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Select item 112982031.

Deciphering the neuroprotective mechanisms of RACK1 in cerebral ischemia‐reperfusion injury: Pioneering insights into mitochondrial autophagy and the PINK1/Parkin axis

Lanqing Zhao, Yu Chen, Hongxi Li, Xiaoxu Ding, Jinwei Li

CNS Neurosci Ther. 2024 Aug; 30(8): e14836. Published online 2024 Aug 4. doi: 10.1111/cns.14836

PMCID:: PMC11298203

Abstract Article PDF–18M

Select item 111604742.

Mechanism of human PINK1 activation at the TOM complex in a reconstituted system

Olawale G. Raimi, Hina Ojha, Kenneth Ehses, Verena Dederer, Sven M. Lange, Cristian Polo Rivera, Tom D. Deegan, Yinchen Chen, Melanie Wightman, Rachel Toth, Karim P. M. Labib, Sebastian Mathea, Neil Ranson, Rubén Fernández-Busnadiego, Miratul M. K. Muqit

Sci Adv. 2024 Jun 7; 10(23): eadn7191. Published online 2024 Jun 7. doi: 10.1126/sciadv.adn7191

PMCID:: PMC11160474

Abstract Article PDF–1.8M

Select item 111147093.

PINK1 stimulates interleukin-1β-mediated inflammatory signaling via the positive regulation of TRAF6 and TAK1

Hyun Jung Lee, Sung Hee Jang, Hyeyoung Kim, Joo Heon Yoon, Kwang Chul Chung

Cell Mol Life Sci. 2012 Oct; 69(19): 3301–3315. Published online 2012 May 29. doi: 10.1007/s00018-012-1004-7

PMCID:: PMC11114709

Abstract Article PDF–896K

Select item 111055384.

Shedding light on mitophagy in neurons: what is the evidence for PINK1/Parkin mitophagy in vivo?

Nadia Cummins, Jürgen Götz

Cell Mol Life Sci. 2018 Apr; 75(7): 1151–1162. Published online 2017 Oct 30. doi: 10.1007/s00018-017-2692-9

PMCID:: PMC11105538

Abstract Article PDF–816K

Select item 110811815.

PINK1/Park2-Mediated Mitophagy Relieve Non-Alcoholic Fatty Liver Disease

Han HE, Yinhe TANG, Lei ZHUANG, Yihua ZHENG, Xiaming HUANG

Physiol Res. 2024 Apr; 73(2): 253–263. Published online 2024 Apr 30. doi: 10.33549/physiolres.934925

PMCID:: PMC11081181

Abstract Article PDF–1.0M

Select item 110267296.

The SCF-FBW7β E3 ligase mediates ubiquitination and degradation of the serine/threonine protein kinase PINK1

Seo Jeong Jeon, Kwang Chul Chung

J Biol Chem. 2024 Apr; 300(4): 107198. Published online 2024 Mar 18. doi: 10.1016/j.jbc.2024.107198

PMCID:: PMC11026729

Abstract Article PDF–4.8M

Select item 109060157.

METTL3/YTHDF2 m6A axis mediates the progression of diabetic nephropathy through epigenetically suppressing PINK1 and mitophagy

Fangfang Wang, Juan Bai, Xin Zhang, Dali Wang, Xin Zhang, Jingwen Xue, Haoyang Chen, Shuxiang Wang, Baojin Chi, Jing Li, Xiaoru Ma

J Diabetes Investig. 2024 Mar; 15(3): 288–299. Published online 2023 Nov 28. doi: 10.1111/jdi.14113

PMCID:: PMC10906015

Abstract Article PDF–3.8M

Select item 107136588.

GRAF1 integrates PINK1-Parkin signaling and actin dynamics to mediate cardiac mitochondrial homeostasis

Qiang Zhu, Matthew E. Combs, Juan Liu, Xue Bai, Wenbo B. Wang, Laura E. Herring, Jiandong Liu, Jason W. Locasale, Dawn E. Bowles, Ryan T. Gross, Michelle Mendiola Pla, Christopher P. Mack, Joan M. Taylor

Nat Commun. 2023; 14: 8187. Published online 2023 Dec 11. doi: 10.1038/s41467-023-43889-6

PMCID:: PMC10713658

Abstract Article PDF–9.0M

Select item 106938239.

Role of Pink1-mediated mitophagy in adenomyosis

Minmin Chen, Wei Wang, Xianyun Fu, Yongli Yi, Kun Wang, Meiling Wang

PeerJ. 2023; 11: e16497. Published online 2023 Nov 30. doi: 10.7717/peerj.16497

PMCID:: PMC10693823

Abstract Article PDF–13M

Select item 1063394310.

PINK1-PTEN axis promotes metastasis and chemoresistance in ovarian cancer via non-canonical pathway

Fang Zheng, Jiamin Zhong, Kelie Chen, Yu Shi, Fang Wang, Shengchao Wang, Song Tang, Xiaoyu Yuan, Zhangjin Shen, Sangsang Tang, Dajing Xia, Yihua Wu, Weiguo Lu

J Exp Clin Cancer Res. 2023; 42: 295. Published online 2023 Nov 9. doi: 10.1186/s13046-023-02823-w

PMCID:: PMC10633943

Abstract Article PDF–14M

Select item 1046704111.

