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Select item 109876621.

Metabolic rewiring of macrophages by epidermal-derived lactate promotes sterile inflammation in the murine skin

Uttkarsh Ayyangar, Aneesh Karkhanis, Heather Tay, Aliya Farissa Binte Afandi, Oindrila Bhattacharjee, Lalitha KS, Sze Han Lee, James Chan, Srikala Raghavan

EMBO J. 2024 Apr; 43(7): 1113–1134. Published online 2024 Feb 28. doi: 10.1038/s44318-024-00039-y

PMCID:: PMC10987662

Abstract Article PDF–12M

Select item 109176602.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 106001733.

IDH1 mutation impairs antiviral response and potentiates oncolytic virotherapy in glioma

Xueqin Chen, Jun Liu, Yuqin Li, Yuequan Zeng, Fang Wang, Zexiong Cheng, Hao Duan, Guopeng Pan, Shangqi Yang, Yuling Chen, Qing Li, Xi Shen, Ying Li, Zixi Qin, Jiahong Chen, Youwei Huang, Xiangyu Wang, Yuli Lu, Minfeng Shu, Yubo Zhang, Guocai Wang, Kai Li, Xi Lin, Fan Xing, Haipeng Zhang

Nat Commun. 2023; 14: 6781. Published online 2023 Oct 25. doi: 10.1038/s41467-023-42545-3

PMCID:: PMC10600173

Abstract Article PDF–11M

Select item 105924524.

Mutant IDH regulates glycogen metabolism from early cartilage development to malignant chondrosarcoma formation

Sinthu Pathmanapan, Raymond Poon, Tomasa Barrientos De Renshaw, Puviindran Nadesan, Makoto Nakagawa, Gireesh A. Seesankar, Adrian Kwan Ho Loe, Hongyuan H. Zhang, Joan J. Guinovart, Jordi Duran, Christopher B. Newgard, Jay S. Wunder, Benjamin A. Alman

Cell Rep. Author manuscript; available in PMC 2023 Oct 23.

Published in final edited form as: Cell Rep. 2023 Jun 27; 42(6): 112578. Published online 2023 Jun 1. doi: 10.1016/j.celrep.2023.112578

PMCID:: PMC10592452

Abstract Article PDF–1.7M

Select item 105395075.

Classification of IDH wild-type glioblastoma tumorspheres into low- and high-invasion groups based on their transcriptional program

Junseong Park, Jin-Kyoung Shim, Mirae Lee, Dokyeong Kim, Seon-Jin Yoon, Ju Hyung Moon, Eui Hyun Kim, Jeong-Yoon Park, Jong Hee Chang, Seok-Gu Kang

Br J Cancer. 2023 Oct 19; 129(7): 1061–1070. Published online 2023 Aug 9. doi: 10.1038/s41416-023-02391-y

PMCID:: PMC10539507

Abstract Article PDF–5.1M

Select item 99428506.

Distinct and opposite effects of leukemogenic Idh and Tet2 mutations in hematopoietic stem and progenitor cells

Jerome Fortin, Ming-Feng Chiang, Cem Meydan, Jonathan Foox, Parameswaran Ramachandran, Julie Leca, François Lemonnier, Wanda Y. Li, Miki S. Gams, Takashi Sakamoto, Mandy Chu, Chantal Tobin, Eric Laugesen, Troy M. Robinson, Annick You-Ten, Daniel J. Butler, Thorsten Berger, Mark D. Minden, Ross L. Levine, Cynthia J. Guidos, Ari M. Melnick, Christopher E. Mason, Tak W. Mak

Proc Natl Acad Sci U S A. 2023 Jan 24; 120(4): e2208176120. Published online 2023 Jan 18. doi: 10.1073/pnas.2208176120

PMCID:: PMC9942850

Abstract Article PDF–9.0M

Select item 96038607.

The Deubiquitinating Enzyme USP48 Interacts with the Retinal Degeneration-Associated Proteins UNC119a and ARL3

Laura Sánchez-Bellver, Andrea Férriz-Gordillo, Marc Carrillo-Pz, Laura Rabanal, Francesc R. Garcia-Gonzalo, Gemma Marfany

Int J Mol Sci. 2022 Oct; 23(20): 12527. Published online 2022 Oct 19. doi: 10.3390/ijms232012527

PMCID:: PMC9603860

Abstract Article PDF–3.4M

Select item 95153868.

