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Select item 112089131.

Leishmania exploits host cAMP/EPAC/calcineurin signaling to induce an IL-33–mediated anti-inflammatory environment for the establishment of infection

Souravi Roy, Shalini Roy, Satyajit Halder, Kuladip Jana, Anindita Ukil

J Biol Chem. 2024 Jun; 300(6): 107366. Published online 2024 May 13. doi: 10.1016/j.jbc.2024.107366

PMCID:: PMC11208913

Abstract Article PDF–4.0M

Select item 111170702.

Epac1 deficiency inhibits basic fibroblast growth factor-mediated vascular smooth muscle cell migration

Yuko Kato, Utako Yokoyama, Takayuki Fujita, Masanari Umemura, Tetsuo Kubota, Yoshihiro Ishikawa

J Physiol Sci. 2019 Mar; 69: 175–184. Published online 2018 Aug 6. doi: 10.1007/s12576-018-0631-7

PMCID:: PMC11117070

Abstract Article PDF–1.2M

Select item 104764493.

Upregulation of Epac1 Promotes Pericyte Loss by Inducing Mitochondrial Fission, Reactive Oxygen Species Production, and Apoptosis

Wenli Yang, Fan Xia, Fang Mei, Shuizhen Shi, William G. Robichaux, III, Wei Lin, Wenbo Zhang, Hua Liu, Xiaodong Cheng

Invest Ophthalmol Vis Sci. 2023 Aug; 64(11): 34. Published online 2023 Aug 31. doi: 10.1167/iovs.64.11.34

PMCID:: PMC10476449

Abstract Article PDF–10M

Select item 101718634.

cAMP−EPAC−PKCε−RIM1α signaling regulates presynaptic long-term potentiation and motor learning

Xin-Tai Wang, Lin Zhou, Bin-Bin Dong, Fang-Xiao Xu, De-Juan Wang, En-Wei Shen, Xin-Yu Cai, Yin Wang, Na Wang, Sheng-Jian Ji, Wei Chen, Martijn Schonewille, J Julius Zhu, Chris I De Zeeuw, Ying Shen

eLife. 2023; 12: e80875. Published online 2023 Apr 26. doi: 10.7554/eLife.80875

PMCID:: PMC10171863

Abstract Article PDF–18M

Select item 99927435.

Inhibition of EPAC1 signaling pathway alters atrial electrophysiology and prevents atrial fibrillation

Bastien Guillot, Arthur Boileve, Richard Walton, Alexandre Harfoush, Caroline Conte, Yannis Sainte-Marie, Sabine Charron, Olivier Bernus, Alice Recalde, Laurent Sallé, Fabien Brette, Frank Lezoualc’h

Front Physiol. 2023; 14: 1120336. Published online 2023 Feb 22. doi: 10.3389/fphys.2023.1120336

PMCID:: PMC9992743

Abstract Article PDF–2.9M

Select item 96352096.

Deficiency of exchange protein directly activated by cAMP (EPAC)-1 in mice augments glucose intolerance, inflammation, and gut dysbiosis associated with Western diet

Preeti Dinesh Virwani, Lin Cai, Patrick Ka Kit Yeung, Gordon Qian, Yingxian Chen, Lei Zhou, Jason Wing Hon Wong, Yu Wang, Joshua Wing Kei Ho, Kui Kai Lau, Pei-Yuan Qian, Sookja Kim Chung

Microbiome. 2022; 10: 187. Published online 2022 Nov 4. doi: 10.1186/s40168-022-01366-0

PMCID:: PMC9635209

Abstract Article PDF–3.1M

Select item 93523657.

TNFAIP3 is anti-inflammatory in the retinal vasculature

Li Liu, Youde Jiang, Jena J. Steinle

Mol Vis. 2022; 28: 124–129. Published online 2022 Jun 30.

PMCID:: PMC9352365

Abstract Article PDF–1.2M

Select item 92941638.

Electroacupuncture Attenuates Post-Inflammatory IBS-Associated Visceral and Somatic Hypersensitivity and Correlates With the Regulatory Mechanism of Epac1–Piezo2 Axis

Jing Guo, Lu Chen, Yu-hang Wang, Ya-fang Song, Zhan-hao Zhao, Ting-ting Zhao, Zhi-ying Lin, Dong-mei Gu, Yun-qi Liu, Yong-jun Peng, Li-xia Pei, Jian-hua Sun

Front Endocrinol (Lausanne) 2022; 13: 918652. Published online 2022 Jul 5. doi: 10.3389/fendo.2022.918652

PMCID:: PMC9294163

Abstract Article PDF–9.9M

Select item 90508709.

Epac1 and PKA regulate of P2X7 and NLRP3 inflammasome proteins in the retinal vasculature

Li Liu, Youde Jiang, Jena J. Steinle

Exp Eye Res. Author manuscript; available in PMC 2023 May 1.

Published in final edited form as: Exp Eye Res. 2022 May; 218: 108987. Published online 2022 Feb 16. doi: 10.1016/j.exer.2022.108987

PMCID:: PMC9050870

Abstract Article PDF–919K

Select item 885582210.

