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Items: 1 to 20 of 91

1.
USP1-dependent nucleolytic expansion of PRIMPOL-generated nascent DNA strand discontinuities during replication stress
Alexandra Nusawardhana, Lindsey M Pale, Claudia M Nicolae, George-Lucian Moldovan
Nucleic Acids Res. 2024 Mar 21; 52(5): 2340–2354. Published online 2024 Jan 5. doi: 10.1093/nar/gkad1237
PMCID:
PMC10954467
AbstractArticlePDF–2.9M
2.
The P53–P21–RB1 pathway promotes BRD4 degradation in liver cancer through USP1
Neng Li, Erlei Zhang, Zhenyong Li, Suli Lv, Xuefeng Zhao, Qian Ke, Qingli Zou, Wensheng Li, Yifei Wang, Haocheng Guo, Tanjing Song, Lidong Sun
J Biol Chem. 2024 Mar; 300(3): 105707. Published online 2024 Feb 1. doi: 10.1016/j.jbc.2024.105707
PMCID:
PMC10907170
AbstractArticlePDF–2.0M
3.
USP1 promotes cholangiocarcinoma progression by deubiquitinating PARP1 to prevent its proteasomal degradation
Deng Yong Zhang, Yan Zhu, Qiong Wu, Shuoshuo Ma, Yang Ma, Zheng chao Shen, Zhonglin Wang, Wanliang Sun, Yong Chun Zhou, Dongdong Wang, Shuo Zhou, Zhong Liu, Lawrence N. Kwong, Zheng Lu
Cell Death Dis. 2023 Oct; 14(10): 669. Published online 2023 Oct 11. doi: 10.1038/s41419-023-06172-6
PMCID:
PMC10567853
AbstractArticlePDF–14M
4.
USP1 promotes the aerobic glycolysis and progression of T-cell acute lymphoblastic leukemia via PLK1/LDHA axis
Shuguang Liu, Yuening Xiang, Boshi Wang, Chao Gao, Zhenping Chen, Shao Xie, Jing Wu, Yi Liu, Xiaoxi Zhao, Chao Yang, Zhixia Yue, Linya Wang, Xiaojia Wen, Ruidong Zhang, Feng Zhang, Heng Xu, Xiaowen Zhai, Huyong Zheng, Hui Zhang, Maoxiang Qian
Blood Adv. 2023 Jul 11; 7(13): 3099–3112. Published online 2023 Mar 15. doi: 10.1182/bloodadvances.2022008284
PMCID:
PMC10362547
AbstractArticlePDF–2.8M
5.
Human cytomegalovirus UL138 interaction with USP1 activates STAT1 in infection
Kristen Zarrella, Pierce Longmire, Sebastian Zeltzer, Donna Collins-McMillen, Meaghan Hancock, Jason Buehler, Justin M. Reitsma, Scott S. Terhune, Jay A. Nelson, Felicia Goodrum
PLoS Pathog. 2023 Jun; 19(6): e1011185. Published online 2023 Jun 8. doi: 10.1371/journal.ppat.1011185
PMCID:
PMC10284425
AbstractArticlePDF–3.3M
6.
Interaction of TAGLN and USP1 promotes ZEB1 ubiquitination degradation in UV-induced skin photoaging
Yinan Li, Xiu Huang, Jing Jin, Haohao Zhang, Kai Yang, Jingxia Han, Ying Lv, Yu Sun, Cheng Yao, Tingting Lin, Caibin Zhu, Huijuan Liu
Cell Biosci. 2023; 13: 80. Published online 2023 May 6. doi: 10.1186/s13578-023-01029-z
PMCID:
PMC10163745
AbstractArticlePDF–11M
7.
USP1 modulates hepatocellular carcinoma progression via the Hippo/TAZ axis
Dongyi Liu, Quanhui Li, Yifeng Zang, Xin Li, Zhongbo Li, Peng Zhang, Chang Feng, Penghe Yang, Jiayao Cui, Yanan Sun, Tian Wei, Peng Su, Xin Zhao, Huijie Yang, Yinlu Ding
Cell Death Dis. 2023 Apr; 14(4): 264. Published online 2023 Apr 12. doi: 10.1038/s41419-023-05777-1
PMCID:
PMC10090121
AbstractArticlePDF–13M
8.
