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Items: 1 to 20 of 61

1.
OTX2 regulates CFTR expression during endoderm differentiation and occupies 3′ cis-regulatory elements
Jenny L. Kerschner, Alekh Paranjapye, Monali NandyMazumdar, Shiyi Yin, Shih-Hsing Leir, Ann Harris
Dev Dyn. Author manuscript; available in PMC 2024 Jul 6.
Published in final edited form as: Dev Dyn. 2021 May; 250(5): 684–700. Published online 2021 Jan 26. doi: 10.1002/dvdy.293
PMCID:
PMC11227118
AbstractArticlePDF–2.2M
2.
The OTX2 Gene Induces Tumor Growth and Triggers Leptomeningeal Metastasis by Regulating the mTORC2 Signaling Pathway in Group 3 Medulloblastomas
Elisabet Ampudia-Mesias, Charles S. Cameron, Eunjae Yoo, Marcus Kelly, Sarah M. Anderson, Riley Manning, Juan E. Abrahante Lloréns, Christopher L. Moertel, Hyungshin Yim, David J. Odde, Nurten Saydam, Okay Saydam
Int J Mol Sci. 2024 Apr; 25(8): 4416. Published online 2024 Apr 17. doi: 10.3390/ijms25084416
PMCID:
PMC11050316
AbstractArticlePDF–2.6M
3.
Interaction network of human early embryonic transcription factors
Lisa Gawriyski, Zenglai Tan, Xiaonan Liu, Iftekhar Chowdhury, Dicle Malaymar Pinar, Qin Zhang, Jere Weltner, Eeva-Mari Jouhilahti, Gong-Hong Wei, Juha Kere, Markku Varjosalo
EMBO Rep. 2024 Mar; 25(3): 1589–1622. Published online 2024 Jan 31. doi: 10.1038/s44319-024-00074-0
PMCID:
PMC10933267
AbstractArticlePDF–2.9M
4.
A comprehensive SARS-CoV-2–human protein–protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets
Yadi Zhou, Yuan Liu, Shagun Gupta, Mauricio I. Paramo, Yuan Hou, Chengsheng Mao, Yuan Luo, Julius Judd, Shayne Wierbowski, Marta Bertolotti, Mriganka Nerkar, Lara Jehi, Nir Drayman, Vlad Nicolaescu, Haley Gula, Savaş Tay, Glenn Randall, Peihui Wang, John T. Lis, Cédric Feschotte, Serpil C. Erzurum, Feixiong Cheng, Haiyuan Yu
Nat Biotechnol. Author manuscript; available in PMC 2023 Jan 20.
Published in final edited form as: Nat Biotechnol. 2023 Jan; 41(1): 128–139. Published online 2022 Oct 10. doi: 10.1038/s41587-022-01474-0
PMCID:
PMC9851973
AbstractArticlePDF–4.0M
5.
The LHX2-OTX2 transcriptional regulatory module controls retinal pigmented epithelium differentiation and underlies genetic risk for age-related macular degeneration
Mazal Cohen-Gulkar, Ahuvit David, Naama Messika-Gold, Mai Eshel, Shai Ovadia, Nitay Zuk-Bar, Maria Idelson, Yamit Cohen-Tayar, Benjamin Reubinoff, Tamar Ziv, Meir Shamay, Ran Elkon, Ruth Ashery-Padan
PLoS Biol. 2023 Jan; 21(1): e3001924. Published online 2023 Jan 17. doi: 10.1371/journal.pbio.3001924
PMCID:
PMC9844853
AbstractArticlePDF–2.8M
6.
Genetic alterations of TP53 and OTX2 indicate increased risk of relapse in WNT medulloblastomas: “it’s a numbers game”—implications for WNT medulloblastoma dose-reduction clinical trials
Nicholas G. Gottardo
Acta Neuropathol. 2023; 145(1): 145–147. Published online 2022 Nov 20. doi: 10.1007/s00401-022-02518-0
PMCID:
PMC9807471
ArticlePDF–422K
7.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
8.
