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Select item 110860391.

IL21R hypomethylation as a biomarker for distinguishing benign and malignant breast tumours

Zishan Zang, Yifei Yin, Chunlan Liu, Qiang Zhu, Xuandong Huang, Hong Li, Rongxi Yang

Epigenetics. 2024; 19(1): 2352683. Published online 2024 May 9. doi: 10.1080/15592294.2024.2352683

PMCID:: PMC11086039

Abstract Article PDF–2.3M

Select item 110778802.

Interleukin-21 receptor signaling promotes metabolic dysfunction-associated steatohepatitis-driven hepatocellular carcinoma by inducing immunosuppressive IgA⁺ B cells

Ying Xie, Yu Huang, Zhi-Yong Li, Weihua Jiang, Nan-Xi Shi, Yuanzhi Lu, Guangchao Cao, Zhinan Yin, Xue-Jia Lin

Mol Cancer. 2024; 23: 95. Published online 2024 May 8. doi: 10.1186/s12943-024-02001-2

PMCID:: PMC11077880

Abstract Article PDF–11M

Select item 101377813.

IL-21 (rs2055979 and rs2221903)/IL-21R (rs3093301) Polymorphism and High Levels of IL-21 Are Associated with Rheumatoid Arthritis in Mexican Patients

Noemi Magdalena Carreño-Saavedra, Itzel Viridiana Reyes-Pérez, Andrea Carolina Machado-Sulbaran, Gloria Esther Martínez-Bonilla, María Guadalupe Ramírez-Dueñas, José Francisco Muñoz-Valle, Valeria Olaya-Valdiviezo, Trinidad García-Iglesias, Erika Aurora Martínez-García, Pedro Ernesto Sánchez-Hernández

Genes (Basel) 2023 Apr; 14(4): 878. Published online 2023 Apr 7. doi: 10.3390/genes14040878

PMCID:: PMC10137781

Abstract Article PDF–904K

Select item 81834764.

HIV-1 infection and the lack of viral control are associated with greater expression of interleukin-21 receptor on CD8⁺ T cells

Jama Dalel, Seng K. Ung, Peter Hayes, S. Lucas Black, Sarah Joseph, Deborah F. King, Julia Makinde, Jill Gilmour

AIDS. 2021 Jul 1; 35(8): 1167–1177. Published online 2021 Mar 11. doi: 10.1097/QAD.0000000000002864

PMCID:: PMC8183476

Abstract Article PDF–487K

Select item 80862295.

Genomic Spectrum and Phenotypic Heterogeneity of Human IL-21 Receptor Deficiency

Deniz Cagdas, Daniel Mayr, Safa Baris, Lisa Worley, David B. Langley, Ayse Metin, Elif Soyak Aytekin, Raziye Atan, Nurhan Kasap, Sevgi Köstel Bal, Jasmin Dmytrus, Raul Jimenez Heredia, Gulsun Karasu, Selda Hancerli Torun, Muge Toyran, Elif Karakoc-Aydiner, Daniel Christ, Baris Kuskonmaz, Duygu Uçkan-Çetinkaya, Aysegul Uner, Felicitas Oberndorfer, Ana-Iris Schiefer, Gulbu Uzel, Elissa K. Deenick, Baerbel Keller, Klaus Warnatz, Bénédicte Neven, Anne Durandy, Ozden Sanal, Cindy S. Ma, Ahmet Özen, Polina Stepensky, Ilhan Tezcan, Kaan Boztug, Stuart G. Tangye

J Clin Immunol. 2021; 41(6): 1272–1290. Published online 2021 Apr 30. doi: 10.1007/s10875-021-01031-5

PMCID:: PMC8086229

Abstract Article PDF–1.4M

Select item 79377246.

WSB1 and IL21R Genetic Variants Are Involved in Th2 Immune Responses to Ascaris lumbricoides

Valdirene Leão Carneiro, Hugo Bernardino Ferreira da Silva, Gerson de Almeida Queiroz, Rafael Valente Veiga, Pablo Rafael Silveira Oliveira, Norma Vilany Queiroz Carneiro, Anaque de Oliveira Pires, Raimon Rios da Silva, Flavia Sena, Emilia Belitardo, Regina Nascimento, Milca Silva, Cintia Rodrigues Marques, Ryan dos Santos Costa, Neuza Maria Alcantra-Neves, Mauricio L. Barreto, Philip J. Cooper, Camila Alexandrina Figueiredo

Front Immunol. 2021; 12: 622051. Published online 2021 Feb 22. doi: 10.3389/fimmu.2021.622051

PMCID:: PMC7937724

Abstract Article PDF–1009K

Select item 71699837.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 69420448.

