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Items: 1 to 20 of 123

1.
The SMC5/6 complex prevents genotoxicity upon APOBEC3A-mediated replication stress
Dylan F Fingerman, David R O’Leary, Ava R Hansen, Thi Tran, Brooke R Harris, Rachel A DeWeerd, Katharina E Hayer, Jiayi Fan, Emily Chen, Mithila Tennakoon, Alice Meroni, Julia H Szeto, Jessica Devenport, Danielle LaVigne, Matthew D Weitzman, Ophir Shalem, Jeffrey Bednarski, Alessandro Vindigni, Xiaolan Zhao, Abby M Green
EMBO J. 2024 Aug; 43(15): 3240–3255. Published online 2024 Jun 17. doi: 10.1038/s44318-024-00137-x
PMCID:
PMC11294446
AbstractArticlePDF–9.0M
2.
Distinguishing preferences of human APOBEC3A and APOBEC3B for cytosines in hairpin loops, and reflection of these preferences in APOBEC-signature cancer genome mutations
Yasha Butt, Ramin Sakhtemani, Rukshana Mohamad-Ramshan, Michael S. Lawrence, Ashok S. Bhagwat
Nat Commun. 2024; 15: 2369. Published online 2024 Mar 18. doi: 10.1038/s41467-024-46231-w
PMCID:
PMC10948833
AbstractArticlePDF–3.7M
3.
Therapy-induced APOBEC3A drives evolution of persistent cancer cells
Hideko Isozaki, Ramin Sakhtemani, Ammal Abbasi, Naveed Nikpour, Marcello Stanzione, Sunwoo Oh, Adam Langenbucher, Susanna Monroe, Wenjia Su, Heidie Frisco Cabanos, Faria M. Siddiqui, Nicole Phan, Pégah Jalili, Daria Timonina, Samantha Bilton, Maria Gomez-Caraballo, Hannah L. Archibald, Varuna Nangia, Kristin Dionne, Amanda Riley, Matthew Lawlor, Mandeep Kaur Banwait, Rosemary G. Cobb, Lee Zou, Nicholas J. Dyson, Christopher J. Ott, Cyril Benes, Gad Getz, Chang S. Chan, Alice T. Shaw, Justin F. Gainor, Jessica J. Lin, Lecia V. Sequist, Zofia Piotrowska, Beow Y. Yeap, Jeffrey A. Engelman, Jake June-Koo Lee, Yosef E. Maruvka, Rémi Buisson, Michael S. Lawrence, Aaron N. Hata
Nature. Author manuscript; available in PMC 2024 Feb 1.
Published in final edited form as: Nature. 2023 Aug; 620(7973): 393–401. Published online 2023 Jul 5. doi: 10.1038/s41586-023-06303-1
PMCID:
PMC10804446
AbstractArticlePDF–5.7M
4.
Regulatory variants of APOBEC3 genes potentially associate with COVID-19 severity in populations with African ancestry
Ke Zhang, Fang Chen, Hu-Yan Shen, Ping-Ping Zhang, Han Gao, Hong Peng, Yu-Si Luo, Zhong-Shan Cheng
Sci Rep. 2023; 13: 22435. Published online 2023 Dec 17. doi: 10.1038/s41598-023-49791-x
PMCID:
PMC10725877
AbstractArticlePDF–4.6M
5.
Mutational impact of APOBEC3A and APOBEC3B in a human cell line and comparisons to breast cancer
Michael A. Carpenter, Nuri A. Temiz, Mahmoud A. Ibrahim, Matthew C. Jarvis, Margaret R. Brown, Prokopios P. Argyris, William L. Brown, Gabriel J. Starrett, Douglas Yee, Reuben S. Harris
PLoS Genet. 2023 Nov; 19(11): e1011043. Published online 2023 Nov 30. doi: 10.1371/journal.pgen.1011043
PMCID:
PMC10715669
AbstractArticlePDF–2.9M
6.