E3 ligase autoinhibition by C-degron mimicry maintains C-degron substrate fidelity
Daniel C. Scott, Moeko T. King, Kheewoong Baek, Clifford T. Gee, Ravi Kalathur, Jerry Li, Nicholas Purser, Amanda Nourse, Sergio C. Chai, Sivaraja Vaithiyalingam, Taosheng Chen, Richard E. Lee, Stephen J. Elledge, Gary Kleiger, Brenda A. Schulman
Mol Cell. Author manuscript; available in PMC 2024 Mar 2.
Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 770–786.e9. Published online 2023 Feb 16. doi: 10.1016/j.molcel.2023.01.019
PMCID:
PMC10080726
AbstractArticlePDF–3.0M
9.
USP1-regulated reciprocal differentiation of Th17 cells and Treg cells by deubiquitinating and stabilizing TAZ
Xiaotong Zhu, Peng Wang, Xiaoxia Zhan, Yuping Zhang, Junli Sheng, Shitong He, Yitian Chen, Dingnai Nie, Xiaolong You, Haiyan Mai, Qinghong Yu, Laisheng Li, Ligang Jie, Shengfeng Hu
Cell Mol Immunol. 2023 Mar; 20(3): 252–263. Published online 2023 Jan 5. doi: 10.1038/s41423-022-00969-9
PMCID:
PMC9970968
AbstractArticlePDF–4.0M
10.
Ubiquitinated PCNA Drives USP1 Synthetic Lethality in Cancer
Antoine Simoneau, Justin L. Engel, Madhavi Bandi, Katherine Lazarides, Shangtao Liu, Samuel R. Meier, Ashley H. Choi, Hongxiang Zhang, Binzhang Shen, Lauren Martires, Deepali Gotur, Truc V. Pham, Fang Li, Lina Gu, Shanzhong Gong, Minjie Zhang, Erik Wilker, Xuewen Pan, Douglas A. Whittington, Scott Throner, John P. Maxwell, Yingnan Chen, Yi Yu, Alan Huang, Jannik N. Andersen, Tianshu Feng
Mol Cancer Ther. 2023 Feb 1; 22(2): 215–226. Published online 2022 Oct 12. doi: 10.1158/1535-7163.MCT-22-0409
PMCID:
PMC9891357
AbstractArticlePDF–5.9M
11.
Structural and biochemical basis of interdependent FANCI‐FANCD2 ubiquitination
Kimon Lemonidis, Martin L Rennie, Connor Arkinson, Viduth K Chaugule, Mairi Clarke, James Streetley, Helen Walden
EMBO J. 2023 Feb; 42(3): e111898. Published online 2022 Nov 17. doi: 10.15252/embj.2022111898
PMCID:
PMC9890228
AbstractArticlePDF–6.8M
12.
Inhibition of USP1 reverses the chemotherapy resistance through destabilization of MAX in the relapsed/refractory B-cell lymphoma
Xi-Ya Li, Ji-Chuan Wu, Ping Liu, Zi-Juan Li, Yong Wang, Bing-Yi Chen, Cheng-Long Hu, Ming-Yue Fei, Peng-Cheng Yu, Yi-Lun Jiang, Chun-Hui Xu, Bin-He Chang, Xin-Chi Chen, Li-Juan Zong, Jia-Ying Zhang, Ying Fang, Xiao-Jian Sun, Kai Xue, Li Wang, Shu-Bei Chen, Shi-Yu Jiang, Ai-ling Gui, Ling Yang, Juan J. Gu, Bao-Hua Yu, Qun-ling Zhang, Lan Wang
Leukemia. 2023; 37(1): 164–177. Published online 2022 Nov 9. doi: 10.1038/s41375-022-01747-2
PMCID:
PMC9883169
AbstractArticlePDF–6.6M
13.
Aberrant activation of β-catenin signaling drives glioma tumorigenesis via USP1-mediated stabilization of EZH2
Li Ma, Kangyu Lin, Guoqiang Chang, Yiwen Chen, Chen Yue, Qing Guo, Sicong Zhang, Zhiliang Jia, Tony T. Huang, Aidong Zhou, Suyun Huang
Cancer Res. Author manuscript; available in PMC 2022 Nov 9.
