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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 107693502.

Identification of new ciliary signaling pathways in the brain and insights into neurological disorders

Abdelhalim Loukil, Emma Ebright, Akiyoshi Uezu, Yudong Gao, Scott H Soderling, Sarah C. Goetz

Version 1. bioRxiv. Preprint. 2023 Dec 21. doi: 10.1101/2023.12.20.572700

PMCID:: PMC10769350

Abstract Article PDF–11M

Select item 101577253.

Gαi1/3 mediate Netrin-1-CD146-activated signaling and angiogenesis

Ya Li, Jin-long Chai, Xin Shi, Yu Feng, Jia-jun Li, Li-na Zhou, Cong Cao, Ke-ran Li

Theranostics. 2023; 13(7): 2319–2336. Published online 2023 Apr 17. doi: 10.7150/thno.80749

PMCID:: PMC10157725

Abstract Article PDF–10M

Select item 99382164.

Rescue of neuropsychiatric phenotypes in a mouse model of 16p11.2 duplication syndrome by genetic correction of an epilepsy network hub

Marc P. Forrest, Marc Dos Santos, Nicolas H. Piguel, Yi-Zhi Wang, Nicole A. Hawkins, Vikram A. Bagchi, Leonardo E. Dionisio, Sehyoun Yoon, Dina Simkin, Maria Dolores Martin-de-Saavedra, Ruoqi Gao, Katherine E. Horan, Alfred L. George, Jr., Mark S. LeDoux, Jennifer A. Kearney, Jeffrey N. Savas, Peter Penzes

Nat Commun. 2023; 14: 825. Published online 2023 Feb 17. doi: 10.1038/s41467-023-36087-x

PMCID:: PMC9938216

Abstract Article PDF–5.3M

Select item 90166195.

SIRT1 regulates cardiomyocyte alignment during maturation

Yi Fang, Wei Fan, Xiaojiang Xu, Agnes K. Janoshazi, David C. Fargo, Xiaoling Li

J Cell Sci. 2022 Apr 1; 135(7): jcs259076. Published online 2022 Apr 1. doi: 10.1242/jcs.259076

PMCID:: PMC9016619

Abstract Article

Select item 86913966.

In Vivo Metabolic Roles of G Proteins of the G_i Family Studied With Novel Mouse Models

Jürgen Wess

Endocrinology. 2022 Jan; 163(1): bqab245. Published online 2021 Dec 5. doi: 10.1210/endocr/bqab245

PMCID:: PMC8691396

Abstract Article

Select item 79782947.

Requirement of Gαi1 and Gαi3 in interleukin-4-induced signaling, macrophage M2 polarization and allergic asthma response

Jin-yu Bai, Ya Li, Guan-hua Xue, Ke-ran Li, Yu-Fan Zheng, Zhi-qing Zhang, Qin Jiang, Yuan-yuan Liu, Xiao-zhong Zhou, Cong Cao

Theranostics. 2021; 11(10): 4894–4909. Published online 2021 Mar 4. doi: 10.7150/thno.56383

PMCID:: PMC7978294

Abstract Article PDF–3.2M

Select item 79387708.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 75637919.

Allosteric Inhibition of Adenylyl Cyclase Type 5 by G-Protein: A Molecular Dynamics Study

Elisa Frezza, Tina-Méryl Amans, Juliette Martin

Biomolecules. 2020 Sep; 10(9): 1330. Published online 2020 Sep 17. doi: 10.3390/biom10091330

PMCID:: PMC7563791

Abstract Article PDF–18M

Select item 734864010.

GINIP, a G_αi-Interacting Protein, Functions as a Key Modulator of Peripheral GABA_B Receptor-Mediated Analgesia

Stéphane Gaillard, Laure Lo Re, Annabelle Mantilleri, Régine Hepp, Louise Urien, Pascale Malapert, Serge Alonso, Michael Deage, Charline Kambrun, Marc Landry, Sarah A. Low, Abdelkrim Alloui, Bertrand Lambolez, Grégory Scherrer, Yves Le Feuvre, Emmanuel Bourinet, Aziz Moqrich

Neuron. Author manuscript; available in PMC 2020 Jul 10.

Published in final edited form as: Neuron. 2014 Oct 1; 84(1): 123–136. Published online 2014 Sep 18. doi: 10.1016/j.neuron.2014.08.056

PMCID:: PMC7348640

Abstract Article PDF–3.1M

Select item 729326711.

Adipocyte G_i signaling is essential for maintaining whole-body glucose homeostasis and insulin sensitivity

Lei Wang, Sai P. Pydi, Lu Zhu, Luiz F. Barella, Yinghong Cui, Oksana Gavrilova, Kendra K. Bence, Cecile Vernochet, Jürgen Wess

Nat Commun. 2020; 11: 2995. Published online 2020 Jun 12. doi: 10.1038/s41467-020-16756-x

PMCID:: PMC7293267

Abstract Article PDF–3.6M

Select item 662826012.

