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Select item 111964001.

Profibrogenic role of IL-15 through IL-15 receptor alpha-mediated trans-presentation in the carbon tetrachloride-induced liver fibrosis model

Maryse Cloutier, Bhavesh Variya, Sara Ali Akbari, Fjolla Rexhepi, Subburaj Ilangumaran, Sheela Ramanathan

Front Immunol. 2024; 15: 1404891. Published online 2024 Jun 11. doi: 10.3389/fimmu.2024.1404891

PMCID:: PMC11196400

Abstract Article PDF–4.8M

Select item 110308772.

Combination of IL-21 and IL-15 enhances tumour-specific cytotoxicity and cytokine production of TCR-transduced primary T cells

Nadine Pouw, Elike Treffers-Westerlaken, Jaco Kraan, Floyd Wittink, Timo ten Hagen, Jaap Verweij, Reno Debets

Cancer Immunol Immunother. 2010 Jun; 59(6): 921–931. Published online 2010 Jan 26. doi: 10.1007/s00262-010-0818-0

PMCID:: PMC11030877

Abstract Article PDF–536K

Select item 109400893.

p40 homodimers bridge ischemic tissue inflammation and heterologous alloimmunity in mice via IL-15 transpresentation

Hidetoshi Tsuda, Karen S. Keslar, William M. Baldwin, III, Peter S. Heeger, Anna Valujskikh, Robert L. Fairchild

J Clin Invest. 2024 Mar 15; 134(6): e172760. Published online 2024 Jan 25. doi: 10.1172/JCI172760

PMCID:: PMC10940089

Abstract Article PDF–3.3M

Select item 109176604.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 107126875.

Molecular mechanisms of snoRNA-IL15 crosstalk in adipocyte lipolysis and NK cell rejuvenation

Yaohua Zhang, Zilong Zhao, Lisa A. Huang, Yuan Liu, Yun Yao, Chengcao Sun, Yajuan Li, Zhao Zhang, Youqiong Ye, Fei Yuan, Tina K. Nguyen, Nikhil Reddy Garlapati, Andrew Wu, Sergey D. Egranov, Abigail S. Caudle, Aysegul A. Sahin, Bora Lim, Laura Beretta, George A. Calin, Dihua Yu, Mien-Chie Hung, Michael Curran, Katayoun Rezvani, Boyi Gan, Zhi Tan, Leng Han, Chunru Lin, Liuqing Yang

Cell Metab. Author manuscript; available in PMC 2024 Aug 8.

Published in final edited form as: Cell Metab. 2023 Aug 8; 35(8): 1457–1473.e13. Published online 2023 Jun 16. doi: 10.1016/j.cmet.2023.05.009

PMCID:: PMC10712687

Abstract Article PDF–4.7M

Select item 105244446.

MDM2 inhibition enhances immune checkpoint inhibitor efficacy by increasing IL-15 and MHC class II production

Marlene Langenbach, Sophie Giesler, Stefan Richtsfeld, Sara Costa-Pereira, Lukas Rindlisbacher, Tobias Wertheimer, Lukas M. Braun, Geoffroy Andrieux, Sandra Duquesne, Dietmar Pfeifer, Nadine M. Woessner, Hans D. Menssen, Sanaz Taromi, Justus Duyster, Melanie Börries, Tilman Brummer, Bruce R. Blazar, Susana Minguet, Patrick Turko, Mitchell P. Levesque, Burkhard Becher, Robert Zeiser

Mol Cancer Res. Author manuscript; available in PMC 2024 Feb 1.

Published in final edited form as: Mol Cancer Res. 2023 Aug 1; 21(8): 849–864. doi: 10.1158/1541-7786.MCR-22-0898

PMCID:: PMC10524444

Abstract Article PDF–3.0M

Select item 104480277.

Glucose oxidation-dependent survival of activated B cells provides a putative novel therapeutic target for lupus treatment

John J. Wilson, Jian Wei, Andrea R. Daamen, John D. Sears, Elaine Bechtel, Colleen L. Mayberry, Grace A. Stafford, Lesley Bechtold, Amrie C. Grammer, Peter E. Lipsky, Derry C. Roopenian, Chih-Hao Chang

iScience. 2023 Sep 15; 26(9): 107487. Published online 2023 Jul 27. doi: 10.1016/j.isci.2023.107487

PMCID:: PMC10448027

Abstract Article PDF–6.9M

Select item 102921218.

