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Select item 106415241.

Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis

Robert S. Kiss, Jarred Chicoine, Youssef Khalil, Robert Sladek, He Chen, Alessandro Pisaturo, Cyril Martin, Jessica D. Dale, Tegan A. Brudenell, Archith Kamath, Jeffrey Kyei-Boahen, Anouar Hafiane, Girija Daliah, Célia Alecki, Tayah S. Hopes, Martin Heier, Irene A. Aligianis, Jean-Jacques Lebrun, Julie Aspden, Emanuele Paci, Anja Kerksiek, Dieter Lütjohann, Peter Clayton, Jimi C. Wills, Alex von Kriegsheim, Tommy Nilsson, Eamonn Sheridan, Mark T. Handley

J Biol Chem. 2023 Nov; 299(11): 105295. Published online 2023 Sep 28. doi: 10.1016/j.jbc.2023.105295

PMCID:: PMC10641524

Abstract Article PDF–3.8M

Select item 101516152.

Cross-linking mass spectrometry discovers, evaluates, and corroborates structures and protein–protein interactions in the human cell

Tara K. Bartolec, Xabier Vázquez-Campos, Alexander Norman, Clement Luong, Marcus Johnson, Richard J. Payne, Marc R. Wilkins, Joel P. Mackay, Jason K. K. Low

Proc Natl Acad Sci U S A. 2023 Apr 25; 120(17): e2219418120. Published online 2023 Apr 18. doi: 10.1073/pnas.2219418120

PMCID:: PMC10151615

Abstract Article PDF–2.9M

Select item 99901203.

Interactomes of Glycogen Synthase Kinase-3 Isoforms

Kevin W. Cormier, Brett Larsen, Anne-Claude Gingras, James R. Woodgett

J Proteome Res. 2023 Mar 3; 22(3): 977–989. Published online 2023 Feb 13. doi: 10.1021/acs.jproteome.2c00825

PMCID:: PMC9990120

Abstract Article PDF–3.7M

Select item 99530404.

Not to Miss: Intronic Variants, Treatment, and Review of the Phenotypic Spectrum in VPS13D-Related Disorder

Martje G. Pauly, Norbert Brüggemann, Stephanie Efthymiou, Anne Grözinger, Sokhna Haissatou Diaw, Viorica Chelban, Valentina Turchetti, Barbara Vona, Vera Tadic, Henry Houlden, Alexander Münchau, Katja Lohmann

Int J Mol Sci. 2023 Feb; 24(3): 1874. Published online 2023 Jan 18. doi: 10.3390/ijms24031874

PMCID:: PMC9953040

Abstract Article PDF–3.8M

Select item 99501835.

CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment

Daphne J. Smits, Jordy Dekker, Rachel Schot, Brahim Tabarki, Amal Alhashem, Jeroen A. A. Demmers, Dick H. W. Dekkers, Antonio Romito, Peter J. van der Spek, Tjakko J. van Ham, Aida M. Bertoli-Avella, Grazia M. S. Mancini

Hum Genet. 2023; 142(3): 379–397. Published online 2022 Dec 20. doi: 10.1007/s00439-022-02511-3

PMCID:: PMC9950183

Abstract Article PDF–2.4M

Select item 99224686.

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia

Xiao-Na Zhu, Yu-Sheng Wei, Qian Yang, Hao-Ran Liu, Zhe Zhi, Di Zhu, Li Xia, Deng-Li Hong, Yun Yu, Guo-Qiang Chen

J Hematol Oncol. 2023; 16: 9. Published online 2023 Feb 11. doi: 10.1186/s13045-023-01400-0

PMCID:: PMC9922468

Abstract Article PDF–4.9M

Select item 90375547.

