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Select item 111937601.

Topography of the GLP-1/GLP-1 receptor system in the spinal cord of male mice

Yvette Ruska, Andrea Csibi, Beáta Dorogházi, Anett Szilvásy-Szabó, Petra Mohácsik, Zsuzsanna Környei, Ádám Dénes, Andrea Kádár, Zita Puskár, Erik Hrabovszky, Balázs Gereben, Gábor Wittmann, Csaba Fekete

Sci Rep. 2024; 14: 14403. Published online 2024 Jun 22. doi: 10.1038/s41598-024-65442-1

PMCID:: PMC11193760

Abstract Article PDF–3.5M

Select item 111801882.

Intra-islet α-cell Gs signaling promotes glucagon release

Liu Liu, Kimberley El, Diptadip Dattaroy, Luiz F. Barella, Yinghong Cui, Sarah M. Gray, Carla Guedikian, Min Chen, Lee S. Weinstein, Emily Knuth, Erli Jin, Matthew J. Merrins, Jeffrey Roman, Klaus H. Kaestner, Nicolai Doliba, Jonathan E. Campbell, Jürgen Wess

Nat Commun. 2024; 15: 5129. Published online 2024 Jun 15. doi: 10.1038/s41467-024-49537-x

Correction in:: Nat Commun. 2024; 15: 6383.

PMCID:: PMC11180188

Abstract Article PDF–3.0M

Select item 110580533.

Differential CpG methylation at Nnat in the early establishment of beta cell heterogeneity

Vanessa Yu, Fiona Yong, Angellica Marta, Sanjay Khadayate, Adrien Osakwe, Supriyo Bhattacharya, Sneha S. Varghese, Pauline Chabosseau, Sayed M. Tabibi, Keran Chen, Eleni Georgiadou, Nazia Parveen, Mara Suleiman, Zoe Stamoulis, Lorella Marselli, Carmela De Luca, Marta Tesi, Giada Ostinelli, Luis Delgadillo-Silva, Xiwei Wu, Yuki Hatanaka, Alex Montoya, James Elliott, Bhavik Patel, Nikita Demchenko, Chad Whilding, Petra Hajkova, Pavel Shliaha, Holger Kramer, Yusuf Ali, Piero Marchetti, Robert Sladek, Sangeeta Dhawan, Dominic J. Withers, Guy A. Rutter, Steven J. Millership

Diabetologia. 2024; 67(6): 1079–1094. Published online 2024 Mar 21. doi: 10.1007/s00125-024-06123-6

PMCID:: PMC11058053

Abstract Article PDF–7.7M

Select item 110084824.

The crucial relationship between miRNA-27 and CSE/H₂S, and the mechanism of action of GLP-1 in myocardial hypertrophy

Shan Gao, Ying Li, Mei-ming Liu, Xue Xiong, Chang-peng Cui, Qing-ji Huo, Ke-xin Li, Xun Sun, Rong Zhang, Di Wu, Bai-yan Li

Int J Med Sci. 2024; 21(5): 965–977. Published online 2024 Mar 31. doi: 10.7150/ijms.93720

PMCID:: PMC11008482

Abstract Article PDF–5.6M

Select item 109453495.

NPC1 is required for postnatal islet β cell differentiation by maintaining mitochondria turnover

Bei Liu, Duanyi Hua, Linyan Shen, Tingting Li, Zheying Tao, Chenyang Fu, Zhongzheng Tang, Jie Yang, Li Zhang, Aifang Nie, Yiran Jiang, Jiqiu Wang, Yang Li, Yanyun Gu, Guang Ning

Theranostics. 2024; 14(5): 2058–2074. Published online 2024 Feb 24. doi: 10.7150/thno.90946

PMCID:: PMC10945349

Abstract Article PDF–9.7M

Select item 109194476.

Paracrine signaling by pancreatic δ cells determines the glycemic set point in mice

Jessica L Huang, Mohammad S Pourhosseinzadeh, Sharon Lee, Niels Krämer, Jaresley V Guillen, Naomi H Cinque, Paola Aniceto, Ariana T Momen, Shinichiro Koike, Mark O Huising

Nat Metab. Author manuscript; available in PMC 2024 Mar 7.

Published in final edited form as: Nat Metab. 2024 Jan; 6(1): 61–77. Published online 2024 Jan 9. doi: 10.1038/s42255-023-00944-2

PMCID:: PMC10919447

Abstract Article PDF–4.6M

Select item 109176607.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 108509718.

Renal tubule-specific Atgl deletion links kidney lipid metabolism to glucagon-like peptide 1 and insulin secretion independent of renal inflammation or lipotoxicity

Maria F. Fernandes, Juan J. Aristizabal-Henao, Phillip M. Marvyn, Iman M'Hiri, Meghan A. Wiens, Monica Hoang, Manuel Sebastian, Renato Nachbar, Philippe St-Pierre, Kalsha Diaguarachchige De Silva, Geoffrey A. Wood, Jamie W. Joseph, Christine A. Doucette, André Marette, Ken D. Stark, Robin E. Duncan

Mol Metab. 2024 Mar; 81: 101887. Published online 2024 Jan 26. doi: 10.1016/j.molmet.2024.101887

PMCID:: PMC10850971

Abstract Article PDF–2.5M

Select item 107001409.

Sequential appetite suppression by oral and visceral feedback to the brainstem

Truong Ly, Jun Y. Oh, Nilla Sivakumar, Sarah Shehata, Naymalis La Santa Medina, Heidi Huang, Zhengya Liu, Wendy Fang, Chris Barnes, Naz Dundar, Brooke C. Jarvie, Anagh Ravi, Olivia K. Barnhill, Chelsea Li, Grace R. Lee, Jaewon Choi, Heeun Jang, Zachary A. Knight

Nature. 2023; 624(7990): 130–137. Published online 2023 Nov 22. doi: 10.1038/s41586-023-06758-2

PMCID:: PMC10700140

Abstract Article PDF–19M

Select item 1067029110.

