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Select item 111436071.

cFLIP in the molecular regulation of astroglia-driven neuroinflammation in experimental glaucoma

Xiangjun Yang, Qun Zeng, Maide Gözde İnam, Onur İnam, Chyuan-Sheng Lin, Gülgün Tezel

J Neuroinflammation. 2024; 21: 145. Published online 2024 Jun 1. doi: 10.1186/s12974-024-03141-4

PMCID:: PMC11143607

Abstract Article PDF–6.0M

Select item 109176602.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 105624923.

Fibroblast growth factor 18 stimulates the proliferation of hepatic stellate cells, thereby inducing liver fibrosis

Yuichi Tsuchiya, Takao Seki, Kenta Kobayashi, Sachiko Komazawa-Sakon, Shigeyuki Shichino, Takashi Nishina, Kyoko Fukuhara, Kenichi Ikejima, Hidenari Nagai, Yoshinori Igarashi, Satoshi Ueha, Akira Oikawa, Shinya Tsurusaki, Soh Yamazaki, Chiharu Nishiyama, Tetuo Mikami, Hideo Yagita, Ko Okumura, Taketomo Kido, Atsushi Miyajima, Kouji Matsushima, Mai Imasaka, Kimi Araki, Toru Imamura, Masaki Ohmuraya, Minoru Tanaka, Hiroyasu Nakano

Nat Commun. 2023; 14: 6304. Published online 2023 Oct 9. doi: 10.1038/s41467-023-42058-z

PMCID:: PMC10562492

Abstract Article PDF–15M

Select item 103710244.

Cleavage of cFLIP restrains cell death during viral infection and tissue injury and favors tissue repair

Kristel Martinez Lagunas, Deniz Pinar Savcigil, Matea Zrilic, Carlos Carvajal Fraile, Andrew Craxton, Emily Self, Iratxe Uranga-Murillo, Diego de Miguel, Maykel Arias, Sebastian Willenborg, Michael Piekarek, Marie Christine Albert, Kalvin Nugraha, Ina Lisewski, Erika Janakova, Natalia Igual, Wulf Tonnus, Ximena Hildebrandt, Mohammed Ibrahim, Marlies Ballegeer, Xavier Saelens, Andrew Kueh, Pascal Meier, Andreas Linkermann, Julian Pardo, Sabine Eming, Henning Walczak, Marion MacFarlane, Nieves Peltzer, Alessandro Annibaldi

Sci Adv. 2023 Jul; 9(30): eadg2829. Published online 2023 Jul 26. doi: 10.1126/sciadv.adg2829

PMCID:: PMC10371024

Abstract Article PDF–2.4M

Select item 101932305.

Mechanisms regulating the loss of Tregs in HUPO mice that develop spontaneous inflammatory arthritis

Qi-Quan Huang, Yiwei Hang, Renee Doyle, Qinwen Mao, Deyu Fang, Richard M. Pope

iScience. 2023 May 19; 26(5): 106734. Published online 2023 Apr 25. doi: 10.1016/j.isci.2023.106734

PMCID:: PMC10193230

Abstract Article PDF–5.2M

Select item 90145596.

Functional genomic landscape of cancer-intrinsic evasion of killing by T cells

Keith A. Lawson, Cristovão M. Sousa, Xiaoyu Zhang, Eiru Kim, Rummy Akthar, Joseph J. Caumanns, Yuxi Yao, Nicholas Mikolajewicz, Catherine Ross, Kevin R. Brown, Abdelrahman Abou Zid, Zi Peng Fan, Shirley Hui, Jordan A. Krall, Donald M. Simons, Chloe J. Slater, Victor De Jesus, Lujia Tang, Richa Singh, Joshua E. Goldford, Sarah Martin, Qian Huang, Elizabeth A. Francis, Andrea Habsid, Ryan Climie, David Tieu, Jiarun Wei, Ren Li, Amy Hin Yan Tong, Michael Aregger, Katherine S. Chan, Hong Han, Xiaowei Wang, Patricia Mero, John H. Brumell, Antonio Finelli, Laurie Ailles, Gary Bader, Gromoslaw A. Smolen, Gillian A. Kingsbury, Traver Hart, Charles Kung, Jason Moffat

Nature. Author manuscript; available in PMC 2022 Apr 18.

Published in final edited form as: Nature. 2020 Oct; 586(7827): 120–126. Published online 2020 Sep 23. doi: 10.1038/s41586-020-2746-2

PMCID:: PMC9014559

Abstract Article PDF–6.6M

Select item 87286277.

