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Select item 99429161.

HER2-driven breast cancer suppression by the JNK signaling pathway

Zeynep Itah, Shanzah Chaudhry, Sithara Raju Ponny, Ozkan Aydemir, Alexandra Lee, Julie Cavanagh-Kyros, Cathy Tournier, William J. Muller, Roger J. Davis

Proc Natl Acad Sci U S A. 2023 Jan 24; 120(4): e2218373120. Published online 2023 Jan 19. doi: 10.1073/pnas.2218373120

PMCID:: PMC9942916

Abstract Article PDF–5.9M

Select item 84317452.

Mitogen Kinase Kinase (MKK7) Controls Cytokine Production In Vitro and In Vivo in Mice

Amada D. Caliz, Hyung-Jin Yoo, Anastassiia Vertii, Ana C. Dolan, Cathy Tournier, Roger J. Davis, John F. Keaney, Jr., Shashi Kant

Int J Mol Sci. 2021 Sep; 22(17): 9364. Published online 2021 Aug 29. doi: 10.3390/ijms22179364

PMCID:: PMC8431745

Abstract Article PDF–1.9M

Select item 84305063.

Dual Mkk4 and Mkk7 Gene Deletion in Adult Mouse Causes an Impairment of Hippocampal Immature Granule Cells

Rubén Darío Castro-Torres, Jordi Olloquequi, Miren Etchetto, Pablo Caruana, Luke Steele, Kyra-Mae Leighton, Jesús Ureña, Carlos Beas-Zarate, Antoni Camins, Ester Verdaguer, Carme Auladell

Int J Mol Sci. 2021 Sep; 22(17): 9545. Published online 2021 Sep 2. doi: 10.3390/ijms22179545

PMCID:: PMC8430506

Abstract Article PDF–27M

Select item 82474224.

The role of MKK4 in T‐cell development and immunity to viral infections

Simon P Preston, Marcel Doerflinger, Hamish W Scott, Cody C Allison, Miles Horton, James Cooney, Marc Pellegrini

Immunol Cell Biol. 2021 Apr; 99(4): 428–435. Published online 2020 Dec 8. doi: 10.1111/imcb.12426

PMCID:: PMC8247422

Abstract Article PDF–525K

Select item 79387705.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 74022916.

Dual Leucine Zipper Kinase Is Constitutively Active in the Adult Mouse Brain and Has Both Stress-Induced and Homeostatic Functions

Sunil Goodwani, Celia Fernandez, Paul J. Acton, Virginie Buggia-Prevot, Morgan L. McReynolds, Jiacheng Ma, Cheng Hui Hu, Mary E. Hamby, Yongying Jiang, Kang Le, Michael J. Soth, Philip Jones, William J. Ray

Int J Mol Sci. 2020 Jul; 21(14): 4849. Published online 2020 Jul 9. doi: 10.3390/ijms21144849

PMCID:: PMC7402291

Abstract Article PDF–4.2M

Select item 66333087.

Stress-Activated Protein Kinase MKK7 Regulates Axon Elongation in the Developing Cerebral Cortex

Tokiwa Yamasaki, Hiroshi Kawasaki, Satoko Arakawa, Kimiko Shimizu, Shigeomi Shimizu, Orly Reiner, Hideyuki Okano, Sachiko Nishina, Noriyuki Azuma, Josef M. Penninger, Toshiaki Katada, Hiroshi Nishina

J Neurosci. 2011 Nov 16; 31(46): 16872–16883. doi: 10.1523/JNEUROSCI.1111-11.2011

PMCID:: PMC6633308

Abstract Article PDF–4.7M

Select item 66238498.

The Loss of c-Jun N-Terminal Protein Kinase Activity Prevents the Amyloidogenic Cleavage of Amyloid Precursor Protein and the Formation of Amyloid Plaques In Vivo

Sonia Mazzitelli, Ping Xu, Isidre Ferrer, Roger J. Davis, Cathy Tournier

J Neurosci. 2011 Nov 23; 31(47): 16969–16976. doi: 10.1523/JNEUROSCI.4491-11.2011

PMCID:: PMC6623849

Abstract Article PDF–1.3M

Select item 62037459.

