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Items: 1 to 20 of 65

1.
AI-guided pipeline for protein-protein interaction drug discovery identifies a SARS-CoV-2 inhibitor
Philipp Trepte, Christopher Secker, Simona Kostova, Sibusiso B. Maseko, Soon Gang Choi, Jeremy Blavier, Igor Minia, Eduardo Silva Ramos, Patricia Cassonnet, Sabrina Golusik, Martina Zenkner, Stephanie Beetz, Mara J. Liebich, Nadine Scharek, Anja Schütz, Marcel Sperling, Michael Lisurek, Yang Wang, Kerstin Spirohn, Tong Hao, Michael A. Calderwood, David E. Hill, Markus Landthaler, Julien Olivet, Jean-Claude Twizere, Marc Vidal, Erich E. Wanker
Version 1. bioRxiv. Preprint. 2023 Jun 14. doi: 10.1101/2023.06.14.544560
Published in:
Mol Syst Biol. 2024 Apr; 20(4): 428–457.
PMCID:
PMC10312674
AbstractArticlePDF–9.6M
2.
Genome-wide CRISPR screens using isogenic cells reveal vulnerabilities conferred by loss of tumor suppressors
Xu Feng, Mengfan Tang, Merve Dede, Dan Su, Guangsheng Pei, Dadi Jiang, Chao Wang, Zhen Chen, Mi Li, Litong Nie, Yun Xiong, Siting Li, Jeong-Min Park, Huimin Zhang, Min Huang, Klaudia Szymonowicz, Zhongming Zhao, Traver Hart, Junjie Chen
Sci Adv. 2022 May; 8(19): eabm6638. Published online 2022 May 13. doi: 10.1126/sciadv.abm6638
PMCID:
PMC9106303
AbstractArticlePDF–918K
3.
Loss of an Immunodominant HLA-Α *01:01 Restricted Epitope for CD8+ Cytotoxic T Lymphocytes (CTLs) in the Delta Variant of COVID-19: An Example of Immunologic Escape and Implications for Immunologic Treatment
Neal Flomenberg, Dolores Grosso, Yuri Sykulev, Nadezhda Anikeyeva, Yanping Huang, Michael Sun, Kaitlin Keck, Allyson O'Connor, Alexis Peedin, Julie Karp, Phyllis Flomenberg, AnnaMaria Chang, Patricia Henwood, Kristin Rising, Neda Nikbakht, Liza McGuire, Samuel Flomenberg, Ryan Saadi, John L. Wagner
Blood. 2021 Nov 23; 138: 738. Published online 2021 Dec 24. doi: 10.1182/blood-2021-147487
PMCID:
PMC8701634
AbstractPDF–406K
4.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
5.
DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity
Rajat Gupta, Kumar Somyajit, Takeo Narita, Elina Maskey, Andre Stanlie, Magdalena Kremer, Dimitris Typas, Michael Lammers, Niels Mailand, Andre Nussenzweig, Jiri Lukas, Chunaram Choudhary
Cell. Author manuscript; available in PMC 2021 May 10.
Published in final edited form as: Cell. 2018 May 3; 173(4): 972–988.e23. Published online 2018 Apr 12. doi: 10.1016/j.cell.2018.03.050
PMCID:
PMC8108093
AbstractArticlePDF–3.5M
6.
The interplay of UBE2T and Mule in regulating Wnt/β-catenin activation to promote hepatocellular carcinoma progression
Nicole Pui Yu Ho, Carmen Oi Ning Leung, Tin Lok Wong, Eunice Yuen Ting Lau, Martina Mang Leng Lei, Etienne Ho Kit Mok, Hoi Wing Leung, Man Tong, Irene Oi Lin Ng, Jing Ping Yun, Stephanie Ma, Terence Kin Wah Lee
Cell Death Dis. 2021 Feb; 12(2): 148. Published online 2021 Feb 1. doi: 10.1038/s41419-021-03403-6
PMCID:
PMC7862307
AbstractArticlePDF–4.0M
7.