C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy

Bing-Ru Yan, Taoyingnan Li, Etienne Coyaud, Estelle M. N. Laurent, Jonathan St-Germain, Yuhuan Zhou, Peter K. Kim, Brian Raught, John H. Brumell

Autophagy. 2022; 18(4): 829–840. Published online 2021 Aug 25. doi: 10.1080/15548627.2021.1960116

PMCID:: PMC9037554

Abstract Article PDF–4.1M

Select item 86396688.

TRIP12 Ubiquitination of Glucocerebrosidase Contributes to Neurodegeneration in Parkinson’s Disease

Bo Am Seo, Donghoon Kim, Heehong Hwang, Min Seong Kim, Shi-Xun Ma, Seung-Hwan Kwon, Sin Ho Kweon, Hu Wang, Je Min Yoo, Seulah Choi, Sang Ho Kwon, Sung-Ung Kang, Tae-In Kam, Kwangsoo Kim, Senthilkumar S Karuppagounder, Bong Gu Kang, Saebom Lee, Hyejin Park, Sangjune Kim, Wei Yan, Yong-Shi Li, Sheng-Han Kuo, Javier Redding-Ochoa, Olga Pletnikova, Juan C. Troncoso, Gabsang Lee, Xiaobo Mao, Valina L. Dawson, Ted M. Dawson, Han Seok Ko

Neuron. Author manuscript; available in PMC 2022 Dec 1.

Published in final edited form as: Neuron. 2021 Dec 1; 109(23): 3758–3774.e11. Published online 2021 Oct 12. doi: 10.1016/j.neuron.2021.09.031

PMCID:: PMC8639668

Abstract Article PDF–2.6M

Select item 83641819.

Protein interaction landscapes revealed by advanced in vivo cross-linking–mass spectrometry

Andrew Wheat, Clinton Yu, Xiaorong Wang, Anthony M. Burke, Ilan E. Chemmama, Robyn M. Kaake, Peter Baker, Scott D. Rychnovsky, Jing Yang, Lan Huang

Proc Natl Acad Sci U S A. 2021 Aug 10; 118(32): e2023360118. Published online 2021 Aug 4. doi: 10.1073/pnas.2023360118

PMCID:: PMC8364181

Abstract Article PDF–3.0M

Select item 835296410.

Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer

Athea Vichas, Amanda K. Riley, Naomi T. Nkinsi, Shriya Kamlapurkar, Phoebe C. R. Parrish, April Lo, Fujiko Duke, Jennifer Chen, Iris Fung, Jacqueline Watson, Matthew Rees, Austin M. Gabel, James D. Thomas, Robert K. Bradley, John K. Lee, Emily M. Hatch, Marina K. Baine, Natasha Rekhtman, Marc Ladanyi, Federica Piccioni, Alice H. Berger

Nat Commun. 2021; 12: 4789. Published online 2021 Aug 9. doi: 10.1038/s41467-021-24841-y

PMCID:: PMC8352964

Abstract Article PDF–4.5M

Select item 835174011.

VPS13D interacts with VCP/p97 and negatively regulates endoplasmic reticulum–mitochondria interactions

Yuanjiao Du, Jingru Wang, Juan Xiong, Na Fang, Wei-Ke Ji

Mol Biol Cell. 2021 Aug 1; 32(16): 1474–1486. doi: 10.1091/mbc.E21-03-0097

PMCID:: PMC8351740

Abstract Article PDF–2.7M

Select item 831908112.

Vmp1, Vps13D and Marf/Mfn2 function in a conserved pathway to regulate mitochondria and ER contact in development and disease

James L. Shen, Tina M. Fortier, Yan G. Zhao, Ruoxi Wang, Margit Burmeister, Eric H. Baehrecke

Curr Biol. Author manuscript; available in PMC 2022 Jul 26.

Published in final edited form as: Curr Biol. 2021 Jul 26; 31(14): 3028–3039.e7. Published online 2021 May 20. doi: 10.1016/j.cub.2021.04.062

PMCID:: PMC8319081

Abstract Article PDF–2.2M

Select item 816503013.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 807718514.