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity

Jae Jin Kim, Seo Yun Lee, Fade Gong, Anna M. Battenhouse, Daniel R. Boutz, Aarti Bashyal, Samantha T. Refvik, Cheng-Ming Chiang, Blerta Xhemalce, Tanya T. Paull, Jennifer S. Brodbelt, Edward M. Marcotte, Kyle M. Miller

Genes Dev. 2019 Dec 1; 33(23-24): 1751–1774. doi: 10.1101/gad.331231.119

PMCID:: PMC6942044

Abstract Article PDF–10M

Select item 67776729.

IL-21/IL-21R inhibit tumor growth and invasion in non-small cell lung cancer cells via suppressing Wnt/β-catenin signaling and PD-L1 expression

Dan Xue, Ping Yang, Qiongying Wei, Xiaoping Li, Lan Lin, Tingyan Lin

Int J Mol Med. 2019 Nov; 44(5): 1697–1706. Published online 2019 Sep 26. doi: 10.3892/ijmm.2019.4354

PMCID:: PMC6777672

Abstract Article PDF–1.0M

Select item 659533010.

Interleukin‐21 receptor gene polymorphism is associated with hepatitis B virus‐related hepatocellular carcinoma in Chinese patients

Tangyuheng Liu, Jiajia Song, Mei Zhang, Siyue Li, Jinya Zhang, Xuejiao Hu, Zhenzhen Zhao, Wu Peng, Qian Wu, Hao Bai, Yinyu Li, Xiaojun Lu, Binwu Ying

J Clin Lab Anal. 2019 Jun; 33(5): e22860. Published online 2019 Feb 13. doi: 10.1002/jcla.22860

PMCID:: PMC6595330

Abstract Article PDF–397K

Select item 625506211.

IL-21R functions as an oncogenic factor and is regulated by the lncRNA MALAT1/miR-125a-3p axis in gastric cancer

Lei Yan, Jing Zhang, Dong Guo, Ji Ma, Shao-Feng Shui, Xin-Wei Han

Int J Oncol. 2019 Jan; 54(1): 7–16. Published online 2018 Oct 31. doi: 10.3892/ijo.2018.4612

PMCID:: PMC6255062

Abstract Article PDF–1.8M

Select item 539511812.

IL21R expressing CD14⁺CD16⁺ monocytes expand in multiple myeloma patients leading to increased osteoclasts

Marina Bolzoni, Domenica Ronchetti, Paola Storti, Gaetano Donofrio, Valentina Marchica, Federica Costa, Luca Agnelli, Denise Toscani, Rosanna Vescovini, Katia Todoerti, Sabrina Bonomini, Gabriella Sammarelli, Andrea Vecchi, Daniela Guasco, Fabrizio Accardi, Benedetta Dalla Palma, Barbara Gamberi, Carlo Ferrari, Antonino Neri, Franco Aversa, Nicola Giuliani

Haematologica. 2017 Apr; 102(4): 773–784. Prepublished online 2017 Jan 5. doi: 10.3324/haematol.2016.153841

PMCID:: PMC5395118

Abstract Article PDF–2.2M

Select item 535786213.

IL-21 restricts T follicular regulatory T cell proliferation through Bcl-6 mediated inhibition of responsiveness to IL-2

Christoph Jandl, Sue M. Liu, Pablo F. Cañete, Joanna Warren, William E. Hughes, Alexis Vogelzang, Kylie Webster, Maria E. Craig, Gulbu Uzel, Alexander Dent, Polina Stepensky, Bärbel Keller, Klaus Warnatz, Jonathan Sprent, Cecile King

Nat Commun. 2017; 8: 14647. Published online 2017 Mar 17. doi: 10.1038/ncomms14647

PMCID:: PMC5357862

Abstract Article PDF–1.5M

Select item 534753214.

Endothelial interleukin-21 receptor up-regulation in peripheral artery disease

Tao Wang, Alexis Cunningham, Kevin Houston, Aditya M Sharma, Lingdan Chen, Ayotunde O Dokun, R John Lye, Rosanne Spolski, Warren J Leonard, Brian H Annex

Vasc Med. Author manuscript; available in PMC 2017 Mar 13.

Published in final edited form as: Vasc Med. 2016 Apr; 21(2): 99–104. Published online 2015 Dec 24. doi: 10.1177/1358863X15621798

PMCID:: PMC5347532

Abstract Article PDF–626K

Select item 480313215.