Published in final edited form as: Cancer Res. 2019 Jan 1; 79(1): 72–85. Published online 2018 Nov 13. doi: 10.1158/0008-5472.CAN-18-1304
PMCID:
PMC9646285
AbstractArticlePDF–3.2M
14.
Cryo-EM reveals a mechanism of USP1 inhibition through a cryptic binding site
Martin L. Rennie, Connor Arkinson, Viduth K. Chaugule, Helen Walden
Sci Adv. 2022 Sep; 8(39): eabq6353. Published online 2022 Sep 28. doi: 10.1126/sciadv.abq6353
PMCID:
PMC9519042
AbstractArticlePDF–1.0M
15.
Inhibition of USP1 enhances anticancer drugs-induced cancer cell death through downregulation of survivin and miR-216a-5p-mediated upregulation of DR5
Seon Min Woo, Seok Kim, Seung Un Seo, Shin Kim, Jong-Wook Park, Gyeonghwa Kim, Yu-Ra Choi, Keun Hur, Taeg Kyu Kwon
Cell Death Dis. 2022 Sep; 13(9): 821. Published online 2022 Sep 24. doi: 10.1038/s41419-022-05271-0
PMCID:
PMC9509337
AbstractArticlePDF–4.2M
16.
CAF-derived exosomal WEE2-AS1 facilitates colorectal cancer progression via promoting degradation of MOB1A to inhibit the Hippo pathway
Peng Yang, Dongsheng Zhang, Tuo Wang, Jiangzhou Ji, Chi Jin, Chaofan Peng, Yuqian Tan, Jiahui Zhou, Lu Wang, Yifei Feng, Yueming Sun
Cell Death Dis. 2022 Sep; 13(9): 796. Published online 2022 Sep 19. doi: 10.1038/s41419-022-05240-7
PMCID:
PMC9485119
AbstractArticlePDF–8.2M
17.
Diet high in branched-chain amino acid promotes PDAC development by USP1-mediated BCAT2 stabilization
Jin-Tao Li, Kai-Yue Li, Ying Su, Yuan Shen, Ming-Zhu Lei, Fan Zhang, Miao Yin, Zheng-Jun Chen, Wen-Yu Wen, Wei-Guo Hu, Dan Su, Jia Qu, Qun-Ying Lei
Natl Sci Rev. 2022 May; 9(5): nwab212. Published online 2021 Nov 26. doi: 10.1093/nsr/nwab212
PMCID:
PMC9154341
AbstractArticlePDF–1.5M
18.
USP1 inhibition suppresses the progression of osteosarcoma via destabilizing TAZ
Putao Yuan, Zhenhua Feng, Hai Huang, Gangliang Wang, Zhijun Chen, Guang Xu, Ziang Xie, Zhiwei Jie, Xiangde Zhao, Qingliang Ma, Shiyu Wang, Yang Shen, Yizhen Huang, Ying Han, Huali Ye, Jiying Wang, Peihua Shi, Xuewu Sun
Int J Biol Sci. 2022; 18(8): 3122–3136. Published online 2022 May 1. doi: 10.7150/ijbs.65428
PMCID:
PMC9134912
AbstractArticlePDF–3.0M
19.
OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization
Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti
Science. Author manuscript; available in PMC 2022 Sep 11.
Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983
PMCID:
PMC9119736
AbstractArticlePDF–3.3M
20.
Genome-wide CRISPR screens using isogenic cells reveal vulnerabilities conferred by loss of tumor suppressors
Xu Feng, Mengfan Tang, Merve Dede, Dan Su, Guangsheng Pei, Dadi Jiang, Chao Wang, Zhen Chen, Mi Li, Litong Nie, Yun Xiong, Siting Li, Jeong-Min Park, Huimin Zhang, Min Huang, Klaudia Szymonowicz, Zhongming Zhao, Traver Hart, Junjie Chen
Sci Adv. 2022 May; 8(19): eabm6638. Published online 2022 May 13. doi: 10.1126/sciadv.abm6638
PMCID:
PMC9106303
AbstractArticlePDF–918K

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