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Select item 109298391.

Pan-cancer analysis of NUDT21 and its effect on the proliferation of human head and neck squamous cell carcinoma

Wenjing Liu, Yingna Pang, Xiaolu Yu, Doudou Lu, Yating Yang, Fandi Meng, Chengbi Xu, Ling Yuan, Yi Nan

Aging (Albany NY) 2024 Feb 28; 16(4): 3363–3385. Published online 2024 Feb 12. doi: 10.18632/aging.205539

PMCID:: PMC10929839

Abstract Article PDF–5.7M

Select item 108698002.

The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation

Christopher B. Nelson, Samuel Rogers, Kaushik Roychoudhury, Yaw Sing Tan, Caroline J. Atkinson, Alexander P. Sobinoff, Christopher G. Tomlinson, Anton Hsu, Robert Lu, Eloise Dray, Michelle Haber, Jamie I. Fletcher, Anthony J. Cesare, Rashmi S. Hegde, Hilda A. Pickett

Nat Commun. 2024; 15: 1385. Published online 2024 Feb 15. doi: 10.1038/s41467-024-45683-4

PMCID:: PMC10869800

Abstract Article PDF–9.3M

Select item 108452633.

Predictive Value of CFIm25 Expression in Peripheral Blood Monocytes for Coronary Atherosclerosis

Meng Liu, Xiaoxiao Chen, Zhan Gu, Hao He, Mingyue Chen, Lin Kuai, Zhiqiang Jia, Yi Li, Yizhou Chen, Mei Hong, Fangping Xiao

Int J Med Sci. 2024; 21(3): 562–570. Published online 2024 Jan 20. doi: 10.7150/ijms.91148

PMCID:: PMC10845263

Abstract Article PDF–1.8M

Select item 107999034.

Proteomic analysis of SARS-CoV-2 particles unveils a key role of G3BP proteins in viral assembly

Emilie Murigneux, Laurent Softic, Corentin Aubé, Carmen Grandi, Delphine Judith, Johanna Bruce, Morgane Le Gall, François Guillonneau, Alain Schmitt, Vincent Parissi, Clarisse Berlioz-Torrent, Laurent Meertens, Maike M. K. Hansen, Sarah Gallois-Montbrun

Nat Commun. 2024; 15: 640. Published online 2024 Jan 20. doi: 10.1038/s41467-024-44958-0

PMCID:: PMC10799903

Abstract Article PDF–25M

Select item 107875425.

Chromatin accessibility complex subunit 1 enhances tumor growth by regulating the oncogenic transcription of YAP in breast and cervical cancer

Shasha Li, Lulu Wang, Jing Shi, Yi Chen, Ang Xiao, Bingyue Huo, Wenjing Tian, Shilu Zhang, Gang Yang, Wensheng Gong, Huixia Zhang

PeerJ. 2024; 12: e16752. Published online 2024 Jan 10. doi: 10.7717/peerj.16752

PMCID:: PMC10787542

Abstract Article PDF–13M

Select item 107766986.

NUDT21 interacts with NDUFS2 to activate the PI3K/AKT pathway and promotes pancreatic cancer pathogenesis

Xiao-Dong Huang, Yong-Wei Chen, Lv Tian, Li Du, Xiao-Chen Cheng, Yu-Xin Lu, Dong-Dong Lin, Feng-Jun Xiao

J Cancer Res Clin Oncol. 2024; 150(1): 8. Published online 2024 Jan 9. doi: 10.1007/s00432-023-05540-1

PMCID:: PMC10776698

Abstract Article PDF–14M

Select item 106277867.

ESYT1 tethers the ER to mitochondria and is required for mitochondrial lipid and calcium homeostasis

Alexandre Janer, Jordan L Morris, Michiel Krols, Hana Antonicka, Mari J Aaltonen, Zhen-Yuan Lin, Hanish Anand, Anne-Claude Gingras, Julien Prudent, Eric A Shoubridge

Life Sci Alliance. 2024 Jan; 7(1): e202302335. Published online 2023 Nov 6. doi: 10.26508/lsa.202302335

PMCID:: PMC10627786

Abstract Article PDF–5.2M

Select item 105617248.

