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Select item 112169881.

NFKBIE mutations are selected by the tumor microenvironment and contribute to immune escape in chronic lymphocytic leukemia

Alice Bonato, Supriya Chakraborty, Riccardo Bomben, Giulia Canarutto, Giulia Felician, Claudio Martines, Antonella Zucchetto, Federico Pozzo, Marija Vujovikj, Jerry Polesel, Annalisa Chiarenza, Maria Ilaria Del Principe, Giovanni Del Poeta, Giovanni D’Arena, Roberto Marasca, Agostino Tafuri, Luca Laurenti, Silvano Piazza, Aleksandar J. Dimovski, Valter Gattei, Dimitar G. Efremov

Leukemia. 2024; 38(7): 1511–1521. Published online 2024 Mar 15. doi: 10.1038/s41375-024-02224-8

PMCID:: PMC11216988

Abstract Article PDF–1.8M

Select item 84898552.

NFκB Dynamics Determine the Stimulus-Specificity of Epigenomic Reprogramming in Macrophages

Quen J. Cheng, Sho Ohta, Katherine M. Sheu, Roberto Spreafico, Adewunmi Adelaja, Brooks Taylor, Alexander Hoffmann

Science. Author manuscript; available in PMC 2021 Oct 4.

Published in final edited form as: Science. 2021 Jun 18; 372(6548): 1349–1353. doi: 10.1126/science.abc0269

PMCID:: PMC8489855

Abstract Article PDF–1.4M

Select item 81841273.

Six distinct NFκB signaling codons convey discrete information to distinguish stimuli and enable appropriate macrophage responses

Adewunmi Adelaja, Brooks Taylor, Katherine M. Sheu, Yi Liu, Stefanie Luecke, Alexander Hoffmann

Immunity. Author manuscript; available in PMC 2021 Jun 7.

Published in final edited form as: Immunity. 2021 May 11; 54(5): 916–930.e7. doi: 10.1016/j.immuni.2021.04.011

PMCID:: PMC8184127

Abstract Article PDF–3.0M

Select item 72716494.

IκBα deficiency imposes a fetal phenotype to intestinal stem cells

Laura Marruecos, Joan Bertran, Yolanda Guillén, Jéssica González, Raquel Batlle, Erika López‐Arribillaga, Marta Garrido, Cristina Ruiz‐Herguido, Dominique Lisiero, Mónica González‐Farré, Sara Arce‐Gallego, Mar Iglesias, Angel R Nebreda, Shigeki Miyamoto, Anna Bigas, Lluís Espinosa

EMBO Rep. 2020 Jun 4; 21(6): e49708. Published online 2020 Apr 9. doi: 10.15252/embr.201949708

PMCID:: PMC7271649

Abstract Article PDF–12M

Select item 64433375.

Proteasome activator REGγ promotes inflammation in Leydig cells via IkBε signaling

Tiancheng Xie, Hui Chen, Shihui Shen, Tingmei Huang, Bisheng Huang, Guanghui Hu, Lei Li, Yunfei Xu

Int J Mol Med. 2019 May; 43(5): 1961–1968. Published online 2019 Feb 27. doi: 10.3892/ijmm.2019.4115

PMCID:: PMC6443337

Abstract Article PDF–1.6M

Select item 57464556.

A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals Molecular Determinants of Redox Homeostasis and NF-κB Signaling

Ramy H. Malty, Hiroyuki Aoki, Ashwani Kumar, Sadhna Phanse, Shahreen Amin, Qingzhou Zhang, Zoran Minic, Florian Goebels, Gabriel Musso, Zhuoran Wu, Hosam Abou-tok, Michael Meyer, Viktor Deineko, Sandy Kassir, Vishaldeep Sidhu, Matthew Jessulat, Nichollas E. Scott, Xuejian Xiong, James Vlasblom, Bhanu Prasad, Leonard J. Foster, Tiziana Alberio, Barbara Garavaglia, Haiyuan Yu, Gary D. Bader, Ken Nakamura, John Parkinson, Mohan Babu

Cell Syst. Author manuscript; available in PMC 2018 Dec 27.

Published in final edited form as: Cell Syst. 2017 Dec 27; 5(6): 564–577.e12. Published online 2017 Nov 8. doi: 10.1016/j.cels.2017.10.010

PMCID:: PMC5746455

Abstract Article PDF–3.3M

Select item 50340637.

The Nuclear Protein IκBζ Forms a Transcriptionally Active Complex with Nuclear Factor-κB (NF-κB) p50 and the Lcn2 Promoter via the N- and C-terminal Ankyrin Repeat Motifs

Akira Kohda, Soh Yamazaki, Hideki Sumimoto

J Biol Chem. 2016 Sep 23; 291(39): 20739–20752. Published online 2016 Aug 3. doi: 10.1074/jbc.M116.719302

PMCID:: PMC5034063

Abstract Article PDF–6.2M

Select item 47648998.