De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma

Diana D. Shi, Milan R. Savani, Michael M. Levitt, Adam C. Wang, Jennifer E. Endress, Cylaina E. Bird, Joseph Buehler, Sylwia A. Stopka, Michael S. Regan, Yu-Fen Lin, Vinesh T. Puliyappadamba, Wenhua Gao, Januka Khanal, Laura Evans, Joyce H. Lee, Lei Guo, Yi Xiao, Min Xu, Bofu Huang, Rebecca B. Jennings, Dennis M. Bonal, Misty S. Martin-Sandoval, Tammie Dang, Lauren C. Gattie, Amy B. Cameron, Sungwoo Lee, John M. Asara, Harley I. Kornblum, Tak W. Mak, Ryan E. Looper, Quang-De Nguyen, Sabina Signoretti, Stefan Gradl, Andreas Sutter, Michael Jeffers, Andreas Janzer, Mark A. Lehrman, Lauren G. Zacharias, Thomas P. Mathews, Julie-Aurore Losman, Timothy E. Richardson, Daniel P. Cahill, Ralph J. DeBerardinis, Keith L. Ligon, Lin Xu, Peter Ly, Nathalie Y.R. Agar, Kalil G. Abdullah, Isaac S. Harris, William G. Kaelin, Jr., Samuel K. McBrayer

Cancer Cell. Author manuscript; available in PMC 2022 Sep 28.

Published in final edited form as: Cancer Cell. 2022 Sep 12; 40(9): 939–956.e16. Published online 2022 Aug 18. doi: 10.1016/j.ccell.2022.07.011

PMCID:: PMC9515386

Abstract Article PDF–4.1M

Select item 94819339.

ALS-linked loss of Cyclin-F function affects HSP90

Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends

Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359

PMCID:: PMC9481933

Abstract Article PDF–3.5M

Select item 934880310.

Transcriptional variability accelerates preleukemia by cell diversification and perturbation of protein synthesis

Shikha Gupta, Oliver M. Dovey, Ana Filipa Domingues, Oliwia W. Cyran, Caitlin M. Cash, George Giotopoulos, Justyna Rak, Jonathan Cooper, Malgorzata Gozdecka, Liza Dijkhuis, Ryan J. Asby, Noor Al-Jabery, Victor Hernandez-Hernandez, Sudhakaran Prabakaran, Brian J. Huntly, George S. Vassiliou, Cristina Pina

Sci Adv. 2022 Aug; 8(31): eabn4886. Published online 2022 Aug 3. doi: 10.1126/sciadv.abn4886

PMCID:: PMC9348803

Abstract Article PDF–2.2M

Select item 890429811.

Mutant-IDH inhibits Interferon-TET2 signaling to promote immunoevasion and tumor maintenance in cholangiocarcinoma

Meng-Ju Wu, Lei Shi, Juan Dubrot, Joshua Merritt, Vindhya Vijay, Ting-Yu Wei, Emily Kessler, Kira E. Olander, Ramzi Adil, Amaya Pankaj, Krishna Seshu Tummala, Vajira Weeresekara, Yuanli Zhen, Qibiao Wu, Meiqi Luo, William Shen, María García-Beccaria, Mirian Fernández-Vaquero, Christine Hudson, Sebastien Ronseaux, Yi Sun, Rodrigo Saad-Berreta, Russell W. Jenkins, Tong Wang, Mathias Heikenwälder, Cristina R. Ferrone, Lipika Goyal, Brandon Nicolay, Vikram Deshpande, Rahul M. Kohli, Hongwu Zheng, Robert T. Manguso, Nabeel Bardeesy

Cancer Discov. Author manuscript; available in PMC 2022 Sep 1.

Published in final edited form as: Cancer Discov. 2022 Mar 1; 12(3): 812–835. doi: 10.1158/2159-8290.CD-21-1077

PMCID:: PMC8904298

Abstract Article PDF–3.2M

Select item 879206212.