Alternative polyadenylation reprogramming of MORC2 induced by NUDT21 loss promotes KIRC carcinogenesis

Yuqin Tan, Tong Zheng, Zijun Su, Min Chen, Suxiang Chen, Rui Zhang, Ruojiao Wang, Ke Li, Ning Na

JCI Insight. 2023 Sep 22; 8(18): e162893. Published online 2023 Sep 22. doi: 10.1172/jci.insight.162893

PMCID:: PMC10561724

Abstract Article PDF–14M

Select item 104037309.

PABPN1 aggregation is driven by Ala expansion and poly(A)-RNA binding, leading to CFIm25 sequestration that impairs alternative polyadenylation

Wen-Liang Guan, Lei-Lei Jiang, Xiao-Fang Yin, Hong-Yu Hu

J Biol Chem. 2023 Aug; 299(8): 105019. Published online 2023 Jul 7. doi: 10.1016/j.jbc.2023.105019

PMCID:: PMC10403730

Abstract Article PDF–4.6M

Select item 1032596010.

Formation of nuclear CPSF6/CPSF5 biomolecular condensates upon HIV-1 entry into the nucleus is important for productive infection

Charlotte Luchsinger, KyeongEun Lee, Gonzalo A. Mardones, Vineet N. KewalRamani, Felipe Diaz-Griffero

Sci Rep. 2023; 13: 10974. Published online 2023 Jul 6. doi: 10.1038/s41598-023-37364-x

PMCID:: PMC10325960

Abstract Article PDF–7.1M

Select item 1023742211.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 997863512.

Fibril treatment changes protein interactions of tau and α-synuclein in human neurons

Tagan A. Griffin, Paul D. Schnier, Elisa M. Cleveland, Robert W. Newberry, Julia Becker, George A. Carlson

J Biol Chem. 2023 Mar; 299(3): 102888. Published online 2023 Jan 10. doi: 10.1016/j.jbc.2023.102888

PMCID:: PMC9978635

Abstract Article PDF–10M

Select item 995044713.

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma

Yu-Fei Cao, Lei Xie, Bei-Bei Tong, Man-Yu Chu, Wen-Qi Shi, Xiang Li, Jian-Zhong He, Shao-Hong Wang, Zhi-Yong Wu, Dan-Xia Deng, Ya-Qi Zheng, Zhi-Mao Li, Xiu-E Xu, Lian-Di Liao, Yin-Wei Cheng, Li-Yan Li, Li-Yan Xu, En-Min Li

Cell Death Differ. 2023 Feb; 30(2): 527–543. Published online 2022 Dec 16. doi: 10.1038/s41418-022-01104-x

PMCID:: PMC9950447

Abstract Article PDF–8.4M

Select item 992561414.

The emerging roles of CFIm25 (NUDT21/CPSF5) in human biology and disease

Chioniso Patience Masamha

Wiley Interdiscip Rev RNA. Author manuscript; available in PMC 2024 May 1.

Published in final edited form as: Wiley Interdiscip Rev RNA. 2023 May-Jun; 14(3): e1757. Published online 2022 Aug 14. doi: 10.1002/wrna.1757

PMCID:: PMC9925614

Abstract Article PDF–1.0M

Select item 979798815.

TBK1 posphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1

Jianwen Zhou, Nikoline Lander Rasmussen, Hallvard Lauritz Olsvik, Vyacheslav Akimov, Zehan Hu, Gry Evjen, Stéphanie Kaeser-Pebernard, Devanarayanan Siva Sankar, Carole Roubaty, Pauline Verlhac, Nicole van de Beek, Fulvio Reggiori, Yakubu Princely Abudu, Blagoy Blagoev, Trond Lamark, Terje Johansen, Jörn Dengjel

J Cell Biol. 2023 Feb 6; 222(2): e202108144. Published online 2022 Dec 27. doi: 10.1083/jcb.202108144

PMCID:: PMC9797988

Abstract Article PDF–6.9M

Select item 977255816.