The REGγ-proteasome forms a regulatory circuit with IκBɛ and NFκB in experimental colitis

Jinjin Xu, Lei Zhou, Lei Ji, Fengyuan Chen, Karen Fortmann, Kun Zhang, Qingwu Liu, Ke Li, Weicang Wang, Hao Wang, Wei Xie, Qingwei Wang, Jiang Liu, Biao Zheng, Pei Zhang, Shixia Huang, Tieliu Shi, Biaohong Zhang, Yongyan Dang, Jiwu Chen, Bert W. O'Malley, Robb E. Moses, Ping Wang, Lei Li, Jianru Xiao, Alexander Hoffmann, Xiaotao Li

Nat Commun. 2016; 7: 10761. Published online 2016 Feb 22. doi: 10.1038/ncomms10761

PMCID:: PMC4764899

Abstract Article PDF–2.9M

Select item 43195599.

A high resolution spatiotemporal atlas of gene expression of the developing mouse brain

Carol L. Thompson, Lydia Ng, Vilas Menon, Salvador Martinez, Chang-Kyu Lee, Katie Glattfelder, Susan M. Sunkin, Alex Henry, Christopher Lau, Chinh Dang, Raquel Garcia-Lopez, Almudena Martinez-Ferre, Ana Pombero, John L.R. Rubenstein, Wayne B. Wakeman, John Hohmann, Nick Dee, Andrew J. Sodt, Rob Young, Kimberly Smith, Thuc-Nghi Nguyen, Jolene Kidney, Leonard Kuan, Andreas Jeromin, Ajamete Kaykas, Jeremy Miller, Damon Page, Geri Orta, Amy Bernard, Zackery Riley, Simon Smith, Paul Wohnoutka, Mike Hawrylycz, Luis Puelles, Allan R. Jones

Neuron. Author manuscript; available in PMC 2015 Jul 16.

Published in final edited form as: Neuron. 2014 Jul 16; 83(2): 309–323. Published online 2014 Jun 19. doi: 10.1016/j.neuron.2014.05.033

PMCID:: PMC4319559

Abstract Article PDF–3.0M

Select item 396564210.

IκBε is a key regulator of B-cell expansion by providing negative feedback on cRel and RelA in a stimulus-specific manner

Bryce N. Alves, Rachel Tsui, Jon Almaden, Maxim N. Shokhirev, Jeremy Davis-Turak, Jessica Fujimoto, Harry Birnbaum, Julia Ponomarenko, Alexander Hoffmann

J Immunol. Author manuscript; available in PMC 2015 Apr 1.

Published in final edited form as: J Immunol. 2014 Apr 1; 192(7): 3121–3132. Published online 2014 Mar 3. doi: 10.4049/jimmunol.1302351

PMCID:: PMC3965642

Abstract Article PDF–3.2M

Select item 363461111.

Control of RelB during dendritic cell activation integrates canonical and non-canonical NF-?B pathways

Vincent F.-S. Shih, Jeremy Davis-Turak, Monica Macal, Jenny Q. Huang, Julia Ponomarenko, Jeffrey D. Kearns, Tony Yu, Riku Fagerlund, Masataka Asagiri, Elina I. Zuniga, Alexander Hoffmann

Nat Immunol. Author manuscript; available in PMC 2013 Jun 1.

Published in final edited form as: Nat Immunol. 2012 Dec; 13(12): 1162–1170. Published online 2012 Oct 21. doi: 10.1038/ni.2446

PMCID:: PMC3634611

Abstract Article PDF–1.3M

Select item 357241012.

A conditional knockout resource for the genome–wide study of mouse gene function

William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley

Nature. Author manuscript; available in PMC 2013 Feb 14.

Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163

PMCID:: PMC3572410

Abstract Article PDF–1.1M

Select item 343984513.

A Genome-Wide Screen to Identify Transcription Factors Expressed in Pelvic Ganglia of the Lower Urinary Tract

Carrie B. Wiese, Sara Ireland, Nicole L. Fleming, Jing Yu, M. Todd Valerius, Kylie Georgas, Han Sheng Chiu, Jane Brennan, Jane Armstrong, Melissa H. Little, Andrew P. McMahon, E. Michelle Southard-Smith

Front Neurosci. 2012; 6: 130. Published online 2012 Sep 12. doi: 10.3389/fnins.2012.00130

PMCID:: PMC3439845

Abstract Article PDF–1.4M

Select item 317805914.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 316784715.

Inhibitor of Kappa B Epsilon (IκBε) Is a Non-Redundant Regulator of c-Rel-Dependent Gene Expression in Murine T and B Cells

Joanna M. Clark, Karolina Aleksiyadis, Alex Martin, Kay McNamee, Tharsana Tharmalingam, Richard O. Williams, Sylvie Mémet, Andrew P. Cope

PLoS One. 2011; 6(9): e24504. Published online 2011 Sep 6. doi: 10.1371/journal.pone.0024504

PMCID:: PMC3167847

Abstract Article PDF–1.8M

Select item 311015116.

