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Select item 106415241.

Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis

Robert S. Kiss, Jarred Chicoine, Youssef Khalil, Robert Sladek, He Chen, Alessandro Pisaturo, Cyril Martin, Jessica D. Dale, Tegan A. Brudenell, Archith Kamath, Jeffrey Kyei-Boahen, Anouar Hafiane, Girija Daliah, Célia Alecki, Tayah S. Hopes, Martin Heier, Irene A. Aligianis, Jean-Jacques Lebrun, Julie Aspden, Emanuele Paci, Anja Kerksiek, Dieter Lütjohann, Peter Clayton, Jimi C. Wills, Alex von Kriegsheim, Tommy Nilsson, Eamonn Sheridan, Mark T. Handley

J Biol Chem. 2023 Nov; 299(11): 105295. Published online 2023 Sep 28. doi: 10.1016/j.jbc.2023.105295

PMCID:: PMC10641524

Abstract Article PDF–3.8M

Select item 106277862.

ESYT1 tethers the ER to mitochondria and is required for mitochondrial lipid and calcium homeostasis

Alexandre Janer, Jordan L Morris, Michiel Krols, Hana Antonicka, Mari J Aaltonen, Zhen-Yuan Lin, Hanish Anand, Anne-Claude Gingras, Julien Prudent, Eric A Shoubridge

Life Sci Alliance. 2024 Jan; 7(1): e202302335. Published online 2023 Nov 6. doi: 10.26508/lsa.202302335

PMCID:: PMC10627786

Abstract Article PDF–5.2M

Select item 104067143.

TRIM64 promotes ox-LDL-induced foam cell formation, pyroptosis, and inflammation in THP-1-derived macrophages by activating a feedback loop with NF-κB via IκBα ubiquitination

Chao Zhu, Wei Chen, Haiming Cui, Zhigang Huang, Ru Ding, Na Li, Qinqin Wang, Feng Wu, Yanmin Zhao, Xiaoliang Cong

Cell Biol Toxicol. 2023; 39(3): 607–620. Published online 2022 Oct 14. doi: 10.1007/s10565-022-09768-4

PMCID:: PMC10406714

Abstract Article PDF–6.6M

Select item 102841174.

Exploring an Alternative Cysteine-Reactive Chemistry to Enable Proteome-Wide PPI Analysis by Cross-Linking Mass Spectrometry

Fenglong Jiao, Leah J. Salituro, Clinton Yu, Craig B. Gutierrez, Scott D. Rychnovsky, Lan Huang

Anal Chem. Author manuscript; available in PMC 2023 Jun 21.

Published in final edited form as: Anal Chem. 2023 Jan 31; 95(4): 2532–2539. Published online 2023 Jan 18. doi: 10.1021/acs.analchem.2c04986

PMCID:: PMC10284117

Abstract Article PDF–2.5M

Select item 102374225.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 101645646.

The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing

Yingxiao Chen, Yanping Li, Roselyn S Dai, Jonathan C Savage, Ujwal Shinde, John Klimek, Larry L David, Emma A Young, Markus Hafner, Rosalie C Sears, Xiao-Xin Sun, Mu-Shui Dai

Nucleic Acids Res. 2023 May 8; 51(8): 3934–3949. Published online 2023 Mar 13. doi: 10.1093/nar/gkad140

PMCID:: PMC10164564

Abstract Article PDF–3.8M

Select item 101516157.

Cross-linking mass spectrometry discovers, evaluates, and corroborates structures and protein–protein interactions in the human cell

Tara K. Bartolec, Xabier Vázquez-Campos, Alexander Norman, Clement Luong, Marcus Johnson, Richard J. Payne, Marc R. Wilkins, Joel P. Mackay, Jason K. K. Low

Proc Natl Acad Sci U S A. 2023 Apr 25; 120(17): e2219418120. Published online 2023 Apr 18. doi: 10.1073/pnas.2219418120

PMCID:: PMC10151615

Abstract Article PDF–2.9M

Select item 100729068.

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong

Mol Cell. Author manuscript; available in PMC 2023 Apr 4.

Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015

PMCID:: PMC10072906

Abstract Article PDF–4.2M

Select item 100254259.

Protein interaction studies in human induced neurons indicate convergent biology underlying autism spectrum disorders

Greta Pintacuda, Yu-Han H. Hsu, Kalliopi Tsafou, Ka Wan Li, Jacqueline M. Martín, Jackson Riseman, Julia C. Biagini, Joshua K.T. Ching, Daya Mena, Miguel A. Gonzalez-Lozano, Shawn B. Egri, Jake Jaffe, August B. Smit, Nadine Fornelos, Kevin C. Eggan, Kasper Lage

Cell Genom. 2023 Mar 8; 3(3): 100250. Published online 2023 Jan 24. doi: 10.1016/j.xgen.2022.100250

PMCID:: PMC10025425

Abstract Article PDF–22M

Select item 1000589810.

The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA

Ellis G. Jaffray, Michael H. Tatham, Barbara Mojsa, Magda Liczmanska, Alejandro Rojas-Fernandez, Yili Yin, Graeme Ball, Ronald T. Hay

J Cell Biol. 2023 Apr 3; 222(4): e202201027. Published online 2023 Feb 28. doi: 10.1083/jcb.202201027

PMCID:: PMC10005898

Abstract Article PDF–6.7M

Select item 999012011.

Interactomes of Glycogen Synthase Kinase-3 Isoforms

Kevin W. Cormier, Brett Larsen, Anne-Claude Gingras, James R. Woodgett

J Proteome Res. 2023 Mar 3; 22(3): 977–989. Published online 2023 Feb 13. doi: 10.1021/acs.jproteome.2c00825

PMCID:: PMC9990120

Abstract Article PDF–3.7M

Select item 997119512.

