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Items: 1 to 20 of 287

1.
WDR34 is a novel TAK1-associated suppressor of the IL-1R/TLR3/TLR4-induced NF-κB activation pathway
Dong Gao, Ruipeng Wang, Bingfeng Li, Yongkang Yang, Zhonghe Zhai, Dan-Ying Chen
Cell Mol Life Sci. 2009 Aug; 66(15): 2573–2584. Published online 2009 Jun 12. doi: 10.1007/s00018-009-0059-6
PMCID:
PMC11115612
AbstractArticlePDF–618K
2.
PINK1 stimulates interleukin-1β-mediated inflammatory signaling via the positive regulation of TRAF6 and TAK1
Hyun Jung Lee, Sung Hee Jang, Hyeyoung Kim, Joo Heon Yoon, Kwang Chul Chung
Cell Mol Life Sci. 2012 Oct; 69(19): 3301–3315. Published online 2012 May 29. doi: 10.1007/s00018-012-1004-7
PMCID:
PMC11114709
AbstractArticlePDF–896K
3.
The F-box protein FBXO7 positively regulates bone morphogenetic protein-mediated signaling through Lys-63-specific ubiquitination of neurotrophin receptor-interacting MAGE (NRAGE)
Jengmin Kang, Kwang Chul Chung
Cell Mol Life Sci. 2015 Jan; 72(1): 181–195. Published online 2014 Jun 20. doi: 10.1007/s00018-014-1665-5
PMCID:
PMC11113242
AbstractArticlePDF–1.4M
4.
K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors
Anita Waltho, Oliver Popp, Christopher Lenz, Lukas Pluska, Mahil Lambert, Volker Dötsch, Philipp Mertins, Thomas Sommer
Life Sci Alliance. 2024 Aug; 7(8): e202402740. Published online 2024 May 21. doi: 10.26508/lsa.202402740
PMCID:
PMC11109483
AbstractArticlePDF–2.9M
5.
TAK1 inhibition leads to RIPK1-dependent apoptosis in immune-activated cancers
Helene Damhofer, Tülin Tatar, Benjamin Southgate, Scott Scarneo, Karl Agger, Daria Shlyueva, Lene Uhrbom, Gillian M. Morrison, Philip F. Hughes, Timothy Haystead, Steven M. Pollard, Kristian Helin
Cell Death Dis. 2024 Apr; 15(4): 273. Published online 2024 Apr 17. doi: 10.1038/s41419-024-06654-1
PMCID:
PMC11024179
AbstractArticlePDF–6.6M
6.
Cancer‐associated FBXW7 loss is synthetic lethal with pharmacological targeting of CDC7
Joseph S. Baxter, Rachel Brough, Dragomir B. Krastev, Feifei Song, Sandhya Sridhar, Aditi Gulati, John Alexander, Theodoros I. Roumeliotis, Zuza Kozik, Jyoti S. Choudhary, Syed Haider, Stephen J. Pettitt, Andrew N. J. Tutt, Christopher J. Lord
Mol Oncol. 2024 Feb; 18(2): 369–385. Published online 2023 Oct 22. doi: 10.1002/1878-0261.13537
PMCID:
PMC10850818
AbstractArticlePDF–2.7M
7.
Pacritinib Inhibition of IRAK1 Blocks Aberrant TLR8 Signalling by SARS-CoV-2 and HIV-1-Derived RNA
Grant R. Campbell, Pratima Rawat, Stephen A. Spector
J Innate Immun. 2023 Jan-Dec; 15(1): 96–106. Published online 2022 Jul 4. doi: 10.1159/000525292
PMCID:
PMC10643889
AbstractArticlePDF–1.2M
8.
USP4 promotes the proliferation, migration, and invasion of esophageal squamous cell carcinoma by targeting TAK1
Hongdian Zhang, Youming Han, Wanyi Xiao, Yongyin Gao, Zhilin Sui, Peng Ren, Fanbiao Meng, Peng Tang, Zhentao Yu
Cell Death Dis. 2023 Nov; 14(11): 730. Published online 2023 Nov 10. doi: 10.1038/s41419-023-06259-0
PMCID:
PMC10638297
AbstractArticlePDF–4.8M
9.
Association of XIST/miRNA155/Gab2/TAK1 cascade with the pathogenesis of anti-phospholipid syndrome and its effect on cell adhesion molecules and inflammatory mediators
Mai A. Abd-Elmawla, Yumn A. Elsabagh, Nora M. Aborehab
Sci Rep. 2023; 13: 18790. Published online 2023 Nov 1. doi: 10.1038/s41598-023-45214-z
PMCID:
PMC10620142
AbstractArticlePDF–2.2M
10.
Pharmacological inhibition of TAK1 prevents and induces regression of experimental organ fibrosis
Swarna Bale, Priyanka Verma, Bharath Yalavarthi, Scott Arthur Scarneo, Philip Hughes, M. Asif Amin, Pei-Suen Tsou, Dinesh Khanna, Timothy A.J. Haystead, Swati Bhattacharyya, John Varga
JCI Insight. 2023 Jul 24; 8(14): e165358. Published online 2023 Jul 24. doi: 10.1172/jci.insight.165358
PMCID:
PMC10443806
AbstractArticlePDF–14M
11.
