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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 104504482.

Reversal of an existing hearing loss by gene activation in Spns2 mutant mice

Elisa Martelletti, Neil J. Ingham, Karen P. Steel

Proc Natl Acad Sci U S A. 2023 Aug 22; 120(34): e2307355120. Published online 2023 Aug 8. doi: 10.1073/pnas.2307355120

PMCID:: PMC10450448

Abstract Article PDF–11M

Select item 84834583.

Endothelial Spns2 and ApoM Regulation of Vascular Tone and Hypertension Via Sphingosine‐1‐Phosphate

Ilaria Del Gaudio, Luisa Rubinelli, Linda Sasset, Christian Wadsack, Timothy Hla, Annarita Di Lorenzo

J Am Heart Assoc. 2021 Jul 20; 10(14): e021261. Published online 2021 Jul 9. doi: 10.1161/JAHA.121.021261

PMCID:: PMC8483458

Abstract Article PDF–1.4M

Select item 83517974.

SPNS2 enables T cell egress from lymph nodes during an immune response

Martyna Okuniewska, Victoria Fang, Audrey Baeyens, Varsha Raghavan, June-Yong Lee, Dan R. Littman, Susan R. Schwab

Cell Rep. Author manuscript; available in PMC 2021 Aug 9.

Published in final edited form as: Cell Rep. 2021 Jul 13; 36(2): 109368. doi: 10.1016/j.celrep.2021.109368

PMCID:: PMC8351797

Abstract Article PDF–1.2M

Select item 81001705.

Osteocyte transcriptome mapping identifies a molecular landscape controlling skeletal homeostasis and susceptibility to skeletal disease

Scott E. Youlten, John P. Kemp, John G. Logan, Elena J. Ghirardello, Claudio M. Sergio, Michael R. G. Dack, Siobhan E. Guilfoyle, Victoria D. Leitch, Natalie C. Butterfield, Davide Komla-Ebri, Ryan C. Chai, Alexander P. Corr, James T. Smith, Sindhu T. Mohanty, John A. Morris, Michelle M. McDonald, Julian M. W. Quinn, Amelia R. McGlade, Nenad Bartonicek, Matt Jansson, Konstantinos Hatzikotoulas, Melita D. Irving, Ana Beleza-Meireles, Fernando Rivadeneira, Emma Duncan, J. Brent Richards, David J. Adams, Christopher J. Lelliott, Robert Brink, Tri Giang Phan, John A. Eisman, David M. Evans, Eleftheria Zeggini, Paul A. Baldock, J. H. Duncan Bassett, Graham R. Williams, Peter I. Croucher

Nat Commun. 2021; 12: 2444. Published online 2021 May 5. doi: 10.1038/s41467-021-22517-1

PMCID:: PMC8100170

Abstract Article PDF–11M

Select item 80939476.

Direct uptake of sphingosine-1-phosphate independent of phospholipid phosphatases

Hirotaka Goto, Masatoshi Miyamoto, Akio Kihara

J Biol Chem. 2021 Jan-Jun; 296: 100605. Published online 2021 Mar 27. doi: 10.1016/j.jbc.2021.100605

PMCID:: PMC8093947

Abstract Article PDF–1.7M

Select item 79484827.

Erythrocytes efficiently utilize exogenous sphingosines for S1P synthesis and export via Mfsd2b

Toan Q. Nguyen, Thiet Minh Vu, Farhana Tukijan, Sneha Muralidharan, Juat Chin Foo, Jasmine Fei Li Chin, Zafrul Hasan, Federico Torta, Long N. Nguyen

J Biol Chem. 2021 Jan-Jun; 296: 100201. Published online 2021 Jan 23. doi: 10.1074/jbc.RA120.012941

PMCID:: PMC7948482

Abstract Article PDF–3.3M

Select item 72636718.

A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation

Louise van der Weyden, Agnieszka Swiatkowska, Vivek Iyer, Anneliese O. Speak, David J. Adams

G3 (Bethesda) 2020 Jun; 10(6): 1869–1877. Published online 2020 Apr 3. doi: 10.1534/g3.120.401128

PMCID:: PMC7263671

Abstract Article PDF–1.0M

Select item 67734419.

High-endothelial cell-derived S1P regulates dendritic cell localization and vascular integrity in the lymph node

Szandor Simmons, Naoko Sasaki, Eiji Umemoto, Yutaka Uchida, Shigetomo Fukuhara, Yusuke Kitazawa, Michiyo Okudaira, Asuka Inoue, Kazuo Tohya, Keita Aoi, Junken Aoki, Naoki Mochizuki, Kenjiro Matsuno, Kiyoshi Takeda, Masayuki Miyasaka, Masaru Ishii

eLife. 2019; 8: e41239. Published online 2019 Oct 1. doi: 10.7554/eLife.41239

PMCID:: PMC6773441

Abstract Article PDF–8.6M

Select item 645951010.