CEMIP, acting as a scaffold protein for bridging GRAF1 and MIB1, promotes colorectal cancer metastasis via activating CDC42/MAPK pathway

Guojie Xu, Lei Zhao, Qingling Hua, Lanqing Wang, Hongli Liu, Zhenyu Lin, Min Jin, Jing Wang, Pengfei Zhou, Kunyu Yang, Gang Wu, Dandan Yu, Dejun Zhang, Tao Zhang

Cell Death Dis. 2023 Feb; 14(2): 167. Published online 2023 Feb 27. doi: 10.1038/s41419-023-05644-z

PMCID:: PMC9971195

Abstract Article PDF–15M

Select item 995044713.

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma

Yu-Fei Cao, Lei Xie, Bei-Bei Tong, Man-Yu Chu, Wen-Qi Shi, Xiang Li, Jian-Zhong He, Shao-Hong Wang, Zhi-Yong Wu, Dan-Xia Deng, Ya-Qi Zheng, Zhi-Mao Li, Xiu-E Xu, Lian-Di Liao, Yin-Wei Cheng, Li-Yan Li, Li-Yan Xu, En-Min Li

Cell Death Differ. 2023 Feb; 30(2): 527–543. Published online 2022 Dec 16. doi: 10.1038/s41418-022-01104-x

PMCID:: PMC9950447

Abstract Article PDF–8.4M

Select item 994041914.

ER ribosomal-binding protein 1 regulates blood pressure and potassium homeostasis by modulating intracellular renin trafficking

Chu-Hsuan Chiu, Chin-Feng Hsuan, Shih-Hua Lin, Yi-Jen Hung, Chii-Min Hwu, Siow-Wey Hee, Shu-Wha Lin, Sitt-Wai Fong, Patrick Ching-Ho Hsieh, Wei-Shun Yang, Wei-Chou Lin, Hsiao-Lin Lee, Meng-Lun Hsieh, Wen-Yi Li, Jou-Wei Lin, Chih-Neng Hsu, Vin-Cent Wu, Gwo-Tsann Chuang, Yi-Cheng Chang, Lee-Ming Chuang

J Biomed Sci. 2023; 30: 13. Published online 2023 Feb 19. doi: 10.1186/s12929-023-00905-7

PMCID:: PMC9940419

Abstract Article PDF–5.7M

Select item 992246815.

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia

Xiao-Na Zhu, Yu-Sheng Wei, Qian Yang, Hao-Ran Liu, Zhe Zhi, Di Zhu, Li Xia, Deng-Li Hong, Yun Yu, Guo-Qiang Chen

J Hematol Oncol. 2023; 16: 9. Published online 2023 Feb 11. doi: 10.1186/s13045-023-01400-0

PMCID:: PMC9922468

Abstract Article PDF–4.9M

Select item 979798816.

TBK1 posphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1

Jianwen Zhou, Nikoline Lander Rasmussen, Hallvard Lauritz Olsvik, Vyacheslav Akimov, Zehan Hu, Gry Evjen, Stéphanie Kaeser-Pebernard, Devanarayanan Siva Sankar, Carole Roubaty, Pauline Verlhac, Nicole van de Beek, Fulvio Reggiori, Yakubu Princely Abudu, Blagoy Blagoev, Trond Lamark, Terje Johansen, Jörn Dengjel

J Cell Biol. 2023 Feb 6; 222(2): e202108144. Published online 2022 Dec 27. doi: 10.1083/jcb.202108144

PMCID:: PMC9797988

Abstract Article PDF–6.9M

Select item 977255817.

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation

Jingsheng Yuan, Tao Lv, Jian Yang, Zhenru Wu, Lvnan Yan, Jiayin Yang, Yujun Shi, Li Jiang

Cell Mol Gastroenterol Hepatol. 2023; 15(2): 307–325. Published online 2022 Oct 14. doi: 10.1016/j.jcmgh.2022.10.005

PMCID:: PMC9772558

Abstract Article PDF–8.2M

Select item 976969818.

A whole genome CRISPR screen identifies AHR loss as a mechanism of resistance to a PARP7 inhibitor

Huadong Chen, Morgan E. Diolaiti, Patrick C. O’Leary, Ajda Rojc, Nevan J. Krogan, Minkyu Kim, Alan Ashworth

Mol Cancer Ther. Author manuscript; available in PMC 2023 Jan 5.

Published in final edited form as: Mol Cancer Ther. 2022 Jul 5; 21(7): 1076–1089. doi: 10.1158/1535-7163.MCT-21-0841

PMCID:: PMC9769698

Abstract Article PDF–2.7M

Select item 970808619.

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers

Martina Oravcová, Minghua Nie, Nicola Zilio, Shintaro Maeda, Yasaman Jami-Alahmadi, Eros Lazzerini-Denchi, James A Wohlschlegel, Helle D Ulrich, Takanori Otomo, Michael N Boddy

eLife. 2022; 11: e79676. Published online 2022 Nov 14. doi: 10.7554/eLife.79676

PMCID:: PMC9708086

Abstract Article PDF–8.5M

Select item 956995520.

A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation

Yulemi Gonzalez Quesada, Luc DesGroseillers

Int J Mol Sci. 2022 Oct; 23(19): 11588. Published online 2022 Sep 30. doi: 10.3390/ijms231911588

PMCID:: PMC9569955

Abstract Article PDF–2.1M

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