Mitochondrial double-stranded RNA triggers induction of the antiviral DNA deaminase APOBEC3A and nuclear DNA damage
Chloe Wick, Seyed Arad Moghadasi, Jordan T. Becker, Elisa Fanunza, Sunwoo Oh, Elodie Bournique, Rémi Buisson, Reuben S. Harris
J Biol Chem. 2023 Sep; 299(9): 105073. Published online 2023 Jul 19. doi: 10.1016/j.jbc.2023.105073
PMCID:
PMC10457583
AbstractArticlePDF–2.0M
7.
Apobec3A Deamination Functions Are Involved in Antagonizing Efficient Human Adenovirus Replication and Gene Expression
Lilian Göttig, Christina Weiß, Miona Stubbe, Lisa Hanrieder, Samuel Hofmann, Alessandro Grodziecki, Daniela Stadler, Arnaud Carpentier, Ulrike Protzer, Sabrina Schreiner
mBio. 2023 May-Jun; 14(3): e03478-22. Published online 2023 May 8. doi: 10.1128/mbio.03478-22
PMCID:
PMC10294656
AbstractArticlePDF–5.7M
8.
Seven-membered ring nucleobases as inhibitors of human cytidine deaminase and APOBEC3A
Harikrishnan M. Kurup, Maksim V. Kvach, Stefan Harjes, Geoffrey B. Jameson, Elena Harjes, Vyacheslav V. Filichev
Org Biomol Chem. 2023 Jun 21; 21(24): 5117–5128. Published online 2023 Jun 7. doi: 10.1039/d3ob00392b
PMCID:
PMC10282898
AbstractArticle
9.
DNA Deamination Is Required for Human APOBEC3A-Driven Hepatocellular Carcinoma In Vivo
Jordan A. Naumann, Prokopios P. Argyris, Michael A. Carpenter, Harshita B. Gupta, Yanjun Chen, Nuri A. Temiz, Yufan Zhou, Cameron Durfee, Joshua Proehl, Brenda L. Koniar, Silvestro G. Conticello, David A. Largaespada, William L. Brown, Hideki Aihara, Rachel I. Vogel, Reuben S. Harris
Int J Mol Sci. 2023 Jun; 24(11): 9305. Published online 2023 May 26. doi: 10.3390/ijms24119305
PMCID:
PMC10253583
AbstractArticlePDF–13M
10.
APOBEC3A/B deletion polymorphism and endometrial cancer risk
Nigar Sofiyeva, Camilla Krakstad, Mari K. Halle, Tracy A. O'Mara, Pål Romundstad, Kristian Hveem, Lars Vatten, Per E. Lønning, Liv B. Gansmo, Stian Knappskog
Cancer Med. 2023 Mar; 12(6): 6659–6667. Published online 2022 Nov 16. doi: 10.1002/cam4.5448
PMCID:
PMC10067079
AbstractArticlePDF–646K
11.
The base-editing enzyme APOBEC3A catalyzes cytosine deamination in RNA with low proficiency and high selectivity
Aleksia Barka, Kiara N. Berríos, Peter Bailer, Emily K. Schutsky, Tong Wang, Rahul M. Kohli
ACS Chem Biol. Author manuscript; available in PMC 2023 Mar 18.
Published in final edited form as: ACS Chem Biol. 2022 Mar 18; 17(3): 629–636. Published online 2022 Mar 9. doi: 10.1021/acschembio.1c00919
PMCID:
PMC9949940
AbstractArticlePDF–1.1M
12.
Cellular APOBEC3A deaminase drives mutations in the SARS-CoV-2 genome
Yoshihiro Nakata, Hirotaka Ode, Mai Kubota, Takaaki Kasahara, Kazuhiro Matsuoka, Atsuko Sugimoto, Mayumi Imahashi, Yoshiyuki Yokomaku, Yasumasa Iwatani
Nucleic Acids Res. 2023 Jan 25; 51(2): 783–795. Published online 2023 Jan 5. doi: 10.1093/nar/gkac1238
PMCID:
PMC9881129
AbstractArticlePDF–2.1M
13.