Loss of Mitochondrial Localization of Human FANCG Causes Defective FANCJ Helicase
Jagadeesh Chandra Bose K, Bishwajit Singh Kapoor, Kamal Mandal, Shubhrima Ghosh, Raveendra B. Mokhamatam, Sunil K. Manna, Sudit S. Mukhopadhyay
Mol Cell Biol. 2020 Dec; 40(23): e00306-20. Prepublished online 2020 Sep 28. Published online 2020 Nov 6. doi: 10.1128/MCB.00306-20
PMCID:
PMC7652403
AbstractArticlePDF–5.3M
8.
Histone methyltransferase DOT1L coordinates AR and MYC stability in prostate cancer
R. Vatapalli, V. Sagar, Y. Rodriguez, J. C. Zhao, K. Unno, S. Pamarthy, B. Lysy, J. Anker, H. Han, Y. A. Yoo, M. Truica, Z. R. Chalmers, F. Giles, J. Yu, D. Chakravarti, B. Carneiro, S. A. Abdulkadir
Nat Commun. 2020; 11: 4153. Published online 2020 Aug 19. doi: 10.1038/s41467-020-18013-7
PMCID:
PMC7438336
AbstractArticlePDF–2.4M
9.
Endocrine profiling in patients with Fanconi anemia, homozygous for a FANCG founder mutation
Bronwyn Dillon, Candice Feben, David Segal, Johannes du Plessis, David Reynders, Rosalind Wainwright, Janet Poole, Amanda Krause
Mol Genet Genomic Med. 2020 Aug; 8(8): e1351. Published online 2020 Jun 11. doi: 10.1002/mgg3.1351
PMCID:
PMC7434606
AbstractArticlePDF–771K
10.
A reference map of the human binary protein interactome
Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood
Nature. Author manuscript; available in PMC 2020 Oct 8.
Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x
PMCID:
PMC7169983
AbstractArticlePDF–5.4M
11.
Cooperation of the NEIL3 and Fanconi anemia/BRCA pathways in interstrand crosslink repair
Niu Li, Jian Wang, Susan S Wallace, Jing Chen, Jia Zhou, Alan D D’Andrea
Nucleic Acids Res. 2020 Apr 6; 48(6): 3014–3028. Published online 2020 Jan 25. doi: 10.1093/nar/gkaa038
PMCID:
PMC7102959
AbstractArticlePDF–3.1M
12.
Proteomic characterization of chromosomal common fragile site (CFS)-associated proteins uncovers ATRX as a regulator of CFS stability
David Pladevall-Morera, Stephanie Munk, Andreas Ingham, Lorenza Garribba, Eliene Albers, Ying Liu, Jesper V Olsen, Andres J Lopez-Contreras
Nucleic Acids Res. 2019 Sep 5; 47(15): 8004–8018. Published online 2019 Jun 10. doi: 10.1093/nar/gkz510
Correction in:
Nucleic Acids Res. 2019 Sep 5; 47(15): 8332.
PMCID:
PMC6735892
AbstractArticlePDF–5.4M
13.
PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation
Cristina Guardia-Laguarta, Yuhui Liu, Knut H. Lauritzen, Hediye Erdjument-Bromage, Brittany Martin, Theresa C. Swayne, Xuejun Jiang, Serge Przedborski
J Neurosci. 2019 Sep 4; 39(36): 7074–7085. doi: 10.1523/JNEUROSCI.1691-18.2019
PMCID:
PMC6733537
AbstractArticlePDF–3.0M
14.
Maximizing binary interactome mapping with a minimal number of assays
Soon Gang Choi, Julien Olivet, Patricia Cassonnet, Pierre-Olivier Vidalain, Katja Luck, Luke Lambourne, Kerstin Spirohn, Irma Lemmens, Mélanie Dos Santos, Caroline Demeret, Louis Jones, Sudharshan Rangarajan, Wenting Bian, Eloi P. Coutant, Yves L. Janin, Sylvie van der Werf, Philipp Trepte, Erich E. Wanker, Javier De Las Rivas, Jan Tavernier, Jean-Claude Twizere, Tong Hao, David E. Hill, Marc Vidal, Michael A. Calderwood, Yves Jacob
Nat Commun. 2019; 10: 3907. Published online 2019 Aug 29. doi: 10.1038/s41467-019-11809-2
PMCID:
PMC6715725
AbstractArticlePDF–1.7M
15.
