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Select item 108000741.

YAP represses intestinal inflammation through epigenetic silencing of JMJD3

Hua Zhu, Jiali Lu, MingYue Fu, Ping Chen, Yali Yu, Min Chen, Qiu Zhao, Min Wu, Mei Ye

Clin Epigenetics. 2024; 16: 14. Published online 2024 Jan 20. doi: 10.1186/s13148-024-01626-w

PMCID:: PMC10800074

Abstract Article PDF–2.2M

Select item 107879972.

MicroRNA-93-5p regulates odontogenic differentiation and dentin formation via KDM6B

Si Wu, Xin Xu, Shiqi Gao, Sibei Huo, Mian Wan, Xin Zhou, Xuedong Zhou, Liwei Zheng, Yachuan Zhou

J Transl Med. 2024; 22: 54. Published online 2024 Jan 13. doi: 10.1186/s12967-024-04862-z

PMCID:: PMC10787997

Abstract Article PDF–11M

Select item 107609613.

Targeting lysine demethylase 6B ameliorates ASXL1 truncation–mediated myeloid malignancies in preclinical models

Guo Ge, Peng Zhang, Pinpin Sui, Shi Chen, Hui Yang, Ying Guo, Ivan P. Rubalcava, Asra Noor, Caroline R. Delma, Joel Agosto-Peña, Hui Geng, Edward A. Medina, Ying Liang, Stephen D. Nimer, Ruben Mesa, Omar Abdel-Wahab, Mingjiang Xu, Feng-Chun Yang

J Clin Invest. 2024 Jan 2; 134(1): e163964. Published online 2024 Jan 2. doi: 10.1172/JCI163964

PMCID:: PMC10760961

Abstract Article PDF–12M

Select item 106865654.

KDM6B drives epigenetic reprogramming associated with lymphoid stromal cell early commitment and immune properties

Marvin Sylvestre, Nicolas Barbier, Vonick Sibut, Saba Nayar, Céline Monvoisin, Simon Leonard, Julien Saint-Vanne, Ansie Martin, Marion Guirriec, Maëlle Latour, Florence Jouan, Sylvain Baulande, Mylène Bohec, Léa Verdière, Fatima Mechta-Grigoriou, Frédéric Mourcin, Nicolas Bertheuil, Francesca Barone, Karin Tarte, David Roulois

Sci Adv. 2023 Dec 1; 9(48): eadh2708. Published online 2023 Nov 29. doi: 10.1126/sciadv.adh2708

PMCID:: PMC10686565

Abstract Article PDF–1.7M

Select item 106524545.

Echinococcus granulosus cyst fluid inhibits KDM6B-mediated demethylation of trimethylated histone H3 lysine 27 and interleukin-1β production in macrophages

Ruolin Lin, Xiaopeng Wang, Caiya Ni, Chunxue Fu, Chun Yang, Dan Dong, Xiangwei Wu, Xueling Chen, Lianghai Wang, Jun Hou

Parasit Vectors. 2023; 16: 422. Published online 2023 Nov 16. doi: 10.1186/s13071-023-06041-3

PMCID:: PMC10652454

Abstract Article PDF–4.4M

Select item 105454106.

Loss of KDM6B epigenetically confers resistance to lipotoxicity in nonalcoholic fatty liver disease–related HCC

Megumi Hatano, Yoshimitsu Akiyama, Shu Shimada, Kohei Yagi, Keiichi Akahoshi, Michiko Itoh, Minoru Tanabe, Yoshihiro Ogawa, Shinji Tanaka

Hepatol Commun. 2023 Oct; 7(10): e0277. Published online 2023 Oct 2. doi: 10.1097/HC9.0000000000000277

PMCID:: PMC10545410

Abstract Article PDF–1.5M

Select item 104860687.