Mouse screen reveals multiple new genes underlying mouse and human hearing loss

Neil J. Ingham, Selina A. Pearson, Valerie E. Vancollie, Victoria Rook, Morag A. Lewis, Jing Chen, Annalisa Buniello, Elisa Martelletti, Lorenzo Preite, Chi Chung Lam, Felix D. Weiss, Zӧe Powis, Pim Suwannarat, Christopher J. Lelliott, Sally J. Dawson, Jacqueline K. White, Karen P. Steel

PLoS Biol. 2019 Apr; 17(4): e3000194. Published online 2019 Apr 11. doi: 10.1371/journal.pbio.3000194

PMCID:: PMC6459510

Abstract Article PDF–5.1M

Select item 635534111.

Lipid transporter Spns2 promotes microglia pro-inflammatory activation in response to amyloid-beta peptide

Liansheng Zhong, Xue Jiang, Zhihui Zhu, Haiyan Qin, Michael B. Dinkins, Ji-Na Kong, Silvia Leanhart, Rebecca Wang, Ahmed Elsherbini, Erhard Bieberich, Yujie Zhao, Guanghu Wang

Glia. Author manuscript; available in PMC 2020 Mar 1.

Published in final edited form as: Glia. 2019 Mar; 67(3): 498–511. Published online 2018 Nov 28. doi: 10.1002/glia.23558

PMCID:: PMC6355341

Abstract Article PDF–1013K

Select item 568317912.

Lymphatic endothelial S1P promotes naïve T cell mitochondrial function and survival

Alejandra Mendoza, Victoria Fang, Cynthia Chen, Madhavika Serasinghe, Akanksha Verma, James Muller, V. Sai Chaluvadi, Michael L. Dustin, Timothy Hla, Olivier Elemento, Jerry E. Chipuk, Susan R. Schwab

Nature. Author manuscript; available in PMC 2017 Nov 24.

Published in final edited form as: Nature. 2017 Jun 1; 546(7656): 158–161. Published online 2017 May 24. doi: 10.1038/nature22352

PMCID:: PMC5683179

Article PDF–3.0M

Select item 567502013.

Lymph node S1P gradients position natural killer cells and regulate their interferon-γ response

Victoria Fang, V. Sai Chaluvadi, Willy D. Ramos-Perez, Alejandra Mendoza, Audrey Baeyens, Richard Rivera, Jerold Chun, Michael Cammer, Susan R. Schwab

Nat Immunol. Author manuscript; available in PMC 2017 Nov 7.

Published in final edited form as: Nat Immunol. 2017 Jan; 18(1): 15–25. Published online 2016 Nov 14. doi: 10.1038/ni.3619

PMCID:: PMC5675020

Abstract Article PDF–1.5M

Select item 560328614.

Genome-wide in vivo screen identifies novel host regulators of metastatic colonization

Louise van der Weyden, Mark J. Arends, Andrew D. Campbell, Tobias Bald, Hannah Wardle-Jones, Nicola Griggs, Martin Del Castillo Velasco-Herrera, Thomas Tüting, Owen J. Sansom, Natasha A. Karp, Simon Clare, Diane Gleeson, Edward Ryder, Antonella Galli, Elizabeth Tuck, Emma L. Cambridge, Thierry Voet, Iain C. Macaulay, Kim Wong, Sanger Mouse Genetics Project, Sarah Spiegel, Anneliese O. Speak, David J. Adams

Nature. Author manuscript; available in PMC 2018 Jan 12.

Published in final edited form as: Nature. 2017 Jan 12; 541(7636): 233–236. Published online 2017 Jan 4. doi: 10.1038/nature20792

PMCID:: PMC5603286

Abstract Article PDF–3.7M

Select item 529582115.

High-throughput discovery of novel developmental phenotypes

Mary E. Dickinson, Ann M. Flenniken, Xiao Ji, Lydia Teboul, Michael D. Wong, Jacqueline K. White, Terrence F. Meehan, Wolfgang J. Weninger, Henrik Westerberg, Hibret Adissu, Candice N. Baker, Lynette Bower, James M. Brown, L. Brianna Caddle, Francesco Chiani, Dave Clary, James Cleak, Mark J. Daly, James M. Denegre, Brendan Doe, Mary E. Dolan, Sarah M. Edie, Helmut Fuchs, Valerie Gailus-Durner, Antonella Galli, Alessia Gambadoro, Juan Gallegos, Shiying Guo, Neil R. Horner, Chih-wei Hsu, Sara J. Johnson, Sowmya Kalaga, Lance C. Keith, Louise Lanoue, Thomas N. Lawson, Monkol Lek, Manuel Mark, Susan Marschall, Jeremy Mason, Melissa L. McElwee, Susan Newbigging, Lauryl M.J. Nutter, Kevin A. Peterson, Ramiro Ramirez-Solis, Douglas J. Rowland, Edward Ryder, Kaitlin E. Samocha, John R. Seavitt, Mohammed Selloum, Zsombor Szoke-Kovacs, Masaru Tamura, Amanda G Trainor, Ilinca Tudose, Shigeharu Wakana, Jonathan Warren, Olivia Wendling, David B. West, Leeyean Wong, Atsushi Yoshiki, The International Mouse Phenotyping Consortium, Daniel G. MacArthur, Glauco P. Tocchini-Valentini, Xiang Gao, Paul Flicek, Allan Bradley, William C. Skarnes, Monica J. Justice, Helen E. Parkinson, Mark Moore, Sara Wells, Robert E. Braun, Karen L. Svenson, Martin Hrabe de Angelis, Yann Herault, Tim Mohun, Ann-Marie Mallon, R. Mark Henkelman, Steve D.M. Brown, David J. Adams, K.C. Kent Lloyd, Colin McKerlie, Arthur L. Beaudet, Maja Bucan, Stephen A. Murray