FANCA promotes DNA double strand break repair by catalyzing single-strand annealing and strand exchange
Anaid Benitez, Wenjun Liu, Anna Palovcak, Guanying Wang, Jaewon Moon, Kevin An, Anna Kim, Kevin Zheng, Yu Zhang, Feng Bai, Alexander V. Mazin, Xin-Hai Pei, Fenghua Yuan, Yanbin Zhang
Mol Cell. Author manuscript; available in PMC 2019 Aug 16.
Published in final edited form as: Mol Cell. 2018 Aug 16; 71(4): 621–628.e4. Published online 2018 Jul 26. doi: 10.1016/j.molcel.2018.06.030
PMCID:
PMC6097932
AbstractArticlePDF–1.2M
16.
Architecture of the human interactome defines protein communities and disease networks
Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper
Nature. Author manuscript; available in PMC 2017 Nov 17.
Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366
PMCID:
PMC5531611
AbstractArticlePDF–2.7M
17.
HSP90 shapes the consequences of human genetic variation
Georgios I. Karras, Song Yi, Nidhi Sahni, Máté Fischer, Jenny Xie, Marc Vidal, Alan D. D'Andrea, Luke Whitesell, Susan Lindquist
Cell. Author manuscript; available in PMC 2018 Feb 23.
Published in final edited form as: Cell. 2017 Feb 23; 168(5): 856–866.e12. Published online 2017 Feb 16. doi: 10.1016/j.cell.2017.01.023
PMCID:
PMC5325763
AbstractArticlePDF–2.4M
18.
AMP-activated protein kinase is involved in the activation of the Fanconi anemia/BRCA pathway in response to DNA interstrand crosslinks
Min Jeong Chun, Sunshin Kim, Soo Kyung Hwang, Bong Sub Kim, Hyoun Geun Kim, Hae In Choi, Jong Heon Kim, Sung Ho Goh, Chang-Hun Lee
Oncotarget. 2016 Aug 16; 7(33): 53642–53653. Published online 2016 Jul 18. doi: 10.18632/oncotarget.10686
PMCID:
PMC5288211
AbstractArticlePDF–3.0M
19.
HES1 is a novel interactor of the Fanconi anemia core complex
Cédric S. Tremblay, Feng F. Huang, Ouassila Habi, Caroline C. Huard, Chantal Godin, Georges Lévesque, Madeleine Carreau
Blood. Author manuscript; available in PMC 2016 Dec 13.
Published in final edited form as: Blood. 2008 Sep 1; 112(5): 2062–2070. Published online 2008 Jun 11. doi: 10.1182/blood-2008-04-152710
PMCID:
PMC5154739
AbstractArticlePDF–1.1M
20.
Widespread expansion of protein interaction capabilities by alternative splicing
Xinping Yang, Jasmin Coulombe-Huntington, Shuli Kang, Gloria M. Sheynkman, Tong Hao, Aaron Richardson, Song Sun, Fan Yang, Yun A. Shen, Ryan R. Murray, Kerstin Spirohn, Bridget E. Begg, Miquel Duran-Frigola, Andrew MacWilliams, Samuel J. Pevzner, Quan Zhong, Shelly A. Wanamaker, Stanley Tam, Lila Ghamsari, Nidhi Sahni, Song Yi, Maria D. Rodriguez, Dawit Balcha, Guihong Tan, Michael Costanzo, Brenda Andrews, Charles Boone, Xianghong J. Zhou, Kourosh Salehi-Ashtiani, Benoit Charloteaux, Alyce A. Chen, Michael A. Calderwood, Patrick Aloy, Frederick P. Roth, David E. Hill, Lilia M. Iakoucheva, Yu Xia, Marc Vidal
Cell. Author manuscript; available in PMC 2017 Feb 11.
Published in final edited form as: Cell. 2016 Feb 11; 164(4): 805–817. doi: 10.1016/j.cell.2016.01.029
PMCID:
PMC4882190
AbstractArticlePDF–1.9M

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