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Items: 1 to 20 of 46

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
Tonic prime-boost of STING signalling mediates Niemann–Pick disease type C
Ting-Ting Chu, Xintao Tu, Kun Yang, Jianjun Wu, Joyce J. Repa, Nan Yan
Nature. Author manuscript; available in PMC 2022 Feb 21.
Published in final edited form as: Nature. 2021 Aug; 596(7873): 570–575. Published online 2021 Jul 21. doi: 10.1038/s41586-021-03762-2
PMCID:
PMC8859990
AbstractArticlePDF–5.6M
3.
Ezh2 is essential for the generation of functional yolk sac derived erythro-myeloid progenitors
Wen Hao Neo, Yiran Meng, Alba Rodriguez-Meira, Muhammad Z. H. Fadlullah, Christopher A. G. Booth, Emanuele Azzoni, Supat Thongjuea, Marella F. T. R. de Bruijn, Sten Eirik W. Jacobsen, Adam J. Mead, Georges Lacaud
Nat Commun. 2021; 12: 7019. Published online 2021 Dec 2. doi: 10.1038/s41467-021-27140-8
PMCID:
PMC8640066
AbstractArticlePDF–3.3M
4.
Proteotyping of knockout mouse strains reveals sex- and strain-specific signatures in blood plasma
Yassene Mohammed, Sarah A. Michaud, Helena Pětrošová, Juncong Yang, Milan Ganguly, David Schibli, Ann M. Flenniken, Lauryl M. J. Nutter, Hibret A. Adissu, K. C. Kent Lloyd, Colin McKerlie, Christoph H. Borchers
NPJ Syst Biol Appl. 2021; 7: 25. Published online 2021 May 28. doi: 10.1038/s41540-021-00184-8
PMCID:
PMC8163790
AbstractArticlePDF–6.9M
5.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
6.
The involvement of Cathepsin B and L in inflammation and cholesterol trafficking protein NPC2 secretion in macrophages
Jennifer Hannaford, Hong Guo, Xiaoli Chen
Obesity (Silver Spring) Author manuscript; available in PMC 2019 Apr 2.
Published in final edited form as: Obesity (Silver Spring). 2013 Aug; 21(8): 1586–1595. Published online 2013 May 13. doi: 10.1002/oby.20136
PMCID:
PMC6445554
AbstractArticlePDF–2.0M
7.
Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors
Hyeonwoo Kim, Christiane D. Wrann, Mark Jedrychowski, Sara Vidoni, Yukiko Kitase, Kenichi Nagano, Chenhe Zhou, Joshua Chou, Virginia-Jeni A. Parkman, Scott J. Novick, Timothy S. Strutzenberg, Bruce D. Pascal, Phuong T. Le, Daniel J. Brooks, Alexander M. Roche, Kaitlyn K. Gerber, Laura Mattheis, Wenjing Chen, Hua Tu, Mary L. Bouxsein, Patrick R. Griffin, Roland Baron, Clifford J. Rosen, Lynda F. Bonewald, Bruce M. Spiegelman
Cell. Author manuscript; available in PMC 2019 Dec 13.
Published in final edited form as: Cell. 2018 Dec 13; 175(7): 1756–1768.e17. doi: 10.1016/j.cell.2018.10.025
Correction in:
Cell. 2019 Jul 11; 178(2): 507–508.
PMCID:
PMC6298040
AbstractArticlePDF–1.2M
8.
Loss of CLN7 results in depletion of soluble lysosomal proteins and impaired mTOR reactivation
Tatyana Danyukova, Khandsuren Ariunbat, Melanie Thelen, Nahal Brocke-Ahmadinejad, Sara E Mole, Stephan Storch
Hum Mol Genet. 2018 May 15; 27(10): 1711–1722. Published online 2018 Mar 5. doi: 10.1093/hmg/ddy076
PMCID:
PMC5932567
AbstractArticlePDF–710K
9.
