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Select item 103650131.

Structure of the SHOC2–MRAS–PP1C complex provides insights into RAF activation and Noonan syndrome

Daniel A. Bonsor, Patrick Alexander, Kelly Snead, Nicole Hartig, Matthew Drew, Simon Messing, Lorenzo I. Finci, Dwight V. Nissley, Frank McCormick, Dominic Esposito, Pablo Rodriguez-Viciana, Andrew G. Stephen, Dhirendra K. Simanshu

Nat Struct Mol Biol. Author manuscript; available in PMC 2023 Oct 1.

Published in final edited form as: Nat Struct Mol Biol. 2022 Oct; 29(10): 966–977. Published online 2022 Sep 29. doi: 10.1038/s41594-022-00841-4

PMCID:: PMC10365013

Abstract Article PDF–6.2M

Select item 96943382.

Structure-function analysis of the SHOC2-MRAS-PP1C holophosphatase complex

Jason J. Kwon, Behnoush Hajian, Yuemin Bian, Lucy C. Young, Alvaro J. Amor, James R. Fuller, Cara V. Fraley, Abbey M. Sykes, Jonathan So, Joshua Pan, Laura Baker, Sun Joo Lee, Douglas B. Wheeler, David L. Mayhew, Nicole S. Persky, Xiaoping Yang, David E. Root, Anthony M. Barsotti, Andrew W. Stamford, Charles K. Perry, Alex Burgin, Frank McCormick, Christopher T. Lemke, William C. Hahn, Andrew J. Aguirre

Nature. Author manuscript; available in PMC 2022 Nov 25.

Published in final edited form as: Nature. 2022 Sep; 609(7926): 408–415. Published online 2022 Jul 13. doi: 10.1038/s41586-022-04928-2

PMCID:: PMC9694338

Abstract Article PDF–5.8M

Select item 94523013.

Structural basis for SHOC2 modulation of RAS signalling

Nicholas P. D. Liau, Matthew C. Johnson, Saeed Izadi, Luca Gerosa, Michal Hammel, John M. Bruning, Timothy J. Wendorff, Wilson Phung, Sarah G. Hymowitz, Jawahar Sudhamsu

Nature. 2022; 609(7926): 400–407. Published online 2022 Jun 29. doi: 10.1038/s41586-022-04838-3

PMCID:: PMC9452301

Abstract Article PDF–21M

Select item 94522954.

Structure of the MRAS–SHOC2–PP1C phosphatase complex

Zachary J. Hauseman, Michelle Fodor, Anxhela Dhembi, Jessica Viscomi, David Egli, Melusine Bleu, Stephanie Katz, Eunyoung Park, Dong Man Jang, Kathryn A. Porter, Fabian Meili, Hongqiu Guo, Grainne Kerr, Sandra Mollé, Camilo Velez-Vega, Kim S. Beyer, Giorgio G. Galli, Saveur-Michel Maira, Travis Stams, Kirk Clark, Michael J. Eck, Luca Tordella, Claudio R. Thoma, Daniel A. King

Nature. 2022; 609(7926): 416–423. Published online 2022 Jul 13. doi: 10.1038/s41586-022-05086-1

PMCID:: PMC9452295

Abstract Article PDF–21M

Select item 72060115.

LZTR1 facilitates polyubiquitination and degradation of RAS-GTPases

Taiki Abe, Ikumi Umeki, Shin-ichiro Kanno, Shin-ichi Inoue, Tetsuya Niihori, Yoko Aoki

Cell Death Differ. 2020 Mar; 27(3): 1023–1035. Published online 2019 Jul 23. doi: 10.1038/s41418-019-0395-5

PMCID:: PMC7206011

Abstract Article PDF–3.4M

Select item 69866826.

RIT1 oncoproteins escape LZTR1-mediated proteolysis

Pau Castel, Alice Cheng, Antonio Cuevas-Navarro, David B. Everman, Alex G. Papageorge, Dhirendra K. Simanshu, Alexandra Tankka, Jacqueline Galeas, Anatoly Urisman, Frank McCormick

Science. Author manuscript; available in PMC 2020 Jan 28.

Published in final edited form as: Science. 2019 Mar 15; 363(6432): 1226–1230. doi: 10.1126/science.aav1444

PMCID:: PMC6986682

Abstract Article PDF–1.1M

Select item 68903627.

