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Select item 110343551.

ZNF692 promotes osteosarcoma cell proliferation, migration, and invasion through TNK2-mediated activation of the MEK/ERK pathway

Di Zheng, Zhun Wei, Chong Zhang, Wenda Liu, Changtian Gong, Fei Wu, Weichun Guo

Biol Direct. 2024; 19: 28. Published online 2024 Apr 22. doi: 10.1186/s13062-024-00472-3

PMCID:: PMC11034355

Abstract Article PDF–15M

Select item 101938772.

ACKnowledging the role of the Activated-Cdc42 associated kinase (ACK) in regulating protein stability in cancer

Samantha Hodder, Millie Fox, Ana Masara Binti Ahmad Mokhtar, Helen R. Mott, Darerca Owen

Small GTPases. 2023; 14(1): 14–25. Published online 2023 May 16. doi: 10.1080/21541248.2023.2212573

PMCID:: PMC10193877

Abstract Article PDF–2.6M

Select item 100729063.

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong

Mol Cell. Author manuscript; available in PMC 2023 Apr 4.

Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015

PMCID:: PMC10072906

Abstract Article PDF–4.2M

Select item 100528384.

Biochemical Studies of Systemic Lupus Erythematosus-Associated Mutations in Nonreceptor Tyrosine Kinases Ack1 and Brk

Yagmur Kan, YiTing Paung, Yunyoung Kim, Markus A. Seeliger, W. Todd Miller

Biochemistry. Author manuscript; available in PMC 2023 Mar 29.

Published in final edited form as: Biochemistry. 2023 Mar 21; 62(6): 1124–1137. Published online 2023 Feb 28. doi: 10.1021/acs.biochem.2c00685

PMCID:: PMC10052838

Abstract Article PDF–1.1M

Select item 100474195.

Domain Architecture of the Nonreceptor Tyrosine Kinase Ack1

Yagmur Kan, YiTing Paung, Markus A. Seeliger, W. Todd Miller

Cells. 2023 Mar; 12(6): 900. Published online 2023 Mar 15. doi: 10.3390/cells12060900

PMCID:: PMC10047419

Abstract Article PDF–8.4M

Select item 99806976.

TNK2/ACK1-mediated phosphorylation of ATP5F1A (ATP synthase F1 subunit alpha) selectively augments survival of prostate cancer while engendering mitochondrial vulnerability

Surbhi Chouhan, Mithila Sawant, Cody Weimholt, Jingqin Luo, Robert W. Sprung, Mailyn Terrado, David M. Mueller, H. Shelton Earp, Nupam P. Mahajan

Autophagy. 2023; 19(3): 1000–1025. Published online 2022 Jul 27. doi: 10.1080/15548627.2022.2103961

PMCID:: PMC9980697

Abstract Article PDF–6.9M

Select item 98793037.

Activity of the nonreceptor tyrosine kinase Ack1 is regulated by tyrosine phosphorylation of its Mig6 homology region

Yağmur Kan, W. Todd Miller

FEBS Lett. Author manuscript; available in PMC 2023 Jan 26.

Published in final edited form as: FEBS Lett. 2022 Nov; 596(21): 2808–2820. Published online 2022 Oct 5. doi: 10.1002/1873-3468.14505

PMCID:: PMC9879303

Abstract Article PDF–1.1M

Select item 97337518.

ACK1 upregulated the proliferation of head and neck squamous cell carcinoma cells by promoting p27 phosphorylation and degradation

Hsuan-Hsiang Peng, Hao-Chin Yang, Darius Rupa, Chun-Han Yen, Ya-Wen Chiu, Wei-Jia Yang, Fuh-Jinn Luo, Ta-Chun Yuan

J Cell Commun Signal. 2022 Dec; 16(4): 567–578. Published online 2022 Mar 5. doi: 10.1007/s12079-022-00670-6

PMCID:: PMC9733751

Abstract Article PDF–2.5M

Select item 92626149.

A dual-activity topoisomerase complex regulates mRNA translation and turnover

Shuaikun Su, Yutong Xue, Alexei Sharov, Yongqing Zhang, Seung Kyu Lee, Jennifer L Martindale, Wen Li, Wai Lim Ku, Keji Zhao, Supriyo De, Weiping Shen, Payel Sen, Myriam Gorospe, Dongyi Xu, Weidong Wang

Nucleic Acids Res. 2022 Jul 8; 50(12): 7013–7033. Published online 2022 Jun 24. doi: 10.1093/nar/gkac538

PMCID:: PMC9262614

Abstract Article PDF–3.6M

Select item 912737110.

Assembly of nuclear dimers of PI3K regulatory subunits is regulated by the Cdc42-activated tyrosine kinase ACK

Natasha S. Clayton, Millie Fox, Jose J. Vicenté-Garcia, Courtney M. Schroeder, Trevor D. Littlewood, Jonathon I. Wilde, Kadalmani Krishnan, Murray J.B. Brown, Claire Crafter, Helen R. Mott, Darerca Owen

J Biol Chem. 2022 Jun; 298(6): 101916. Published online 2022 Apr 13. doi: 10.1016/j.jbc.2022.101916

PMCID:: PMC9127371

Abstract Article PDF–2.6M

Select item 876907211.

