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Select item 111510501.

Thrombospondin‐1 Regulates Trophoblast Necroptosis via NEDD4‐Mediated Ubiquitination of TAK1 in Preeclampsia

Haoyue Hu, Jing Ma, You Peng, Rixuan Feng, Chenling Luo, Minyi Zhang, Zixin Tao, Lu Chen, Tao Zhang, Wenqian Chen, Qian Yin, Jinguo Zhai, Jun Chen, Ailan Yin, Chi Chiu Wang, Mei Zhong

Adv Sci (Weinh) 2024 Jun; 11(21): 2309002. Published online 2024 Apr 3. doi: 10.1002/advs.202309002

PMCID:: PMC11151050

Abstract Article PDF–15M

Select item 111147092.

PINK1 stimulates interleukin-1β-mediated inflammatory signaling via the positive regulation of TRAF6 and TAK1

Hyun Jung Lee, Sung Hee Jang, Hyeyoung Kim, Joo Heon Yoon, Kwang Chul Chung

Cell Mol Life Sci. 2012 Oct; 69(19): 3301–3315. Published online 2012 May 29. doi: 10.1007/s00018-012-1004-7

PMCID:: PMC11114709

Abstract Article PDF–896K

Select item 109332673.

Interaction network of human early embryonic transcription factors

Lisa Gawriyski, Zenglai Tan, Xiaonan Liu, Iftekhar Chowdhury, Dicle Malaymar Pinar, Qin Zhang, Jere Weltner, Eeva-Mari Jouhilahti, Gong-Hong Wei, Juha Kere, Markku Varjosalo

EMBO Rep. 2024 Mar; 25(3): 1589–1622. Published online 2024 Jan 31. doi: 10.1038/s44319-024-00074-0

PMCID:: PMC10933267

Abstract Article PDF–2.9M

Select item 109080154.

TR4 worsen urosepsis by regulating GSDMD

Huan Wang, Shibin Zhu, Zhenwei Zhou, Zhenghui Wang, Wei Zhuang, Dingwei Xue, Zeyi Lu, Qiming Zheng, Lifeng Ding, Liangliang Ren, Wenqing Luo, Ruyue Wang, Guangju Ge, Liqun Xia, Gonghui Li, Haiyang Wu

Eur J Med Res. 2024; 29: 151. Published online 2024 Mar 1. doi: 10.1186/s40001-024-01742-6

PMCID:: PMC10908015

Abstract Article PDF–6.5M

Select item 105658765.

Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates

Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert

Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644

PMCID:: PMC10565876

Abstract Article PDF–3.7M

Select item 99436806.

Structures of human TR4_LBD–JAZF1 and TR4_DBD–DNA complexes reveal the molecular basis of transcriptional regulation

Yunlong Liu, Lulu Ma, Min Li, Zizi Tian, Meiting Yang, Xi Wu, Xue Wang, Guohui Shang, Mengjia Xie, Yiyun Chen, Xin Liu, Lun Jiang, Wei Wu, Chaoqun Xu, Liqun Xia, Gonghui Li, Shaodong Dai, Zhongzhou Chen

Nucleic Acids Res. 2023 Feb 22; 51(3): 1443–1457. Published online 2023 Jan 18. doi: 10.1093/nar/gkac1259

PMCID:: PMC9943680

Abstract Article PDF–8.8M

Select item 97080867.

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers

Martina Oravcová, Minghua Nie, Nicola Zilio, Shintaro Maeda, Yasaman Jami-Alahmadi, Eros Lazzerini-Denchi, James A Wohlschlegel, Helle D Ulrich, Takanori Otomo, Michael N Boddy

eLife. 2022; 11: e79676. Published online 2022 Nov 14. doi: 10.7554/eLife.79676

PMCID:: PMC9708086

Abstract Article PDF–8.5M

Select item 95872868.

HDAC6-dependent deacetylation of TAK1 enhances sIL-6R release to promote macrophage M2 polarization in colon cancer

Guangying Xu, Liling Niu, Youhui Wang, Guang Yang, Xingwu Zhu, Yuan Yao, Gang Zhao, Shaowei Wang, Hui Li

Cell Death Dis. 2022 Oct; 13(10): 888. Published online 2022 Oct 21. doi: 10.1038/s41419-022-05335-1

PMCID:: PMC9587286

Abstract Article PDF–6.5M

Select item 95403459.

The in vivo Interaction Landscape of Histones H3.1 and H3.3

Robert Siddaway, Scott Milos, Étienne Coyaud, Hwa Young Yun, Shahir M. Morcos, Sanja Pajovic, Eric I. Campos, Brian Raught, Cynthia Hawkins

Mol Cell Proteomics. 2022 Oct; 21(10): 100411. Published online 2022 Sep 9. doi: 10.1016/j.mcpro.2022.100411

PMCID:: PMC9540345

Abstract Article PDF–3.9M

Select item 929024110.

Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer

Annamaria Salvati, Viola Melone, Assunta Sellitto, Francesca Rizzo, Roberta Tarallo, Tuula A. Nyman, Giorgio Giurato, Giovanni Nassa, Alessandro Weisz

Breast Cancer Res. 2022; 24: 52. Published online 2022 Jul 18. doi: 10.1186/s13058-022-01547-7

PMCID:: PMC9290241

Abstract Article PDF–8.2M

Select item 923162311.

