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Items: 1 to 20 of 138

1.
Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability
YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Carmen Florencia Suarez, Nicolas S Gonzalez-Foutel, Ahmad Malik, Sebastien Martinez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N Al-Zahrani, Lisa Hoeg, Zhen Yuan Lin, Ricky Tsai, Geraldine Mbamalu, Varda Rotter, Patricia Ashton-Prolla, Jason Moffat, Lucia Beatriz Chemes, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek
Mol Syst Biol. 2024 Jun; 20(6): 719–740. Published online 2024 Apr 5. doi: 10.1038/s44320-024-00032-x
PMCID:
PMC11148184
AbstractArticlePDF–8.1M
2.
Recent advances of NFATc1 in rheumatoid arthritis-related bone destruction: mechanisms and potential therapeutic targets
Hao Zheng, Yuexuan Liu, Yasi Deng, Yunzhe Li, Shiqi Liu, Yong Yang, Yun Qiu, Bin Li, Wenbing Sheng, Jinzhi Liu, Caiyun Peng, Wei Wang, Huanghe Yu
Mol Med. 2024; 30: 20. Published online 2024 Feb 3. doi: 10.1186/s10020-024-00788-w
PMCID:
PMC10838448
AbstractArticlePDF–3.3M
3.
Exosome-targeted delivery of METTL14 regulates NFATc1 m6A methylation levels to correct osteoclast-induced bone resorption
Jin-Gang Yang, Bao Sun, Zheng Wang, Xing Li, Jia-hui Gao, Jia-jun Qian, Jiang Li, Wen-jia Wei, Ping Zhang, Wei Wang
Cell Death Dis. 2023 Nov; 14(11): 738. Published online 2023 Nov 13. doi: 10.1038/s41419-023-06263-4
PMCID:
PMC10643436
AbstractArticlePDF–8.2M
4.
Risk Variants in or Near ZBTB40 AND NFATC1 Increase the Risk of Both IBD and Adverse Bone Health Outcomes Highlighting Common Genetic Underpinnings Across Both Diseases
Kelly C Cushing, Yanhua Chen, Xiaomeng Du, Vincent Chen, Annapurna Kuppa, Peter Higgins, Elizabeth K Speliotes
Inflamm Bowel Dis. 2023 Jun; 29(6): 938–945. Published online 2023 Jan 21. doi: 10.1093/ibd/izac273
PMCID:
PMC10465078
AbstractArticlePDF–1.1M
5.
Human bone marrow-derived mesenchymal stem overexpressing microRNA-124-3p inhibit DLBCL progression by downregulating the NFATc1/cMYC pathway
Xiaoxuan Zhao, Mingxi Xu, Xuemeng Hu, Xiaolei Ding, Xian Zhang, Liye Xu, Li Li, Xiuhua Sun, Jincheng Song
Stem Cell Res Ther. 2023; 14: 148. Published online 2023 May 29. doi: 10.1186/s13287-023-03373-w
PMCID:
PMC10228039
AbstractArticlePDF–7.7M
6.
CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment
Daphne J. Smits, Jordy Dekker, Rachel Schot, Brahim Tabarki, Amal Alhashem, Jeroen A. A. Demmers, Dick H. W. Dekkers, Antonio Romito, Peter J. van der Spek, Tjakko J. van Ham, Aida M. Bertoli-Avella, Grazia M. S. Mancini
Hum Genet. 2023; 142(3): 379–397. Published online 2022 Dec 20. doi: 10.1007/s00439-022-02511-3
PMCID:
PMC9950183
AbstractArticlePDF–2.4M
7.
NFATc1 Regulation of Dexamethasone-Induced TGFB2 Expression Is Cell Cycle Dependent in Trabecular Meshwork Cells
Mark S. Filla, Jennifer A. Faralli, Caleigh R. Dunn, Haania Khan, Donna M. Peters
Cells. 2023 Feb; 12(3): 504. Published online 2023 Feb 3. doi: 10.3390/cells12030504
PMCID:
PMC9914240
AbstractArticlePDF–46M
8.