Mkk4 and Mkk7 are important for retinal development and axonal injury-induced retinal ganglion cell death

Stephanie B. Syc-Mazurek, Rebecca L. Rausch, Kimberly A. Fernandes, Michael P. Wilson, Richard T. Libby

Cell Death Dis. 2018 Nov; 9(11): 1095. Published online 2018 Oct 26. doi: 10.1038/s41419-018-1079-7

Correction in:: Cell Death Dis. 2019 Feb; 10(2): 64.

PMCID:: PMC6203745

Abstract Article PDF–3.8M

Select item 564508210.

Spatio-temporal profile of postynaptic interactomes integrates components of complex brain disorders

Jing Li, Wangshu Zhang, Hui Yang, Daniel P. Howrigan, Brent Wilkinson, Tade Souaiaia, Oleg V. Evgrafov, Giulio Genovese, Veronica A. Clementel, Jennifer C. Tudor, Ted Abel, James A. Knowles, Benjamin M. Neale, Kai Wang, Fengzhu Sun, Marcelo P. Coba

Nat Neurosci. Author manuscript; available in PMC 2018 Aug 1.

Published in final edited form as: Nat Neurosci. 2017 Aug; 20(8): 1150–1161. Published online 2017 Jun 26. doi: 10.1038/nn.4594

PMCID:: PMC5645082

Abstract Article PDF–2.3M

Select item 558457511.

The role of MAP2 kinases and p38 kinase in acute murine liver injury models

Jun Zhang, Robert W M Min, Khanh Le, Sheng Zhou, Mariam Aghajan, Tin A Than, Sanda Win, Neil Kaplowitz

Cell Death Dis. 2017 Jun; 8(6): e2903. Published online 2017 Jun 29. doi: 10.1038/cddis.2017.295

PMCID:: PMC5584575

Abstract Article PDF–1.7M

Select item 555355512.

Enhanced functional genomic screening identifies novel mediators of dual leucine zipper kinase-dependent injury signaling in neurons

Derek S. Welsbie, Katherine L. Mitchell, Vinod Ranganathan, Valentin M. Sluch, Zhiyong Yang, Jessica Kim, Eugen Buehler, Amit Patel, Scott E. Martin, Ping-Wu Zhang, Yan Ge, Yukan Duan, John Fuller, Byung-Jin Kim, Eman Hamed, Xitiz Chamling, Lei Lei, Iain D.C. Fraser, Ze’ev A. Ronai, Cynthia A. Berlinicke, Donald J. Zack

Neuron. Author manuscript; available in PMC 2018 Jun 21.

Published in final edited form as: Neuron. 2017 Jun 21; 94(6): 1142–1154.e6. doi: 10.1016/j.neuron.2017.06.008

PMCID:: PMC5553555

Abstract Article PDF–959K

Select item 479434313.

Fibroblast growth factor 21 mediates glycemic regulation by hepatic JNK

Santiago Vernia, Julie Cavanagh-Kyros, Tamera Barrett, Cathy Tournier, Roger J. Davis

Cell Rep. Author manuscript; available in PMC 2016 Mar 16.

Published in final edited form as: Cell Rep. 2016 Mar 15; 14(10): 2273–2280. Published online 2016 Mar 3. doi: 10.1016/j.celrep.2016.02.026

PMCID:: PMC4794343

Abstract Article PDF–1.5M

Select item 420011114.

ZPK/DLK and MKK4 Form the Critical Gateway to Axotomy-Induced Motoneuron Death in Neonates

Takayuki Itoh, Makoto Horiuchi, Raymond H. Ikeda, Jr, Jie Xu, Peter Bannerman, David Pleasure, Josef M. Penninger, Cathy Tournier, Aki Itoh

J Neurosci. 2014 Aug 6; 34(32): 10729–10742. doi: 10.1523/JNEUROSCI.0539-14.2014

PMCID:: PMC4200111

Abstract Article PDF–11M

Select item 418750815.