The influence of MRAS gene variants on ischemic stroke and serum lipid levels in Chinese Han population

Yan Song, Rui Ma, Hongjuan Zhang

Medicine (Baltimore) 2019 Nov; 98(48): e18065. Published online 2019 Nov 27. doi: 10.1097/MD.0000000000018065

PMCID:: PMC6890362

Abstract Article PDF–277K

Select item 63773388.

Genome-wide association reveals contribution of MRAS to painful temporomandibular disorder in males

Shad B. Smith, Marc Parisien, Eric Bair, Inna Belfer, Anne-Julie Chabot-Doré, Pavel Gris, Samar Khoury, Shannon Tansley, Yelizaveta Torosyan, Dmitri V. Zaykin, Olaf Bernhardt, Priscila de Oliveira Serrano, Richard H. Gracely, Deepti Jain, Marjo-Riitta Järvelin, Linda M. Kaste, Kathleen F. Kerr, Thomas Kocher, Raija Lähdesmäki, Nadia Laniado, Cathy C. Laurie, Cecelia A. Laurie, Minna Männikkö, Carolina B. Meloto, Andrea G. Nackley, Sarah C. Nelson, Paula Pesonen, Margarete C. Ribeiro-Dasilva, Celia M. Rizzatti-Barbosa, Anne E. Sanders, Christian Schwahn, Kirsi Sipilä, Tamar Sofer, Alexander Teumer, Jeffrey S. Mogil, Roger B. Fillingim, Joel D. Greenspan, Richard Ohrbach, Gary D. Slade, William Maixner, Luda Diatchenko

Pain. 2019 Mar; 160(3): 579–591. Published online 2018 Nov 13. doi: 10.1097/j.pain.0000000000001438

PMCID:: PMC6377338

Abstract Article PDF–1013K

Select item 55316119.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 533396210.

Elucidation of MRAS-mediated Noonan syndrome with cardiac hypertrophy

Erin M. Higgins, J. Martijn Bos, Heather Mason-Suares, David J. Tester, Jaeger P. Ackerman, Calum A. MacRae, Katia Sol-Church, Karen W. Gripp, Raul Urrutia, Michael J. Ackerman

JCI Insight. 2017 Mar 9; 2(5): e91225. Published online 2017 Mar 9. doi: 10.1172/jci.insight.91225

PMCID:: PMC5333962

Abstract Article PDF–1.6M

Select item 526969211.

Muscle RAS oncogene homolog (MRAS) recurrent mutation in Borrmann type IV gastric cancer

Makiko Yasumoto, Etsuko Sakamoto, Sachiko Ogasawara, Taro Isobe, Junya Kizaki, Akiko Sumi, Hironori Kusano, Jun Akiba, Takuji Torimura, Yoshito Akagi, Hiraku Itadani, Tsutomu Kobayashi, Shinichi Hasako, Masafumi Kumazaki, Shinji Mizuarai, Shinji Oie, Hirohisa Yano

Cancer Med. 2017 Jan; 6(1): 235–244. Published online 2016 Nov 28. doi: 10.1002/cam4.959

PMCID:: PMC5269692

Abstract Article PDF–391K

Select item 471281912.

Spatial control of Shoc2-scaffold-mediated ERK1/2 signaling requires remodeling activity of the ATPase PSMC5

Eun Ryoung Jang, HyeIn Jang, Ping Shi, Gabriel Popa, Myoungkun Jeoung, Emilia Galperin

J Cell Sci. 2015 Dec 1; 128(23): 4428–4441. doi: 10.1242/jcs.177543

PMCID:: PMC4712819

Abstract Article

Select item 465716113.

PAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesion

Anna E. Dart, Gary M. Box, William Court, Madeline E. Gale, John P. Brown, Sarah E. Pinder, Suzanne A. Eccles, Claire M. Wells

J Cell Biol. 2015 Nov 23; 211(4): 863–879. doi: 10.1083/jcb.201501072

PMCID:: PMC4657161

Abstract Article PDF–8.1M

Select item 439626914.

Association between the MARS rs6782181 polymorphism and serum lipid levels

Jian Wu, Rui-Xing Yin, Tao Guo, Quan-Zhen Lin, Guang-Yuan Shi, Jia-Qi Sun, Shao-Wen Shen, Yi-Ming Wang, Hui Li, Jin-Zhen Wu

Int J Clin Exp Pathol. 2015; 8(2): 1855–1866. Published online 2015 Feb 1.

PMCID:: PMC4396269

Abstract Article PDF–501K

Select item 421326515.