Functional and long-lived melanocytes from human pluripotent stem cells with transient ectopic expression of JMJD3

Chie Kobori, Ryo Takagi, Ryo Yokomizo, Sakie Yoshihara, Mai Mori, Hiroto Takahashi, Palaksha Kanive Javaregowda, Tomohiko Akiyama, Minoru S. H. Ko, Kazuo Kishi, Akihiro Umezawa

Stem Cell Res Ther. 2023; 14: 242. Published online 2023 Sep 8. doi: 10.1186/s13287-023-03479-1

PMCID:: PMC10486068

Abstract Article PDF–6.6M

Select item 100819588.

KDM6B protects T-ALL cells from NOTCH1-induced oncogenic stress

Nancy Issa, Hassan Bjeije, Elisabeth R. Wilson, Aishwarya Krishnan, Wangisa M.B. Dunuwille, Tyler M. Parsons, Christine R. Zhang, Wentao Han, Andrew L. Young, Zhizhong Ren, Kai Ge, Eunice S. Wang, Andrew P. Weng, Amanda Cashen, David H. Spencer, Grant A. Challen

Leukemia. Author manuscript; available in PMC 2023 Apr 8.

Published in final edited form as: Leukemia. 2023 Apr; 37(4): 728–740. Published online 2023 Feb 17. doi: 10.1038/s41375-023-01853-9

PMCID:: PMC10081958

Abstract Article PDF–2.9M

Select item 97891249.

KDM6B promotes gastric carcinogenesis and metastasis via upregulation of CXCR4 expression

Fen Liu, Yue Wang, Zongcheng Yang, Xiujie Cui, Lixin Zheng, Yue Fu, Wei Shao, Lu Zhang, Qing Yang, Jihui Jia

Cell Death Dis. 2022 Dec; 13(12): 1068. Published online 2022 Dec 23. doi: 10.1038/s41419-022-05458-5

PMCID:: PMC9789124

Abstract Article PDF–5.9M

Select item 957025010.

A Screening of Epigenetic Therapeutic Targets for Non-Small Cell Lung Cancer Reveals PADI4 and KDM6B as Promising Candidates

Jéssika Cristina Chagas Lesbon, Taismara Kustro Garnica, Pedro Luiz Porfírio Xavier, Arina Lázaro Rochetti, Rui Manuel Reis, Susanne Müller, Heidge Fukumasu

Int J Mol Sci. 2022 Oct; 23(19): 11911. Published online 2022 Oct 7. doi: 10.3390/ijms231911911

PMCID:: PMC9570250

Abstract Article PDF–2.1M

Select item 953470211.

Decreased Jumonji Domain-Containing 3 at the Promoter Downregulates Hematopoietic Progenitor Kinase 1 Expression and Cytoactivity of T Follicular Helper Cells from Systemic Lupus Erythematosus Patients

Shuaihantian Luo, Yuming Xie, Junke Huang, Juan Liu, Qing Zhang

J Immunol Res. 2022; 2022: 3690892. Published online 2022 Sep 28. doi: 10.1155/2022/3690892

PMCID:: PMC9534702

Abstract Article PDF–1023K

Select item 941656212.

JMJD3 Promotes Porphyromonas gingivalis Lipopolysaccharide-Induced Th17-Cell Differentiation by Modulating the STAT3-RORc Signaling Pathway

Doudou Huang, Chi Zhang, Panpan Wang, Xiting Li, Li Gao, Chuanjiang Zhao

DNA Cell Biol. August 2022; 41(8): 778–787. Published online 2022 Aug 4. doi: 10.1089/dna.2022.0149

PMCID:: PMC9416562

Abstract Article PDF–582K

Select item 934857613.

Chr21 protein–protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer’s disease

Julia Viard, Yann Loe-Mie, Rachel Daudin, Malik Khelfaoui, Christine Plancon, Anne Boland, Francisco Tejedor, Richard L Huganir, Eunjoon Kim, Makoto Kinoshita, Guofa Liu, Volker Haucke, Thomas Moncion, Eugene Yu, Valérie Hindie, Henri Bléhaut, Clotilde Mircher, Yann Herault, Jean-François Deleuze, Jean-Christophe Rain, Michel Simonneau, Aude-Marie Lepagnol-Bestel

Life Sci Alliance. 2022 Dec; 5(12): e202101205. Published online 2022 Aug 1. doi: 10.26508/lsa.202101205

PMCID:: PMC9348576

Abstract Article PDF–3.0M

Select item 927941014.

