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Select item 99504471.

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma

Yu-Fei Cao, Lei Xie, Bei-Bei Tong, Man-Yu Chu, Wen-Qi Shi, Xiang Li, Jian-Zhong He, Shao-Hong Wang, Zhi-Yong Wu, Dan-Xia Deng, Ya-Qi Zheng, Zhi-Mao Li, Xiu-E Xu, Lian-Di Liao, Yin-Wei Cheng, Li-Yan Li, Li-Yan Xu, En-Min Li

Cell Death Differ. 2023 Feb; 30(2): 527–543. Published online 2022 Dec 16. doi: 10.1038/s41418-022-01104-x

PMCID:: PMC9950447

Abstract Article PDF–8.4M

Select item 96647172.

Hepatitis B virus suppresses complement C9 synthesis by limiting the availability of transcription factor USF-1 and inhibits formation of membrane attack complex: implications in disease pathogenesis

Ayana Baidya, Mousumi Khatun, Rajiv Kumar Mondal, Suchandrima Ghosh, Bidhan Chandra Chakraborty, Shreya Mallik, S. K. Mahiuddin Ahammed, Abhijit Chowdhury, Soma Banerjee, Simanti Datta

J Biomed Sci. 2022; 29: 97. Published online 2022 Nov 14. doi: 10.1186/s12929-022-00876-1

PMCID:: PMC9664717

Abstract Article PDF–4.4M

Select item 82127643.

The rare C9 P167S risk variant for age-related macular degeneration increases polymerization of the terminal component of the complement cascade

O McMahon, T M Hallam, S Patel, C L Harris, A Menny, W M Zelek, R Widjajahakim, A Java, T E Cox, N Tzoumas, D H W Steel, V G Shuttleworth, K Smith-Jackson, V Brocklebank, H Griffiths, A J Cree, J P Atkinson, A J Lotery, D Bubeck, B P Morgan, K J Marchbank, J M Seddon, D Kavanagh

Hum Mol Genet. 2021 Jul 1; 30(13): 1188–1199. Published online 2021 Mar 30. doi: 10.1093/hmg/ddab086

PMCID:: PMC8212764

Abstract Article PDF–1011K

Select item 81650304.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 76060085.

BCAR1 promotes proliferation and cell growth in lung adenocarcinoma via upregulation of POLR2A

Chun‐guo Mao, Sha‐sha Jiang, Cheng Shen, Tan Long, Hua Jin, Qun‐You Tan, Bo Deng

Thorac Cancer. 2020 Nov; 11(11): 3326–3336. Published online 2020 Oct 1. doi: 10.1111/1759-7714.13676

PMCID:: PMC7606008

Abstract Article PDF–2.5M

Select item 67728556.

Deficiency of Complement Defense Protein CD59 May Contribute to Neurodegeneration in Alzheimer's Disease

Li-Bang Yang, Rena Li, Seppo Meri, Joseph Rogers, Yong Shen

J Neurosci. 2000 Oct 15; 20(20): 7505–7509. doi: 10.1523/JNEUROSCI.20-20-07505.2000

PMCID:: PMC6772855

Abstract Article PDF–343K

Select item 62942497.

CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers

Anaïs Menny, Marina Serna, Courtney M. Boyd, Scott Gardner, Agnel Praveen Joseph, B. Paul Morgan, Maya Topf, Nicholas J. Brooks, Doryen Bubeck

Nat Commun. 2018; 9: 5316. Published online 2018 Dec 14. doi: 10.1038/s41467-018-07653-5

PMCID:: PMC6294249

Abstract Article PDF–3.4M

Select item 60938608.

The first transmembrane region of complement component-9 acts as a brake on its self-assembly

Bradley A. Spicer, Ruby H. P. Law, Tom T. Caradoc-Davies, Sue M. Ekkel, Charles Bayly-Jones, Siew-Siew Pang, Paul J. Conroy, Georg Ramm, Mazdak Radjainia, Hariprasad Venugopal, James C. Whisstock, Michelle A. Dunstone

Nat Commun. 2018; 9: 3266. Published online 2018 Aug 15. doi: 10.1038/s41467-018-05717-0

PMCID:: PMC6093860

Abstract Article PDF–1.4M

Select item 60662739.

Osmotic and hypoxic induction of the complement factor C9 in cultured human retinal pigment epithelial cells: Regulation of VEGF and NLRP3 expression

Margrit Hollborn, Charlotte Ackmann, Heidrun Kuhrt, Fabian Doktor, Leon Kohen, Peter Wiedemann, Andreas Bringmann

Mol Vis. 2018; 24: 518–535. Published online 2018 Jul 28.