Proteome‐scale mapping of binding sites in the unstructured regions of the human proteome

Caroline Benz, Muhammad Ali, Izabella Krystkowiak, Leandro Simonetti, Ahmed Sayadi, Filip Mihalic, Johanna Kliche, Eva Andersson, Per Jemth, Norman E Davey, Ylva Ivarsson

Mol Syst Biol. 2022 Jan; 18(1): e10584. Published online 2022 Jan 19. doi: 10.15252/msb.202110584

PMCID:: PMC8769072

Abstract Article PDF–2.9M

Select item 849099712.

BioID reveals an ATG9A interaction with ATG13‐ATG101 in the degradation of p62/SQSTM1‐ubiquitin clusters

Ashari R Kannangara, Daniel M Poole, Colten M McEwan, Joshua C Youngs, Vajira K Weerasekara, Alex M Thornock, Misael T Lazaro, Eranga R Balasooriya, Laura M Oh, Erik J Soderblom, Jonathan J Lee, Daniel L Simmons, Joshua L Andersen

EMBO Rep. 2021 Oct 5; 22(10): e51136. Published online 2021 Aug 9. doi: 10.15252/embr.202051136

PMCID:: PMC8490997

Abstract Article PDF–4.5M

Select item 842113913.

TDRD3 promotes DHX9 chromatin recruitment and R-loop resolution

Wei Yuan, Qais Al-Hadid, Zhihao Wang, Lei Shen, Hyejin Cho, Xiwei Wu, Yanzhong Yang

Nucleic Acids Res. 2021 Sep 7; 49(15): 8573–8591. Published online 2021 Jul 30. doi: 10.1093/nar/gkab642

PMCID:: PMC8421139

Abstract Article PDF–5.1M

Select item 816503014.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 795800515.

TNK2 promoted esophageal cancer progression via activating egfr‐akt signaling

Anqing Zhang, Rongxin Zhang, Zhiming Yang, Rui Tian

J Clin Lab Anal. 2021 Mar; 35(3): e23700. Published online 2021 Jan 23. doi: 10.1002/jcla.23700

PMCID:: PMC7958005

Abstract Article PDF–404K

Select item 790614816.

Identification of downstream signaling cascades of ACK1 and prognostic classifiers in non-small cell lung cancer

Jinhong Zhu, Yang Liu, Meng Zhao, Kui Cao, Jianqun Ma, Shiyun Peng

Aging (Albany NY) 2021 Feb 15; 13(3): 4482–4502. Published online 2021 Jan 20. doi: 10.18632/aging.202408

PMCID:: PMC7906148

Abstract Article PDF–4.9M

Select item 742732717.

Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases

Marija Buljan, Rodolfo Ciuffa, Audrey van Drogen, Anton Vichalkovski, Martin Mehnert, George Rosenberger, Sohyon Lee, Markku Varjosalo, Lucia Espona Pernas, Vincent Spegg, Berend Snijder, Ruedi Aebersold, Matthias Gstaiger

Mol Cell. 2020 Aug 6; 79(3): 504–520.e9. doi: 10.1016/j.molcel.2020.07.001

PMCID:: PMC7427327

Abstract Article

Select item 716998318.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 698120619.

Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS^G13D

Susan A. Kennedy, Mohamed-Ali Jarboui, Sriganesh Srihari, Cinzia Raso, Kenneth Bryan, Layal Dernayka, Theodosia Charitou, Manuel Bernal-Llinares, Carlos Herrera-Montavez, Aleksandar Krstic, David Matallanas, Max Kotlyar, Igor Jurisica, Jasna Curak, Victoria Wong, Igor Stagljar, Thierry LeBihan, Lisa Imrie, Priyanka Pillai, Miriam A. Lynn, Erik Fasterius, Cristina Al-Khalili Szigyarto, James Breen, Christina Kiel, Luis Serrano, Nora Rauch, Oleksii Rukhlenko, Boris N. Kholodenko, Luis F. Iglesias-Martinez, Colm J. Ryan, Ruth Pilkington, Patrizia Cammareri, Owen Sansom, Steven Shave, Manfred Auer, Nicola Horn, Franziska Klose, Marius Ueffing, Karsten Boldt, David J. Lynn, Walter Kolch

Nat Commun. 2020; 11: 499. Published online 2020 Jan 24. doi: 10.1038/s41467-019-14224-9

PMCID:: PMC6981206

Abstract Article PDF–3.7M

Select item 690421220.

Entry by multiple picornaviruses is dependent on a pathway that includes TNK2, WASL, and NCK1

Hongbing Jiang, Christian Leung, Stephen Tahan, David Wang

eLife. 2019; 8: e50276. Published online 2019 Nov 26. doi: 10.7554/eLife.50276

PMCID:: PMC6904212

Abstract Article PDF–2.3M

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