Differences in integration frequencies and APOBEC3 profiles of five high-risk HPV types adheres to phylogeny
Alexander Hesselberg Løvestad, Adina Repesa, Jean-Marc Costanzi, Sonja Lagström, Irene Kraus Christiansen, Trine B. Rounge, Ole Herman Ambur
Tumour Virus Res. 2022 Dec; 14: 200247. Published online 2022 Sep 11. doi: 10.1016/j.tvr.2022.200247
PMCID:
PMC9485212
AbstractArticlePDF–2.3M
14.
The roles of APOBEC-mediated RNA editing in SARS-CoV-2 mutations, replication and fitness
Kyumin Kim, Peter Calabrese, Shanshan Wang, Chao Qin, Youliang Rao, Pinghui Feng, Xiaojiang S. Chen
Sci Rep. 2022; 12: 14972. Published online 2022 Sep 13. doi: 10.1038/s41598-022-19067-x
PMCID:
PMC9470679
AbstractArticlePDF–5.8M
15.
Evaluation of APOBEC3 expression as prognostic marker in squamous cell carcinoma of the penis
Bettina Trimmel, Andre Oszwald, Christoph Diemand, Iris E. Ertl, Ursula Lemberger, Andreas Bruchbacher, Robert Brettner, Stephan Korn, Irene Resch, Eva Comperat, Shahrokh F. Shariat, Melanie R. Hassler
Sci Rep. 2022; 12: 12911. Published online 2022 Jul 28. doi: 10.1038/s41598-022-17056-8
PMCID:
PMC9334367
AbstractArticlePDF–2.2M
16.
Mechanisms of APOBEC3 mutagenesis in human cancer cells
Mia Petljak, Alexandra Dananberg, Kevan Chu, Erik N. Bergstrom, Josefine Striepen, Patrick von Morgen, Yanyang Chen, Hina Shah, Julian E. Sale, Ludmil B. Alexandrov, Michael R. Stratton, John Maciejowski
Nature. 2022; 607(7920): 799–807. Published online 2022 Jul 20. doi: 10.1038/s41586-022-04972-y
PMCID:
PMC9329121
AbstractArticlePDF–15M
17.
Prospectively defined patterns of APOBEC3A mutagenesis are prevalent in human cancers
Rachel A. DeWeerd, Eszter Németh, Ádám Póti, Nataliya Petryk, Chun-Long Chen, Olivier Hyrien, Dávid Szüts, Abby M. Green
Cell Rep. Author manuscript; available in PMC 2022 Jul 14.
Published in final edited form as: Cell Rep. 2022 Mar 22; 38(12): 110555. doi: 10.1016/j.celrep.2022.110555
PMCID:
PMC9283007
AbstractArticlePDF–2.2M
18.
APOBEC3A regulates transcription from interferon-stimulated response elements
Manabu Taura, John A. Frank, Takehiro Takahashi, Yong Kong, Eriko Kudo, Eric Song, Maria Tokuyama, Akiko Iwasaki
Proc Natl Acad Sci U S A. 2022 May 17; 119(20): e2011665119. Published online 2022 May 12. doi: 10.1073/pnas.2011665119
PMCID:
PMC9171812
AbstractArticlePDF–1.1M
19.
Induction of APOBEC3-mediated genomic damage in urothelium implicates BK polyomavirus (BKPyV) as a hit-and-run driver for bladder cancer
Simon C. Baker, Andrew S. Mason, Raphael G. Slip, Katie T. Skinner, Andrew Macdonald, Omar Masood, Reuben S. Harris, Tim R. Fenton, Manikandan Periyasamy, Simak Ali, Jennifer Southgate
Oncogene. 2022; 41(15): 2139–2151. Published online 2022 Feb 22. doi: 10.1038/s41388-022-02235-8
PMCID:
PMC8862006
AbstractArticlePDF–4.4M
20.
Two different kinds of interaction modes of deaminase APOBEC3A with single‐stranded DNA in solution detected by nuclear magnetic resonance
Yaping Liu, Wenxian Lan, Chunxi Wang, Chunyang Cao
Protein Sci. 2022 Feb; 31(2): 443–453. Published online 2021 Nov 26. doi: 10.1002/pro.4242
PMCID:
PMC8819843
AbstractArticlePDF–2.6M

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