SWAP70 Overexpression Protects Against Pathological Cardiac Hypertrophy in a TAK1‐Dependent Manner
Qiaofeng Qian, Fengjiao Hu, Wenjun Yu, Dewen Leng, Yang Li, Hongjie Shi, Dawei Deng, Kehan Ding, Chuan Liang, Jinping Liu
J Am Heart Assoc. 2023 Apr 4; 12(7): e028628. Published online 2023 Mar 28. doi: 10.1161/JAHA.122.028628
PMCID:
PMC10122912
AbstractArticlePDF–25M
12.
Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity
Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong
Mol Cell. Author manuscript; available in PMC 2023 Apr 4.
Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015
PMCID:
PMC10072906
AbstractArticlePDF–4.2M
13.
E3 ligase RNF99 negatively regulates TLR-mediated inflammatory immune response via K48-linked ubiquitination of TAB2
Jie Zhang, Lei Cao, Amy Gao, Ruiqing Ren, Liwen Yu, Qian Li, Yapeng Liu, Wenqian Qi, Yonghao Hou, Wenhai Sui, Guohai Su, Yun Zhang, Cheng Zhang, Meng Zhang
Cell Death Differ. 2023 Apr; 30(4): 966–978. Published online 2023 Jan 21. doi: 10.1038/s41418-023-01115-2
PMCID:
PMC10070438
AbstractArticlePDF–11M
14.
Emerging role of TAK1 in the regulation of skeletal muscle mass
Anirban Roy, Vihang A. Narkar, Ashok Kumar
Bioessays. Author manuscript; available in PMC 2024 Apr 1.
Published in final edited form as: Bioessays. 2023 Apr; 45(4): e2300003. Published online 2023 Feb 15. doi: 10.1002/bies.202300003
PMCID:
PMC10023406
AbstractArticlePDF–1.4M
15.
Human ZBP1 induces cell death‐independent inflammatory signaling via RIPK3 and RIPK1
Ruoshi Peng, Chris Kedong Wang, Xuan Wang‐Kan, Manja Idorn, Majken Kjær, Felix Y Zhou, Berthe Katrine Fiil, Frederik Timmermann, Susana L Orozco, Julia McCarthy, Carol S Leung, Xin Lu, Katrin Bagola, Jan Rehwinkel, Andrew Oberst, Jonathan Maelfait, Søren R Paludan, Mads Gyrd‐Hansen
EMBO Rep. 2022 Dec; 23(12): e55839. Published online 2022 Oct 21. doi: 10.15252/embr.202255839
PMCID:
PMC9724671
AbstractArticlePDF–1.8M
16.
Co-ordinated control of the ADP-heptose/ALPK1 signalling network by the E3 ligases TRAF6, TRAF2/c-IAP1 and LUBAC
Tom Snelling, Natalia Shpiro, Robert Gourlay, Frederic Lamoliatte, Philip Cohen
Biochem J. 2022 Oct 28; 479(20): 2195–2216. Published online 2022 Oct 21. doi: 10.1042/BCJ20220401
PMCID:
PMC9704527
AbstractArticlePDF–7.7M
17.
MAP3K7 is an innate immune regulatory gene with increased expression in human and murine kidney intercalated cells following uropathogenic Escherichia coli exposure
Vijay Saxena, Samuel Arregui, Malgorzata Maria Kamocka, David S. Hains, Andrew Schwaderer
J Cell Biochem. 2022 Nov; 123(11): 1817–1826. Published online 2022 Aug 12. doi: 10.1002/jcb.30318
PMCID:
PMC9671826
AbstractArticlePDF–1.0M
18.
E3 ubiquitin ligase NEDD4L negatively regulates inflammation by promoting ubiquitination of MEKK2
Hui Li, Ning Wang, Yu Jiang, Haofei Wang, Zengfeng Xin, Huazhang An, Hao Pan, Wangqian Ma, Ting Zhang, Xiaojian Wang, Wenlong Lin
EMBO Rep. 2022 Nov; 23(11): e54603. Published online 2022 Sep 26. doi: 10.15252/embr.202254603
PMCID:
PMC9638856
AbstractArticlePDF–4.2M
19.
HDAC6-dependent deacetylation of TAK1 enhances sIL-6R release to promote macrophage M2 polarization in colon cancer
Guangying Xu, Liling Niu, Youhui Wang, Guang Yang, Xingwu Zhu, Yuan Yao, Gang Zhao, Shaowei Wang, Hui Li
Cell Death Dis. 2022 Oct; 13(10): 888. Published online 2022 Oct 21. doi: 10.1038/s41419-022-05335-1
PMCID:
PMC9587286
AbstractArticlePDF–6.5M
20.
TAK1 protein kinase activity is required for TLR signalling and cytokine production in myeloid cells
Melissa Rodrigues, Tsvetana Petrova, Brendan Tibbs, J. Simon C. Arthur, Philip Cohen
Biochem J. 2022 Sep 16; 479(17): 1891–1907. Prepublished online 2022 Sep 5. Published online 2022 Sep 16. doi: 10.1042/BCJ20220314
PMCID:
PMC9555797
AbstractArticlePDF–6.9M

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