Impact of cytosine methylation on DNA binding specificities of human transcription factors
Yimeng Yin, Ekaterina Morgunova, Arttu Jolma, Eevi Kaasinen, Biswajyoti Sahu, Syed Khund-Sayeed, Pratyush K. Das, Teemu Kivioja, Kashyap Dave, Fan Zhong, Kazuhiro R. Nitta, Minna Taipale, Alexander Popov, Paul A. Ginno, Silvia Domcke, Jian Yan, Dirk Schübeler, Charles Vinson, Jussi Taipale
Science. Author manuscript; available in PMC 2021 Mar 30.
Published in final edited form as: Science. 2017 May 5; 356(6337): eaaj2239. doi: 10.1126/science.aaj2239
PMCID:
PMC8009048
AbstractArticlePDF–2.6M
9.
Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism
Michael Aregger, Keith A. Lawson, Maximillian Billmann, Michael Costanzo, Amy H. Y. Tong, Katherine Chan, Mahfuzur Rahman, Kevin R. Brown, Catherine Ross, Matej Usaj, Lucy Nedyalkova, Olga Sizova, Andrea Habsid, Judy Pawling, Zhen-Yuan Lin, Hala Abdouni, Cassandra J. Wong, Alexander Weiss, Patricia Mero, James W. Dennis, Anne-Claude Gingras, Chad L. Myers, Brenda J. Andrews, Charles Boone, Jason Moffat
Nat Metab. Author manuscript; available in PMC 2020 Dec 1.
Published in final edited form as: Nat Metab. 2020 Jun; 2(6): 499–513. Published online 2020 Jun 1. doi: 10.1038/s42255-020-0211-z
PMCID:
PMC7566881
AbstractArticlePDF–4.8M
10.
Otx2b mutant zebrafish have pituitary, eye and mandible defects that model mammalian disease
Hironori Bando, Peter Gergics, Brenda L Bohnsack, Kevin P Toolan, Catherine E Richter, Jordan A Shavit, Sally A Camper
Hum Mol Genet. 2020 Jun 27; 29(10): 1648–1657. Published online 2020 Apr 9. doi: 10.1093/hmg/ddaa064
PMCID:
PMC7322578
AbstractArticlePDF–946K
11.
A reference map of the human binary protein interactome
Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood
Nature. Author manuscript; available in PMC 2020 Oct 8.
Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x
PMCID:
PMC7169983
AbstractArticlePDF–5.4M
12.
Congenital pituitary hypoplasia model demonstrates hypothalamic OTX2 regulation of pituitary progenitor cells
Ryusaku Matsumoto, Hidetaka Suga, Takashi Aoi, Hironori Bando, Hidenori Fukuoka, Genzo Iguchi, Satoshi Narumi, Tomonobu Hasegawa, Keiko Muguruma, Wataru Ogawa, Yutaka Takahashi
J Clin Invest. 2020 Feb 3; 130(2): 641–654. Published online 2019 Dec 17. doi: 10.1172/JCI127378
PMCID:
PMC6994153
AbstractArticlePDF–13M
13.
Methylation in OTX2 and related genes, maltreatment, and depression in children
Joan Kaufman, Nicholas F. Wymbs, Janitza L. Montalvo-Ortiz, Catherine Orr, Matthew D. Albaugh, Robert Althoff, Kerry O’Loughlin, Hannah Holbrook, Hugh Garavan, Catherine Kearney, Bao-Zhu Yang, Hongyu Zhao, Catherine Peña, Eric J. Nestler, Richard S. Lee, Stewart Mostofsky, Joel Gelernter, James Hudziak
Neuropsychopharmacology. 2018 Oct; 43(11): 2204–2211. Published online 2018 Jul 21. doi: 10.1038/s41386-018-0157-y
PMCID:
PMC6135753
AbstractArticlePDF–1.5M
14.
Characterization of a novel OTX2‐driven stem cell program in Group 3 and Group 4 medulloblastoma
Margaret Stromecki, Nazanin Tatari, Ludivine Coudière Morrison, Ravinder Kaur, Jamie Zagozewski, Gareth Palidwor, Vijay Ramaswamy, Patryk Skowron, Matthias Wölfl, Till Milde, Marc R. Del Bigio, Michael D. Taylor, Tamra E. Werbowetski‐Ogilvie
Mol Oncol. 2018 Apr; 12(4): 495–513. Published online 2018 Mar 1. doi: 10.1002/1878-0261.12177
PMCID:
PMC5891039
AbstractArticlePDF–1.6M
15.
