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Select item 110670311.

PML::RARA and GATA2 proteins interact via DNA templates to induce aberrant self-renewal in mouse and human hematopoietic cells

Casey D. S. Katerndahl, Olivia R. S. Rogers, Ryan B. Day, Ziheng Xu, Nichole M. Helton, Sai Mukund Ramakrishnan, Christopher A. Miller, Timothy J. Ley

Proc Natl Acad Sci U S A. 2024 Apr 30; 121(18): e2317690121. Published online 2024 Apr 22. doi: 10.1073/pnas.2317690121

PMCID:: PMC11067031

Abstract Article PDF–7.2M

Select item 110154972.

Y chromosome damage underlies testicular abnormalities in ATR-X syndrome

Nayla Y. León, Thanh Nha Uyen Le, Andrew Garvie, Lee H. Wong, Stefan Bagheri-Fam, Vincent R. Harley

iScience. 2024 May 17; 27(5): 109629. Published online 2024 Mar 28. doi: 10.1016/j.isci.2024.109629

PMCID:: PMC11015497

Abstract Article PDF–4.6M

Select item 109176603.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 90665194.

The Paget's disease of bone risk gene PML is a negative regulator of osteoclast differentiation and bone resorption

Sachin Wani, Anna Daroszewska, Donald M. Salter, Rob J. van ‘t Hof, Stuart H. Ralston, Omar M. E. Albagha

Dis Model Mech. 2022 Apr 1; 15(4): dmm049318. Published online 2022 Apr 26. doi: 10.1242/dmm.049318

PMCID:: PMC9066519

Abstract Article

Select item 86470225.

Promyelocytic leukemia protein targets MK2 to promote cytotoxicity

I‐Ting Chen, Hsiao‐Chi Chen, Yu‐Hsun Lo, Peng‐Yeh Lai, Fu‐Yi Hsieh, Yung‐Hsuan Wu, Hsiu‐Ming Shih, Ming‐Zong Lai

EMBO Rep. 2021 Dec 6; 22(12): e52254. Published online 2021 Oct 11. doi: 10.15252/embr.202052254

PMCID:: PMC8647022

Abstract Article PDF–3.1M

Select item 80265636.

Robust p53 stabilization is dispensable for its activation and tumor suppressor function

Ning Kon, Michael Churchill, Huan Li, Siddhartha Mukherjee, James J. Manfredi, Wei Gu

Cancer Res. Author manuscript; available in PMC 2021 Aug 15.

Published in final edited form as: Cancer Res. 2021 Feb 15; 81(4): 935–944. Published online 2020 Dec 15. doi: 10.1158/0008-5472.CAN-20-1804

PMCID:: PMC8026563

Abstract Article PDF–1.5M

Select item 78805947.

Usp11 controls cortical neurogenesis and neuronal migration through Sox11 stabilization

Shang-Yin Chiang, Hsin-Chieh Wu, Shu-Yu Lin, Hsin-Yi Chen, Chia-Fang Wang, Nai-Hsing Yeh, Jou-Ho Shih, Yi-Shuian Huang, Hung-Chih Kuo, Shen-Ju Chou, Ruey-Hwa Chen

Sci Adv. 2021 Feb; 7(7): eabc6093. Published online 2021 Feb 12. doi: 10.1126/sciadv.abc6093

PMCID:: PMC7880594

Abstract Article PDF–6.1M

Select item 75797378.

JAK2^V617F myeloproliferative neoplasm eradication by a novel interferon/arsenic therapy involves PML

Tracy Dagher, Nabih Maslah, Valérie Edmond, Bruno Cassinat, William Vainchenker, Stéphane Giraudier, Florence Pasquier, Emmanuelle Verger, Michiko Niwa-Kawakita, Valérie Lallemand-Breitenbach, Isabelle Plo, Jean-Jacques Kiladjian, Jean-Luc Villeval, Hugues de Thé

J Exp Med. 2021 Feb 1; 218(2): e20201268. Published online 2020 Oct 19. doi: 10.1084/jem.20201268

PMCID:: PMC7579737

Abstract Article PDF–3.9M

Select item 67149809.

An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer

Ming Chen, Jiangwen Zhang, Katia Sampieri, John G. Clohessy, Lourdes Mendez, Enrique Gonzalez-Billalabeitia, Xue-Song Liu, Yu-Ru Lee, Jacqueline Fung, Jesse M. Katon, Archita Venugopal Menon, Kaitlyn A. Webster, Christopher Ng, Maria Dilia Palumbieri, Moussa S. Diolombi, Susanne B. Breitkopf, Julie Teruya-Feldstein, Sabina Signoretti, Roderick T. Bronson, John M. Asara, Mireia Castillo-Martin, Carlos Cordon-Cardo, Pier Paolo Pandolfi

Nat Genet. Author manuscript; available in PMC 2019 Aug 29.

Published in final edited form as: Nat Genet. 2018 Feb; 50(2): 206–218. Published online 2018 Jan 15. doi: 10.1038/s41588-017-0027-2

PMCID:: PMC6714980

Abstract Article PDF–1.6M

Select item 641197910.

Loss of SET reveals both the p53-dependent and the p53-independent functions in vivo

Ning Kon, Donglai Wang, Wei Gu

Cell Death Dis. 2019 Mar; 10(3): 237. Published online 2019 Mar 11. doi: 10.1038/s41419-019-1484-6

PMCID:: PMC6411979

Abstract Article PDF–2.3M

Select item 580548911.