Normalization of Hepatic Homeostasis in the Npc1nmf164 Mouse Model of Niemann-Pick Type C Disease Treated with the Histone Deacetylase Inhibitor Vorinostat
Andrew B. Munkacsi, Natalie Hammond, Remy T. Schneider, Dinindu S. Senanayake, Katsumi Higaki, Kirill Lagutin, Stephen J. Bloor, Daniel S. Ory, Robert A. Maue, Fannie W. Chen, Antonio Hernandez-Ono, Nicole Dahlson, Joyce J. Repa, Henry N. Ginsberg, Yiannis A. Ioannou, Stephen L. Sturley
J Biol Chem. 2017 Mar 17; 292(11): 4395–4410. Published online 2016 Dec 28. doi: 10.1074/jbc.M116.770578
PMCID:
PMC5377760
AbstractArticlePDF–2.8M
10.
FTY720/fingolimod increases NPC1 and NPC2 expression and reduces cholesterol and sphingolipid accumulation in Niemann-Pick type C mutant fibroblasts
Jason Newton, Nitai C. Hait, Michael Maceyka, Alexandria Colaco, Melissa Maczis, Christopher A. Wassif, Antony Cougnoux, Forbes D. Porter, Sheldon Milstien, Nicholas Platt, Frances M. Platt, Sarah Spiegel
FASEB J. 2017 Apr; 31(4): 1719–1730. Published online 2017 Jan 12. doi: 10.1096/fj.201601041R
PMCID:
PMC5349795
AbstractArticle
11.
AAV9-NPC1 significantly ameliorates Purkinje cell death and behavioral abnormalities in mouse NPC disease
Chang Xie, Xue-Min Gong, Jie Luo, Bo-Liang Li, Bao-Liang Song
J Lipid Res. 2017 Mar; 58(3): 512–518. Published online 2017 Feb 27. doi: 10.1194/jlr.M071274
PMCID:
PMC5335581
AbstractArticlePDF–2.0M
12.
High-throughput discovery of novel developmental phenotypes
Mary E. Dickinson, Ann M. Flenniken, Xiao Ji, Lydia Teboul, Michael D. Wong, Jacqueline K. White, Terrence F. Meehan, Wolfgang J. Weninger, Henrik Westerberg, Hibret Adissu, Candice N. Baker, Lynette Bower, James M. Brown, L. Brianna Caddle, Francesco Chiani, Dave Clary, James Cleak, Mark J. Daly, James M. Denegre, Brendan Doe, Mary E. Dolan, Sarah M. Edie, Helmut Fuchs, Valerie Gailus-Durner, Antonella Galli, Alessia Gambadoro, Juan Gallegos, Shiying Guo, Neil R. Horner, Chih-wei Hsu, Sara J. Johnson, Sowmya Kalaga, Lance C. Keith, Louise Lanoue, Thomas N. Lawson, Monkol Lek, Manuel Mark, Susan Marschall, Jeremy Mason, Melissa L. McElwee, Susan Newbigging, Lauryl M.J. Nutter, Kevin A. Peterson, Ramiro Ramirez-Solis, Douglas J. Rowland, Edward Ryder, Kaitlin E. Samocha, John R. Seavitt, Mohammed Selloum, Zsombor Szoke-Kovacs, Masaru Tamura, Amanda G Trainor, Ilinca Tudose, Shigeharu Wakana, Jonathan Warren, Olivia Wendling, David B. West, Leeyean Wong, Atsushi Yoshiki, The International Mouse Phenotyping Consortium, Daniel G. MacArthur, Glauco P. Tocchini-Valentini, Xiang Gao, Paul Flicek, Allan Bradley, William C. Skarnes, Monica J. Justice, Helen E. Parkinson, Mark Moore, Sara Wells, Robert E. Braun, Karen L. Svenson, Martin Hrabe de Angelis, Yann Herault, Tim Mohun, Ann-Marie Mallon, R. Mark Henkelman, Steve D.M. Brown, David J. Adams, K.C. Kent Lloyd, Colin McKerlie, Arthur L. Beaudet, Maja Bucan, Stephen A. Murray
Nature. Author manuscript; available in PMC 2017 Mar 14.
Published in final edited form as: Nature. 2016 Sep 22; 537(7621): 508–514. Published online 2016 Sep 14. doi: 10.1038/nature19356
Correction in:
Nature. 2017 Nov 16; 551(7680): 398.
PMCID:
PMC5295821
AbstractArticlePDF–3.0M
13.