Mkk4 Is a Negative Regulator of the Transforming Growth Factor Beta 1 Signaling Associated With Atrial Remodeling and Arrhythmogenesis With Age

Laura Davies, Jiawei Jin, Weijin Shen, Hoyee Tsui, Ying Shi, Yanwen Wang, Yanmin Zhang, Guoliang Hao, Jingjing Wu, Si Chen, James A. Fraser, Nianguo Dong, Vincent Christoffels, Ursula Ravens, Christopher L.‐H. Huang, Henggui Zhang, Elizabeth J. Cartwright, Xin Wang, Ming Lei

J Am Heart Assoc. 2014 Apr; 3(2): e000340. Published online 2014 Apr 25. doi: 10.1161/JAHA.113.000340

PMCID:: PMC4187508

Abstract Article PDF–1.5M

Select item 414389516.

miR-92a inhibits vascular smooth muscle cell apoptosis: role of the MKK4–JNK pathway

Lan Zhang, Mi Zhou, Yingjie Wang, Weibin Huang, Gangjian Qin, Neal L. Weintraub, Yaoliang Tang

Apoptosis. Author manuscript; available in PMC 2014 Aug 26.

Published in final edited form as: Apoptosis. 2014 Jun; 19(6): 975–983. doi: 10.1007/s10495-014-0987-y

PMCID:: PMC4143895

Abstract Article PDF–1.7M

Select item 405831417.

Impaired JNK signaling cooperates with Kras^G12D expression to accelerate pancreatic ductal adenocarcinoma

Clare C. Davies, Emma Harvey, Raymond F.T. McMahon, Katherine G. Finegan, Frances Connor, Roger J. Davis, David A. Tuveson, Cathy Tournier

Cancer Res. Author manuscript; available in PMC 2014 Dec 15.

Published in final edited form as: Cancer Res. 2014 Jun 15; 74(12): 3344–3356. Published online 2014 Apr 8. doi: 10.1158/0008-5472.CAN-13-2941

PMCID:: PMC4058314

Abstract Article PDF–4.7M

Select item 359783218.

MicroRNA-92a Negatively Regulates Toll-like Receptor (TLR)-triggered Inflammatory Response in Macrophages by Targeting MKK4 Kinase

Lihua Lai, Yinjing Song, Yang Liu, Qingyun Chen, Quan Han, Weilin Chen, Ting Pan, Yuanyuan Zhang, Xuetao Cao, Qingqing Wang

J Biol Chem. 2013 Mar 15; 288(11): 7956–7967. Published online 2013 Jan 25. doi: 10.1074/jbc.M112.445429

PMCID:: PMC3597832

Abstract Article PDF–3.6M

Select item 346571319.

MKK4 Suppresses Metastatic Colonization by Multiple Highly Metastatic Prostate Cancer Cell Lines Through a Transient Impairment in Cell Cycle Progression

Russell Z Szmulewitz, Robert Clark, Tamara Lotan, Kristen Otto, Jennifer Taylor Veneris, Kay Macleod, Carrie Rinker-Schaeffer

Int J Cancer. Author manuscript; available in PMC 2013 Feb 1.

Published in final edited form as: Int J Cancer. 2012 Feb 1; 130(3): 509–520. Published online 2011 Apr 25. doi: 10.1002/ijc.26005

PMCID:: PMC3465713

Abstract Article PDF–2.1M

Select item 340973220.

JNK and PTEN cooperatively control the development of invasive adenocarcinoma of the prostate

Anette Hübner, David J. Mulholland, Claire L. Standen, Maria Karasarides, Julie Cavanagh-Kyros, Tamera Barrett, Hongbo Chi, Dale L. Greiner, Cathy Tournier, Charles L. Sawyers, Richard A. Flavell, Hong Wu, Roger J. Davis

Proc Natl Acad Sci U S A. 2012 Jul 24; 109(30): 12046–12051. Published online 2012 Jul 2. doi: 10.1073/pnas.1209660109

PMCID:: PMC3409732

Abstract Article PDF–1.5M

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