VPS13D promotes peroxisome biogenesis

Heather A. Baldwin, Chunxin Wang, Gil Kanfer, Hetal V. Shah, Antonio Velayos-Baeza, Marija Dulovic-Mahlow, Norbert Brüggemann, Allyson Anding, Eric H. Baehrecke, Dragan Maric, William A. Prinz, Richard J. Youle

J Cell Biol. 2021 May 3; 220(5): e202001188. Published online 2021 Apr 23. doi: 10.1083/jcb.202001188

PMCID:: PMC8077185

Abstract Article PDF–8.0M

Select item 807718415.

VPS13D bridges the ER to mitochondria and peroxisomes via Miro

Andrés Guillén-Samander, Marianna Leonzino, Michael G. Hanna, IV, Ni Tang, Hongying Shen, Pietro De Camilli

J Cell Biol. 2021 May 3; 220(5): e202010004. Published online 2021 Apr 23. doi: 10.1083/jcb.202010004

Correction in:: J Cell Biol. 2021 Aug 2; 220(8): e20201000405052021c.

PMCID:: PMC8077184

Abstract Article PDF–5.5M

Select item 798799516.

The lncRNA Snhg1-Vps13D vesicle trafficking system promotes memory CD8 T cell establishment via regulating the dual effects of IL-7 signaling

Yanyan Zhang, Baohua Li, Qiang Bai, Pengcheng Wang, Gang Wei, Zhirong Li, Li Hu, Qin Tian, Jing Zhou, Qizhao Huang, Zhiming Wang, Shuai Yue, Jialin Wu, Liuqing Yang, Xinyuan Zhou, Lubin Jiang, Ting Ni, Lilin Ye, Yuzhang Wu

Signal Transduct Target Ther. 2021; 6: 126. Published online 2021 Mar 24. doi: 10.1038/s41392-021-00492-9

PMCID:: PMC7987995

Abstract Article PDF–5.5M

Select item 790263117.

An ESCRT-dependent step in fatty acid transfer from lipid droplets to mitochondria through VPS13D−TSG101 interactions

Jingru Wang, Na Fang, Juan Xiong, Yuanjiao Du, Yue Cao, Wei-Ke Ji

Nat Commun. 2021; 12: 1252. Published online 2021 Feb 23. doi: 10.1038/s41467-021-21525-5

PMCID:: PMC7902631

Abstract Article PDF–6.7M

Select item 773761018.

Receptor‐mediated clustering of FIP200 bypasses the role of LC3 lipidation in autophagy

Amelia E Ohnstad, Jose M Delgado, Brian J North, Isha Nasa, Arminja N Kettenbach, Sebastian W Schultz, Christopher J Shoemaker

EMBO J. 2020 Dec 15; 39(24): e104948. Published online 2020 Nov 23. doi: 10.15252/embj.2020104948

PMCID:: PMC7737610

Abstract Article PDF–3.7M

Select item 706811819.

A VPS13D spastic ataxia mutation disrupts the conserved adaptor-binding site in yeast Vps13

Samantha K Dziurdzik, Björn D M Bean, Michael Davey, Elizabeth Conibear

Hum Mol Genet. 2020 Mar 13; 29(4): 635–648. Published online 2020 Jan 15. doi: 10.1093/hmg/ddz318

PMCID:: PMC7068118

Abstract Article PDF–1.5M

Select item 705710720.

Kishin Koh, Hiroyuki Ishiura, Haruo Shimazaki, Michiko Tsutsumiuchi, Yuta Ichinose, Haitian Nan, Shun Hamada, Toshihisa Ohtsuka, Shoji Tsuji, Yoshihisa Takiyama

Mol Genet Genomic Med. 2020 Mar; 8(3): e1108. Published online 2019 Dec 26. doi: 10.1002/mgg3.1108

PMCID:: PMC7057107

Abstract Article PDF–486K

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