Extending the clinical and immunological phenotype of human interleukin-21 receptor deficiency

Polina Stepensky, Baerbel Keller, Omar Abuzaitoun, Avraham Shaag, Barak Yaacov, Susanne Unger, Maximilian Seidl, Marta Rizzi, Michael Weintraub, Orly Elpeleg, Klaus Warnatz

Haematologica. 2015 Feb; 100(2): e72–e76. doi: 10.3324/haematol.2014.112508

PMCID:: PMC4803132

Article PDF–398K

Select item 445112916.

STAT3 is a critical cell-intrinsic regulator of human unconventional T cell numbers and function

Robert P. Wilson, Megan L. Ives, Geetha Rao, Anthony Lau, Kathryn Payne, Masao Kobayashi, Peter D. Arkwright, Jane Peake, Melanie Wong, Stephen Adelstein, Joanne M. Smart, Martyn A. French, David A. Fulcher, Capucine Picard, Jacinta Bustamante, Stephanie Boisson-Dupuis, Paul Gray, Polina Stepensky, Klaus Warnatz, Alexandra F. Freeman, Jamie Rossjohn, James McCluskey, Steven M. Holland, Jean-Laurent Casanova, Gulbu Uzel, Cindy S. Ma, Stuart G. Tangye, Elissa K. Deenick

J Exp Med. 2015 Jun 1; 212(6): 855–864. doi: 10.1084/jem.20141992

PMCID:: PMC4451129

Abstract Article PDF–2.1M

Select item 378523717.

STAT3 mutations underlying autosomal dominant hyper-IgE syndrome impair human CD8⁺ T cell memory formation and function

Megan L Ives, Cindy S Ma, Umaimainthan Palendira, Anna Chan, Jacinta Bustamante, Stephanie Boisson-Dupuis, Peter D Arkwright, Dan Engelhard, Diana Averbuch, Klaus Magdorf, Joachim Roesler, Jane Peake, Melanie Wong, Stephen Adelstein, Sharon Choo, Joanne M Smart, Martyn A French, David A Fulcher, Matthew C Cook, Capucine Picard, Anne Durandy, Miyuki Tsumura, Masao Kobayashi, Gulbu Uzel, Jean-Laurent Casanova, Stuart G Tangye, Elissa K Deenick

J Allergy Clin Immunol. Author manuscript; available in PMC 2014 Feb 1.

Published in final edited form as: J Allergy Clin Immunol. 2013 Aug; 132(2): 400–11.e9. Published online 2013 Jul 4. doi: 10.1016/j.jaci.2013.05.029

PMCID:: PMC3785237

Abstract Article PDF–1.9M

Select item 375340718.

A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci

David A. Hinds, George McMahon, Amy K. Kiefer, Chuong B. Do, Nicholas Eriksson, David M. Evans, Beate St Pourcain, Susan M. Ring, Joanna L. Mountain, Uta Francke, George Davey-Smith, Nicholas J. Timpson, Joyce Y. Tung

Nat Genet. Author manuscript; available in PMC 2014 Feb 1.

Published in final edited form as: Nat Genet. 2013 Aug; 45(8): 907–911. Published online 2013 Jun 30. doi: 10.1038/ng.2686

PMCID:: PMC3753407

Article PDF–455K

Select item 360090119.

Loss-of-function mutations in the IL-21 receptor gene cause a primary immunodeficiency syndrome

Daniel Kotlarz, Natalia Ziętara, Gulbu Uzel, Thomas Weidemann, Christian J. Braun, Jana Diestelhorst, Peter M. Krawitz, Peter N. Robinson, Jochen Hecht, Jacek Puchałka, E. Michael Gertz, Alejandro A. Schäffer, Monica G. Lawrence, Lela Kardava, Dietmar Pfeifer, Ulrich Baumann, Eva-Doreen Pfister, Eric P. Hanson, Axel Schambach, Roland Jacobs, Hans Kreipe, Susan Moir, Joshua D. Milner, Petra Schwille, Stefan Mundlos, Christoph Klein

J Exp Med. 2013 Mar 11; 210(3): 433–443. doi: 10.1084/jem.20111229

PMCID:: PMC3600901

Abstract Article PDF–2.2M

Select item 330877520.

Crystal Structure of Interleukin-21 Receptor (IL-21R) Bound to IL-21 Reveals That Sugar Chain Interacting with WSXWS Motif Is Integral Part of IL-21R

Ole J. Hamming, Lishan Kang, Anders Svensson, Jesper L. Karlsen, Henrik Rahbek-Nielsen, Søren R. Paludan, Siv A. Hjorth, Kent Bondensgaard, Rune Hartmann

J Biol Chem. 2012 Mar 16; 287(12): 9454–9460. Published online 2012 Jan 10. doi: 10.1074/jbc.M111.311084

PMCID:: PMC3308775

Abstract Article PDF–1.3M

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