Pml nuclear body disruption cooperates in APL pathogenesis and impairs DNA damage repair pathways in mice

Edwige Voisset, Eva Moravcsik, Eva W. Stratford, Amie Jaye, Christopher J. Palgrave, Robert K. Hills, Paolo Salomoni, Scott C. Kogan, Ellen Solomon, David Grimwade

Blood. 2018 Feb 8; 131(6): 636–648. Prepublished online 2017 Nov 30. doi: 10.1182/blood-2017-07-794784

PMCID:: PMC5805489

Abstract Article

Select item 577020112.

A Functional Screen to Identify Novel Effectors of Hematopoietic Stem Cell Activity

Eric Deneault, Sonia Cellot, Amélie Faubert, Jean-Philippe Laverdure, Mélanie Fréchette, Jalila Chagraoui, Nadine Mayotte, Martin Sauvageau, Stephen B. Ting, Guy Sauvageau

Cell. Author manuscript; available in PMC 2018 Jan 16.

Published in final edited form as: Cell. 2009 Apr 17; 137(2): 369–379. doi: 10.1016/j.cell.2009.03.026

PMCID:: PMC5770201

Abstract Article PDF–1.6M

Select item 575435713.

A non-cell-autonomous role for Pml in the maintenance of leukemia from the niche

Jlenia Guarnerio, Lourdes Maria Mendez, Noboru Asada, Archita Venugopal Menon, Jacqueline Fung, Kelsey Berry, Paul S. Frenette, Keisuke Ito, Pier Paolo Pandolfi

Nat Commun. 2018; 9: 66. Published online 2018 Jan 4. doi: 10.1038/s41467-017-02427-x

PMCID:: PMC5754357

Abstract Article PDF–2.5M

Select item 567916514.

PML is a ROS sensor activating p53 upon oxidative stress

Michiko Niwa-Kawakita, Omar Ferhi, Hassane Soilihi, Morgane Le Bras, Valérie Lallemand-Breitenbach, Hugues de Thé

J Exp Med. 2017 Nov 6; 214(11): 3197–3206. doi: 10.1084/jem.20160301

PMCID:: PMC5679165

Abstract Article PDF–1.9M

Select item 547321215.

Dual regulation of Stat1 and Stat3 by the tumor suppressor protein PML contributes to interferon α-mediated inhibition of angiogenesis

Kuo-Sheng Hsu, Xuan Zhao, Xiwen Cheng, Dongyin Guan, Ganapati H. Mahabeleshwar, Yu Liu, Ernest Borden, Mukesh K. Jain, Hung-Ying Kao

J Biol Chem. 2017 Jun 16; 292(24): 10048–10060. Published online 2017 Apr 21. doi: 10.1074/jbc.M116.771071

PMCID:: PMC5473212

Abstract Article PDF–2.4M

Select item 545332516.

PML protein organizes heterochromatin domains where it regulates histone H3.3 deposition by ATRX/DAXX

Erwan Delbarre, Kristina Ivanauskiene, Jane Spirkoski, Akshay Shah, Kristin Vekterud, Jan Øivind Moskaug, Stig Ove Bøe, Lee H. Wong, Thomas Küntziger, Philippe Collas

Genome Res. 2017 Jun; 27(6): 913–921. doi: 10.1101/gr.215830.116

PMCID:: PMC5453325

Abstract Article PDF–1.0M

Select item 538654617.

Myogenic differentiation triggers PML nuclear body loss and DAXX relocalization to chromocentres

Jayme Salsman, Lindsy M Rapkin, Nandini N Margam, Roy Duncan, David P Bazett-Jones, Graham Dellaire

Cell Death Dis. 2017 Mar; 8(3): e2724. Published online 2017 Mar 30. doi: 10.1038/cddis.2017.151

PMCID:: PMC5386546

Abstract Article PDF–4.3M

Select item 538122618.

Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function

Tingting Zhang, Wei Du, Andrew F. Wilson, Satoshi H. Namekawa, Paul R. Andreassen, Amom Ruhikanta Meetei, Qishen Pang

Sci Rep. 2017; 7: 45626. Published online 2017 Apr 5. doi: 10.1038/srep45626

PMCID:: PMC5381226

Abstract Article PDF–1.4M

Select item 536321719.

Manipulating PML SUMOylation via Silencing UBC9 and RNF4 Regulates Cardiac Fibrosis

Yu Liu, Dan Zhao, Fang Qiu, Ling-Ling Zhang, Shang-Kun Liu, Yuan-Yuan Li, Mei-Tong Liu, Di Wu, Jia-Xin Wang, Xiao-Qing Ding, Yan-Xin Liu, Chang-Jiang Dong, Xiao-Qi Shao, Bao-Feng Yang, Wen-Feng Chu

Mol Ther. 2017 Mar 1; 25(3): 666–678. Published online 2017 Jan 28. doi: 10.1016/j.ymthe.2016.12.021

PMCID:: PMC5363217

Abstract Article PDF–4.5M

Select item 501940020.

Latency Entry of Herpes Simplex Virus 1 Is Determined by the Interaction of Its Genome with the Nuclear Environment

Mohamed Ali Maroui, Aleth Callé, Camille Cohen, Nathalie Streichenberger, Pascale Texier, Julie Takissian, Antoine Rousseau, Nolwenn Poccardi, Jérémy Welsch, Armelle Corpet, Laurent Schaeffer, Marc Labetoulle, Patrick Lomonte

PLoS Pathog. 2016 Sep; 12(9): e1005834. Published online 2016 Sep 12. doi: 10.1371/journal.ppat.1005834

PMCID:: PMC5019400

Abstract Article PDF–14M

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