Bclaf1 regulates c‐FLIP expression and protects cells from TNF‐induced apoptosis and tissue injury

Rui Zhang, Teng Xue, Anwen Shao, Yue Lang, Chao Qin, Mingliang Zhao, Yu Kuang, Zhengquan Yu, Yunyun Geng, Chenyang Zhao, Jun Tang

EMBO Rep. 2022 Jan 5; 23(1): e52702. Published online 2021 Oct 25. doi: 10.15252/embr.202152702

PMCID:: PMC8728627

Abstract Article PDF–2.2M

Select item 84527658.

Oncogenic signaling inhibits c-FLIP_L expression and its non-apoptotic function during ECM-detachment

Matyas Abel Tsegaye, Jianping He, Kyle McGeehan, Ireland M. Murphy, Mati Nemera, Zachary T. Schafer

Sci Rep. 2021; 11: 18606. Published online 2021 Sep 20. doi: 10.1038/s41598-021-97715-4

PMCID:: PMC8452765

Abstract Article PDF–2.2M

Select item 82668079.

c-FLIP regulates autophagy by interacting with Beclin-1 and influencing its stability

Luana Tomaipitinca, Simonetta Petrungaro, Pasquale D’Acunzo, Angelo Facchiano, Amit Dubey, Salvatore Rizza, Federico Giulitti, Eugenio Gaudio, Antonio Filippini, Elio Ziparo, Francesco Cecconi, Claudia Giampietri

Cell Death Dis. 2021 Jul; 12(7): 686. Published online 2021 Jul 8. doi: 10.1038/s41419-021-03957-5

PMCID:: PMC8266807

Abstract Article PDF–2.1M

Select item 773586210.

Honokiol Alleviates Methionine-Choline Deficient Diet-Induced Hepatic Steatosis and Oxidative Stress in C57BL/6 Mice by Regulating CFLAR-JNK Pathway

Ting Zhai, Wei Xu, Yayun Liu, Kun Qian, Yanling Xiong, Yong Chen

Oxid Med Cell Longev. 2020; 2020: 2313641. Published online 2020 Nov 27. doi: 10.1155/2020/2313641

PMCID:: PMC7735862

Abstract Article PDF–1.9M

Select item 771787711.

hnRNPK knockdown alleviates NLRP3 inflammasome priming by repressing FLIP expression in Raw264.7 macrophages

Junxia Feng, Hongyan Li, Jingchun Li, Ping Meng, Lina Wang, Chunli Liu, Shili Zhao, Wei Sun, Yunfang Zhang

Redox Rep. 2020; 25(1): 104–111. Published online 2020 Dec 3. doi: 10.1080/13510002.2020.1857157

PMCID:: PMC7717877

Abstract Article PDF–1.2M

Select item 770065612.

TNF Is Partially Required for Cell-Death-Triggered Skin Inflammation upon Acute Loss of cFLIP

Maria Feoktistova, Roman Makarov, Martin Leverkus, Amir S. Yazdi, Diana Panayotova-Dimitrova

Int J Mol Sci. 2020 Nov; 21(22): 8859. Published online 2020 Nov 23. doi: 10.3390/ijms21228859

PMCID:: PMC7700656

Abstract Article PDF–2.8M

Select item 737525913.

cFLIP_L protects macrophages from LPS-induced pyroptosis via inhibition of complex II formation

Hayley I. Muendlein, David Jetton, Wilson M. Connolly, Keith P. Eidell, Zoie Magri, Irina Smirnova, Alexander Poltorak

Science. Author manuscript; available in PMC 2020 Jul 22.

Published in final edited form as: Science. 2020 Mar 20; 367(6484): 1379–1384. doi: 10.1126/science.aay3878

PMCID:: PMC7375259

Abstract Article PDF–1.6M

Select item 704444014.

c-FLIP is crucial for IL-7/IL-15-dependent NKp46⁺ ILC development and protection from intestinal inflammation in mice

Ute Bank, Katrin Deiser, Carlos Plaza-Sirvent, Lisa Osbelt, Amelie Witte, Laura Knop, Rebecca Labrenz, Robert Jänsch, Felix Richter, Aindrila Biswas, Ana C. Zenclussen, Eric Vivier, Chiara Romagnani, Anja A. Kühl, Ildiko R. Dunay, Till Strowig, Ingo Schmitz, Thomas Schüler

Nat Commun. 2020; 11: 1056. Published online 2020 Feb 26. doi: 10.1038/s41467-020-14782-3

PMCID:: PMC7044440

Abstract Article PDF–3.2M

Select item 674444115.

K63-linked ubiquitination regulates RIPK1 kinase activity to prevent cell death during embryogenesis and inflammation

Yong Tang, Hailin Tu, Jie Zhang, Xueqiang Zhao, Yini Wang, Jun Qin, Xin Lin

Nat Commun. 2019; 10: 4157. Published online 2019 Sep 13. doi: 10.1038/s41467-019-12033-8

PMCID:: PMC6744441

Abstract Article PDF–7.9M

Select item 667269216.