In vivo availability of the cytokine IL-7 constrains the survival and homeostasis of peripheral iNKT cells

Joo-Young Park, Hee Yeun Won, Devon T. DiPalma, Hye Kyung Kim, Tae-Hyoun Kim, Can Li, Noriko Sato, Changwan Hong, Ninan Abraham, Ronald E. Gress, Jung-Hyun Park

Cell Rep. Author manuscript; available in PMC 2023 Jun 26.

Published in final edited form as: Cell Rep. 2022 Jan 11; 38(2): 110219. doi: 10.1016/j.celrep.2021.110219

PMCID:: PMC10292121

Abstract Article PDF–2.8M

Select item 102168019.

An XBP1s–PIM-2 positive feedback loop controls IL-15–mediated survival of natural killer cells

Shoubao Ma, Jingjing Han, Zhenlong Li, Sai Xiao, Jianying Zhang, Jiazhuo Yan, Tingting Tang, Tasha Barr, Andrew S. Kraft, Michael A. Caligiuri, Jianhua Yu

Sci Immunol. Author manuscript; available in PMC 2023 May 26.

Published in final edited form as: Sci Immunol. 2023 Mar 17; 8(81): eabn7993. Published online 2023 Mar 10. doi: 10.1126/sciimmunol.abn7993

PMCID:: PMC10216801

Abstract Article PDF–2.2M

Select item 1019886710.

Evaluation of the clinical molecule anti-human-PD-L1/IL-15 KD033 in the human-PD-1/PD-L1-expressing murine model demonstrates PD-L1 targeting of IL-15 in vivo

Stella A. Martomo, Jeegar Patel

Cancer Immunol Immunother. 2023 Jun; 72(6): 1941–1950. Published online 2022 Dec 1. doi: 10.1007/s00262-022-03331-0

PMCID:: PMC10198867

Abstract Article PDF–4.0M

Select item 1014054711.

Myc controls NK cell development, IL-15-driven expansion, and translational machinery

Hanif J Khameneh, Nicolas Fonta, Alessandro Zenobi, Charlène Niogret, Pedro Ventura, Concetta Guerra, Ivo Kwee, Andrea Rinaldi, Matteo Pecoraro, Roger Geiger, Andrea Cavalli, Francesco Bertoni, Eric Vivier, Andreas Trumpp, Greta Guarda

Life Sci Alliance. 2023 Jul; 6(7): e202302069. Published online 2023 Apr 27. doi: 10.26508/lsa.202302069

PMCID:: PMC10140547

Abstract Article PDF–2.9M

Select item 949526112.

IL-2 and IL-15 drive intrathymic development of distinct periphery-seeding CD4⁺Foxp3⁺ regulatory T lymphocytes

Cécile Apert, Ariel O. Galindo-Albarrán, Sarah Castan, Claire Detraves, Héloise Michaud, Nicola McJannett, Bart Haegeman, Simon Fillatreau, Bernard Malissen, Georg Holländer, Saulius Žuklys, Jérémy C. Santamaria, Olivier P. Joffre, Paola Romagnoli, Joost P. M. van Meerwijk

Front Immunol. 2022; 13: 965303. Published online 2022 Sep 8. doi: 10.3389/fimmu.2022.965303

PMCID:: PMC9495261

Abstract Article PDF–6.3M

Select item 925010213.

Programme of Self-Reactive Innate-Like T Cell-Mediated Cancer Immunity

Chun Chou, Xian Zhang, Chirag Krishna, Briana G. Nixon, Saida Dadi, Kristelle J. Capistrano, Emily R. Kansler, Miranda Steele, Jian Han, Amy Shyu, Jing Zhang, Efstathios G. Stamatiades, Ming Liu, Shun Li, Mytrang H. Do, Davina S. Kang, Chin-Tung Chen, Iris H. Wei, Emmanouil P Pappou, Martin R. Weiser, J. Garcia-Aguilar, J. Joshua Smith, Christina S. Leslie, Ming O. Li

Nature. Author manuscript; available in PMC 2022 Jul 2.

Published in final edited form as: Nature. 2022 May; 605(7908): 139–145. Published online 2022 Apr 20. doi: 10.1038/s41586-022-04632-1

PMCID:: PMC9250102

Abstract Article PDF–7.2M

Select item 920250414.