Histone demethylase JMJD3 downregulation protects against aberrant force-induced osteoarthritis through epigenetic control of NR4A1

Yu Jin, Zhen Liu, Zhenxia Li, Hairui Li, Cheng Zhu, Ruomei Li, Ting Zhou, Bing Fang

Int J Oral Sci. 2022; 14: 34. Published online 2022 Jul 14. doi: 10.1038/s41368-022-00190-4

PMCID:: PMC9279410

Abstract Article PDF–5.9M

Select item 926261415.

A dual-activity topoisomerase complex regulates mRNA translation and turnover

Shuaikun Su, Yutong Xue, Alexei Sharov, Yongqing Zhang, Seung Kyu Lee, Jennifer L Martindale, Wen Li, Wai Lim Ku, Keji Zhao, Supriyo De, Weiping Shen, Payel Sen, Myriam Gorospe, Dongyi Xu, Weidong Wang

Nucleic Acids Res. 2022 Jul 8; 50(12): 7013–7033. Published online 2022 Jun 24. doi: 10.1093/nar/gkac538

PMCID:: PMC9262614

Abstract Article PDF–3.6M

Select item 911973616.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 907048417.

Jumonji Domain–containing Protein-3 (JMJD3/Kdm6b) Is Critical for Normal Ovarian Function and Female Fertility

Sambit Roy, Niharika Sinha, Binbin Huang, Holly Cline-Fedewa, Norbert Gleicher, Jianrong Wang, Aritro Sen

Endocrinology. 2022 May; 163(5): bqac047. Published online 2022 Apr 9. doi: 10.1210/endocr/bqac047

PMCID:: PMC9070484

Abstract Article

Select item 866484218.

KDM6B promotes activation of the oncogenic CDK4/6-pRB-E2F pathway by maintaining enhancer activity in MYCN-amplified neuroblastoma

Alexandra D’Oto, Jie Fang, Hongjian Jin, Beisi Xu, Shivendra Singh, Anoushka Mullasseril, Victoria Jones, Ahmed Abu-Zaid, Xinyu von Buttlar, Bailey Cooke, Dongli Hu, Jason Shohet, Andrew J. Murphy, Andrew M. Davidoff, Jun Yang

Nat Commun. 2021; 12: 7204. Published online 2021 Dec 10. doi: 10.1038/s41467-021-27502-2

PMCID:: PMC8664842

Abstract Article PDF–6.7M

Select item 855553819.

Activation of epigenetic regulator KDM6B by Salmonella Typhimurium enables chronic infections

Sarika Rana, Sonalika Maurya, Gayatree Mohapatra, Savita Singh, Rohan Babar, Hridya Chandrasekhar, Garima Chamoli, Deepak Rathore, Pallavi Kshetrapal, C. V. Srikanth

Gut Microbes. 2021; 13(1): 1986665. Published online 2021 Oct 25. doi: 10.1080/19490976.2021.1986665

PMCID:: PMC8555538

Abstract Article PDF–2.9M

Select item 852944620.

Pharmacological Inhibition of Core Regulatory Circuitry Liquid–liquid Phase Separation Suppresses Metastasis and Chemoresistance in Osteosarcoma

Bing Lu, Changye Zou, Meiling Yang, Yangyang He, Jincan He, Chuanxia Zhang, Siyun Chen, Jiaming Yu, Kilia Yun Liu, Qi Cao, Wei Zhao

Adv Sci (Weinh) 2021 Oct; 8(20): 2101895. Published online 2021 Aug 25. doi: 10.1002/advs.202101895

PMCID:: PMC8529446

Abstract Article PDF–5.3M

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