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Select item 107039681.

Human parietal epithelial cells (PECs) and proteinuria in lupus nephritis: a role for ClC-5, megalin, and cubilin?

Monica Ceol, Lisa Gianesello, Hernan Trimarchi, Alberto Migliorini, Giovanna Priante, Claudia M. Radu, Elena Naso, Annalisa Angelini, Lorenzo A. Calò, Franca Anglani, Dorella Del Prete

J Nephrol. 2023; 36(9): 2499–2506. Published online 2023 Aug 18. doi: 10.1007/s40620-023-01725-6

PMCID:: PMC10703968

Abstract Article PDF–3.4M

Select item 99938422.

Structures of LRP2 reveal a molecular machine for endocytosis

Andrew Beenken, Gabriele Cerutti, Julia Brasch, Yicheng Guo, Zizhang Sheng, Hediye Erdjument-Bromage, Zainab Aziz, Shelief Y Robbins-Juarez, Estefania Y Chavez, Goran Ahlsen, Phinikoula S Katsamba, Thomas A. Neubert, Anthony W.P. Fitzpatrick, Jonathan Barasch, Lawrence Shapiro

Cell. Author manuscript; available in PMC 2023 Mar 8.

Published in final edited form as: Cell. 2023 Feb 16; 186(4): 821–836.e13. Published online 2023 Feb 6. doi: 10.1016/j.cell.2023.01.016

PMCID:: PMC9993842

Abstract Article PDF–3.6M

Select item 99833583.

Regulation of Prostate Androgens by Megalin and 25-hydroxyvitamin D Status: Mechanism for High Prostate Androgens in African American Men

Jason Garcia, Kirsten D. Krieger, Candice Loitz, Lillian M. Perez, Zachary A. Richards, Yves Helou, Steve Kregel, Sasha Celada, Clementina A. Mesaros, Maarten Bosland, Peter H. Gann, Thomas E. Willnow, Donald Vander Griend, Rick Kittles, Gail S. Prins, Trevor Penning, Larisa Nonn

Cancer Res Commun. 2023 Mar; 3(3): 371–382. Published online 2023 Mar 3. doi: 10.1158/2767-9764.CRC-22-0362

PMCID:: PMC9983358

Abstract Article PDF–11M

Select item 93485764.

Chr21 protein–protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer’s disease

Julia Viard, Yann Loe-Mie, Rachel Daudin, Malik Khelfaoui, Christine Plancon, Anne Boland, Francisco Tejedor, Richard L Huganir, Eunjoon Kim, Makoto Kinoshita, Guofa Liu, Volker Haucke, Thomas Moncion, Eugene Yu, Valérie Hindie, Henri Bléhaut, Clotilde Mircher, Yann Herault, Jean-François Deleuze, Jean-Christophe Rain, Michel Simonneau, Aude-Marie Lepagnol-Bestel

Life Sci Alliance. 2022 Dec; 5(12): e202101205. Published online 2022 Aug 1. doi: 10.26508/lsa.202101205

PMCID:: PMC9348576

Abstract Article PDF–3.0M

Select item 91714115.

Physical and functional interactome atlas of human receptor tyrosine kinases

Kari Salokas, Xiaonan Liu, Tiina Öhman, Iftekhar Chowdhury, Lisa Gawriyski, Salla Keskitalo, Markku Varjosalo

EMBO Rep. 2022 Jun; 23(6): e54041. Published online 2022 Apr 5. doi: 10.15252/embr.202154041

PMCID:: PMC9171411

Abstract Article PDF–1.9M

Select item 91052356.

Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling

Ilektra Kouranti, Waed Abdel Khalek, Stephani Mazurkiewicz, Irmine Loisel-Ferreira, Alexis M. Gautreau, Lionel Pintard, Xavier Jeunemaitre, Eric Clauser

Int J Mol Sci. 2022 May; 23(9): 5151. Published online 2022 May 5. doi: 10.3390/ijms23095151

PMCID:: PMC9105235

Abstract Article PDF–5.8M

Select item 90649417.

