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Items: 1 to 20 of 140

1.
Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis
Robert S. Kiss, Jarred Chicoine, Youssef Khalil, Robert Sladek, He Chen, Alessandro Pisaturo, Cyril Martin, Jessica D. Dale, Tegan A. Brudenell, Archith Kamath, Jeffrey Kyei-Boahen, Anouar Hafiane, Girija Daliah, Célia Alecki, Tayah S. Hopes, Martin Heier, Irene A. Aligianis, Jean-Jacques Lebrun, Julie Aspden, Emanuele Paci, Anja Kerksiek, Dieter Lütjohann, Peter Clayton, Jimi C. Wills, Alex von Kriegsheim, Tommy Nilsson, Eamonn Sheridan, Mark T. Handley
J Biol Chem. 2023 Nov; 299(11): 105295. Published online 2023 Sep 28. doi: 10.1016/j.jbc.2023.105295
PMCID:
PMC10641524
AbstractArticlePDF–3.8M
2.
Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates
Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert
Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644
PMCID:
PMC10565876
AbstractArticlePDF–3.7M
3.
TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing
Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan
Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233
PMCID:
PMC10237422
AbstractArticlePDF–23M
4.
Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma
Yu-Fei Cao, Lei Xie, Bei-Bei Tong, Man-Yu Chu, Wen-Qi Shi, Xiang Li, Jian-Zhong He, Shao-Hong Wang, Zhi-Yong Wu, Dan-Xia Deng, Ya-Qi Zheng, Zhi-Mao Li, Xiu-E Xu, Lian-Di Liao, Yin-Wei Cheng, Li-Yan Li, Li-Yan Xu, En-Min Li
Cell Death Differ. 2023 Feb; 30(2): 527–543. Published online 2022 Dec 16. doi: 10.1038/s41418-022-01104-x
PMCID:
PMC9950447
AbstractArticlePDF–8.4M
5.
A bio-orthogonal linear ubiquitin probe identifies STAT3 as a direct substrate of OTULIN in glioblastoma
Xianli Du, Jing Pang, Bin Gu, Tian Si, Yan Chang, Tianqi Li, Min Wu, Zicheng Wang, Yuxia Wang, Jiannan Feng, Ning Wu, Jianghong Man, Huiyan Li, Ailing Li, Tong Zhang, Bo Wang, Xiaotao Duan
Nucleic Acids Res. 2023 Feb 22; 51(3): 1050–1066. Published online 2023 Jan 20. doi: 10.1093/nar/gkad002
PMCID:
PMC9943648
AbstractArticlePDF–5.3M
6.
SARS-CoV-2 viral protein ORF3A injures renal tubules by interacting with TRIM59 to induce STAT3 activation
Hong Cai, Ya Chen, Ye Feng, Morad Asadi, Lewis Kaufman, Kyung Lee, Thomas Kehrer, Lisa Miorin, Adolfo Garcia-Sastre, G. Luca Gusella, Leyi Gu, Zhaohui Ni, Shan Mou, John Cijiang He, Weibin Zhou
Mol Ther. 2023 Mar 1; 31(3): 774–787. Published online 2022 Dec 15. doi: 10.1016/j.ymthe.2022.12.008
PMCID:
PMC9750503
AbstractArticlePDF–4.3M
7.
Stem-Cell-Derived β-Like Cells with a Functional PTPN2 Knockout Display Increased Immunogenicity
Taylor M. Triolo, J. Quinn Matuschek, Roberto Castro-Gutierrez, Ali H. Shilleh, Shane P. M. Williams, Maria S. Hansen, Kristen McDaniel, Jessie M. Barra, Aaron Michels, Holger A. Russ
Cells. 2022 Dec; 11(23): 3845. Published online 2022 Nov 30. doi: 10.3390/cells11233845
PMCID:
PMC9737324
AbstractArticlePDF–37M
8.
PTPN2 in the Immunity and Tumor Immunotherapy: A Concise Review
Jiachun Song, Jinxin Lan, Jiaping Tang, Na Luo
Int J Mol Sci. 2022 Sep; 23(17): 10025. Published online 2022 Sep 2. doi: 10.3390/ijms231710025
PMCID:
PMC9456094
AbstractArticlePDF–719K
9.
Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery
Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili
Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z
PMCID:
PMC9279285
AbstractArticlePDF–2.5M
10.
OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization
Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti
Science. Author manuscript; available in PMC 2022 Sep 11.
Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983
PMCID:
PMC9119736
AbstractArticlePDF–3.3M
11.
Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy
Xin Sun, Yuhan Shu, Guiqin Ye, Caixia Wu, Mengting Xu, Ruilan Gao, Dongsheng Huang, Jianbin Zhang
Acta Pharm Sin B. 2022 Feb; 12(2): 838–852. Published online 2021 Jul 21. doi: 10.1016/j.apsb.2021.07.003
PMCID:
PMC8897022
AbstractArticlePDF–3.0M
12.