ATF4 May Be Essential for Adaption of the Ocular Lens to Its Avascular Environment

Jiawen Xiang, Anthony J. Pompetti, Adam P. Faranda, Yan Wang, Samuel G. Novo, David Wan-Cheng Li, Melinda K. Duncan

Cells. 2023 Nov; 12(22): 2636. Published online 2023 Nov 16. doi: 10.3390/cells12222636

PMCID:: PMC10670291

Abstract Article PDF–9.2M

Select item 1049284211.

NEUROD1 reinforces endocrine cell fate acquisition in pancreatic development

Romana Bohuslavova, Valeria Fabriciova, Ondrej Smolik, Laura Lebrón-Mora, Pavel Abaffy, Sarka Benesova, Daniel Zucha, Lukas Valihrach, Zuzana Berkova, Frantisek Saudek, Gabriela Pavlinkova

Nat Commun. 2023; 14: 5554. Published online 2023 Sep 9. doi: 10.1038/s41467-023-41306-6

PMCID:: PMC10492842

Abstract Article PDF–15M

Select item 1048242912.

Coordination between ECM and cell-cell adhesion regulates the development of islet aggregation, architecture, and functional maturation

Wilma Tixi, Maricela Maldonado, Ya-Ting Chang, Amy Chiu, Wilson Yeung, Nazia Parveen, Michael S Nelson, Ryan Hart, Shihao Wang, Wu Jih Hsu, Patrick Fueger, Janel L Kopp, Mark O Huising, Sangeeta Dhawan, Hung Ping Shih

eLife. 2023; 12: e90006. Published online 2023 Aug 23. doi: 10.7554/eLife.90006

PMCID:: PMC10482429

Abstract Article PDF–26M

Select item 1044847413.

The SSBP3 co-regulator is required for glucose homeostasis, pancreatic islet architecture, and beta-cell identity

Eliana Toren, Jessica D. Kepple, Kristen V. Coutinho, Samuel O. Poole, Iztiba M. Deeba, Tanya H. Pierre, Yanping Liu, Maigen M. Bethea, Chad S. Hunter

Mol Metab. 2023 Oct; 76: 101785. Published online 2023 Aug 1. doi: 10.1016/j.molmet.2023.101785

PMCID:: PMC10448474

Abstract Article PDF–4.8M

Select item 1039319314.

Major β cell-specific functions of NKX2.2 are mediated via the NK2-specific domain

Vladimir Abarinov, Joshua A. Levine, Angela J. Churchill, Bryce Hopwood, Cailin S. Deiter, Michelle A. Guney, Kristen L. Wells, Jessica M. Schrunk, Yuchun Guo, Jennifer Hammelman, David K. Gifford, Mark A. Magnuson, Hynek Wichterle, Lori Sussel

Genes Dev. 2023 Jun 1; 37(11-12): 490–504. doi: 10.1101/gad.350569.123

PMCID:: PMC10393193

Abstract Article PDF–22M

Select item 1025300215.

TCF7L1 Controls the Differentiation of Tuft Cells in Mouse Small Intestine

Valeriya V. Zinina, Melanie Sauer, Lira Nigmatullina, Nastasja Kreim, Natalia Soshnikova

Cells. 2023 Jun; 12(11): 1452. Published online 2023 May 23. doi: 10.3390/cells12111452

PMCID:: PMC10253002

Abstract Article PDF–2.4M

Select item 1023325116.

Alpha Cell Thioredoxin-interacting Protein Deletion Improves Diabetes-associated Hyperglycemia and Hyperglucagonemia

Brian Lu, Junqin Chen, Guanlan Xu, Truman B Grayson, Gu Jing, SeongHo Jo, Anath Shalev

Endocrinology. 2022 Nov; 163(11): bqac133. Published online 2022 Aug 12. doi: 10.1210/endocr/bqac133

PMCID:: PMC10233251

Abstract Article

Select item 1021275217.

The local GLP-1 system in the olfactory bulb is required for odor-evoked cephalic phase of insulin release in mice

Mireia Montaner, Jessica Denom, Wanqing Jiang, Christophe Magnan, Stefan Trapp, Hirac Gurden

Mol Metab. 2023 Jul; 73: 101738. Published online 2023 May 13. doi: 10.1016/j.molmet.2023.101738

PMCID:: PMC10212752

Abstract Article PDF–1.4M

Select item 1014760418.

USP7 controls NGN3 stability and pancreatic endocrine lineage development

Teodora Manea, Jessica Kristine Nelson, Cristina Maria Garrone, Karin Hansson, Ian Evans, Axel Behrens, Rocio Sancho

Nat Commun. 2023; 14: 2457. Published online 2023 Apr 28. doi: 10.1038/s41467-023-38146-9

PMCID:: PMC10147604

Abstract Article PDF–9.0M

Select item 1013048719.

DNA Methylation–Dependent Restriction of Tyrosine Hydroxylase Contributes to Pancreatic β-Cell Heterogeneity

Nazia Parveen, Jean Kimi Wang, Supriyo Bhattacharya, Janielle Cuala, Mohan Singh Rajkumar, Alexandra E. Butler, Xiwei Wu, Hung-Ping Shih, Senta K. Georgia, Sangeeta Dhawan

Diabetes. 2023 May; 72(5): 575–589. Published online 2023 Jan 6. doi: 10.2337/db22-0506