Epac1^–/– and Epac2^–/– mice exhibit deficient epithelial Na⁺ channel regulation and impaired urinary Na⁺ conservation

Viktor N. Tomilin, Kyrylo Pyrshev, Anna Stavniichuk, Naghmeh Hassanzadeh Khayyat, Guohui Ren, Oleg Zaika, Sherif Khedr, Alexander Staruschenko, Fang C. Mei, Xiaodong Cheng, Oleh Pochynyuk

JCI Insight. 2022 Feb 8; 7(3): e145653. Published online 2022 Feb 8. doi: 10.1172/jci.insight.145653

PMCID:: PMC8855822

Abstract Article PDF–6.4M

Select item 876271711.

PKA and Epac1 Reduce Nek7 to Block the NLRP3 Inflammasome Proteins in the Retinal Vasculature

Li Liu, Youde Jiang, Jena J. Steinle

Invest Ophthalmol Vis Sci. 2022 Jan; 63(1): 14. Published online 2022 Jan 10. doi: 10.1167/iovs.63.1.14

PMCID:: PMC8762717

Abstract Article PDF–1.8M

Select item 852611312.

Intracellular receptor EPAC regulates von Willebrand factor secretion from endothelial cells in a PI3K-/eNOS-dependent manner during inflammation

Jie Xiao, Ben Zhang, Zhengchen Su, Yakun Liu, Thomas R. Shelite, Qing Chang, Yuan Qiu, Jiani Bei, Pingyuan Wang, Alexander Bukreyev, Lynn Soong, Yang Jin, Thomas Ksiazek, Angelo Gaitas, Shannan L. Rossi, Jia Zhou, Michael Laposata, Tais B. Saito, Bin Gong

J Biol Chem. 2021 Nov; 297(5): 101315. Published online 2021 Oct 20. doi: 10.1016/j.jbc.2021.101315

PMCID:: PMC8526113

Abstract Article PDF–2.6M

Select item 841084613.

Cyclic AMP-binding protein Epac1 acts as a metabolic sensor to promote cardiomyocyte lipotoxicity

Marion Laudette, Yannis Sainte-Marie, Grégoire Cousin, Dorian Bergonnier, Ismahane Belhabib, Stéphanie Brun, Karina Formoso, Loubna Laib, Florence Tortosa, Camille Bergoglio, Bertrand Marcheix, Jan Borén, Olivier Lairez, Jérémy Fauconnier, Alexandre Lucas, Jeanne Mialet-Perez, Cédric Moro, Frank Lezoualc’h

Cell Death Dis. 2021 Sep; 12(9): 824. Published online 2021 Sep 1. doi: 10.1038/s41419-021-04113-9

PMCID:: PMC8410846

Abstract Article PDF–4.3M

Select item 818464114.

Epac1 regulates TLR4 signaling in the diabetic retinal vasculature

Li Liu, Youde Jiang, Jena Steinle

Cytokine. Author manuscript; available in PMC 2022 Aug 1.

Published in final edited form as: Cytokine. 2021 Aug; 144: 155576. Published online 2021 May 18. doi: 10.1016/j.cyto.2021.155576

PMCID:: PMC8184641

Abstract Article PDF–1.2M

Select item 812572715.

Cellular Mechanisms of the Anti-Arrhythmic Effect of Cardiac PDE2 Overexpression

Michael Wagner, Mirna S. Sadek, Nataliya Dybkova, Fleur E. Mason, Johann Klehr, Rebecca Firneburg, Eleder Cachorro, Kurt Richter, Erik Klapproth, Stephan R. Kuenzel, Kristina Lorenz, Jordi Heijman, Dobromir Dobrev, Ali El-Armouche, Samuel Sossalla, Susanne Kämmerer

Int J Mol Sci. 2021 May; 22(9): 4816. Published online 2021 May 1. doi: 10.3390/ijms22094816

PMCID:: PMC8125727

Abstract Article PDF–3.7M

Select item 783185116.

Epac1 upregulates LOX-1 to promote foam cell formation and atherosclerosis development

William G. Robichaux, III, Fang C. Mei, Wenli Yang, Hui Wang, Hua Sun, Zhen Zhou, Dianna M. Milewicz, Ba-Bie Teng, Xiaodong Cheng

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2021 Dec 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2020 Dec; 40(12): e322–e335. Published online 2020 Oct 15. doi: 10.1161/ATVBAHA.119.314238

PMCID:: PMC7831851

Abstract Article PDF–1.2M

Select item 764330017.

β-Adrenergic Receptors/Epac Signaling Increases the Size of the Readily Releasable Pool of Synaptic Vesicles Required for Parallel Fiber LTP

Ricardo Martín, Nuria García-Font, Alberto Samuel Suárez-Pinilla, David Bartolomé-Martín, José Javier Ferrero, Rafael Luján, Magdalena Torres, José Sánchez-Prieto

J Neurosci. 2020 Nov 4; 40(45): 8604–8617. doi: 10.1523/JNEUROSCI.0716-20.2020