion, but binding to CST limits ATR repression by POT1b
Katja Kratz, Titia de Lange
J Biol Chem. 2018 Sep 14; 293(37): 14384–14392. Published online 2018 Aug 6. doi: 10.1074/jbc.RA118.004598
PMCID:
PMC6139565
AbstractArticlePDF–2.5M
8.
Involvement of Atm and Trp53 in neural cell loss due to Terf2 inactivation during mouse brain development
Jusik Kim, Inseo Choi, Youngsoo Lee
Histochem Cell Biol. 2017; 148(5): 489–501. Published online 2017 Jun 15. doi: 10.1007/s00418-017-1591-3
PMCID:
PMC5641282
AbstractArticlePDF–12M
9.
The telomere binding protein Pot1 maintains haematopoietic stem cell activity with age
Kentaro Hosokawa, Ben D. MacArthur, Yoshiko Matsumoto Ikushima, Hirofumi Toyama, Yoshikazu Masuhiro, Shigemasa Hanazawa, Toshio Suda, Fumio Arai
Nat Commun. 2017; 8: 804. Published online 2017 Oct 6. doi: 10.1038/s41467-017-00935-4
PMCID:
PMC5630588
AbstractArticlePDF–3.1M
10.
The differential spatiotemporal expression pattern of shelterin genes throughout lifespan
Kay-Dietrich Wagner, Yilin Ying, Waiian Leong, Jie Jiang, Xuefei Hu, Yi Chen, Jean-François Michiels, Yiming Lu, Eric Gilson, Nicole Wagner, Jing Ye
Aging (Albany NY) 2017 Apr; 9(4): 1219–1228. Published online 2017 Apr 17. doi: 10.18632/aging.101223
PMCID:
PMC5425123
AbstractArticlePDF–4.4M
11.
Human Pot1 OB-fold mutations unleash rampant telomere instability to initiate tumorigenesis
Peili Gu, Yang Wang, Kamlesh K. Bisht, Ling Wu, Lidiya Kukova, Eric M. Smith, Yang Xiao, Susan Bailey, Ming Lei, Jayakrishnan Nandakumar, Sandy Chang
Oncogene. Author manuscript; available in PMC 2017 May 21.
Published in final edited form as: Oncogene. 2017 Apr 6; 36(14): 1939–1951. Published online 2016 Nov 21. doi: 10.1038/onc.2016.405
PMCID:
PMC5383532
AbstractArticlePDF–1.2M
12.
PHF11 promotes DSB resection, ATR signaling, and HR
Yi Gong, Naofumi Handa, Stephen C. Kowalczykowski, Titia de Lange
Genes Dev. 2017 Jan 1; 31(1): 46–58. doi: 10.1101/gad.291807.116
PMCID:
PMC5287112
AbstractArticlePDF–664K
13.
Shelterin Telomere Protection Protein 1 Reduction Causes Telomere Attrition and Cellular Senescence via Sirtuin 1 Deacetylase in Chronic Obstructive Pulmonary Disease
Tanveer Ahmad, Isaac K. Sundar, Ana M. Tormos, Chad A. Lerner, Janice Gerloff, Hongwei Yao, Irfan Rahman
Am J Respir Cell Mol Biol. 2017 Jan; 56(1): 38–49. doi: 10.1165/rcmb.2016-0198OC
PMCID:
PMC5248966
AbstractArticlePDF–3.0M
14.
Binding of TPP1 Protein to TIN2 Protein Is Required for POT1a,b Protein-mediated Telomere Protection
David Frescas, Titia de Lange
J Biol Chem. 2014 Aug 29; 289(35): 24180–24187. Published online 2014 Jul 23. doi: 10.1074/jbc.M114.592592
PMCID:
PMC4148849
AbstractArticlePDF–2.5M
15.
Super-resolution fluorescence imaging of telomeres reveals TRF2-dependent t-loop formation
Ylli Doksani, John Y. Wu, Titia de Lange, Xiaowei Zhuang
Cell. Author manuscript; available in PMC 2014 Oct 10.
Published in final edited form as: Cell. 2013 Oct 10; 155(2): 345–356. doi: 10.1016/j.cell.2013.09.048
PMCID:
PMC4062873
AbstractArticlePDF–438K
16.
Pot1a Prevents Telomere Dysfunction and ATM-Dependent Neuronal Loss
Youngsoo Lee, Eric J. Brown, Sandy Chang, Peter J. McKinnon
J Neurosci. 2014 Jun 4; 34(23): 7836–7844. doi: 10.1523/JNEUROSCI.4245-13.2014
PMCID:
PMC4044246
AbstractArticlePDF–4.0M
17.
TRF2-Tethered TIN2 Can Mediate Telomere Protection by TPP1/POT1
David Frescas, Titia de Lange
Mol Cell Biol. 2014 Apr; 34(7): 1349–1362. doi: 10.1128/MCB.01052-13
PMCID:
PMC3993560
AbstractArticlePDF–5.2M
18.
HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitment
Dennis Kappei, Falk Butter, Christian Benda, Marion Scheibe, Irena Draškovič, Michelle Stevense, Clara Lopes Novo, Claire Basquin, Masatake Araki, Kimi Araki, Dragomir Blazhev Krastev, Ralf Kittler, Rolf Jessberger, J Arturo Londoño-Vallejo, Matthias Mann, Frank Buchholz
EMBO J. 2013 Jun 12; 32(12): 1681–1701. Published online 2013 May 17. doi: 10.1038/emboj.2013.105
PMCID:
PMC3680732
AbstractArticlePDF–1.6M
19.
The E3 ubiquitin ligase RNF8 stabilizes TPP1 to promote telomere end protection
Rekha Rai, Ju-Mei Li, Hong Zheng, Gabriel Tsz-Mei Lok, Yu Deng, Michael Huen, Junjie Chen, Jianping Jin, Sandy Chang
Nat Struct Mol Biol. Author manuscript; available in PMC 2013 May 20.
Published in final edited form as: Nat Struct Mol Biol. 2011 Nov 20; 18(12): 1400–1407. Published online 2011 Nov 20. doi: 10.1038/nsmb.2172
PMCID:
PMC3657743
AbstractArticlePDF–1.5M
20.
Cooperation between p53 and the telomere-protecting shelterin component Pot1a in endometrial carcinogenesis
E A Akbay, C G Peña, D Ruder, J A Michel, Y Nakada, S Pathak, A S Multani, S Chang, D H Castrillon
Oncogene. 2013 Apr 25; 32(17): 2211–2219. Published online 2012 Jun 11. doi: 10.1038/onc.2012.232
PMCID:
PMC3636499
AbstractArticlePDF–2.9M

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