PTPN2 elicits cell autonomous and non–cell autonomous effects on antitumor immunity in triple-negative breast cancer
Pei Kee Goh, Florian Wiede, Mara N. Zeissig, Kara L. Britt, Shuwei Liang, Tim Molloy, Nathan Goode, Rachel Xu, Sherene Loi, Mathias Muller, Patrick O. Humbert, Catriona McLean, Tony Tiganis
Sci Adv. 2022 Feb; 8(8): eabk3338. Published online 2022 Feb 23. doi: 10.1126/sciadv.abk3338
PMCID:
PMC8865802
AbstractArticlePDF–5.2M
13.
PTPN2, A Key Predictor of Prognosis for Pancreatic Adenocarcinoma, Significantly Regulates Cell Cycles, Apoptosis, and Metastasis
Wenbin Kuang, Xiao Wang, Jiayu Ding, Jiaxing Li, Minghui Ji, Weijiao Chen, Liping Wang, Peng Yang
Front Immunol. 2022; 13: 805311. Published online 2022 Jan 27. doi: 10.3389/fimmu.2022.805311
PMCID:
PMC8829144
AbstractArticlePDF–17M
14.
Structural characterization of a pathogenic mutant of human protein tyrosine phosphatase PTPN2 (Cys216Gly) that causes very early onset autoimmune enteropathy
Qing Nian, Jérémy Berthelet, Marianna Parlato, Ariel E. Mechaly, Rongxing Liu, Jean‐Marie Dupret, Nadine Cerf‐Bensussan, Ahmed Haouz, Fernando Rodrigues Lima
Protein Sci. 2022 Feb; 31(2): 538–544. Published online 2021 Nov 27. doi: 10.1002/pro.4246
PMCID:
PMC8820110
AbstractArticlePDF–4.8M
15.
Long non-coding RNA TINCR promotes hepatocellular carcinoma proliferation and invasion via STAT3 signaling by direct interacting with T-cell protein tyrosine phosphatase (TCPTP)
Chengwu Tang, Wenming Feng, Ying Bao, Huimin Du
Bioengineered. 2021; 12(1): 2119–2131. Published online 2021 May 30. doi: 10.1080/21655979.2021.1930336
PMCID:
PMC8806792
AbstractArticlePDF–2.4M
16.
The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin
Dragomir B. Krastev, Shudong Li, Yilun Sun, Andrew J. Wicks, Gwendoline Hoslett, Daniel Weekes, Luned M. Badder, Eleanor G. Knight, Rebecca Marlow, Mercedes Calvo Pardo, Lu Yu, Tanaji T. Talele, Jiri Bartek, Jyoti S. Choudhary, Yves Pommier, Stephen J. Pettitt, Andrew N. J. Tutt, Kristijan Ramadan, Christopher J. Lord
Nat Cell Biol. 2022; 24(1): 62–73. Published online 2022 Jan 10. doi: 10.1038/s41556-021-00807-6
PMCID:
PMC8760077
AbstractArticlePDF–12M
17.
The catalytic activity of TCPTP is auto-regulated by its intrinsically disordered tail and activated by Integrin alpha-1
Jai Prakash Singh, Yang Li, Yi-Yun Chen, Shang-Te Danny Hsu, Rebecca Page, Wolfgang Peti, Tzu-Ching Meng
Nat Commun. 2022; 13: 94. Published online 2022 Jan 10. doi: 10.1038/s41467-021-27633-6
PMCID:
PMC8748766
AbstractArticlePDF–3.5M
18.
Loss of protein tyrosine phosphatase non-receptor type 2 reduces IL-4-driven alternative macrophage activation
Marianne R. Spalinger, Meli’sa Crawford, Sarah D. Bobardt, Jiang Li, Anica Sayoc-Becerra, Alina N. Santos, Ali Shawki, Pritha Chatterjee, Meera G. Nair, Declan F. McCole
Mucosal Immunol. 2022; 15(1): 74–83. Published online 2021 Aug 21. doi: 10.1038/s41385-021-00441-3
PMCID:
PMC8732276
AbstractArticlePDF–1.8M
19.
T cell protein tyrosine phosphatase protects intestinal barrier function by restricting epithelial tight junction remodeling
Ronald R. Marchelletta, Moorthy Krishnan, Marianne R. Spalinger, Taylaur W. Placone, Rocio Alvarez, Anica Sayoc-Becerra, Vinicius Canale, Ali Shawki, Young Su Park, Lucas H.P. Bernts, Stephen Myers, Michel L. Tremblay, Kim E. Barrett, Evan Krystofiak, Bechara Kachar, Dermot P.B. McGovern, Christopher R. Weber, Elaine M. Hanson, Lars Eckmann, Declan F. McCole
J Clin Invest. 2021 Sep 1; 131(17): e138230. Published online 2021 Sep 1. doi: 10.1172/JCI138230
PMCID:
PMC8409587
AbstractArticlePDF–18M
20.
Gene Polymorphisms of NOD2, IL23R, PTPN2 and ATG16L1 in Patients with Crohn’s Disease: On the Way to Personalized Medicine?
Peter Hoffmann, David Lamerz, Petra Hill, Marietta Kirchner, Annika Gauss
Genes (Basel) 2021 Jun; 12(6): 866. Published online 2021 Jun 5. doi: 10.3390/genes12060866
PMCID:
PMC8227795
AbstractArticlePDF–250K

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