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Items: 1 to 20 of 122

1.
Unspliced XBP1 contributes to cholesterol biosynthesis and tumorigenesis by stabilizing SREBP2 in hepatocellular carcinoma
Mankun Wei, Uli Nurjanah, Arin Herkilini, Can Huang, Yanjun Li, Makoto Miyagishi, Shourong Wu, Vivi Kasim
Cell Mol Life Sci. 2022 Sep; 79(9): 472. Published online 2022 Aug 6. doi: 10.1007/s00018-022-04504-x
PMCID:
PMC11073046
AbstractArticlePDF–14M
2.
ALOX15B controls macrophage cholesterol homeostasis via lipid peroxidation, ERK1/2 and SREBP2
Yvonne Benatzy, Megan A. Palmer, Dieter Lütjohann, Rei-Ichi Ohno, Nadja Kampschulte, Nils Helge Schebb, Dominik C. Fuhrmann, Ryan G. Snodgrass, Bernhard Brüne
Redox Biol. 2024 Jun; 72: 103149. Published online 2024 Apr 3. doi: 10.1016/j.redox.2024.103149
PMCID:
PMC11002893
AbstractArticlePDF–8.3M
3.
A single-nucleus transcriptomic atlas of primate liver aging uncovers the pro-senescence role of SREBP2 in hepatocytes
Shanshan Yang, Chengyu Liu, Mengmeng Jiang, Xiaoqian Liu, Lingling Geng, Yiyuan Zhang, Shuhui Sun, Kang Wang, Jian Yin, Shuai Ma, Si Wang, Juan Carlos Izpisua Belmonte, Weiqi Zhang, Jing Qu, Guang-Hui Liu
Protein Cell. 2024 Feb; 15(2): 98–120. Published online 2023 Jun 28. doi: 10.1093/procel/pwad039
PMCID:
PMC10833472
AbstractArticlePDF–31M
4.
Enhanced SREBP2-driven cholesterol biosynthesis by PKCλ/ι deficiency in intestinal epithelial cells promotes aggressive serrated tumorigenesis
Yu Muta, Juan F. Linares, Anxo Martinez-Ordoñez, Angeles Duran, Tania Cid-Diaz, Hiroto Kinoshita, Xiao Zhang, Qixiu Han, Yuki Nakanishi, Naoko Nakanishi, Thekla Cordes, Gurpreet K. Arora, Marc Ruiz-Martinez, Miguel Reina-Campos, Hiroaki Kasashima, Masakazu Yashiro, Kiyoshi Maeda, Ana Albaladejo-Gonzalez, Daniel Torres-Moreno, José García-Solano, Pablo Conesa-Zamora, Giorgio Inghirami, Christian M. Metallo, Timothy F. Osborne, Maria T. Diaz-Meco, Jorge Moscat
Nat Commun. 2023; 14: 8075. Published online 2023 Dec 13. doi: 10.1038/s41467-023-43690-5
PMCID:
PMC10719313
AbstractArticlePDF–7.4M
5.
Sterol regulatory element-binding protein 2 maintains glioblastoma stem cells by keeping the balance between cholesterol biosynthesis and uptake
Danling Gu, Fengqi Zhou, Hao You, Jiancheng Gao, Tao Kang, Deobrat Dixit, Qiulian Wu, Kailin Yang, Shusheng Ci, Danyang Shan, Xiao Fan, Wei Yuan, Qian Zhang, Chenfei Lu, Daqi Li, Ningwei Zhao, Zhumei Shi, Wei Gao, Fan Lin, Jianghong Man, Qianghu Wang, Xu Qian, Stephen C Mack, Weiwei Tao, Sameer Agnihotri, Nu Zhang, Yongping You, Jeremy N Rich, Junxia Zhang, Xiuxing Wang
Neuro Oncol. 2023 Sep; 25(9): 1578–1591. Published online 2023 Mar 19. doi: 10.1093/neuonc/noad060
PMCID:
PMC10651206
AbstractArticlePDF–11M
6.
Inhibiting sorting nexin 10 promotes mucosal healing through SREBP2-mediated stemness restoration of intestinal stem cells
Weilian Bao, Yan You, Jiahui Ni, Hui Hou, Jiaren Lyu, Guize Feng, Yirui Wang, Keyuan You, Sulin Zhang, Lijie Zhang, Xinyue Cao, Xu Wang, Haidong Li, Hong Li, Jiake Xu, Chenying Liu, Xiaomin Luo, Peng Du, Daofeng Chen, Xiaoyan Shen
Sci Adv. 2023 Sep; 9(35): eadh5016. Published online 2023 Aug 30. doi: 10.1126/sciadv.adh5016
Correction in:
Sci Adv. 2024 Apr 12; 10(15): eadp3968.