A novel SHOC2 variant in Rasopathy

Vickie Hannig, Myoungkun Jeoung, Eun Ryoung Jang, John A. Phillips, III, Emilia Galperin

Hum Mutat. Author manuscript; available in PMC 2015 Nov 1.

Published in final edited form as: Hum Mutat. 2014 Nov; 35(11): 1290–1294. Published online 2014 Sep 11. doi: 10.1002/humu.22634

PMCID:: PMC4213265

Abstract Article PDF–950K

Select item 418773616.

HUWE1 Is a Molecular Link Controlling RAF-1 Activity Supported by the Shoc2 Scaffold

Eun Ryoung Jang, Ping Shi, Jamal Bryant, Jing Chen, Vikas Dukhande, Matthew S. Gentry, HyeIn Jang, Myoungkun Jeoung, Emilia Galperin

Mol Cell Biol. 2014 Oct; 34(19): 3579–3593. doi: 10.1128/MCB.00811-14

PMCID:: PMC4187736

Abstract Article PDF–3.3M

Select item 411210217.

Shared genetic susceptibility to ischemic stroke and coronary artery disease – a genome-wide analysis of common variants

Martin Dichgans, Rainer Malik, Inke R. König, Jonathan Rosand, Robert Clarke, Solveig Gretarsdottir, Gudmar Thorleifsson, Braxton D. Mitchell, Themistocles L. Assimes, Christopher Levi, Christopher J. O′Donnell, Myriam Fornage, Unnur Thorsteinsdottir, Bruce M. Psaty, Christian Hengstenberg, Sudha Seshadri, Jeanette Erdmann, Joshua C. Bis, Annette Peters, Giorgio B. Boncoraglio, Winfried März, James F. Meschia, Sekar Kathiresan, M. Arfan Ikram, Ruth McPherson, Kari Stefansson, Cathie Sudlow, Muredach P. Reilly, John R. Thompson, Pankaj Sharma, Jemma C. Hopewell, John C. Chambers, Hugh Watkins, Peter M. Rothwell, Robert Roberts, the METASTROKE Consortium, the CARDIoGRAM consortium, the C4D consortium, the International Stroke Genetics Consortium, Hugh S. Markus, Nilesh J. Samani, Martin Farrall, Heribert Schunkert

Stroke. Author manuscript; available in PMC 2015 Jan 1.

Published in final edited form as: Stroke. 2014 Jan; 45(1): 24–36. Published online 2013 Nov 21. doi: 10.1161/STROKEAHA.113.002707

PMCID:: PMC4112102

Abstract Article PDF–979K

Select item 385466918.

Genome Wide Association Study (GWAS) of Chagas Cardiomyopathy in Trypanosoma cruzi Seropositive Subjects

Xutao Deng, Ester C. Sabino, Edecio Cunha-Neto, Antonio L. Ribeiro, Barbara Ianni, Charles Mady, Michael P. Busch, Mark Seielstad, the REDSII Chagas study group from the NHLBI Retrovirus Epidemiology Donor Study-II (REDS-II), International Component

PLoS One. 2013; 8(11): e79629. Published online 2013 Nov 20. doi: 10.1371/journal.pone.0079629

PMCID:: PMC3854669

Abstract Article PDF–408K

Select item 326170819.

Toward an understanding of the protein interaction network of the human liver

Jian Wang, Keke Huo, Lixin Ma, Liujun Tang, Dong Li, Xiaobi Huang, Yanzhi Yuan, Chunhua Li, Wei Wang, Wei Guan, Hui Chen, Chaozhi Jin, Junchen Wei, Wanqiao Zhang, Yongsheng Yang, Qiongming Liu, Ying Zhou, Cuili Zhang, Zhihao Wu, Wangxiang Xu, Ying Zhang, Tao Liu, Donghui Yu, Yaping Zhang, Liang Chen, Dewu Zhu, Xing Zhong, Lixin Kang, Xiang Gan, Xiaolan Yu, Qi Ma, Jing Yan, Li Zhou, Zhongyang Liu, Yunping Zhu, Tao Zhou, Fuchu He, Xiaoming Yang

Mol Syst Biol. 2011; 7: 536. Published online 2011 Oct 11. doi: 10.1038/msb.2011.67

Correction in:: Mol Syst Biol. 2017 Dec; 13(12): 965.

PMCID:: PMC3261708

Abstract Article PDF–2.0M

Select item 317805920.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

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