The role of FOXO4/NFAT2 signaling pathway in dysfunction of human coronary endothelial cells and inflammatory infiltration of vasculitis in Kawasaki disease
Hongbiao Huang, Jinfeng Dong, Jiaqi Jiang, Fang Yang, Yiming Zheng, Shuhui Wang, Nana Wang, Jin Ma, Miao Hou, Yueyue Ding, Lijun Meng, Wenyu Zhuo, Daoping Yang, Weiguo Qian, Qiaobin Chen, Guoping You, Guanghui Qian, Lei Gu, Haitao Lv
Front Immunol. 2022; 13: 1090056. Published online 2023 Jan 9. doi: 10.3389/fimmu.2022.1090056
PMCID:
PMC9869249
AbstractArticlePDF–17M
9.
Regulation of Cyclooxygenase-2 Expression in Human T Cells by Glucocorticoid Receptor-Mediated Transrepression of Nuclear Factor of Activated T Cells
Cristina Cacheiro-Llaguno, Elena Hernández-Subirá, Manuel D. Díaz-Muñoz, Manuel Fresno, Juan M. Serrador, Miguel A. Íñiguez
Int J Mol Sci. 2022 Nov; 23(21): 13275. Published online 2022 Oct 31. doi: 10.3390/ijms232113275
PMCID:
PMC9653600
AbstractArticlePDF–2.0M
10.
Cav2.2-NFAT2-USP43 axis promotes invadopodia formation and breast cancer metastasis through cortactin stabilization
Ying Xue, Min Li, Jie Hu, Yuanlin Song, Wei Guo, Changhong Miao, Di Ge, Yingyong Hou, Xuefei Wang, Xingxu Huang, Tianshu Liu, Xiaoping Zhang, Qihong Huang
Cell Death Dis. 2022 Sep; 13(9): 812. Published online 2022 Sep 22. doi: 10.1038/s41419-022-05174-0
PMCID:
PMC9500045
AbstractArticlePDF–4.3M
11.
FBXO42 facilitates Notch signaling activation and global chromatin relaxation by promoting K63-linked polyubiquitination of RBPJ
Hua Jiang, Weixiang Bian, Yue Sui, Huanle Li, Han Zhao, Wenqi Wang, Xu Li
Sci Adv. 2022 Sep; 8(38): eabq4831. Published online 2022 Sep 21. doi: 10.1126/sciadv.abq4831
PMCID:
PMC9491713
AbstractArticlePDF–12M
12.
A dual-activity topoisomerase complex regulates mRNA translation and turnover
Shuaikun Su, Yutong Xue, Alexei Sharov, Yongqing Zhang, Seung Kyu Lee, Jennifer L Martindale, Wen Li, Wai Lim Ku, Keji Zhao, Supriyo De, Weiping Shen, Payel Sen, Myriam Gorospe, Dongyi Xu, Weidong Wang
Nucleic Acids Res. 2022 Jul 8; 50(12): 7013–7033. Published online 2022 Jun 24. doi: 10.1093/nar/gkac538
PMCID:
PMC9262614
AbstractArticlePDF–3.6M
13.
DNA methylation of Nuclear Factor of Activated T Cells 1 mediates the prospective relation between exposure to different traumatic event types and post-traumatic stress disorder
James R. Occean, Agaz H. Wani, Janelle Donglasan, Allison E. Aiello, Sandro Galea, Karestan C. Koenen, Annie Qu, Derek E. Wildman, Monica Uddin
Psychiatry Res. Author manuscript; available in PMC 2023 May 1.
Published in final edited form as: Psychiatry Res. 2022 May; 311: 114510. Published online 2022 Mar 19. doi: 10.1016/j.psychres.2022.114510
PMCID:
PMC9018623
AbstractArticlePDF–605K
14.