Arf6 controls retromer traffic and intracellular cholesterol distribution via a phosphoinositide-based mechanism
Catherine Marquer, Huasong Tian, Julie Yi, Jayson Bastien, Claudia Dall'Armi, YoungJoo Yang-Klingler, Bowen Zhou, Robin Barry Chan, Gilbert Di Paolo
Nat Commun. 2016; 7: 11919. Published online 2016 Jun 23. doi: 10.1038/ncomms11919
PMCID:
PMC4931008
AbstractArticlePDF–3.7M
14.
The cholesterol-binding protein NPC2 restrains recruitment of stromal macrophage-lineage cells to early-stage lung tumours
Tamihiro Kamata, Hong Jin, Susan Giblett, Bipin Patel, Falguni Patel, Charles Foster, Catrin Pritchard
EMBO Mol Med. 2015 Sep; 7(9): 1119–1137. Published online 2015 Jul 16. doi: 10.15252/emmm.201404838
PMCID:
PMC4568947
AbstractArticlePDF–4.8M
15.
Expression profile analysis of vulnerable CA1 pyramidal neurons in young-middle aged Ts65Dn mice
Melissa J. Alldred, Sang Han Lee, Eva Petkova, Stephen D. Ginsberg
J Comp Neurol. Author manuscript; available in PMC 2016 Jan 1.
Published in final edited form as: J Comp Neurol. 2015 Jan 1; 523(1): 61–74. Published online 2014 Aug 30. doi: 10.1002/cne.23663
PMCID:
PMC4232465
AbstractArticlePDF–909K
16.
Ontogenic changes in lung cholesterol metabolism, lipid content, and histology in mice with Niemann-Pick type C disease
Charina M. Ramirez, Adam M. Lopez, Lam Q. Le, Kenneth S. Posey, Arthur G. Weinberg, Stephen D. Turley
Biochim Biophys Acta. Author manuscript; available in PMC 2015 Jan 1.
Published in final edited form as: Biochim Biophys Acta. 2014 Jan; 1841(1): 10.1016/j.bbalip.2013.09.010. Published online 2013 Sep 26. doi: 10.1016/j.bbalip.2013.09.010
PMCID:
PMC3849124
AbstractArticlePDF–2.9M
17.
Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates
Jeremy A. Miller, Jason Nathanson, Daniel Franjic, Sungbo Shim, Rachel A. Dalley, Sheila Shapouri, Kimberly A. Smith, Susan M. Sunkin, Amy Bernard, Jeffrey L. Bennett, Chang-Kyu Lee, Michael J. Hawrylycz, Allan R. Jones, David G. Amaral, Nenad Sestan, Fred H. Gage, Ed S. Lein
Development. 2013 Nov 15; 140(22): 4633–4644. doi: 10.1242/dev.097212
PMCID:
PMC3817946
AbstractArticle
18.
Pulmonary Abnormalities in Animal Models Due to Niemann-Pick Type C1 (NPC1) or C2 (NPC2) Disease
Blair R. Roszell, Jian-Qin Tao, Kevin J. Yu, Ling Gao, Shaohui Huang, Yue Ning, Sheldon I. Feinstein, Charles H. Vite, Sandra R. Bates
PLoS One. 2013; 8(7): e67084. Published online 2013 Jul 2. doi: 10.1371/journal.pone.0067084
PMCID:
PMC3699545
AbstractArticlePDF–6.0M
19.
A conditional knockout resource for the genome–wide study of mouse gene function
William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley
Nature. Author manuscript; available in PMC 2013 Feb 14.
Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163
PMCID:
PMC3572410
AbstractArticlePDF–1.1M
20.
Glycine N-Methyltransferase Deficiency Affects Niemann-Pick Type C2 Protein Stability and Regulates Hepatic Cholesterol Homeostasis
Yi-Jen Liao, Tzu-Lang Chen, Tzong-Shyuan Lee, Hsiang-An Wang, Chung-Kwe Wang, Li-Ying Liao, Ren-Shyan Liu, Shiu-Feng Huang, Yi-Ming Arthur Chen
Mol Med. 2012; 18(1): 412–422. Published online 2011 Dec 15. doi: 10.2119/molmed.2011.00258
PMCID:
PMC3356423
AbstractArticlePDF–11M

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