PMCID:: PMC6066273

Abstract Article PDF–5.5M

Select item 598335010.

Association between the SERPING1 gene and age-related macular degeneration: a two-stage case–control study

Sarah Ennis, Catherine Jomary, Robert Mullins, Angela Cree, Xiaoli Chen, Alex MacLeod, Stephen Jones, Prof Andrew Collins, Prof Edwin Stone, Prof Andrew Lotery

Lancet. Author manuscript; available in PMC 2018 Jun 1.

Published in final edited form as: Lancet. 2008 Nov 22; 372(9652): 1828–1834. Published online 2008 Oct 6. doi: 10.1016/S0140-6736(08)61348-3

PMCID:: PMC5983350

Abstract Article PDF–675K

Select item 553161111.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 474299812.

Structure of the poly-C9 component of the complement membrane attack complex

Natalya V. Dudkina, Bradley A. Spicer, Cyril F. Reboul, Paul J. Conroy, Natalya Lukoyanova, Hans Elmlund, Ruby H. P. Law, Susan M. Ekkel, Stephanie C. Kondos, Robert J. A. Goode, Georg Ramm, James C. Whisstock, Helen R. Saibil, Michelle A. Dunstone

Nat Commun. 2016; 7: 10588. Published online 2016 Feb 4. doi: 10.1038/ncomms10588

PMCID:: PMC4742998

Abstract Article PDF–1.4M

Select item 463804413.

Serum Glycoprotein Biomarker Discovery and Qualification Pipeline Reveals Novel Diagnostic Biomarker Candidates for Esophageal Adenocarcinoma

Alok K. Shah, Kim-Anh Lê Cao, Eunju Choi, David Chen, Benoît Gautier, Derek Nancarrow, David C. Whiteman, Nicholas A. Saunders, Andrew P. Barbour, Virendra Joshi, Michelle M. Hill

Mol Cell Proteomics. 2015 Nov; 14(11): 3023–3039. Published online 2015 Sep 24. doi: 10.1074/mcp.M115.050922

PMCID:: PMC4638044

Abstract Article PDF–2.6M

Select item 434850514.

Exposure to the complement C5b-9 complex sensitizes 661W photoreceptor cells to both apoptosis and necroptosis

Hui Shi, Jennifer A. E. Williams, Li Guo, Dimitrios Stampoulis, M. Francesca Cordeiro, Stephen E. Moss

Apoptosis. 2015; 20(4): 433–443. Published online 2015 Jan 21. doi: 10.1007/s10495-015-1091-7

PMCID:: PMC4348505

Abstract Article PDF–2.0M

Select item 403155215.

Mortalin/GRP75 Binds to Complement C9 and Plays a Role in Resistance to Complement-dependent Cytotoxicity

Moran Saar Ray, Oren Moskovich, Ohad Iosefson, Zvi Fishelson

J Biol Chem. 2014 May 23; 289(21): 15014–15022. Published online 2014 Apr 9. doi: 10.1074/jbc.M114.552406

PMCID:: PMC4031552

Abstract Article PDF–1.9M

Select item 383242416.

Characterization of Molecules Binding to the 70K N-terminal Region of Fibronectin by IFAST Purification Coupled with Mass Spectrometry

S. Farshid Moussavi-Harami, Douglas S. Annis, Wenjiang Ma, Scott M. Berry, Emma E. Coughlin, Lindsay N. Strotman, Lisa M. Maurer, Michael S. Westphall, Joshua J. Coon, Deane F. Mosher, David J. Beebe

J Proteome Res. Author manuscript; available in PMC 2014 Jul 5.

Published in final edited form as: J Proteome Res. 2013 Jul 5; 12(7): 10.1021/pr400225p. Published online 2013 Jun 21. doi: 10.1021/pr400225p

PMCID:: PMC3832424

Abstract Article PDF–462K

Select item 377350517.

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

Simona Principe, E. Ellen Jones, Yunee Kim, Ankit Sinha, Julius O. Nyalwidhe, Jasmin Brooks, O. John Semmes, Dean A. Troyer, Raymond S. Lance, Thomas Kislinger, Richard R. Drake

Proteomics. Author manuscript; available in PMC 2014 May 1.

Published in final edited form as: Proteomics. 2013 May; 13(0): 1667–1671. Published online 2013 Apr 23. doi: 10.1002/pmic.201200561