GNAI1 and GNAI3 Reduce Colitis-Associated Tumorigenesis in Mice by Blocking IL6 Signaling and Down-regulating Expression of GNAI2

Zhi-Wei Li, Beicheng Sun, Ting Gong, Sheng Guo, Jianhua Zhang, Junlong Wang, Atsushi Sugawara, Meisheng Jiang, Junjun Yan, Alexandra Gurary, Xin Zheng, Bifeng Gao, Shu-Yuan Xiao, Wenlian Chen, Chi Ma, Christine Farrar, Chenjun Zhu, Owen T. M. Chan, Can Xin, Andrew Winnicki, John Winnicki, Mingxin Tang, Ryan Park, Mary Winnicki, Katrina Diener, Zhanwei Wang, Qicai Liu, Catherine H. Chu, Zhaohui L. Arter, Peibin Yue, Lindsay Alpert, George S. Hui, Peiwen Fei, James Turkson, Wentian Yang, Guangyu Wu, Ailin Tao, Joe W. Ramos, Stefan Moisyadi, Randall F. Holcombe, Wei Jia, Lutz Birnbaumer, Xiqiao Zhou, Wen-Ming Chu

Gastroenterology. Author manuscript; available in PMC 2020 Jun 1.

Published in final edited form as: Gastroenterology. 2019 Jun; 156(8): 2297–2312. Published online 2019 Mar 2. doi: 10.1053/j.gastro.2019.02.040

PMCID:: PMC6628260

Abstract Article PDF–4.3M

Select item 655698113.

Constitutive inhibitory G protein activity upon adenylyl cyclase-dependent cardiac contractility is limited to adenylyl cyclase type 6

Caroline Bull Melsom, Marie-Victoire Cosson, Øivind Ørstavik, Ngai Chin Lai, H. Kirk Hammond, Jan-Bjørn Osnes, Tor Skomedal, Viacheslav Nikolaev, Finn Olav Levy, Kurt Allen Krobert

PLoS One. 2019; 14(6): e0218110. Published online 2019 Jun 7. doi: 10.1371/journal.pone.0218110

PMCID:: PMC6556981

Abstract Article PDF–2.3M

Select item 651439814.

A link between planar polarity and staircase-like bundle architecture in hair cells

Basile Tarchini, Abigail L. D. Tadenev, Nicholas Devanney, Michel Cayouette

Development. 2016 Nov 1; 143(21): 3926–3932. Published online 2016 Nov 1. doi: 10.1242/dev.139089

PMCID:: PMC6514398

Abstract Article

Select item 650011115.

Intrinsic planar polarity mechanisms influence the position-dependent regulation of synapse properties in inner hair cells

Philippe Jean, Özge Demet Özçete, Basile Tarchini, Tobias Moser

Proc Natl Acad Sci U S A. 2019 Apr 30; 116(18): 9084–9093. Published online 2019 Apr 11. doi: 10.1073/pnas.1818358116

PMCID:: PMC6500111

Abstract Article PDF–17M

Select item 631390016.

Proteomic Analysis of the Spinophilin Interactome in Rodent Striatum Following Psychostimulant Sensitization

Darryl S. Watkins, Jason D. True, Amber L. Mosley, Anthony J. Baucum, II

Proteomes. 2018 Dec; 6(4): 53. Published online 2018 Dec 17. doi: 10.3390/proteomes6040053

Correction in:: Proteomes. 2019 Mar; 7(1): 7.

PMCID:: PMC6313900

Abstract Article PDF–2.5M

Select item 606970517.

RNA binding proteins co-localize with small tau inclusions in tauopathy

Brandon F. Maziuk, Daniel J. Apicco, Anna Lourdes Cruz, Lulu Jiang, Peter E. A. Ash, Edroaldo Lummertz da Rocha, Cheng Zhang, Wai Haung Yu, John Leszyk, Jose F. Abisambra, Hu Li, Benjamin Wolozin

Acta Neuropathol Commun. 2018; 6: 71. Published online 2018 Aug 1. doi: 10.1186/s40478-018-0574-5

PMCID:: PMC6069705

Abstract Article PDF–5.5M

Select item 600807118.

Differential effects of inhibitory G protein isoforms on G protein-gated inwardly rectifying K⁺ currents in adult murine atria

Muriel Nobles, David Montaigne, Sonia Sebastian, Lutz Birnbaumer, Andrew Tinker

Am J Physiol Cell Physiol. 2018 May 1; 314(5): C616–C626. Published online 2018 Jan 17. doi: 10.1152/ajpcell.00271.2016

PMCID:: PMC6008071

Abstract Article

Select item 589948119.

Antidepression action of BDNF requires and is mimicked by Gαi1/3 expression in the hippocampus

John Marshall, Xiao-zhong Zhou, Gang Chen, Su-qing Yang, Ya Li, Yin Wang, Zhi-qing Zhang, Qin Jiang, Lutz Birnbaumer, Cong Cao

Proc Natl Acad Sci U S A. 2018 Apr 10; 115(15): E3549–E3558. Published online 2018 Mar 5. doi: 10.1073/pnas.1722493115

PMCID:: PMC5899481

Abstract Article PDF–1.9M

Select item 564508220.

Spatio-temporal profile of postynaptic interactomes integrates components of complex brain disorders

Jing Li, Wangshu Zhang, Hui Yang, Daniel P. Howrigan, Brent Wilkinson, Tade Souaiaia, Oleg V. Evgrafov, Giulio Genovese, Veronica A. Clementel, Jennifer C. Tudor, Ted Abel, James A. Knowles, Benjamin M. Neale, Kai Wang, Fengzhu Sun, Marcelo P. Coba

Nat Neurosci. Author manuscript; available in PMC 2018 Aug 1.

Published in final edited form as: Nat Neurosci. 2017 Aug; 20(8): 1150–1161. Published online 2017 Jun 26. doi: 10.1038/nn.4594

PMCID:: PMC5645082

Abstract Article PDF–2.3M

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