Nature. Author manuscript; available in PMC 2017 Mar 14.

Published in final edited form as: Nature. 2016 Sep 22; 537(7621): 508–514. Published online 2016 Sep 14. doi: 10.1038/nature19356

Correction in:: Nature. 2017 Nov 16; 551(7680): 398.

PMCID:: PMC5295821

Abstract Article PDF–3.0M

Select item 465305616.

Spinster 2, a sphingosine-1-phosphate transporter, plays a critical role in inflammatory and autoimmune diseases

Michael S. Donoviel, Nitai C. Hait, Subramaniam Ramachandran, Michael Maceyka, Kazuaki Takabe, Sheldon Milstien, Tamas Oravecz, Sarah Spiegel

FASEB J. 2015 Dec; 29(12): 5018–5028. Published online 2015 Aug 31. doi: 10.1096/fj.15-274936

PMCID:: PMC4653056

Abstract Article

Select item 421459817.

Spinster Homolog 2 (Spns2) Deficiency Causes Early Onset Progressive Hearing Loss

Jing Chen, Neil Ingham, John Kelly, Shalini Jadeja, David Goulding, Johanna Pass, Vinit B. Mahajan, Stephen H. Tsang, Anastasia Nijnik, Ian J. Jackson, Jacqueline K. White, Andrew Forge, Daniel Jagger, Karen P. Steel

PLoS Genet. 2014 Oct; 10(10): e1004688. Published online 2014 Oct 30. doi: 10.1371/journal.pgen.1004688

PMCID:: PMC4214598

Abstract Article PDF–3.2M

Select item 400740318.

Histopathology reveals correlative and unique phenotypes in a high-throughput mouse phenotyping screen

Hibret A. Adissu, Jeanne Estabel, David Sunter, Elizabeth Tuck, Yvette Hooks, Damian M. Carragher, Kay Clarke, Natasha A. Karp, Sanger Mouse Genetics Project, Susan Newbigging, Nora Jones, Lily Morikawa, Jacqueline K. White, Colin McKerlie

Dis Model Mech. 2014 May; 7(5): 515–524. Published online 2014 Mar 20. doi: 10.1242/dmm.015263

PMCID:: PMC4007403

Abstract Article

Select item 371720719.

Genome-wide Generation and Systematic Phenotyping of Knockout Mice Reveals New Roles for Many Genes

Jacqueline K. White, Anna-Karin Gerdin, Natasha A. Karp, Ed Ryder, Marija Buljan, James N. Bussell, Jennifer Salisbury, Simon Clare, Neil J. Ingham, Christine Podrini, Richard Houghton, Jeanne Estabel, Joanna R. Bottomley, David G. Melvin, David Sunter, Niels C. Adams, The Sanger Institute Mouse Genetics Project, David Tannahill, Darren W. Logan, Daniel G. MacArthur, Jonathan Flint, Vinit B. Mahajan, Stephen H. Tsang, Ian Smyth, Fiona M. Watt, William C. Skarnes, Gordon Dougan, David J. Adams, Ramiro Ramirez-Solis, Allan Bradley, Karen P. Steel

Cell. 2013 Jul 18; 154(2): 452–464. doi: 10.1016/j.cell.2013.06.022

PMCID:: PMC3717207

Abstract Article PDF–3.4M

Select item 361649820.

The transporter Spns2 is required for secretion of lymph but not plasma sphingosine-1-phosphate

Alejandra Mendoza, Béatrice Bréart, Willy D. Ramos-Perez, Lauren A. Pitt, Michael Gobert, Manjula Sunkara, Juan J. Lafaille, Andrew J. Morris, Susan R. Schwab

Cell Rep. Author manuscript; available in PMC 2013 Nov 29.

Published in final edited form as: Cell Rep. 2012 Nov 29; 2(5): 1104–1110. Published online 2012 Oct 25. doi: 10.1016/j.celrep.2012.09.021

PMCID:: PMC3616498

Abstract Article PDF–2.2M

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