The Osteogenesis Imperfecta Type V Mutant BRIL/IFITM5 Promotes Transcriptional Activation of MEF2, NFATc, and NR4A in Osteoblasts
Vincent Maranda, Marie-Hélène Gaumond, Pierre Moffatt
Int J Mol Sci. 2022 Feb; 23(4): 2148. Published online 2022 Feb 15. doi: 10.3390/ijms23042148
PMCID:
PMC8875491
AbstractArticlePDF–4.1M
15.
Estrogen receptor alpha and NFATc1 bind to a bone mineral density-associated SNP to repress WNT5B in osteoblasts
Sarocha Suthon, Jianjian Lin, Rachel S. Perkins, John R. Crockarell, Jr., Gustavo A. Miranda-Carboni, Susan A. Krum
Am J Hum Genet. 2022 Jan 6; 109(1): 97–115. Published online 2021 Dec 31. doi: 10.1016/j.ajhg.2021.11.018
PMCID:
PMC8764205
AbstractArticlePDF–2.7M
16.
EZH2 depletion potentiates MYC degradation inhibiting neuroblastoma and small cell carcinoma tumor formation
Liyuan Wang, Chan Chen, Zemin Song, Honghong Wang, Minghui Ye, Donghai Wang, Wenqian Kang, Hudan Liu, Guoliang Qing
Nat Commun. 2022; 13: 12. Published online 2022 Jan 10. doi: 10.1038/s41467-021-27609-6
PMCID:
PMC8748958
AbstractArticlePDF–3.0M
17.
Predicting the targets of IRF8 and NFATc1 during osteoclast differentiation using the machine learning method framework cTAP
Honglin Wang, Pujan Joshi, Seung-Hyun Hong, Peter F. Maye, David W. Rowe, Dong-Guk Shin
BMC Genomics. 2022; 23: 14. Published online 2022 Jan 7. doi: 10.1186/s12864-021-08159-z
PMCID:
PMC8740472
AbstractArticlePDF–2.0M
18.
Immunosuppression Affects Neutrophil Functions: Does Calcineurin-NFAT Signaling Matter?
Ondřej Vymazal, Kamila Bendíčková, Marco De Zuani, Marcela Vlková, Marcela Hortová-Kohoutková, Jan Frič
Front Immunol. 2021; 12: 770515. Published online 2021 Nov 2. doi: 10.3389/fimmu.2021.770515
PMCID:
PMC8593005
AbstractArticlePDF–344K
19.
Increased Expression of the lncRNA NRON Along With NFATc1/PIM-1 in Labial Salivary Glands of Sjögren’s Syndrome Patients
Yoshiro Horai, Hideki Nakamura, Toshimasa Shimizu, Shinya Nishihata, Naoki Iwamoto, Tamotsu Kuroki, Shinji Okano, Atsushi Kawakami
Appl Immunohistochem Mol Morphol. 2021 Nov-Dec; 29(10): 734–740. Published online 2021 Jul 14. doi: 10.1097/PAI.0000000000000959
PMCID:
PMC8579987
AbstractArticlePDF–642K
20.
Nuclear factor of activated T-cells (NFAT) regulation of IL-1β-induced retinal vascular inflammation
Meredith J. Giblin, Taylor E. Smith, Garrett Winkler, Hannah A. Pendergrass, Minjae J. Kim, Megan E. Capozzi, Rong Yang, Gary W. McCollum, John S. Penn
Biochim Biophys Acta Mol Basis Dis. Author manuscript; available in PMC 2022 Dec 1.
Published in final edited form as: Biochim Biophys Acta Mol Basis Dis. 2021 Dec 1; 1867(12): 166238. Published online 2021 Jul 31. doi: 10.1016/j.bbadis.2021.166238
PMCID:
PMC8565496
AbstractArticlePDF–803K

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