Antagonism between the transcription factors NANOG and OTX2 specifies rostral or caudal cell fate during neural patterning transition
Zhenghui Su, Yanqi Zhang, Baojian Liao, Xiaofen Zhong, Xin Chen, Haitao Wang, Yiping Guo, Yongli Shan, Lihui Wang, Guangjin Pan
J Biol Chem. 2018 Mar 23; 293(12): 4445–4455. Published online 2018 Jan 31. doi: 10.1074/jbc.M117.815449
PMCID:
PMC5868256
AbstractArticlePDF–3.6M
16.
Otx2-Genetically Modified Retinal Pigment Epithelial Cells Rescue Photoreceptors after Transplantation
Christo Kole, Laurence Klipfel, Ying Yang, Vanessa Ferracane, Frederic Blond, Sacha Reichman, Géraldine Millet-Puel, Emmanuelle Clérin, Najate Aït-Ali, Delphine Pagan, Hawa Camara, Marie-Noëlle Delyfer, Emeline F. Nandrot, Jose-Alain Sahel, Olivier Goureau, Thierry Léveillard
Mol Ther. 2018 Jan 3; 26(1): 219–237. Published online 2017 Sep 8. doi: 10.1016/j.ymthe.2017.09.007
PMCID:
PMC5762984
AbstractArticlePDF–6.3M
17.
Heterozygous mutation in OTX2 associated with early-onset retinal dystrophy with atypical maculopathy
Maram EA Abdalla-Elsayed, Patrik Schatz, Christine Neuhaus, Arif O. Khan
Mol Vis. 2017; 23: 778–784. Published online 2017 Nov 13.
PMCID:
PMC5693023
AbstractArticlePDF–1.4M
18.
OTX2 activity at distal regulatory elements shapes the chromatin landscape of Group 3 medulloblastoma
Gaylor Boulay, Mary E. Awad, Nicolo Riggi, Tenley C. Archer, Sowmya Iyer, Wannaporn E. Boonseng, Nikki E Rossetti, Beverly Naigles, Shruthi Rengarajan, Angela Volorio, James C. Kim, Jill P. Mesirov, Pablo Tamayo, Scott L. Pomeroy, Martin J. Aryee, Miguel N. Rivera
Cancer Discov. Author manuscript; available in PMC 2018 Mar 1.
Published in final edited form as: Cancer Discov. 2017 Mar; 7(3): 288–301. Published online 2017 Feb 17. doi: 10.1158/2159-8290.CD-16-0844
PMCID:
PMC5340587
AbstractArticlePDF–810K
19.
OTX1 and OTX2 as Possible Molecular Markers of Sinonasal Carcinomas and Olfactory Neuroblastomas
Cristina Pirrone, Anna M. Chiaravalli, Alessandro Marando, Andrea Conti, Alessia Rainero, Andrea Pistochini, Francesco Lo Curto, Francesco Pasquali, Paolo Castelnuovo, Carlo Capella, Giovanni Porta
Eur J Histochem. 2017 Jan 23; 61(1): 2730. Published online 2017 Feb 9. doi: 10.4081/ejh.2017.2730
PMCID:
PMC5304267
AbstractArticlePDF–252K
20.
Activated monocytes resist elimination by retinal pigment epithelium and downregulate their OTX2 expression via TNF‐α
Thibaud Mathis, Michael Housset, Chiara Eandi, Fanny Beguier, Sara Touhami, Sacha Reichman, Sebastien Augustin, Pauline Gondouin, José‐Alain Sahel, Laurent Kodjikian, Olivier Goureau, Xavier Guillonneau, Florian Sennlaub
Aging Cell. 2017 Feb; 16(1): 173–182. Published online 2016 Sep 22. doi: 10.1111/acel.12540
PMCID:
PMC5242302
AbstractArticlePDF–1.6M

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