PMCID:
PMC10468130
AbstractArticlePDF–3.3M
7.
USP28 controls SREBP2 and the mevalonate pathway to drive tumour growth in squamous cancer
Carina R. Maier, Oliver Hartmann, Cristian Prieto-Garcia, Kamal M. Al-Shami, Lisa Schlicker, Felix C. E. Vogel, Silke Haid, Kevin Klann, Viktoria Buck, Christian Münch, Werner Schmitz, Elias Einig, Bastian Krenz, Marco A. Calzado, Martin Eilers, Nikita Popov, Mathias T. Rosenfeldt, Markus E. Diefenbacher, Almut Schulze
Cell Death Differ. 2023 Jul; 30(7): 1710–1725. Published online 2023 May 18. doi: 10.1038/s41418-023-01173-6
PMCID:
PMC10307777
AbstractArticlePDF–6.3M
8.
Parkin regulates neuronal lipid homeostasis through SREBP2-lipoprotein lipase pathway—implications for Parkinson’s disease
Willcyn Tang, John Thundyil, Grace Gui Yin Lim, Teddy J W Tng, Sean Qing Zhang Yeow, Aditya Nair, Chou Chai, Tso-Pang Yao, Kah-Leong Lim
Hum Mol Genet. 2023 May 1; 32(9): 1466–1482. Published online 2022 Nov 26. doi: 10.1093/hmg/ddac297
Correction in:
Hum Mol Genet. 2023 Jun 1; 32(11): 1943.
PMCID:
PMC10117165
AbstractArticlePDF–2.3M
9.
SREBF2–STARD4 axis confers sorafenib resistance in hepatocellular carcinoma by regulating mitochondrial cholesterol homeostasis
Xuetian Yue, Youzi Kong, Yankun Zhang, Min Sun, Shuyue Liu, Zhuanchang Wu, Lifen Gao, Xiaohong Liang, Chunhong Ma
Cancer Sci. 2023 Feb; 114(2): 477–489. Published online 2022 Dec 1. doi: 10.1111/cas.15449
PMCID:
PMC9899602
AbstractArticlePDF–17M
10.
Inflammatory stress signaling via NF-kB alters accessible cholesterol to upregulate SREBP2 transcriptional activity in endothelial cells
Joseph Wayne M Fowler, Rong Zhang, Bo Tao, Nabil E Boutagy, William C Sessa
eLife. 2022; 11: e79529. Published online 2022 Aug 12. doi: 10.7554/eLife.79529
PMCID:
PMC9395194
AbstractArticlePDF–4.6M
11.
TDP-43 regulates cholesterol biosynthesis by inhibiting sterol regulatory element-binding protein 2
Naohiro Egawa, Yuishin Izumi, Hidefumi Suzuki, Itaru Tsuge, Koji Fujita, Hitoshi Shimano, Keiichi Izumikawa, Nobuhiro Takahashi, Kayoko Tsukita, Takako Enami, Masahiro Nakamura, Akira Watanabe, Motoko Naitoh, Shigehiko Suzuki, Tsuneyoshi Seki, Kazuhiro Kobayashi, Tatsushi Toda, Ryuji Kaji, Ryosuke Takahashi, Haruhisa Inoue
Sci Rep. 2022; 12: 7988. Published online 2022 May 14. doi: 10.1038/s41598-022-12133-4
PMCID:
PMC9107471
AbstractArticlePDF–5.8M
12.
C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy
Bing-Ru Yan, Taoyingnan Li, Etienne Coyaud, Estelle M. N. Laurent, Jonathan St-Germain, Yuhuan Zhou, Peter K. Kim, Brian Raught, John H. Brumell
Autophagy. 2022; 18(4): 829–840. Published online 2021 Aug 25. doi: 10.1080/15548627.2021.1960116
PMCID:
PMC9037554
AbstractArticlePDF–4.1M
13.
SREBP2 promotes the viability, proliferation, and migration and inhibits apoptosis in TGF-β1-induced airway smooth muscle cells by regulating TLR2/NF-κB/NFATc1/ABCA1 regulatory network
Yuebin Wang, Huike Yang, Xian Su, Anqiang Cao, Feng Chen, Peng Chen, Fangtao Yan, Huirong Hu
Bioengineered. 2022; 13(2): 3137–3147. Published online 2022 Jan 17. doi: 10.1080/21655979.2022.2026550
PMCID:
PMC8973716
AbstractArticlePDF–3.8M
14.