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation

Jingsheng Yuan, Tao Lv, Jian Yang, Zhenru Wu, Lvnan Yan, Jiayin Yang, Yujun Shi, Li Jiang

Cell Mol Gastroenterol Hepatol. 2023; 15(2): 307–325. Published online 2022 Oct 14. doi: 10.1016/j.jcmgh.2022.10.005

PMCID:: PMC9772558

Abstract Article PDF–8.2M

Select item 970808617.

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers

Martina Oravcová, Minghua Nie, Nicola Zilio, Shintaro Maeda, Yasaman Jami-Alahmadi, Eros Lazzerini-Denchi, James A Wohlschlegel, Helle D Ulrich, Takanori Otomo, Michael N Boddy

eLife. 2022; 11: e79676. Published online 2022 Nov 14. doi: 10.7554/eLife.79676

PMCID:: PMC9708086

Abstract Article PDF–8.5M

Select item 966294518.

Interactome of Aiolos/Ikaros Reveals Combination Rationale of Cereblon Modulators with HDAC Inhibitors in DLBCL

Patrick R. Hagner, Hsiling Chiu, Vivek S. Chopra, Martino Colombo, Nisha Patel, Maria Ortiz Estevez, Michelle F. Waldman, Remco Loos, Fadi Towfic, Anita K. Gandhi

Clin Cancer Res. 2022 Aug 2; 28(15): 3367–3377. Published online 2022 May 18. doi: 10.1158/1078-0432.CCR-21-3347

PMCID:: PMC9662945

Abstract Article PDF–1.6M

Select item 961150619.

NUDT21 limits CD19 levels through alternative mRNA polyadenylation in B cell acute lymphoblastic leukemia

Matthew T. Witkowski, Soobeom Lee, Eric Wang, Anna K. Lee, Alexis Talbot, Chao Ma, Nikolaos Tsopoulidis, Justin Brumbaugh, Yaqi Zhao, Kathryn G. Roberts, Simon J. Hogg, Sofia Nomikou, Yohana Ghebrechristos, Palaniraja Thandapani, Charles G. Mullighan, Konrad Hochedlinger, Weiqiang Chen, Omar Abdel-Wahab, Justin Eyquem, Iannis Aifantis

Nat Immunol. Author manuscript; available in PMC 2023 Apr 1.

Published in final edited form as: Nat Immunol. 2022 Oct; 23(10): 1424–1432. Published online 2022 Sep 22. doi: 10.1038/s41590-022-01314-y

PMCID:: PMC9611506

Abstract Article PDF–5.2M

Select item 958489420.

Role of the E3 ubiquitin-ligase Hakai in intestinal inflammation and cancer bowel disease

Daniel Roca-Lema, Macarena Quiroga, Vineeta Khare, Andrea Díaz-Díaz, Aida Barreiro-Alonso, Andrea Rodríguez-Alonso, Ángel Concha, Gabriela Romay, M. Esperanza Cerdán, Christoph Gasche, Angélica Figueroa

Sci Rep. 2022; 12: 17571. Published online 2022 Oct 20. doi: 10.1038/s41598-022-22295-w

PMCID:: PMC9584894

Abstract Article PDF–2.5M

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PMC Links for GEO Profiles (Select 36713263) (141)
PMC
RBBP9 RB binding protein 9, serine hydrolase [Homo sapiens]
RBBP9 RB binding protein 9, serine hydrolase [Homo sapiens]
Gene ID:10741

Gene
NUDT21 nudix hydrolase 21 [Homo sapiens]
NUDT21 nudix hydrolase 21 [Homo sapiens]
Gene ID:11051

Gene
Gene Links for GEO Profiles (Select 36713263) (1)
Gene
Homo sapiens mRNA for hypothetical protein (ORF1), clone vir17
Homo sapiens mRNA for hypothetical protein (ORF1), clone vir17
gi|16580687|emb|AJ301562.1|

Nucleotide

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