FLIP_L Protects Neurons against In Vivo Ischemia and In Vitro Glucose Deprivation-Induced Cell Death

Era Taoufik, Samuel Valable, Georg J. Müller, Michael L. Roberts, Didier Divoux, Antoine Tinel, Anda Voulgari-Kokota, Vivian Tseveleki, Fiorella Altruda, Hans Lassmann, Edwige Petit, Lesley Probert

J Neurosci. 2007 Jun 20; 27(25): 6633–6646. doi: 10.1523/JNEUROSCI.1091-07.2007

PMCID:: PMC6672692

Abstract Article PDF–829K

Select item 663261117.

The Death Receptor Antagonist FLIP-L Interacts with Trk and Is Necessary for Neurite Outgrowth Induced by Neurotrophins

Rana S. Moubarak, Carme Solé, Marta Pascual, Humberto Gutierrez, Marta Llovera, M. José Pérez-García, Raffaella Gozzelino, Miguel F. Segura, Victoria Iglesias-Guimarais, Stéphanie Reix, Rosa M. Soler, Alun M. Davies, Eduardo Soriano, Victor J. Yuste, Joan X. Comella

J Neurosci. 2010 Apr 28; 30(17): 6094–6105. doi: 10.1523/JNEUROSCI.0537-10.2010

PMCID:: PMC6632611

Abstract Article PDF–1.9M

Select item 654146418.

Control of antiviral innate immune response by protein geranylgeranylation

Shigao Yang, Alfred T. Harding, Catherine Sweeney, David Miao, Gregory Swan, Connie Zhou, Zhaozhao Jiang, Katherine A. Fitzgerald, Gianna Hammer, Martin O. Bergo, Heather K. Kroh, D. Borden Lacy, Chunxiang Sun, Michael Glogauer, Loretta G. Que, Nicholas S. Heaton, Donghai Wang

Sci Adv. 2019 May; 5(5): eaav7999. Published online 2019 May 29. doi: 10.1126/sciadv.aav7999

PMCID:: PMC6541464

Abstract Article PDF–2.7M

Select item 653896119.

Necroptosis of Intestinal Epithelial Cells Induces Type 3 Innate Lymphoid Cell-Dependent Lethal Ileitis

Ryodai Shindo, Masaki Ohmuraya, Sachiko Komazawa-Sakon, Sanae Miyake, Yutaka Deguchi, Soh Yamazaki, Takashi Nishina, Takayuki Yoshimoto, Soichiro Kakuta, Masato Koike, Yasuo Uchiyama, Hiroyuki Konishi, Hiroshi Kiyama, Tetuo Mikami, Kenta Moriwaki, Kimi Araki, Hiroyasu Nakano

iScience. 2019 May 31; 15: 536–551. Published online 2019 May 14. doi: 10.1016/j.isci.2019.05.011

PMCID:: PMC6538961

Abstract Article PDF–19M

Select item 646191920.

RIPK1 prevents TRADD-driven, but TNFR1 independent, apoptosis during development

Holly Anderton, Esther Bandala-Sanchez, Daniel S Simpson, James A Rickard, Ashley P Ng, Ladina Di Rago, Cathrine Hall, James E Vince, John Silke, Gianmaria Liccardi, Rebecca Feltham

Cell Death Differ. 2019 May; 26(5): 877–889. Published online 2018 Sep 5. doi: 10.1038/s41418-018-0166-8

Correction in:: Cell Death Differ. 2024 Nov 7

PMCID:: PMC6461919

Abstract Article PDF–6.5M

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PMC Links for GEO Profiles (Select 69439092) (83)
PMC
PREDICTED: Homo sapiens phosphatidylinositol-5-phosphate 4-kinase type 2 beta (P...
PREDICTED: Homo sapiens phosphatidylinositol-5-phosphate 4-kinase type 2 beta (PIP4K2B), transcript variant X6, mRNA
gi|2217314257|ref|XM_047436890.1|

Nucleotide
Homo sapiens phospholamban (PLN), mRNA
Homo sapiens phospholamban (PLN), mRNA
gi|1519242997|ref|NM_002667.5|

Nucleotide
unnamed protein product [Homo sapiens]
unnamed protein product [Homo sapiens]
gi|194386326|dbj|BAG59727.1|

Protein
Homo sapiens plexin B2 (PLXNB2), transcript variant 2, mRNA
Homo sapiens plexin B2 (PLXNB2), transcript variant 2, mRNA
gi|1777375923|ref|NM_001376865.1|

Nucleotide

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