Alpha‐synuclein‐associated changes in PINK1‐PRKN‐mediated mitophagy are disease context dependent

Xu Hou, Taylor Hsuan‐Yu Chen, Shunsuke Koga, Jenny M. Bredenberg, Ayman H. Faroqi, Marion Delenclos, Guojun Bu, Zbigniew K. Wszolek, Jonathan A. Carr, Owen A. Ross, Pamela J. McLean, Melissa E. Murray, Dennis W. Dickson, Fabienne C. Fiesel, Wolfdieter Springer

Brain Pathol. 2023 Sep; 33(5): e13175. Published online 2023 May 31. doi: 10.1111/bpa.13175

PMCID:: PMC10467041

Abstract Article PDF–2.9M

Select item 1026278412.

Substitution of PINK1 Gly411 modulates substrate receptivity and turnover

Fabienne C Fiesel, Dominika Fričová, Caleb S Hayes, Mathew A Coban, Roman Hudec, Jenny M Bredenberg, Benjamin J Broadway, Briana N Markham, Tingxiang Yan, Paige K Boneski, Gabriella Fiorino, Jens O Watzlawik, Xu Hou, Arthur M McCarty, Laura J Lewis-Tuffin, Jun Zhong, Benjamin J Madden, Alban Ordureau, Heeseon An, Andreas Puschmann, Zbigniew K Wszolek, Owen A Ross, J Wade Harper, Thomas R Caulfield, Wolfdieter Springer

Autophagy. 2023; 19(6): 1711–1732. Published online 2022 Dec 5. doi: 10.1080/15548627.2022.2151294

PMCID:: PMC10262784

Abstract Article PDF–5.5M

Select item 1026278113.

RHOA, a small G-protein, signals to mitophagy through regulation of PINK1 protein stability and protects cardiomyocytes against ischemia

Michelle Tu, Shigeki Miyamoto

Autophagy. 2023; 19(6): 1865–1866. Published online 2022 Oct 18. doi: 10.1080/15548627.2022.2132707

PMCID:: PMC10262781

Abstract Article PDF–265K

Select item 1024098314.

PINK1-PRKN mediated mitophagy: differences between in vitro and in vivo models

Rui Han, Yanting Liu, Shihua Li, Xiao-Jiang Li, Weili Yang

Autophagy. 2023; 19(5): 1396–1405. Published online 2022 Nov 3. doi: 10.1080/15548627.2022.2139080

PMCID:: PMC10240983

Abstract Article PDF–619K

Select item 1019686815.

MicroRNA-593-5p contributes to cell death following exposure to 1-methyl-4-phenylpyridinium by targeting PTEN-induced putative kinase 1

Myungsik Yoo, Doo Chul Choi, Aleta Murphy, Atiq M. Ahsan, Eunsung Junn

J Biol Chem. 2023 May; 299(5): 104709. Published online 2023 Apr 14. doi: 10.1016/j.jbc.2023.104709

PMCID:: PMC10196868

Abstract Article PDF–3.1M

Select item 1019686516.

PTEN-induced kinase PINK1 supports colorectal cancer growth by regulating the labile iron pool

Brandon Chen, Nupur K. Das, Indrani Talukder, Rashi Singhal, Cristina Castillo, Anthony Andren, Joseph D. Mancias, Costas A. Lyssiotis, Yatrik M. Shah

J Biol Chem. 2023 May; 299(5): 104691. Published online 2023 Apr 8. doi: 10.1016/j.jbc.2023.104691

PMCID:: PMC10196865

Abstract Article PDF–3.2M

Select item 1003957117.

Mitochondrial ROS driven by NOX4 upregulation promotes hepatocellular carcinoma cell survival after incomplete radiofrequency ablation by inducing of mitophagy via Nrf2/PINK1

Chao Peng, Xi Li, Feng Ao, Ting Li, Jingpei Guo, Junfeng Liu, Xiaoting Zhang, Jinyan Gu, Junjie Mao, Bin Zhou

J Transl Med. 2023; 21: 218. Published online 2023 Mar 25. doi: 10.1186/s12967-023-04067-w

PMCID:: PMC10039571

Abstract Article PDF–14M

Select item 997794718.

Targeting ATAD3A-PINK1-mitophagy axis overcomes chemoimmunotherapy resistance by redirecting PD-L1 to mitochondria

Xiao-Qing Xie, Yi Yang, Qiang Wang, Hao-Fei Liu, Xuan-Yu Fang, Cheng-Long Li, Yi-Zhou Jiang, Shuai Wang, Hong-Yu Zhao, Jing-Ya Miao, Shuai-Shuai Ding, Xin-Dong Liu, Xiao-Hong Yao, Wen-Tao Yang, Jun Jiang, Zhi-Ming Shao, Guoxiang Jin, Xiu-Wu Bian

Cell Res. 2023 Mar; 33(3): 215–228. Published online 2023 Jan 10. doi: 10.1038/s41422-022-00766-z

PMCID:: PMC9977947

Abstract Article PDF–5.5M

Select item 994834819.

PINK1 regulates apoptosis of osteosarcoma as the target gene of cisplatin

Zhenxing Si, Zilong Shen, Feiyu Luan, Jinglong Yan

J Orthop Surg Res. 2023; 18: 132. Published online 2023 Feb 23. doi: 10.1186/s13018-023-03615-w

PMCID:: PMC9948348

Abstract Article PDF–2.7M

Select item 976295020.

DJ-1 is an essential downstream mediator in PINK1/parkin-dependent mitophagy

Dorien Imberechts, Inge Kinnart, Fieke Wauters, Joanne Terbeek, Liselot Manders, Keimpe Wierda, Kristel Eggermont, Rodrigo Furtado Madeiro, Carolyn Sue, Catherine Verfaillie, Wim Vandenberghe

Brain. 2022 Dec; 145(12): 4368–4384. Published online 2022 Aug 30. doi: 10.1093/brain/awac313

PMCID:: PMC9762950

Abstract Article PDF–2.0M

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