Cytotoxic Innate Lymphoid Cells Sense Cancer Cell-Expressed Interleukin-15 to Suppress Human and Murine Malignancies

Emily R. Kansler, Saïda Dadi, Chirag Krishna, Briana G. Nixon, Efstathios G. Stamatiades, Ming Liu, Fengshen Kuo, Jing Zhang, Xian Zhang, Kristelle Capistrano, Kyle A. Blum, Kate Weiss, Ross M. Kedl, Guangwei Cui, Koichi Ikuta, Timothy A. Chan, Christina S. Leslie, A. Ari Hakimi, Ming O. Li

Nat Immunol. Author manuscript; available in PMC 2022 Dec 1.

Published in final edited form as: Nat Immunol. 2022 Jun; 23(6): 904–915. Published online 2022 May 26. doi: 10.1038/s41590-022-01213-2

Correction in:: Nat Immunol. 2022 Jun 15

PMCID:: PMC9202504

Abstract Article PDF–5.4M

Select item 904291215.

T cell receptor and IL-2 signaling strength control memory CD8⁺ T cell functional fitness via chromatin remodeling

Shu Shien Chin, Erik Guillen, Laurent Chorro, Sooraj Achar, Karina Ng, Susanne Oberle, Francesca Alfei, Dietmar Zehn, Grégoire Altan-Bonnet, Fabien Delahaye, Grégoire Lauvau

Nat Commun. 2022; 13: 2240. Published online 2022 Apr 26. doi: 10.1038/s41467-022-29718-2

PMCID:: PMC9042912

Abstract Article PDF–2.9M

Select item 889460216.

IL-15 Participates in the Pathogenesis of Polycystic Ovary Syndrome by Affecting the Activity of Granulosa Cells

Yan Liu, Zhi Li, Yang Wang, Qingqing Cai, Haiou Liu, Congjian Xu, Feifei Zhang

Front Endocrinol (Lausanne) 2022; 13: 787876. Published online 2022 Feb 18. doi: 10.3389/fendo.2022.787876

PMCID:: PMC8894602

Abstract Article PDF–7.7M

Select item 870317017.

IL-15Rα-Independent IL-15 Signaling in Non-NK Cell-Derived IFNγ Driven Control of Listeria monocytogenes

Madhuparna Nandi, Mitterrand Muamba Moyo, Sakina Orkhis, Jeanne Masunga Faida Mobulakani, Marc-André Limoges, Fjolla Rexhepi, Marian Mayhue, Anny Armas Cayarga, Gisela Cofino Marrero, Subburaj Ilangumaran, Alfredo Menendez, Sheela Ramanathan

Front Immunol. 2021; 12: 793918. Published online 2021 Dec 10. doi: 10.3389/fimmu.2021.793918

PMCID:: PMC8703170

Abstract Article PDF–7.5M

Select item 858373318.

IL-15 Prevents Renal Fibrosis by Inhibiting Collagen Synthesis: A New Pathway in Chronic Kidney Disease?

Aurore Devocelle, Lola Lecru, Sophie Ferlicot, Thomas Bessede, Jean-Jacques Candelier, Julien Giron-Michel, Hélène François

Int J Mol Sci. 2021 Nov; 22(21): 11698. Published online 2021 Oct 28. doi: 10.3390/ijms222111698

PMCID:: PMC8583733

Abstract Article PDF–4.2M

Select item 849804119.

Venetoclax or Ruxolitinib in Pre-Transplant Conditioning Lowers the Engraftment Barrier by Different Mechanisms in Allogeneic Stem Cell Transplant Recipients

Joanne E. Davis, Kelei Du, Mandy J. Ludford-Menting, Ashvind Prabahran, Eric Wong, Nicholas D. Huntington, Rachel M. Koldej, David S. Ritchie

Front Immunol. 2021; 12: 749094. Published online 2021 Sep 24. doi: 10.3389/fimmu.2021.749094

PMCID:: PMC8498041

Abstract Article PDF–1.4M

Select item 849365320.

Environmental activation of a hypothalamic BDNF-adipocyte IL-15 axis regulates adipose-natural killer cells

Stephen M. Bergin, Run Xiao, Wei Huang, Ryan T. Judd, Xianglan Liu, Anthony G. Mansour, Nicholas Queen, Kyle J. Widstrom, Michael A. Caligiuri, Lei Cao

Brain Behav Immun. Author manuscript; available in PMC 2022 Jul 1.

Published in final edited form as: Brain Behav Immun. 2021 Jul; 95: 477–488. Published online 2021 May 12. doi: 10.1016/j.bbi.2021.05.005

PMCID:: PMC8493653

Abstract Article PDF–1.8M

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