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1

Boris Simonetti, James L. Daly, Lorena Simón-Gracia, Katja Klein, Saroja Weeratunga, Carlos Antón-Plágaro, Allan Tobi, Lorna Hodgson, Philip A. Lewis, Kate J. Heesom, Deborah K. Shoemark, Andrew D. Davidson, Brett M. Collins, Tambet Teesalu, Yohei Yamauchi, Peter J. Cullen

Proc Natl Acad Sci U S A. 2022 Jun 21; 119(25): e2201980119. Published online 2022 Jun 13. doi: 10.1073/pnas.2201980119

PMCID:: PMC9231623

Abstract Article PDF–6.0M

Select item 907235212.

Small extracellular vesicle-mediated miR-320e transmission promotes osteogenesis in OPLL by targeting TAK1

Chen Xu, Zicheng Zhang, Ning Liu, Li Li, Huajian Zhong, Ruizhe Wang, Qianghui Shi, Zifan Zhang, Leixin Wei, Bo Hu, Hao Zhang, Xiaolong Shen, Yue Wang, Yang Liu, Wen Yuan

Nat Commun. 2022; 13: 2467. Published online 2022 May 5. doi: 10.1038/s41467-022-29029-6

PMCID:: PMC9072352

Abstract Article PDF–12M

Select item 897366713.

Effects of transforming growth factor beta-activated kinase 1 (TAK1) on apoptosis of HK-2 cells in the high glucose environment

Yuhan Wang, Li Zhao, DuoJun Qiu, Yonghong Shi, Huijun Duan

Bioengineered. 2022; 13(3): 5880–5891. Published online 2022 Feb 21. doi: 10.1080/21655979.2022.2040875

PMCID:: PMC8973667

Abstract Article PDF–2.9M

Select item 882889514.

Human transcription factor protein interaction networks

Helka Göös, Matias Kinnunen, Kari Salokas, Zenglai Tan, Xiaonan Liu, Leena Yadav, Qin Zhang, Gong-Hong Wei, Markku Varjosalo

Nat Commun. 2022; 13: 766. Published online 2022 Feb 9. doi: 10.1038/s41467-022-28341-5

PMCID:: PMC8828895

Abstract Article PDF–1.7M

Select item 862133515.

Takinib Inhibits Inflammation in Human Rheumatoid Arthritis Synovial Fibroblasts by Targeting the Janus Kinase-Signal Transducer and Activator of Transcription 3 (JAK/STAT3) Pathway

Paul M. Panipinto, Anil K. Singh, Farheen S. Shaikh, Ruby J. Siegel, Mukesh Chourasia, Salahuddin Ahmed

Int J Mol Sci. 2021 Nov; 22(22): 12580. Published online 2021 Nov 22. doi: 10.3390/ijms222212580

PMCID:: PMC8621335

Abstract Article PDF–3.2M

Select item 860245116.

Identification of proximal SUMO-dependent interactors using SUMO-ID

Orhi Barroso-Gomila, Fredrik Trulsson, Veronica Muratore, Iñigo Canosa, Laura Merino-Cacho, Ana Rosa Cortazar, Coralia Pérez, Mikel Azkargorta, Ibon Iloro, Arkaitz Carracedo, Ana M. Aransay, Felix Elortza, Ugo Mayor, Alfred C. O. Vertegaal, Rosa Barrio, James D. Sutherland

Nat Commun. 2021; 12: 6671. Published online 2021 Nov 18. doi: 10.1038/s41467-021-26807-6

PMCID:: PMC8602451

Abstract Article PDF–11M

Select item 827807417.

The stabilization of yes‐associated protein by TGFβ‐activated kinase 1 regulates the self‐renewal and oncogenesis of gastric cancer stem cells

Gang Wang, Qikai Sun, Hai Zhu, Yihui Bi, Haixing Zhu, Aman Xu

J Cell Mol Med. 2021 Jul; 25(14): 6584–6601. Published online 2021 Jun 1. doi: 10.1111/jcmm.16660

PMCID:: PMC8278074

Abstract Article PDF–3.1M

Select item 822039118.

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα

Evelyn Ramberger, Valeria Sapozhnikova, Elisabeth Kowenz-Leutz, Karin Zimmermann, Nathalie Nicot, Petr V. Nazarov, Daniel Perez-Hernandez, Ulf Reimer, Philipp Mertins, Gunnar Dittmar, Achim Leutz

iScience. 2021 Jun 25; 24(6): 102686. Published online 2021 Jun 4. doi: 10.1016/j.isci.2021.102686

PMCID:: PMC8220391

Abstract Article PDF–4.4M

Select item 816503019.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 810809320.

DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity

Rajat Gupta, Kumar Somyajit, Takeo Narita, Elina Maskey, Andre Stanlie, Magdalena Kremer, Dimitris Typas, Michael Lammers, Niels Mailand, Andre Nussenzweig, Jiri Lukas, Chunaram Choudhary

Cell. Author manuscript; available in PMC 2021 May 10.

Published in final edited form as: Cell. 2018 May 3; 173(4): 972–988.e23. Published online 2018 Apr 12. doi: 10.1016/j.cell.2018.03.050

PMCID:: PMC8108093

Abstract Article PDF–3.5M

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