LncCCAT1 interaction protein PKM2 upregulates SREBP2 phosphorylation to promote osteosarcoma tumorigenesis by enhancing the Warburg effect and lipogenesis
Feifei Pu, Jianxiang Liu, Doudou Jing, Fengxia Chen, Xin Huang, Deyao Shi, Wei Wu, Hui Lin, Lei Zhao, Zhenhao Zhang, Xiao Lv, Baichuan Wang, Zhicai Zhang, Zengwu Shao
Int J Oncol. 2022 Apr; 60(4): 44. Published online 2022 Mar 2. doi: 10.3892/ijo.2022.5334
PMCID:
PMC8923656
AbstractArticlePDF–2.8M
15.
Knocking down Sterol regulatory element binding protein 2 (SREBF2) inhibits the Serine Protease 8 (PRSS8) /sodium channel epithelial 1alpha subunit (SCNN1A) axis to reduce the cell proliferation, migration and epithelial-mesenchymal transformation of ovarian cancer
Chunyan Cai, Yumei Zhang, Xing Peng
Bioengineered. 2021; 12(2): 9390–9400. Published online 2021 Nov 25. doi: 10.1080/21655979.2021.1978615
PMCID:
PMC8809903
AbstractArticlePDF–2.9M
16.
TDP-43 mediates SREBF2-regulated gene expression required for oligodendrocyte myelination
Wan Yun Ho, Jer-Cherng Chang, Kenneth Lim, Amaury Cazenave-Gassiot, Aivi T. Nguyen, Juat Chin Foo, Sneha Muralidharan, Ashley Viera-Ortiz, Sarah J.M. Ong, Jin Hui Hor, Ira Agrawal, Shawn Hoon, Olubankole Aladesuyi Arogundade, Maria J. Rodriguez, Su Min Lim, Seung Hyun Kim, John Ravits, Shi-Yan Ng, Markus R. Wenk, Edward B. Lee, Greg Tucker-Kellogg, Shuo-Chien Ling
J Cell Biol. 2021 Sep 6; 220(9): e201910213. Published online 2021 Aug 4. doi: 10.1083/jcb.201910213
PMCID:
PMC8348376
AbstractArticlePDF–11M
17.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
18.
Qki activates Srebp2-mediated cholesterol biosynthesis for maintenance of eye lens transparency
Seula Shin, Hao Zhou, Chenxi He, Yanjun Wei, Yunfei Wang, Takashi Shingu, Ailiang Zeng, Shaobo Wang, Xin Zhou, Hongtao Li, Qiang Zhang, Qinling Mo, Jiafu Long, Fei Lan, Yiwen Chen, Jian Hu
Nat Commun. 2021; 12: 3005. Published online 2021 May 21. doi: 10.1038/s41467-021-22782-0
PMCID:
PMC8139980
AbstractArticlePDF–9.6M
19.
Impact of cytosine methylation on DNA binding specificities of human transcription factors
Yimeng Yin, Ekaterina Morgunova, Arttu Jolma, Eevi Kaasinen, Biswajyoti Sahu, Syed Khund-Sayeed, Pratyush K. Das, Teemu Kivioja, Kashyap Dave, Fan Zhong, Kazuhiro R. Nitta, Minna Taipale, Alexander Popov, Paul A. Ginno, Silvia Domcke, Jian Yan, Dirk Schübeler, Charles Vinson, Jussi Taipale
Science. Author manuscript; available in PMC 2021 Mar 30.
Published in final edited form as: Science. 2017 May 5; 356(6337): eaaj2239. doi: 10.1126/science.aaj2239
PMCID:
PMC8009048
AbstractArticlePDF–2.6M
20.
Identification of a degradation signal at the carboxy terminus of SREBP2: A new role for this domain in cholesterol homeostasis
Daniel L. Kober, Shimeng Xu, Shili Li, Bilkish Bajaj, Guosheng Liang, Daniel M. Rosenbaum, Arun Radhakrishnan
Proc Natl Acad Sci U S A. 2020 Nov 10; 117(45): 28080–28091. Published online 2020 Oct 26. doi: 10.1073/pnas.2018578117
PMCID:
PMC7668084
AbstractArticlePDF–1.2M

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