The disturbed expression of vitamin D and retinoic acid-related orphan receptors α and γ and of megalin in inflammatory skin diseases

Anna A Brozyna, Michał A Żmijewski, Kinga Linowiecka, Tae-Kang Kim, Radomir M Slominski, Andrzej T Slominski

Exp Dermatol. Author manuscript; available in PMC 2023 May 1.

Published in final edited form as: Exp Dermatol. 2022 May; 31(5): 781–788. Published online 2022 Jan 13. doi: 10.1111/exd.14521

PMCID:: PMC9064941

Abstract Article PDF–931K

Select item 90375548.

C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy

Bing-Ru Yan, Taoyingnan Li, Etienne Coyaud, Estelle M. N. Laurent, Jonathan St-Germain, Yuhuan Zhou, Peter K. Kim, Brian Raught, John H. Brumell

Autophagy. 2022; 18(4): 829–840. Published online 2021 Aug 25. doi: 10.1080/15548627.2021.1960116

PMCID:: PMC9037554

Abstract Article PDF–4.1M

Select item 89566049.

CRISPR activation screen identifies BCL-2 proteins and B3GNT2 as drivers of cancer resistance to T cell-mediated cytotoxicity

Julia Joung, Paul C. Kirchgatterer, Ankita Singh, Jang H. Cho, Suchita P. Nety, Rebecca C. Larson, Rhiannon K. Macrae, Rebecca Deasy, Yuen-Yi Tseng, Marcela V. Maus, Feng Zhang

Nat Commun. 2022; 13: 1606. Published online 2022 Mar 25. doi: 10.1038/s41467-022-29205-8

PMCID:: PMC8956604

Abstract Article PDF–3.9M

Select item 882889510.

Human transcription factor protein interaction networks

Helka Göös, Matias Kinnunen, Kari Salokas, Zenglai Tan, Xiaonan Liu, Leena Yadav, Qin Zhang, Gong-Hong Wei, Markku Varjosalo

Nat Commun. 2022; 13: 766. Published online 2022 Feb 9. doi: 10.1038/s41467-022-28341-5

PMCID:: PMC8828895

Abstract Article PDF–1.7M

Select item 864741411.

Expanding the phenotypic spectrum of mutations in LRP2: a novel candidate gene of non-syndromic familial comitant strabismus

Yue Wang, Xuejuan Chen, Tao Jiang, Yayun Gu, Xiaohan Zhang, Wenwen Yuan, Andi Zhao, Rui Li, Zijin Wang, Zhibin Hu, Hu Liu

J Transl Med. 2021; 19: 495. Published online 2021 Dec 6. doi: 10.1186/s12967-021-03155-z

PMCID:: PMC8647414

Abstract Article PDF–5.3M

Select item 855290712.

SARS‐CoV‐2–host proteome interactions for antiviral drug discovery

Xiaonan Liu, Sini Huuskonen, Tuomo Laitinen, Taras Redchuk, Mariia Bogacheva, Kari Salokas, Ina Pöhner, Tiina Öhman, Arun Kumar Tonduru, Antti Hassinen, Lisa Gawriyski, Salla Keskitalo, Maria K Vartiainen, Vilja Pietiäinen, Antti Poso, Markku Varjosalo

Mol Syst Biol. 2021 Nov; 17(11): e10396. Published online 2021 Oct 28. doi: 10.15252/msb.202110396

PMCID:: PMC8552907

Abstract Article PDF–3.9M

Select item 816503013.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 799085114.

Expression profiles of metallothionein-I/II and megalin/LRP-2 in uterine cervical squamous lesions

Hrvoje Jakovac, Nikola Stašić, Maja Krašević, Nives Jonjić, Biserka Radošević-Stašić

Virchows Arch. 2021; 478(4): 735–746. Published online 2020 Oct 21. doi: 10.1007/s00428-020-02947-w

PMCID:: PMC7990851

Abstract Article PDF–15M

Select item 786343015.

Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation

Xiaoqing Fan, Haoran Yang, Chenggang Zhao, Lizhu Hu, Delong Wang, Ruiting Wang, Zhiyou Fang, Xueran Chen

Stem Cell Res Ther. 2021; 12: 107. Published online 2021 Feb 4. doi: 10.1186/s13287-021-02175-2

PMCID:: PMC7863430

Abstract Article PDF–6.5M

Select item 779268916.

Beyond the tubule: pathological variants of LRP2, encoding the megalin receptor, result in glomerular loss and early progressive chronic kidney disease

Jennifer R. Charlton, Weizhen Tan, Ghaleb Daouk, Lisa Teot, Seymour Rosen, Kevin M. Bennett, Aleksandra Cwiek, Sejin Nam, Francesco Emma, François Jouret, João Paulo Oliveira, Lisbeth Tranebjærg, Carina Frykholm, Shrikant Mane, Friedhelm Hildebrandt, Tarak Srivastava, Tina Storm, Erik Ilsø Christensen, Rikke Nielsen

Am J Physiol Renal Physiol. 2020 Dec 1; 319(6): F988–F999. Published online 2020 Oct 26. doi: 10.1152/ajprenal.00295.2020

PMCID:: PMC7792689

Abstract Article

Select item 758142917.

Patient-specific genomics and cross-species functional analysis implicate LRP2 in hypoplastic left heart syndrome

Jeanne L Theis, Georg Vogler, Maria A Missinato, Xing Li, Tanja Nielsen, Xin-Xin I Zeng, Almudena Martinez-Fernandez, Stanley M Walls, Anaïs Kervadec, James N Kezos, Katja Birker, Jared M Evans, Megan M O'Byrne, Zachary C Fogarty, André Terzic, Paul Grossfeld, Karen Ocorr, Timothy J Nelson, Timothy M Olson, Alexandre R Colas, Rolf Bodmer

eLife. 2020; 9: e59554. Published online 2020 Oct 2. doi: 10.7554/eLife.59554

PMCID:: PMC7581429

Abstract Article PDF–3.4M

Select item 742732718.

Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases

Marija Buljan, Rodolfo Ciuffa, Audrey van Drogen, Anton Vichalkovski, Martin Mehnert, George Rosenberger, Sohyon Lee, Markku Varjosalo, Lucia Espona Pernas, Vincent Spegg, Berend Snijder, Ruedi Aebersold, Matthias Gstaiger

Mol Cell. 2020 Aug 6; 79(3): 504–520.e9. doi: 10.1016/j.molcel.2020.07.001

PMCID:: PMC7427327

Abstract Article

Select item 708067619.

A common variant of LDL receptor related protein 2 (LRP2) gene is associated with gout susceptibility: a meta-analysis in a Japanese population

Airi Akashi, Akiyoshi Nakayama, Yoichiro Kamatani, Toshihide Higashino, Seiko Shimizu, Yusuke Kawamura, Misaki Imoto, Mariko Naito, Asahi Hishida, Makoto Kawaguchi, Mikiya Takao, Michinori Matsuo, Tappei Takada, Kimiyoshi Ichida, Hiroshi Ooyama, Nariyoshi Shinomiya, Hirotaka Matsuo

Hum Cell. 2020; 33(2): 303–307. Published online 2020 Jan 24. doi: 10.1007/s13577-019-00318-5

PMCID:: PMC7080676

Abstract Article PDF–533K

Select item 698073320.

Megalin: A Bridge Connecting Kidney, the Renin-angiotensin System, and Atherosclerosis

Masayoshi Kukida, Hisashi Sawada, Alan Daugherty, Hong S. Lu

Pharmacol Res. Author manuscript; available in PMC 2021 Jan 1.

Published in final edited form as: Pharmacol Res. 2020 Jan; 151: 104537. Published online 2019 Nov 7. doi: 10.1016/j.phrs.2019.104537

PMCID:: PMC6980733

Abstract Article PDF–573K

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