A Systems Approach Reveals that the Myogenesis Genome Network Is Regulated by the Transcriptional Repressor RP58

Shigetoshi Yokoyama, Yoshiaki Ito, Hiroe Ueno-Kudoh, Hirohito Shimizu, Kenta Uchibe, Sonia Albini, Kazuhiko Mitsuoka, Shigeru Miyaki, Minako Kiso, Akane Nagai, Tomohiro Hikata, Tadahiro Osada, Noritsugu Fukuda, Satoshi Yamashita, Daisuke Harada, Valeria Mezzano, Masataka Kasai, Pier Lorenzo Puri, Yoshihide Hayashizaki, Haruo Okado, Megumi Hashimoto, Hiroshi Asahara

Dev Cell. Author manuscript; available in PMC 2011 Jun 7.

Published in final edited form as: Dev Cell. 2009 Dec; 17(6): 836–848. doi: 10.1016/j.devcel.2009.10.011

PMCID:: PMC3110151

Abstract Article PDF–2.0M

Select item 302253417.

A High-Resolution Anatomical Atlas of the Transcriptome in the Mouse Embryo

Graciana Diez-Roux, Sandro Banfi, Marc Sultan, Lars Geffers, Santosh Anand, David Rozado, Alon Magen, Elena Canidio, Massimiliano Pagani, Ivana Peluso, Nathalie Lin-Marq, Muriel Koch, Marchesa Bilio, Immacolata Cantiello, Roberta Verde, Cristian De Masi, Salvatore A. Bianchi, Juliette Cicchini, Elodie Perroud, Shprese Mehmeti, Emilie Dagand, Sabine Schrinner, Asja Nürnberger, Katja Schmidt, Katja Metz, Christina Zwingmann, Norbert Brieske, Cindy Springer, Ana Martinez Hernandez, Sarah Herzog, Frauke Grabbe, Cornelia Sieverding, Barbara Fischer, Kathrin Schrader, Maren Brockmeyer, Sarah Dettmer, Christin Helbig, Violaine Alunni, Marie-Annick Battaini, Carole Mura, Charlotte N. Henrichsen, Raquel Garcia-Lopez, Diego Echevarria, Eduardo Puelles, Elena Garcia-Calero, Stefan Kruse, Markus Uhr, Christine Kauck, Guangjie Feng, Nestor Milyaev, Chuang Kee Ong, Lalit Kumar, MeiSze Lam, Colin A. Semple, Attila Gyenesei, Stefan Mundlos, Uwe Radelof, Hans Lehrach, Paolo Sarmientos, Alexandre Reymond, Duncan R. Davidson, Pascal Dollé, Stylianos E. Antonarakis, Marie-Laure Yaspo, Salvador Martinez, Richard A. Baldock, Gregor Eichele, Andrea Ballabio

PLoS Biol. 2011 Jan; 9(1): e1000582. Published online 2011 Jan 18. doi: 10.1371/journal.pbio.1000582

PMCID:: PMC3022534

Abstract Article PDF–3.8M

Select item 289506818.

Population robustness arising from cellular heterogeneity

Pawel Paszek, Sheila Ryan, Louise Ashall, Kate Sillitoe, Claire V. Harper, David G. Spiller, David A. Rand, Michael R. H. White

Proc Natl Acad Sci U S A. 2010 Jun 22; 107(25): 11644–11649. Published online 2010 Jun 7. doi: 10.1073/pnas.0913798107

PMCID:: PMC2895068

Abstract Article PDF–966K

Select item 267370819.

A homeostatic model of IκB metabolism to control constitutive NF-κB activity

Ellen L O'Dea, Derren Barken, Raechel Q Peralta, Kim T Tran, Shannon L Werner, Jeffrey D Kearns, Andre Levchenko, Alexander Hoffmann

Mol Syst Biol. 2007; 3: 111. Published online 2007 May 8. doi: 10.1038/msb4100148

PMCID:: PMC2673708

Abstract Article PDF–216K

Select item 141356820.

BGEM: An In Situ Hybridization Database of Gene Expression in the Embryonic and Adult Mouse Nervous System

Susan Magdaleno, Patricia Jensen, Craig L Brumwell, Anna Seal, Karen Lehman, Andrew Asbury, Tony Cheung, Tommie Cornelius, Diana M Batten, Christopher Eden, Shannon M Norland, Dennis S Rice, Nilesh Dosooye, Sundeep Shakya, Perdeep Mehta, Tom Curran

PLoS Biol. 2006 Apr; 4(4): e86. Published online 2006 Mar 28. doi: 10.1371/journal.pbio.0040086

PMCID:: PMC1413568

Article PDF–99K

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