Bmal1 inhibits phenotypic transformation of hepatic stellate cells in liver fibrosis via IDH1/α-KG-mediated glycolysis

Lei Xu, Tian-yu Yang, Yi-wen Zhou, Mei-fei Wu, Jie Shen, Jie-ling Cheng, Qing-xue Liu, Shi-yang Cao, Jian-qing Wang, Lei Zhang

Acta Pharmacol Sin. 2022 Feb; 43(2): 316–329. Published online 2021 Apr 13. doi: 10.1038/s41401-021-00658-9

Correction in:: Acta Pharmacol Sin. 2022 Mar; 43(3): 757–758.

PMCID:: PMC8792062

Abstract Article PDF–7.4M

Select item 874195413.

Meta-analysis of whole-genome gene expression datasets assessing the effects of IDH1 and IDH2 mutations in isogenic disease models

Hans-Juergen Schulten, Fatima Al-Adwani, Haneen A. Bin Saddeq, Heba Alkhatabi, Nofe Alganmi, Sajjad Karim, Deema Hussein, Khalid B. Al-Ghamdi, Awatif Jamal, Jaudah Al-Maghrabi, Mohammed H. Al-Qahtani

Sci Rep. 2022; 12: 57. Published online 2022 Jan 7. doi: 10.1038/s41598-021-04214-7

PMCID:: PMC8741954

Abstract Article PDF–4.6M

Select item 864227814.

Vulnerability of IDH1 mutant cancers to histone deacetylase inhibition via orthogonal suppression of DNA repair

Jonathan Dow, Adam Krysztofiak, Yanfeng Liu, Daniel A. Colon-Rios, Faye A. Rogers, Peter M. Glazer

Mol Cancer Res. Author manuscript; available in PMC 2022 Jun 1.

Published in final edited form as: Mol Cancer Res. 2021 Sep 17 : 10.1158/1541-7786.MCR-21-0456. Published online 2021 Sep 17. doi: 10.1158/1541-7786.MCR-21-0456

PMCID:: PMC8642278

Abstract Article PDF–2.1M

Select item 862978515.

Identification by proximity labeling of novel lipidic and proteinaceous potential partners of the dopamine transporter

Dolores Piniella, Elena Martínez-Blanco, David Bartolomé-Martín, Ana B. Sanz-Martos, Francisco Zafra

Cell Mol Life Sci. 2021 Dec; 78(23): 7733–7756. Published online 2021 Oct 28. doi: 10.1007/s00018-021-03998-1

PMCID:: PMC8629785

Abstract Article PDF–10M

Select item 843729316.

Cancer-associated IDH mutations induce Glut1 expression and glucose metabolic disorders through a PI3K/Akt/mTORC1-Hif1α axis

Xun Liu, Kiyoshi Yamaguchi, Kiyoko Takane, Chi Zhu, Makoto Hirata, Yoko Hikiba, Shin Maeda, Yoichi Furukawa, Tsuneo Ikenoue

PLoS One. 2021; 16(9): e0257090. Published online 2021 Sep 13. doi: 10.1371/journal.pone.0257090

PMCID:: PMC8437293

Abstract Article PDF–2.2M

Select item 816379017.

Proteotyping of knockout mouse strains reveals sex- and strain-specific signatures in blood plasma

Yassene Mohammed, Sarah A. Michaud, Helena Pětrošová, Juncong Yang, Milan Ganguly, David Schibli, Ann M. Flenniken, Lauryl M. J. Nutter, Hibret A. Adissu, K. C. Kent Lloyd, Colin McKerlie, Christoph H. Borchers

NPJ Syst Biol Appl. 2021; 7: 25. Published online 2021 May 28. doi: 10.1038/s41540-021-00184-8

PMCID:: PMC8163790

Abstract Article PDF–6.9M

Select item 816268618.

PEG3 controls lipogenesis through ACLY

Subash Ghimire, Joomyeong Kim

PLoS One. 2021; 16(5): e0252354. Published online 2021 May 28. doi: 10.1371/journal.pone.0252354

PMCID:: PMC8162686

Abstract Article PDF–2.3M

Select item 793877019.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 765717320.

Withaferin A suppresses tumor promoter 12‐O‐tetradecanoylphorbol 13‐acetate‐induced decreases in isocitrate dehydrogenase 1 activity and mitochondrial function in skin epidermal JB6 cells

Wenjuan Li, Yunfeng Zhao

Cancer Sci. 2013 Feb; 104(2): 143–148. Published online 2012 Dec 7. doi: 10.1111/cas.12051

PMCID:: PMC7657173

Abstract Article PDF–549K

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